Clinical trials: External Validation
Psychopathology
External Validation by Machine Learning and Reduction of the Input Dimensions of the D-PSY Scale for Dimensional Psychopathology
There have been debates about whether psychiatric disorders should be classified according to categories (categorical model) or according to a continuum between normal and pathological functioning (dimensional model).
- Trial name
- D-Psy adultes (NCT05675215)
- Testing
- Psychopathology screening tests
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Institut pour la Pratique et l'Innovation en PSYchologie appliquée (Institut Pi-Psy)
Breast Cancer
Multicentric Study for External Validation of a Deep Learning Model for Mammographic Breast Density Categorization
The correct categorization of breast density is essential to adapt the diagnostic examination to the needs of each patient. Assessment of breast density is performed visually by radiologists.
- Trial name
- NCT05021055
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- Hospital Italiano de Buenos Aires
Mild Cognitive Impairment (MCI)
Validation of Population Characteristics and Dosage Prescriptions for Cognitive Function Intervention Benefits of Different Doses of Tai Chi in Elderly Patients With Mild Cognitive Impairment: A Real-World Cross-Sectional Study
This is a companion real-world external validation study of two pre-registered parent randomized controlled trials (RCTs, protocol IDs: FujianUTCM-1 and FujianUTCM-2).
- Trial name
- NCT07608510
- Testing
- 24-form Simplified Tai Chi (Observational Behavioral Exposure)
- Volunteers
- 150 people
- Sponsor
- Lidian Chen
COVID-19 Pandemic
External Validation of Simplified 4C Mortality Score by Deleting CRP
The (Coronavirus Clinical Characterisation Consortoum) 4C mortality score is an accessible risk stratification score developed by the International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC) based on…
- Trial name
- 4Cs (NCT06354946)
- Where
- Tunisia
- Volunteers
- 1,500 people
- Sponsor
- University of Monastir
Hemophilia, Hemophilic Arthropathy
Validation of Ultrasound as a Diagnostic Tool for Assessment of Hemophilic Arthropathy of Knees and Ankles
The purpose of this study is to test the external validity of the systemic ultrasound protocol for data acquisition and interpretation, in order to diagnose soft tissue and osteochondral abnormalities in hemophilic children.
- Trial name
- NCT01232634
- Where
- 4 sites in Brazil, Canada
- Volunteers
- 57 people
- Sponsor
- The Hospital for Sick Children
Multivariate Risk Assessment for ISUP ≥2 Prostate Cancer
RPCRC Validation Study
Prostate multiparametric MRI (mpMRI) can detect ISUP ≥2 prostate cancer with high sensitivity. Adding biopsies targeting suspicious lesions seen on mpMRI to the classical 'systematic biopsies' (that sample the gland in a blinded…
- Trial name
- PCaRisk (NCT04484103)
- Testing
- Assessment of the diagnostic performance of the PI-RADS score (as a stand-alone) and of the RPCRC for predicting the presence of ISUP ≥2 prostate cancer at subsequent biopsy in 251 patients.
- Where
- France
- Volunteers
- 275 people
- Sponsor
- Hospices Civils de Lyon
Duodenal, Gastrointestinal Stromal Tumors
Development and External Validation of a Prognostic Model for DFS After Curative Resection of Duodenal GIST
Gastrointestinal stromal tumour (GIST) is the most common mesenchymal neoplasm of the digestive tract, originating from the interstitial cells of Cajal.
- Trial name
- NCT07837271
- Where
- 2 sites in China
- Volunteers
- 288 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Female Infertility
The Embryologist's Impact on Blastocyst Vitrification and Thawing
The goal of this monocentric retrospective observational study is to analyse, for the first time in literature, the role of the embryologist who freezes and thaws the embryos.
