Clinical trials: Exposure
Chronic Pain, Neuralgia
GET Living: Graded Exposure Treatment for Children and Adolescents With Chronic Pain
The broad aim of the study is to implement and evaluate the efficacy of Graded Exposure Treatment (GET Living) to target elevated pain-related fears in children with chronic pain.
- Conditions
- Chronic Pain, Neuralgia, Musculoskeletal Pain, Headache
- Trial name
- GET Living (NCT01974791)
- Testing
- GET Living
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Boston Children's Hospital
Dental Caries, Pulp Exposure, Dental
Comparative Clinical and Radiographic Evaluation of Different Pulpotomy Materials in Primary Molars
This randomized clinical trial compared the clinical and radiographic outcomes of ferric sulfate (FS), mineral trioxide aggregate (MTA), calcium-enriched mixture (CEM), and TheraCal PT used for pulpotomy in primary molars.
- Conditions
- Dental Caries, Pulp Exposure, Dental, Primary Teeth, Primary Molar Pulpotomy
- Trial name
- NCT07769697
- Testing
- Pulpotomy, Mineral Trioxide Aggregate (MTA), Calcium-Enriched Mixture (CEM)
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Inonu University
Inflammation, Normal Controls
Natural History of the Human Biological Response to Environmental Exposure and Injury
Background: Environmental exposures like pollution, diet, and stress can help cause human diseases, or make them worse. Researchers want to better understand how injury and inflammation are caused by these exposures.
- Conditions
- Inflammation, Normal Controls, Metabolic Disease
- Trial name
- NCT04888923
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Type 1 Diabetes
A Study to Compare Pharmacokinetics and Pharmacodynamics of SAR342434 to Insulin Lispro in Subjects With Type 1 Diabetes
Primary Objective: To compare exposure and activity of SAR342434 to US-approved and EU-approved Humalog®. Secondary Objective: To assess the safety and tolerability of SAR342434.
- Trial name
- NCT02273258
- Testing
- SAR342434, Insulin Lispro
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Sanofi
Environmental Exposure
Pilot Study to Assess the Quantitative Dermal Transfer Efficiencies of Solids for Multiple Transfer Pathways
Dermal transfer efficiency has been defined as the amount of material that moves from one surface to another following contact. The investigators propose to measure dermal transfer efficiency for the following pathways: (1)…
- Trial name
- NCT02529748
- Testing
- Participants for Surface Skin Sampling, Elemental metallic lead, Tinopal
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
SARS-CoV Infection, Covid19
International Registry of Healthcare Workers Exposed to COVID-19 Patients (UNITY Global)
The International Registry of Healthcare Workers Exposed to COVID-19 Patients (UNITY Global), is an international registry of approximately 10,000 healthcare workers in low- and middle-income countries experiencing increasing…
- Trial name
- NCT04626076
- Testing
- Comparative Observational Cohort Study
- Where
- Pakistan
- Volunteers
- 6,808 people, healthy volunteers welcome
- Sponsor
- Certara
Complex Regional Pain Syndrome Type I
Graded Exposure (GEXP) in Vivo Versus Physiotherapy in Complex Regional Pain Syndrome Type I (CRPS-I)
Background: Research on the treatment of CRPS-I, as described in the Dutch evidence based treatment guidelines (Richtlijn Complex Regional Pain Syndrome type I, 2006), mainly showed improvement at the level of pain and coping…
- Trial name
- NCT00625976
- Testing
- Graded exposure in vivo, Physiotherapy
- Volunteers
- 46 people
- Sponsor
- Maastricht University Medical Center
HIV Infection, Prep Prescription
Sexual Risks in Prep Users
Primary purpose of the study: to describe sexual behavior of Prep users, whatever mode of intake, ie continuous or on-demand; it has been shown in some studies, an increase of sexual risks in Prep users, and therefore an similar…
- Conditions
- HIV Infection, Prep Prescription, Vaccinations, Sexually Transmitted Diseases
- Trial name
- PREP (NCT03975517)
- Testing
- PrEP
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Rabies
Safety and Immunogenicity of Purified Verocell Rabies Vaccine PVRV Administered Intramuscularly and Intradermally
Rabies is fatal disease but preventable with rabies vaccines and immunoglobulins, conventionally involves intramuscular (IM) administration of the vaccine.
- Trial name
- NCT06433440
- Testing
- PVRV
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- University of Peshawar
Abuse Tobacco, Exposure
Perceptions of Vaping Products
This clinical trial studies the effects, appeal, and abuse liability of 6-methyl nicotine (metatine) electronic cigarettes among young adults.
