Clinical trials: Exposure to Pollution
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Lungs on Fire: Wildfire Smoke, Incident Diseases, Susceptible Populations, and Community Values in Canada
Wildfire smoke (WFS) is the leading climate-related risk in Canada and the main source of harmful air pollution. While short-term breathing problems caused by smoke are well known, there is limited knowledge on how repeated…
- Conditions
- Asthma, Chronic Obstructive Pulmonary Disease (COPD), Lung Cancer
- Trial name
- LoF (NCT07536178)
- Testing
- Woodsmoke (Lodgepole Pine) exposure, Filtered air exposure
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Chronic Coronary Syndrome, Microplastics
Microplastics and Nanoplastics in Patients With Chronic Coronary Syndromes
The CCS-plastics is an investigator-initiated, prospective, multicenter study of patients undergoing coronary CT angiography (CCTA) for suspected or known chronic coronary syndromes (CCS) referred to invasive coronary angiography…
- Conditions
- Chronic Coronary Syndrome, Microplastics, Nanoplastics, Coronary Artery Disease
- Trial name
- CCS-Plastics (NCT07291609)
- Where
- 6 sites in Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Ospedaliera "Sant'Andrea"
Healthy
Sympathetic Nerve Activation Evoked by Diesel Exhaust Exposure
The adverse effects of air pollution on cardiovascular and respiratory health have been demonstrated in an extensive series of epidemiological, observational and experimental studies.
- Trial name
- NCT02892279
- Testing
- Diesel exhaust exposure
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Umeå University
Allergic Rhinitis, Allergic Asthma
Environmental Pollutants and Their Effects on Respiratory Allergy
In Latin America and the Caribbean, more than 100 million people are exposed to higher levels of pollution than those recommended by WHO.
- Conditions
- Allergic Rhinitis, Allergic Asthma, Pollution; Exposure
- Trial name
- NCT04902989
- Testing
- pollutants and pollen
- Where
- Mexico
- Volunteers
- 93 people
- Sponsor
- Cindy Elizabeth de Lira-Quezada
Pneumonia, Pollution; Exposure
The Effect of Household Air Pollution on Lung Function Growth in Infants With Pneumonia in Sub-Saharan Africa
This study will evaluate the feasibility and acceptability of a household-based clean air intervention
- Conditions
- Pneumonia, Pollution; Exposure, Lung Function Decreased, Chronic Respiratory Disease
- Trial name
- PLUS2 (NCT05724082)
- Testing
- Clean Air Intervention
- Where
- Uganda
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Healthy Participants
Wildfire Related Air Pollution Exposure and Cognitive Function Pilot Study
This study will examine how breathing wildfire-related air pollution (WRAP) for one hour affects healthy adults. The main question the study will answer if the effect of WRAP exposure on p-tau, a blood marker of cognitive…
- Trial name
- WRAP (NCT07151235)
- Testing
- Simulated wildfire smoke exposure, Clean Air exposure
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Environmental Exposure, Ozone
Lung Mucus Hypersecretion and NQO1
The research plan proposes translational studies in relevant animal models and human subjects in order to identify host (genetic) susceptibility factors that confer vulnerability to the prototypal air pollutant, ozone.
- Conditions
- Environmental Exposure, Ozone, Air Pollution, Genetic Susceptibility
- Trial name
- NCT00729352
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Acute Coronary Syndrome, Atrial Fibrillation
Short- and Long-term Health Effects of Air Pollution in Poland
The effects of air pollution on the frequency of hospital admissions and mortality due to acute coronary syndromes, atrial fibrillation, and renal disfunction are noted also in areas perceived as pollution-free (due to the lack…
- Conditions
- Acute Coronary Syndrome, Atrial Fibrillation, Kidney Diseases, Particulate Matter Inhalation Injury
- Trial name
- EP-PARTICLES (NCT05198492)
- Testing
- Impact of air pollution
- Where
- Poland
- Volunteers
- 8,300,000 people
- Sponsor
- Medical University of Bialystok
Pollution; Exposure
Optimizing Ventilation to Improve Health
Our overall goal is to optimize preferred, ventilating windows/apertures/vents in low-income neighborhoods of Dhaka, Bangladesh. We will: I. Collect baseline data on housing types and finalize windows/vents protoypes. II.
- Trial name
- NCT03894995
- Testing
- Installation of ventilation
- Where
- Bangladesh
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Stanford University
Healthy Adults
Statins Against Bushfire Smoke
The goal of this clinical trial is to test whether statins can protect the heart and brain from the biological stress and inflammatory responses caused by breathing bushfire smoke in healthy adult volunteers aged 18-64 years.