- Trial name
- NCT06220227
- Testing
- vitrification and thawing procedures
- Where
- Italy
- Volunteers
- 6,800 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Coagulation Disorder, Blood, Prolonged APTT
External Multicenter Validation of the APTTO Model for Prolonged APTT Using Clot Waveform Analysis
Prolonged activated partial thromboplastin time (APTT) is a frequent laboratory finding that may reflect a broad spectrum of underlying conditions, ranging from benign laboratory abnormalities to clinically relevant hemostatic…
- Trial name
- APTTO-EXT (NCT07418099)
- Testing
- Clot waveform analysis-based risk stratification (APTTO models)
- Where
- 16 sites in Spain
- Volunteers
- 1,500 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
COPD (Chronic Obstructive Pulmonary Disease), Artificial Intelligence
A Prospective, Multicenter, Portable Pulmonary Function Comparison Study Aimed at Evaluating the External Clinical Validation of the Chronic Obstructive Pulmonary Disease Auxiliary Diagnostic Software LH-002 (Version: 2.0.0) in Clinical Diagnosis Accuracy
Chronic Obstructive Pulmonary Disease (COPD) is widely underdiagnosed in low- and middle-income countries and regions, due to the lack of accessible tools.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Artificial Intelligence, Cough, Diagnosis
- Trial name
- NCT07888712
- Where
- China
- Volunteers
- 466 people
- Sponsor
- Ruijin Hospital
Coronary Artery Calcification, Cardiovascular Risk
Artificial Intelligence - Based Opportunistic Coronary Artery Calcium Scoring on Routine Chest-CT Scan
This retrospective, non-interventional study externally validates a pre-trained open-weight deep-learning algorithm (Swin-UNETR) for the opportunistic quantification of coronary artery calcium (CAC) on non-gated routine chest CT…
- Conditions
- Coronary Artery Calcification, Cardiovascular Risk, Coronary Artery Disease, End-Stage Renal Disease Requiring Haemodialysis
- Trial name
- NCT07808593
- Volunteers
- 1,950 people
- Sponsor
- University of Cologne
Traumatic Brain Injury, Acquired Brain Injury
Venous and Cerebral Glucose Microdialysis in Neurocritical Care: Validation & Correlation
This study evaluates the validity of an intravascular continuous glucose monitoring microdialysis probe, and compares the values to routinely inserted cerebral glucose microdialysis to evaluate the hypothesised relationship…
- Conditions
- Traumatic Brain Injury, Acquired Brain Injury, Intracerebral Hemorrhage, Subarachnoid Hemorrhage
- Trial name
- NCT03246607
- Testing
- MicroEye & ContinuMon
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Dr Andrew Stevens
Chronic Postsurgical Pain
Clinical Prediction Model and External Validation of Chronic Postsurgical Pain in Elders
This study will collect perioperative pain-related data of elderly patients in multi-centers. Analyzing these collected data to find the high-risk factors of chronic postsurgical pain in elderly patients and to establish an…
- Trial name
- NCT05372406
- Testing
- • no intervention
- Where
- China
- Volunteers
- 7,770 people
- Sponsor
- Chinese PLA General Hospital
Kidney Transplant, Rejection of Renal Transplant
Development and Validation of HistoMX, a Gene-Expression Platform for Molecular Interpretation of Kidney Allograft Biopsies
This retrospective multicentre observational study developed and validated HistoMX, an automated gene-expression-based platform for multidimensional molecular interpretation of kidney allograft biopsies.
- Conditions
- Kidney Transplant, Rejection of Renal Transplant, Antibody Mediated Rejection, BK Virus Nephropathy
- Trial name
- HistoMX (NCT07700563)
- Volunteers
- 2,410 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Noninvasive CA Monitoring Validation and Autonomic Modulation in Aneurysmal Subarachnoid Hemorrhage
This is a two-component prospective study of adult aneurysmal subarachnoid hemorrhage (aSAH) patients admitted to the Neurosciences Intensive Care Unit (NSICU) at UT Southwestern Medical Center.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Cerebral Vasospasm, Autonomic Nervous System Diseases
- Trial name
- NCT07577739
- Testing
- Right-Sided Cervical Sympathetic Block at C6, Transcutaneous Auricular Vagal Nerve Stimulation (taVNS)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Mouth Breathing
Speech-language Skills of Orthodontic Residents Through the Use of the "Interdisciplinary Orofacial Examination Protocol for Children and Adolescents"
This single-group pre-post study with external validation will be conducted on 29 orthodontic residents at the University of Pavia to assess their ability to recognize orofacial myofunctional disorders (OMD) before and after…
- Trial name
- NCT06887660
- Testing
- Orthodontic diagnosis
- Where
- Italy
- Volunteers
- 29 people
- Sponsor
- University of Pavia
Postoperative Recovery
Predictors of Length of Stay and DAH30 After Elective Minimally Invasive Surgery in Older Adults
This retrospective observational study aims to evaluate short-term postoperative outcomes in older adults undergoing elective minimally invasive surgery.
- Trial name
- HOME-30 (NCT07377812)
- Testing
- No Intervention (Observational Study)
- Where
- Russia
- Volunteers
- 1,000 people
- Sponsor
- Dmitrii Semenov
Firearm Injury
Clinical Screening for Firearm Violence Risk
The purpose of the proposed work is to harness cutting-edge machine learning methods to optimize prediction of future firearm violence in youth ages 18-24 so that prevention resources can be allocated efficiently.
- Trial name
- NCT05436457
- Where
- 4 sites in United States
- Volunteers
- 1,506 people
- Sponsor
- University of Michigan
Renal Cell Carcinoma, Kidney Neoplasms
Multimodal Prediction of Postoperative Prognosis After Partial Nephrectomy for Endophytic Renal Cell Carcinoma
This retrospective observational cohort study aims to develop and externally validate an imaging-clinical multimodal fusion model for predicting postoperative prognosis in patients with endophytic renal cell carcinoma undergoing…
- Conditions
- Renal Cell Carcinoma, Kidney Neoplasms, Endophytic Renal Tumor, Postoperative Renal Function
- Trial name
- PN-ProMM (NCT07697417)
- Testing
- Imaging-clinical multimodal prognostic modeling
- Where
- China
- Volunteers
- 406 people
- Sponsor
- Tianjin Medical University Second Hospital
Weaning Mechanical Ventilation
External Validation of VVI
Failure of liberation from mechanical ventilation increases days spent being mechanically ventilated, the length of stay and the morbidity of patients.
- Trial name
- E-VVI (NCT07372664)
- Where
- 3 sites in Greece
- Volunteers
- 100 people
- Sponsor
- University of Thessaly