Clinical trials: Exposure, open to volunteers
Glioblastoma
Key Longitudinal Associations With Risk and Glioblastoma Outcomes
The goal of this observational study is to find out what factors affect the health and risks in adults with glioblastoma (GBM), a grade 4 brain cancer.
- Trial name
- Key LARGO (NCT06625684)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Duke University
Acute Myeloid Leukemia
Tagraxofusp and Azacitidine With Venetoclax in Newly Diagnosed Secondary AML After Hypomethylating Agents
A treatment cycle is 28 days. Tagraxofusp will be administered at 9 mcg/kg IV over 15 minutes (-5 or +15 minutes) daily for 3 consecutive days (or 3 doses over a period not to exceed 10 days if postponement is required to allow…
- Trial name
- TAGALONG (NCT05442216)
- Testing
- Tagraxofusp, Azacitidine, Venetoclax
- Where
- 7 sites in United States
- Volunteers
- 53 people
- Sponsor
- Joshua Zeidner
Fibromyalgia
Objective Measurement of Pain Regulation in Individuals Who Have Received Internet-delivered Exposure-based Cognitive Behavior Therapy
Fibromyalgia: a common problem that requires treatment Fibromyalgia (FM) is a highly prevalent pain syndrome characterized by generalized pain and fatigue, often leading to extensive somatic and psychological distress.
- Trial name
- NCT07054333
- Testing
- Internet-delivered exposure-based cognitive behavior therapy
- Where
- 2 sites in Sweden
- Volunteers
- 50 people
- Sponsor
- Karolinska Institutet
Blood Injury Phobia, Injection Fear
Exposure-Based CBT for Youth With Blood and Injection Phobia and Chronic Illness
More than half of all children fear needles, and hospitalized children often describe injections as the most frightening part of medical care.
- Trial name
- NCT07125287
- Testing
- Exposure based CBT
- Volunteers
- 30 people
- Sponsor
- Region Stockholm
Chronic Neck Pain, Radicular Pain
Reliability of MRI and Ultrasound in Cervical Epidural Needle Depth Estimation
This study aims to evaluate the reliability of magnetic resonance imaging (MRI) and ultrasound (USG) in predicting needle depth during cervical epidural injections, compared to fluoroscopy.
- Conditions
- Chronic Neck Pain, Radicular Pain, Cervical Epidural Injection
- Trial name
- CERV-MRI-USG (NCT06747663)
- Testing
- Needle Depth Measurement Using MRI, Ultrasound, and Fluoroscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Damla Yürük
Multiple Sclerosis, Progressive Multifocal Leukoencephalopathy
Risk of Progressive Multifocal Leukoencephalopathy Among Patients With Multiple Sclerosis Exposed to Zeposia
This study will evaluate the risk of progressive multifocal leukoencephalopathy (PML), a rare brain infection caused by John Cunningham virus (JCV), among people with multiple sclerosis who have been treated with ozanimod.
- Trial name
- NCT07732907
- Testing
- Ozanimod
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Bristol-Myers Squibb
Difficult Airway, Intubation, Intratracheal
Correlation Between Bedside Anatomical Indicators and Lifting Force and Glottic Exposure Under Different Video Laryngoscopy Techniques
This single-center prospective observational study plans to enroll 196 patients undergoing elective general anesthesia. The study aims to investigate the correlation between preoperative bedside anatomical indicators (including…
- Trial name
- NCT07846748
- Testing
- Direct Epiglottis Elevation (Subepiglottic Method)
- Volunteers
- 200 people
- Sponsor
- Second Hospital of Shanxi Medical University
TCE-RRMM
ASPIRE: A Registry Study Of Chinese Patients With TCE-RRMM Treated By Elranatamab
This registry study will provide valuable evidence to assess and validate its effectiveness in the Chinese MM population, refine clinical application strategies, and support the optimization of BCMA BsAbs use in MM treatment in…
- Trial name
- ASPIRE (NCT07320326)
- Testing
- Elranatamab
- Where
- China
- Volunteers
- 159 people
- Sponsor
- Peking University People's Hospital
Sjogren's Syndrome, Sjögren
R-2487 in Patients With Sjogren's Syndrome (SS)
The goal of this study is to determine the safety and tolerability of orally taken probiotic (R-2487) in patients with Sjogren's Syndrome.
- Conditions
- Sjogren's Syndrome, Sjögren, Sjögren Syndrome, Unspecified
- Trial name
- R-2487-SS-01 (NCT06297213)
- Testing
- R-2487
- Volunteers
- 36 people
- Sponsor
- Rise Therapeutics LLC
Post-traumatic Stress Disorder (PTSD), Intrusive Memories of Traumatic Event(s)
Tetris Intervention Following Subliminal Reactivation for Intrusive Memories
Intrusive memories of traumatic events are a core feature of Post-Traumatic Stress Disorder (PTSD) and can cause substantial distress and functional impairment.