- Trial name
- NCT06868368
- Testing
- Biospecimen Collection, Survey Administration, Vaping Topography
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Rhinitis, Allergic, Asthma
Animal Allergy in Korean Veterinary Researcher
The investigators will evaluate sensitization to animal allergens and allergic symptom during contacting animal allergens in Korean veterinary researchers who attend their annual conference.
- Conditions
- Rhinitis, Allergic, Asthma, Dermatitis, Atopic, Urticaria
- Trial name
- NCT02866864
- Testing
- Animal allergy +, Animal allergy -
- Where
- South Korea
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Gachon University Gil Medical Center
Anxiety
Integrative Medicine for Hospital Workers Exposed to War
During the "Iron Swords" war in Israel in 2023, the residents of the Gaza Strip and the surrounding area, along with the soldiers of the security service, were exposed to a very high intensity of trauma.
- Trial name
- NCT06190964
- Testing
- Integrative medicine
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Bnai Zion Medical Center
Diabetic Kidney Disease, Chronic Kidney Disease
Long-Term Follow-up Study of Participants Exposed to Renal Autologous Cell Therapy Frozen Product
The purpose of this study is to evaluate the long-term safety, efficacy, and durability in participants with chronic kidney disease (CKD) who received up to four REACT injections, delivered percutaneously into either the same or…
- Trial name
- NCT06790498
- Testing
- Renal Autologous Cell Therapy (REACT)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Prokidney
Obesity, Obesity, Abdominal
Environmental Temperature and Human White Adipose Tissue
Obesity is characterized by excessive white adipose tissue (WAT) that increases risk for disease. About 700 million adults are obese worldwide, designating the need of reducing excessive WAT in humans and subsequently the risk…
- Conditions
- Obesity, Obesity, Abdominal, Obese
- Trial name
- NCT04037371
- Testing
- Cold exposure
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Petros Dinas
Meningococcal Infections
Investigating the Immunogenicity of a U.S.-Licensed Meningococcal Serogroup B Vaccine (Trumenba)
This study will investigate the breadth of protection against meningococcal disease in humans immunized with a newly FDA approved meningococcal B vaccine, trade name "Trumenba®" manufactured by Pfizer Vaccines.
- Trial name
- NCT02569632
- Testing
- Trumenba Vaccine (Wyeth/Pfizer Pharmaceuticals)
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Healthy Volunteer
Following of Atmospheric Pollution Exposure During Pregnancy and Effects on Health
The SEPAGES couple-child cohort is coordinated by an Inserm (French National Institute of Health and Medical Research) team of environmental epidemiology.
- Trial name
- SEPAGES-1337 (NCT02852499)
- Testing
- Urine sampling, Carry a GPS and BET, Carry pollution sensor
- Where
- France
- Volunteers
- 1,010 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Auditory Hallucinations
CHALLENGE. A Randomised Clinical Trial Examining Virtual Reality Therapy
The study is a randomised, assessor-blinded parallel-groups superiority clinical trial, allocating a total of 266 patients to either the experimental intervention or standard intervention.
- Trial name
- NCT04661163
- Testing
- Psychotherapy
- Where
- Denmark
- Volunteers
- 270 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Seasonal Allergic Rhinitis
This Study Contains an Active Drug Treatment Group With Mometasone Furoate Nasal Spray and a Placebo (Dummy) Treatment Group for Seasonal Allergic Rhinitis (SAR). (Study P05073)(COMPLETED)
The purpose of this study is to evaluate how well mometasone furoate nasal spray (MFNS) works to relieve SAR symptoms compared to Placebo when symptoms are induced in a chamber setting.
- Trial name
- NCT00491504
- Testing
- Mometasone Furoate Nasal Spray
- Volunteers
- 310 people
- Sponsor
- Organon and Co
Hoarding Disorder
Cognitive Rehab and Exposure Treatment for Hoarding
This project will utilize a novel behavioral intervention for hoarding disorder that takes into account age and neurocognitive factors.
- Trial name
- CREST (NCT02402647)
- Testing
- Cognitive Rehabilitation and Exposure/Sorting Treatment (CREST), Exposure Therapy (ET)
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Tobacco Use Disorder
Effect of Smoking Exposure on Smoking Relapse Following Brief Abstinence - 2
Recent research on the effects of nicotine on the brain and behavior presents an opportunity to advance medication development. The purpose of this study is to develop a laboratory model for early-stage testing of new and…
- Trial name
- NCT00136838
- Testing
- Neutral or active cigarette cues
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- New York State Psychiatric Institute