- Trial name
- SABS (NCT07462715)
- Testing
- Atorvastatin
- Where
- Australia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Menzies Institute for Medical Research
Pregnancy, Low Birth Weight
Air Pollution and Daily Mobility of Pregnant Women Identification of Critical Windows of Exposure
This study is conducted to assess the role of pregnant women's daily mobility living in the Eurometropole of Strasbourg in a context of the existence of environmental exposure disparities (PM10, PM2.5, NO2).
- Conditions
- Pregnancy, Low Birth Weight, Preterm Birth, Air Pollution
- Trial name
- MOBIFEM (NCT04725734)
- Testing
- Pregnant women
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Strasbourg, France
Chronic Obstructive Pulmonary Disease (COPD)
COPD Prevalence and Risk Factors Among Saudi Adults Over 18 in Taif
This cross-sectional study assesses the prevalence of previously diagnosed chronic obstructive pulmonary disease (COPD) and associated risk factors among Saudi adults aged 18 years and older living in Taif City, Saudi Arabia.
- Trial name
- Taif-COPD (NCT07886346)
- Where
- Saudi Arabia
- Volunteers
- 777 people
- Sponsor
- Taif University
Heart Failure
Project 4: ACHIEVE PATHFINDER
ACHIEVE-P4: PATHFINDER is a randomized, blinded clinical trial of portable air cleaners (PAC) provided at the time of hospital discharge to Heart Failure (HF) patients. It will be carried out at Henry Ford Hospitals.
- Trial name
- PATHFINDER (NCT06070428)
- Testing
- PAC provision at hospital discharge, Control non-intervention; PAC without filter
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Henry Ford Health System
Tobacco Use, Pollution; Exposure
FRESHAIR4Life: Building the Case for Action
The goal of this observational study is to understand the burden and determinants of tobacco use and air pollution (AP) exposure among mid- to late adolescents in Greece, the Kyrgyz Republic, Pakistan, Romania, and Uganda.
- Conditions
- Tobacco Use, Pollution; Exposure, Non-communicable Disease
- Trial name
- NCT06074939
- Volunteers
- 1,750 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Blood Pressure
Reducing AIR Pollution Exposure to Lower Blood PRESSURE Among New York City Public Housing Residents
Fine particulate matter <2.5 µm (PM2.5) air pollution is the fifth leading risk factor for global mortality, with the largest portion of deaths due to cardiovascular disease (CVD).
- Trial name
- AirPressureNYC (NCT05874479)
- Testing
- Active PAC
- Where
- United States
- Volunteers
- 440 people
- Sponsor
- NYU Langone Health
Tobacco Smoke Pollution, Maternal Exposure During Pregnancy
Prenatal Tobacco Exposure and Newborn Outcomes: A Maternal Urinary Cotinine Study
Prenatal exposure to tobacco smoke, through either active maternal smoking or secondhand exposure, has been associated with impaired fetal oxygenation, metabolic stress, and adverse early neonatal outcomes.
- Conditions
- Tobacco Smoke Pollution, Maternal Exposure During Pregnancy, Infant, Newborn, Carbon Monoxide Poisoning
- Trial name
- NCT07201181
- Testing
- Maternal Urinary Cotinine Assessment
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Haseki Training and Research Hospital
Lung Diseases
Assessment of Exposures of the Mother-infant Pair to the Air Pollution of São Paulo
A single group of pregnant women who was analyzed in the first and in the third trimesters of pregnancy
- Trial name
- NCT02807038
- Testing
- Lung function test
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Exposure to Pollution
Responses to Exposure to Low Levels of Concentrated Ambient Particles in Healthy Young Adults
Purpose: To determine whether exposure to levels of fine particles that are close to the current standard will cause cardiovascular changes in healthy individuals.
- Trial name
- RECAP (NCT03232086)
- Testing
- Clean Air, PM2.5
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)
Healthy
Melanin and Dermal Uptake of Thirdhand Cigarette Smoke
This is a pilot study of the effects of dermal melanin on dermal uptake and retention of nicotine. The initial hypothesis is that higher levels of dermal melanin will correlate with lower uptake and longer retention of nicotine…
- Trial name
- THS05 (NCT06020248)
- Testing
- Wear clothing that has been exposed to cigarette smoke for 3 hours.
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Air Pollution
Air Pollution: Strategies for Personalized Intervention to Reduce Exposure
Fine particulate matter < 2.5 microns (PM2.5) air pollution is a leading global risk factor for cardiovascular morbidity and mortality.
- Trial name
- ASPIRE (NCT03744871)
- Testing
- N95 Respirator
- Where
- 2 sites in United States, China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center