- Trial name
- NCT07495917
- Testing
- Subliminal Reactivation Followed by Visuospatial Interference, Computer-based Visuospatial Task (Tetris)
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Shaanxi Normal University
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Anal Cancer, Squamous Intraepithelial Lesions
Screening for Anal Cancer in Men Who Have Sex With Men Using Pre-Exposure Prophylaxis
This study aims to learn more about anal cancer risk in men who have sex with men (MSM) who are using Pre-Exposure Prophylaxis (PrEP) to prevent HIV.
- Conditions
- Anal Cancer, Squamous Intraepithelial Lesions, HSIL, High Grade Squamous Intraepithelial Lesions, LSIL, Low-Grade Squamous Intraepithelial Lesions
- Trial name
- SCOPE (NCT07029152)
- Testing
- Anal smear, Self-administered questionnaire, EQ-5D-5L questionnaire
- Where
- 8 sites in Belgium
- Volunteers
- 296 people
- Sponsor
- Universitair Ziekenhuis Brussel
Obsessive Compulsive Disorder (OCD), Comorbid Post-Traumatic Stress Disorder and OCD
ERP to Improve Functioning in Veterans With OCD
Obsessive compulsive disorder (OCD) is a debilitating psychiatric illness impacting work, social, and family functioning. Exposure and Response Prevention (ERP) is the sole evidence-based psychotherapy for OCD; however, no…
- Trial name
- NCT05240924
- Testing
- Exposure and Response Prevention, Stress Management Training
- Where
- 19 sites in United States
- Volunteers
- 160 people
- Sponsor
- VA Office of Research and Development
Major Depressive Disorder in Patients Taking PrEP
Mental Health and PreP
According to ANSM, by June 2023, almost 85,000 people living in France had initiated medical monitoring for HIV PrEP since 2016.
- Trial name
- SAM-P (NCT06944691)
- Testing
- Major depressive disorder scale
- Volunteers
- 600 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Kidney Neoplasm
Impact of Chronic Renal Failure on Plasma Exposure of Kinase Inhibitors in Patients Treated for Metastatic Kidney Cancer
The study of the blood concentration of ITK what are pazopanib and cabozantinib at 1 month and 3 months from the start of treatment will allow to evaluate the impact of renal failure on their efficacy and toxicity in patients…
- Trial name
- IREKI (NCT04823923)
- Testing
- blood sampling for ITK dosage
- Where
- 5 sites in France
- Volunteers
- 60 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Open Burn Pit Exposure
DNA Methylation Markers in Veterans Exposed to Open Burn Pits
Background: The VA and DoD estimate that 3.5 million Veterans and Service Members were exposed to open burn pits used for waste disposal during military deployments to countries such as Kuwait, Afghanistan, and Iraq since 1990.
- Trial name
- NCT06305091
- Testing
- Health survey for physical and mental health comorbidities, epigenetic marker and heavy metals in blood and urine samples
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Central Arkansas Veterans Healthcare System
Mother-Child Relations, Substance Use
Optimizing Mental Health for Infants Exposed to Early Adversity: A Comparison of Breaking the Cycle and Maxxine Wright
The goal of this clinical trial is to compare the effectiveness of the Breaking the Cycle (BTC) and Maxxine Wright (MW) programs in substance-involved mothers and their children.
- Trial name
- NCT05768815
- Testing
- Breaking the Cycle Program, Maxxine Wright Program
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- University of Ottawa
Systemic Lupus Erythematosus
Anifrolumab Malignancy and Serious Infections Study
This is an observational study, in which the main research question is to evaluate the risk of malignancies and serious infections among moderate/severe SLE patients who receive anifrolumab compared with a comparable population…
- Trial name
- SIMA (NCT07000110)
- Testing
- Anifrolumab
- Where
- 4 sites in Denmark, France and 2 more
- Volunteers
- 3,506 people
- Sponsor
- AstraZeneca
HIV
Implementing Oral (Event-driven and Daily) and Long-acting Pre-Exposure Prophylaxis in Mobile Men in Sub-Saharan Africa
Title: Implementing oral (event-driven and daily) and long-acting Pre-exposure prophylaxis (PrEP) in mobile men in Sub-Saharan Africa Design: A mixed method, multi-setting, multi-country, phase 3b, open-label, hybrid type 2…
- Trial name
- MOBILEMEN (NCT06133686)
- Testing
- Tenofovir disoproxil fumarate/emtricitabine (TDF-FTC), cabotegravir (CAB-LA), Cabotegravir (CAB-LA), Tenofovir disoproxil fumarate/emtricitabine (TDF-FTC)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- MRC/UVRI and LSHTM Uganda Research Unit
Hyperacusis
Role of Exposure in Hyperacusis
This study focuses on patients with a primary complaint of hyperacusis. Hyperacusis has been defined as 'abnormally reduced tolerance to sound'.
- Trial name
- NCT04705246
- Testing
- Psychoeducation
- Volunteers
- 5 people
- Sponsor
- University Hospital, Antwerp