Clinical trials: Exposure to Pollution
Coronary Disease
The Effects of Diesel Exhaust Inhalation on Vascular Function - the Role of Endothelin
The purpose of this study is to identify the role of endothelin 1 (a natural vasoconstrictor) in the adverse vascular effects demonstrated after exposure to air pollution
- Trial name
- NCT00745693
- Testing
- Endothelin-1, BQ-123 and BQ-788
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Exposure to Pollution
Toxicokinetic Study of Lambda-cyhalothrin Biomarkers of Exposure
Exposure to pyrethroid pesticides is a growing concern in the workplace especially since they are also present in the diet of the general population. It is important to monitor human exposure to these contaminants.
- Trial name
- NCT03159013
- Testing
- Exposure
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Université de Montréal
COPD, COPD Exacerbation
Effectiveness of Low-Dose Theophylline for the Management of Biomass-Associated COPD
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide, and over 90% of COPD-related deaths occurring in low- and middle-income countries (LMICs).
- Conditions
- COPD, COPD Exacerbation, COPD Exacerbation Acute, Pollution Related Respiratory Disorder
- Trial name
- NCT03984188
- Testing
- Theophylline ER, Standard of Care Treatment
- Where
- 2 sites in Uganda
- Volunteers
- 100 people
- Sponsor
- University of Miami
Environmental Tobacco Smoke Exposure, Depression
Healthy Outcomes of Pregnancy Education
The purpose of this study is to determine if an integrated intervention addressing active smoking, environmental tobacco smoke exposure, depression and intimate partner violence, would improve pregnancy outcome among African…
- Conditions
- Environmental Tobacco Smoke Exposure, Depression, Partner Abuse, Tobacco Smoking
- Trial name
- NCT00381823
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 1,750 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Experimental
Human Study to Develop a Signature of Occupational Diesel Exhaust Exposure
Strong scientific understanding of how emissions from diesel engines impact the lungs could improve policies and regulations protecting workers exposed to diesel exhaust.
- Trial name
- DICE (NCT03234790)
- Testing
- Filtered Air Exposure, Diesel Exhaust Exposure
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cardiovascular Outcomes
Air Pollution and Cardiometabolic Study
The study mainly focuse on examining the subjects living in traffic polluted area and assessing the popuation health risk using disease and risk assessment models.
- Trial name
- NCT02601352
- Where
- 2 sites in China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- WeiHuang
Tobacco Use and Smoking Behavior
Controlled Trial to Reduce Secondhand Smoke Exposure at Homes in Armenia
This study was designed to test the hypothesis whether a novel intervention that uses motivational interviewing along with immediate feedback and follow-up counseling calls is effective in educating the household members about…
- Trial name
- NCT01630356
- Testing
- in-person counseling, Demonstration of PM2.5 Pollution, Follow-up Counseling Calls
- Where
- Armenia
- Volunteers
- 250 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Sleep Apnea, Allergic Rhinitis
Impact of Pollution on Allergic Rhinitis and Sleep Quality: the POLLAR Study
It has been demonstrated that allergic rhinitis (AR) reduces sleep quality by some components such as nasal obstruction. Pollution and allergen exposure worsening AR, sleep quality is deteriorated.
- Conditions
- Sleep Apnea, Allergic Rhinitis, Allergic Asthma, Pollution Exposure
- Trial name
- POLLAR (NCT03776773)
- Testing
- Pollution exposure
- Where
- France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Healthy Women
Effect of an Antioxidant Dietary Supplement on Skin Radiance
A randomized, double-blind, placebo-controlled study evaluating the effects of an oral antioxidant dietary supplement on skin radiance in women exposed to urban air pollution.
- Trial name
- NCT07793123
- Testing
- Antioxidant Supplement
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Robertet SA
Vascular Endothelium
Health Effects of Biodiesel Exhaust Exposure
Urban air pollution is a major contributor to greenhouse gases and has been shown to increase cardiovascular mortality and morbidity.
- Trial name
- BD100 (NCT01883466)
- Testing
- Forearm venous occlusion plethysmography study
- Where
- Sweden
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Umeå University
PreDiabetes
Cleaner Air for Lower Cardiometabolic Risk
The purpose of this interventional sham-controlled pilot study is to study the effects of using portable air cleaners (PACs) in outpatient adults with prediabetes.
- Trial name
- NCT05994937
- Testing
- PAC with HEPA filter intact, PAC with HEPA filter removed
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- NYU Langone Health
Pulmonary Arterial Hypertension, Air Pollution
The Risk of Adverse Pregnancy Outcomes for Long-term Exposure to Air Pollution in Pregnant Patients With Pulmonary Hypertension
With economic development and rapid urbanization, air pollution has become an increasingly severe public health concern. The risk of adverse pregnancy outcomes is significantly elevated for pregnant women complicated by pulmonary…
- Conditions
- Pulmonary Arterial Hypertension, Air Pollution, Maternal Outcome
- Trial name
- NCT07164157
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Wei Huang
Health Effects of Ambient Air Pollution
Effects of Omega-3 Fatty Acids in Ambient Air Pollution Exposure in Healthy Adults
This observational study recruits healthy individuals who have been routinely taking high amount (at least 3 g/wk) of dietary eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and those who don't, and examines the…
- Trial name
- PISCES (NCT02921048)
- Testing
- omega-3 fatty acids
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- U.S. EPA Human Studies Facility
Air Pollution
The Role of Macrophage Activation in Lung Injury Following Ozone Exposure
The purpose of the study is to better understand the mechanisms of lung injury from ozone exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone.
- Trial name
- NCT05794087
- Testing
- Clean Air, Ozone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Air Pollution, Pollution; Exposure
Modification of Ambient Air Pollution Exposure and Cardiopulmonary Outcomes by Socioeconomic Status and Nutrition
The goal of this observational study is to compare the effects of air pollution exposure and nutrition between neighborhoods with high and low social vulnerability scores.
- Conditions
- Air Pollution, Pollution; Exposure, Nutrition, Healthy
- Trial name
- SENSE (NCT05843370)
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)
Hypertension Arterial, 65 Years Older
Mitigation of Health Effects in Older Adults With Hypertension by Reducing Exposure to Heat and Air Pollution
The goal of this clinical trial is to assess the effectiveness of an intervention (combination of behavioural recommendations and technical measures) in reducing personal exposure to heat and air pollution and related health…
- Trial name
- ISMED CLIM OH (NCT07606859)
- Testing
- Heat intervention, Heat and air pollution mitigation intervention
- Where
- 2 sites in Cyprus, Spain
- Volunteers
- 102 people
- Sponsor
- University of Cyprus
Pollution; Exposure
Effects of Transportation Choices on Commuter Health
The primary project objective is to investigate how an individual's choices influence personal exposures to traffic-related air pollutants (TRAPs) and the corresponding acute health effects.
- Trial name
- ETCH (NCT05758714)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- UConn Health
Pulmonary Disease, Cardiovascular Disease
Cardio-Respiratory Health and Indoor Pollution
The aim of this study is to assess in the sample of population resident in the KHUMBU valley (NEPAL): 1. the respiratory function decline by means of spirometry and the respiratory health by means of questionnaire and six-minute…
- Trial name
- NCT01329159
- Where
- Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Ferrara
Exposure to Pollution, Heart Failure
Effects of Air Pollution Exposure Reduction by Filter Mask on Heart Failure
Exposure to air pollution is associated with increase in cardiovascular morbidity and mortality. Controlled human exposure studies have demonstrated impaired vascular function and heart rate variability on healthy volunteers.
- Trial name
- NCT01960920
- Testing
- Filtered diesel exhaust, Unfiltered diesel exhaust, Clean air
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- InCor Heart Institute
Exposure to Environmental Pollution, Non-occupational
Epigenetic Effect Modifications With Ozone Exposure on Healthy Volunteers
The purpose of this protocol is to assess whether epigenetic factors in healthy individuals make a person more or less responsive to lung inflammation following ozone exposures.
- Trial name
- Geminoz (NCT02469428)
- Testing
- Clean air, Ozone
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)