Clinical trials: Exposure to Polluted Air
Allergies
Air Pollution and Allergens - Attenuation of Health Effects Particle Reduction
The study probes the effects of combined exposures to diesel exhaust and allergens on lung function and on the immune system, specifically focusing on the ability of a particle depletion technique to attenuate effects we and…
- Trial name
- DE3 (NCT02017431)
- Testing
- Allergen, Saline, Particle depleted diesel exhaust
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Blood Pressure, Heart Rate Variability
The Cardiovascular Benefits of Reducing Personal Exposure to Air Pollution
Exposure to air pollution is an important risk factor for cardiovascular morbidity and mortality, and is associated with increased blood pressure, reduced heart rate variability, endothelial dysfunction and myocardial ischaemia.
- Trial name
- NCT00809432
- Testing
- Face mask (Dust Respirator), No Face mask
- Where
- China
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Pollution; Exposure, Hypertension
Solar Lighting to Reduce Indoor Air Pollution in Rural Uganda
This study evaluates the impact of a solar lighting system on kerosene lamp use, levels of indoor air pollution, and health in women living in rural Uganda.
- Conditions
- Pollution; Exposure, Hypertension, Pollution Related Respiratory Disorder
- Trial name
- NCT03351504
- Testing
- Solar lighting system
- Where
- 2 sites in United States, Uganda
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Biomarkers of Air Pollution Exposure
Biomarkers of Exposure to Air Pollutants (AEROTOX-2)
Nowadays, an increase of inflammatory chronic diseases and/or tumors incidence has been reported in part due to the rising in life expectancy.
- Trial name
- AEROTOX-2 (NCT02765529)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Lille Catholic University
Healthy, Exposure to Pollution
Sympathetic Nerve Response Incited by Biodiesel Exhaust Exposure
The adverse effects of current ambient air pollution on cardiovascular and respiratory health have been demonstrated in an extensive series of epidemiological, observational and experimental studies.
- Trial name
- NCT03698344
- Testing
- Biodiesel exhaust exposure
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Umeå University
Exposure to Polluted Air
Association Between PM2.5 and Ferroptosis
This cohort study aims to discover the possible effects of PM2.5 exposures on the Nrf2- dependent ferroptosis pathway. This observational cohort's main question is whether PM2.5 exposures will affect the Nrf2- dependent…
- Trial name
- NCT05753332
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northern Jiangsu People's Hospital
Air Pollution
Health Effects of Repeated Exposure to Low Levels of Concentrated Ambient Particles in Healthy Young Volunteers
Purpose: To determine whether 3-day consecutive exposures to levels of fine particulate matter (PM2.5) that are close to the current 24-hr national standard will cause changes in inflammatory and cardiopulmonary endpoints in…
- Trial name
- NCT05323240
- Testing
- PM exposure, Filtered air exposure
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- U.S. EPA Human Studies Facility
Adverse Pregnancy Outcomes
The Mechanism of Adverse Pregnancy Outcomes Influenced by Maternal Air Pollution Exposure
This research evaluates the effects of maternal exposure to air pollution during pregnancy on adverse pregnancy outcomes, the general demographic information, the level of maternal exposure to air pollution, pregnancy-related…
- Trial name
- NCT04215406
- Testing
- The level of air pollution
- Where
- China
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Cardiovascular Injury
Cardiovascular Effects of Exposure to Ozone
The Multicenter Ozone Study in Elderly Subjects will investigate whether short-term exposure of elderly volunteers to ambient levels of ozone in a controlled exposure setting causes acute cardiovascular responses as assessed by…
- Trial name
- MOSES (NCT01487005)
- Where
- 4 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Health Effects Institute
Coronary Heart Disease
Myocardial Ischaemia After Exposure to Diesel Exhaust
Exposure to particulate air pollution is associated with increases in cardiovascular mortality and morbidity. The pathophysiological mechanisms underlying this observation are emerging, and exposure to particulate air pollution…
- Trial name
- MIDAS (NCT01661582)
- Testing
- CT/PET Myocardial Perfusion Imaging using O-15 water, Coronary blood flow measured by doppler echocardiography
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Exposure to Pollution, Inhalation of Ozone
Epigenetic Effects of Diesel Exhaust and Ozone Exposure
Purpose: The purpose of this protocol is to compare the genetic and epigenetic effects between diesel exhaust and ozone exposure in healthy individuals and in mild/moderate asthmatics.
- Trial name
- Lamarck (NCT01492517)
- Testing
- Ozone exposure, Diesel exhaust, Ozone18
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)
Healthy
Cardioprotective Effects of Omega-3 Fatty Acids Supplementation in Healthy Older Subjects Exposed to Air Pollution Particles
Exposure to ambient levels of air pollution increases cardiovascular morbidity and mortality. Advanced age is among the factors associated with susceptibility to the adverse effects of air pollution.
- Trial name
- NCT01442480
- Testing
- Fish oil, Olive oil
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)
Cardiovascular Function, Genotoxicity
Health Effects of Occupational Exposure to Combustion Particles - a Study on Volunteers Performing as Train Conductors
Ambient air pollution is a complex mixture of gaseous pollutants and particulate matter (PM). PM has a recognized important role in human health.
- Trial name
- BioTrack (NCT03104387)
- Testing
- Electric train, Diesel train
- Where
- Denmark
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Sleep Quality
Mitigation of Health Effects in Pregnant Women by Reducing Exposure to Heat and Air Pollution
The goal of this clinical trial is to assess the effectiveness of an intervention (combination of behavioural recommendations and technical measures) in reducing personal exposure to heat and air pollution and related health…
- Trial name
- ISMED CLIM PW (NCT07609433)
- Testing
- Heat intervention, Heat and air pollution mitigation intervention
- Where
- 3 sites in Cyprus, Italy
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Cyprus
COPD, Lung Cancer (NSCLC)
Tumors and Respiratory System Diseases Due to Air Pollution: New Biomarkers of Exposure and Effects
This study aims to examine the exposure to atmospheric pollutants in a group of non-smoking patients suffering from lung cancer, chronic obstructive pulmonary disease (COPD), and leukemia.
- Conditions
- COPD, Lung Cancer (NSCLC), Leukemia
- Trial name
- RECAP (NCT06800586)
- Where
- 3 sites in Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Respiratory Depression
Effects of Sequential Exposure to Nitrogen Dioxide and Ozone in Healthy Adult Human Volunteers.
The U.S. Environmental Protection Agency has traditionally examined the effects of single pollutant exposure on human health outcomes; however, to provide a better assessment of pollutant exposure-associated effect on human…
- Trial name
- ENDZONE (NCT02133586)
- Testing
- Ozone, Nitrogen dioxide
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)
Ozone Exposure During Rest and Exercise
Susceptibility of Cardiorespiratory Responses to Ozone During Cycling Exercise
Ground level ozone (O3) is a common airborne pollutant that is well recognized to cause negative respiratory symptoms and impair pulmonary function.
- Trial name
- NCT05473000
- Testing
- Exercise, Ozone, Room air
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Respiratory Conditions Due to Unspecified External Agent
Anti-pollution Effects of AP Green Tea Extracts
The objective of this clinical trial is to evaluate the anti-pollution effects of AP green tea extracts in subjects with discomforts related to the respiratory system by prolonged exposure to particulate matter in air pollution
- Trial name
- NCT04340375
- Testing
- AP green tea extracts
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Amorepacific Corporation
Air Pollution, Pregnancy
Immune Tolerance Dysfunction in Pregnancy Due to Ambient Air Pollution Exposure
The purpose of this project is to study the effects of air pollution toxicants on pregnant mothers' immune health during and after pregnancy.
- Trial name
- NCT04549142
- Testing
- There is no intervention
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Stanford University
Exposure to Polluted Air
Neurological Symptoms and Findings in Individuals Exposed to Indoor Air Pollutants
To evaluate neurological findings with TSPO-PET and MRI in patients who have been exposed to indoor air pollutants and have potentially neurological symptoms.
- Trial name
- NCT05111678
- Where
- Finland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital