Clinical trials: Exposure Occupational
TB - Tuberculosis, Silicosis
KAP TB in Senior Management Officials of Companies With Increased Silica Exposure
The study was designed as a descriptive cross-sectional survey conducted between February and October 2022. Senior management officials were targeted because of their role in workplace policy and oversight.
- Conditions
- TB - Tuberculosis, Silicosis, Occupational Exposure, Occupational Health
- Trial name
- KAP TB (NCT07749872)
- Where
- Zambia
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
PFAS, Environmental Exposures
Use of Bile Acid Binding Resins to Decrease PFAS Levels Via Colesevalem in Veterans Study
The goal of this study is to test the efficacy and feasibility of Colesevelam administration (50% of the recommended dose) to reduce serum PFAS concentration in the Veteran population who have serum PFAS levels that exceed the…
- Conditions
- PFAS, Environmental Exposures, Occupational Exposure to Chemicals, Military Exposure
- Trial name
- PAVERS (NCT07592858)
- Testing
- Colesevelam
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
Health Professional
Underreporting of Occupational Blood Exposure (OBE) Among Medical Staff at an University Hospital Center (UHC) in 2017 (OBE PRACTITIONERS UHC 2017)
Regarding 30 to 50% of occupational blood exposure (OBE) are underreporting among health professionals, it's to highlight that the part of medical professionals in OBE reporting is among the lowest (1996 to 2016).
- Trial name
- NCT03424434
- Testing
- Survey diffusion
- Where
- 4 sites in France
- Volunteers
- 1,493 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Occupational Exposure
Reducing Chemical Exposures in Nail Salons
In this intervention study, the investigators engage Vietnamese American nail salon owners to train workers within their salons on how to reduce workplace chemical exposures.
- Trial name
- KHOEDEP (NCT03048630)
- Testing
- Education
- Where
- United States
- Volunteers
- 347 people, healthy volunteers welcome
- Sponsor
- Cancer Prevention Institute of California
Occupational Exposure, Genotoxicity
Biomonitoring of Occupationally Populations Exposed to Micro and Nanoplastic
The biomonitoring study aims to evaluate genotoxic damage and other parameters of exposure in different occupational exposed populations that work directly with different plastics.
- Conditions
- Occupational Exposure, Genotoxicity, Damage Dna
- Trial name
- NCT06323603
- Testing
- Micro and nanoplastic
- Where
- 4 sites in Finland, Spain
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ricard Marcos
HIV Prevention
Biktarvy for Non-Occupational Post-Exposure Prophylaxis (nPEP)
Study will evaluate the safety and tolerability of once daily Biktarvy for 28 days for prevention of HIV infection in HIV-1-seronegative adults after high-risk sexual contact. (non-occupational post exposure prophylaxis - nPEP)
- Trial name
- NCT03499483
- Testing
- bictegravir
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Fenway Community Health
Testicular Germ Cell Tumor
A Case-control Study to Assess the Association Between Environmental, Domestic and Occupational Exposures and the Risk of Testicular Germ Cell Tumor
The incidence of testicular germ cell tumors, the most common cancer in men aged 15 to 45 years, has doubled in France in 30 years.
- Trial name
- TESTIS (NCT02109926)
- Testing
- Phone interview and blood test
- Where
- 22 sites in France
- Volunteers
- 1,367 people, healthy volunteers welcome
- Sponsor
- Centre Leon Berard
Experimental
Human Study to Develop a Signature of Occupational Diesel Exhaust Exposure
Strong scientific understanding of how emissions from diesel engines impact the lungs could improve policies and regulations protecting workers exposed to diesel exhaust.
- Trial name
- DICE (NCT03234790)
- Testing
- Filtered Air Exposure, Diesel Exhaust Exposure
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Core Temperature, Heat Stress, Exertional
Initial Stay Times and Heat Mitigation Controls for Uncompensable Occupational Heat Stress - Part I
Workplaces rely on upper heat stress limits provided by the American Conference of Governmental Industrial Hygienists (ACGIH) to manage the health and safety of workers in hot environments.
- Conditions
- Core Temperature, Heat Stress, Exertional, Heat Fatigue, Exercise
- Trial name
- NCT05847712
- Testing
- Simulated work in the heat
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Radiation; Exposure Occupational, Coronary Interventions
Reduction of Catheterization Radiation Exposure Pad
The RECAP-trial is a randomized controlled, double blinded, superiority trial studying the efficacy of the RADPAD®, a protective drape, that potentially reduces the scattered radiation received by the operator during diagnostic…
- Trial name
- RECAP (NCT03139968)
- Where
- Netherlands
- Volunteers
- 766 people
- Sponsor
- J.P.S Henriques
Occupational Exposure
Occupational Exposure to Dust and the Relationship With the Respiratory Symptoms, Lung Function Among Construction Workers of the University of Malaysia Sabah (UMS)
Background The respiratory tract often becomes the site of injury from occupational exposure. All construction sites generate high levels of dust, typically from concrete, silica, asbestos, cement, wood, stone, sand and…
- Trial name
- NCT05226273
- Testing
- no intervention
- Where
- Malaysia
- Volunteers
- 152 people
- Sponsor
- Universiti Malaysia Sabah
Job Satisfaction, Bullying, Workplace
Mobbing Exposure and Job Satisfaction Among Physiotherapists
Physiotherapists, who hold a significant place in the healthcare sector, are at risk for mobbing and low levels of job satisfaction due to both demanding physical working conditions and emotional stress.
- Trial name
- NCT07402824
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Cancer
Safe Infusion Device in Reducing Occupational Exposure of Nurses
Monocentric comparative before / after study to evaluate the efficacy of Safe Infusion Devices (SIDs) in reducing drug exposure to nurses compared to usual perfusion practices.
- Trial name
- CONTAMOINS-1 (NCT04102332)
- Testing
- Safe Infusion Device
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Institut de Cancérologie de la Loire
Non Hodgkin Lymphoma, Chronic Lymphocytic Leukemia
Identification of Occupational Exposures in Acute Hematologic Malignancy
Lymphoid hemopathies are a group of malignant haematological disorders characterized by clonal proliferation of cells of the lymphoid line.
- Conditions
- Non Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, Multiple Myeloma
- Trial name
- RHELYPRO (NCT03316209)
- Where
- 7 sites in France
- Volunteers
- 205 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Sleep Initiation and Maintenance Disorders, Circadian Rhythm Sleep Disorders
Light Exposure to Treat Sleep Disruption in Older People
The purpose of this study is to test whether shifts in the timing of the biological clock to a later hour (phase delay shifts of the human circadian system) can be produced in response to four successive evenings of light…
- Conditions
- Sleep Initiation and Maintenance Disorders, Circadian Rhythm Sleep Disorders, Hypersomnia
- Trial name
- NCT00427323
- Testing
- light exposure
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Pneumoconiosis
Pneumoconiosis and Dust Exposure China Cohort
The primary objective of this study is to characterize the demographic and clinical features of patients with occupational pneumoconiosis (hereinafter referred to as pneumoconiosis) in China.
- Trial name
- PANDECT (NCT07077382)
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- China-Japan Friendship Hospital
COVID-19
COVID-19 PrEP HCW HCQ Study
Off label study to evaluate the efficacy of HCQ for pre-exposure prophylaxis (PrEP) to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
- Trial name
- NCT04354870
- Testing
- Hydroxychloroquine (HCQ)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- NYU Langone Health
Smoke Inhalation, Exposure, Inhalation
Lung Cancer Screening CT for Firefighters
Firefighters are at increased risk for cancer due to exposure to carcinogenic substances. Current lung cancer screening guidelines are predominantly based on smoking history and do not take into account high risk occupational…
- Conditions
- Smoke Inhalation, Exposure, Inhalation, Exposure to Pollution, Exposure Occupational
- Trial name
- NCT06836414
- Testing
- Low-dose Computerized tomography (CT) of Chest, Questionnaires, Medical History
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Return to Work, Occupational Stress
In Vitro Exposure by VR to Enhance Return to Work After Sick Leave Due to Mental Health Related Complaints
The goal of this pilot randomised controlled trial is to investigate whether in vitro exposure by VR enhances return to work (RTW) in flight cabin crew on sick leave with mental health related complaints.
- Conditions
- Return to Work, Occupational Stress, Self-Efficacy
- Trial name
- NCT06888999
- Testing
- In vitro exposure to workplace by VR plus care as usual, Care as usual: Guidance from occupational physician and psychologist focused on returning to work
- Where
- Netherlands
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Internal and External Contamination of Physiotherapists by Antineoplastic Drugs
Occupational Exposure to Antineoplastic Drugs Among Physiotherapists in Healthcare Settings
Many antineoplastic drugs are considered "hazardous to handle" for healthcare professionals, notably because of their carcinogenic, mutagenic and/or reprotoxic effects.
- Trial name
- KINEMAC (NCT07328464)
- Testing
- urine sample, dermal wipe sampling, questionnaires
- Where
- 2 sites in France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille