Clinical trials: ExtraCorporeal Membrane Oxygenation (ECMO)
Lung Transplant; Complications
Bypass vs. Ecmo in Lung Transplantation (BELT)
This study seeks to compare outcomes of 2 different methods of cardiopulmonary support during lung transplant surgeries.
- Trial name
- BELT (NCT03021538)
- Testing
- Extracorporeal Membrane Oxygenation, Cardiopulmonary Bypass
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- The Cleveland Clinic
Extracorporeal Membrane Oxygenation
Extracorporeal Membrane Oxygenation (ECMO): Blood Cells
The objective of the study is to predict outcomes of patients on extracorporeal membrane oxygenation (ECMO) therapy by correlating cytokines and inflammatory cell patterns to clinical outcomes using data collected in the ECMO…
- Trial name
- NCT02748668
- Testing
- Blood specimen collection
- Where
- United States
- Volunteers
- 371 people
- Sponsor
- Corewell Health West
Respiratory Insufficiency, Circulatory Failure
Comparing Anticoagulation Strategies Using UFH, Argatroban and LMWH for ECMO Support
A three-arm randomized controlled non-inferiority pilot study comparing anticoagulation strategies using unfractionated heparin, argatroban and enoxaparin for extracorporeal membrane oxygenation support conducted as an…
- Conditions
- Respiratory Insufficiency, Circulatory Failure, Thromboembolism, Bleeding
- Trial name
- CASUAL-ECMO (NCT06442267)
- Testing
- Enoxaparin Injectable Solution, Argatroban, 1 Mg/mL Intravenous Solution, Unfractionated heparin
- Where
- Austria
- Volunteers
- 90 people
- Sponsor
- Medical University of Vienna
Extracorporeal Membrane Oxygenation Complication
Distal Perfusion Timing, Early or Conservative, to Prevent Limb Ischemia During Peripheral VA-ECMO
Peripheral VA-ECMO is widely used in refractory cardiogenic shock patients as a salvage therapy. In most cases, the femoral artery and vein are used for the vascular approach.
- Trial name
- DECIDE-ECMO (NCT05698628)
- Testing
- Distal perfusion catheterization
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Min-Seok Kim
Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication
Efficacy and Clinical Outcomes of Levosimendan in E-CPR
Treatment of refractory cardiac arrest requiring cardiopulmonary resuscitation (CPR) may be augmented with Extracorporeal membrane oxygenation (ECMO) to re-establish perfusion in the absence of return of spontaneous circulation.
- Trial name
- ECPR (NCT05730907)
- Testing
- Levosimendan
- Where
- Qatar
- Volunteers
- 100 people
- Sponsor
- Hamad Medical Corporation
Cardiac Arrest, Heart Arrest
ECPR for Refractory Out-Of-Hospital Cardiac Arrest
In the U.S. alone, over 300,000 people per year have sudden out-of-hospital cardiac arrest (OHCA), and less than 1 out of 10 survive.
- Conditions
- Cardiac Arrest, Heart Arrest, Sudden Cardiac Arrest, Cardiopulmonary Arrest
- Trial name
- EROCA (NCT03065647)
- Testing
- Expedited Transport With Mechanical CPR
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
Critical Illness, Muscle Wasting
Acute Skeletal Muscle Wasting and Relation to Physical Function in Patients Requiring ECMO
The purpose of this study is to describe the changes in quadriceps muscle size and quality over the first 10 days on extracorporeal membrane oxygenation (ECMO) using ultrasound imaging.
- Conditions
- Critical Illness, Muscle Wasting, Extracorporeal Membrane Oxygenation
- Trial name
- NCT03026985
- Testing
- Observational cohort
- Where
- Australia
- Volunteers
- 25 people
- Sponsor
- The Alfred
Carbon Dioxide
Validation of Continuous Transcutaneous Carbon Dioxide Monitoring in VA-ECMO Patients
Carbon dioxide in patients on veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is eliminated via respirator as well as via the oxygenator's membrane of the ECMO machine.
- Trial name
- NCT04445909
- Testing
- VA-ECMO
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
ARDS, Extracorporeal Membrane Oxygenation
Blood Recirculation and vvECMO
A prospective, observational study will be performed measuring recirculation of blood through a veno-venous Extracoporeal Membrane Oxygenation (vvECMO) in patients with acute respiratory distress syndrome (ARDS) on vvECMO.
- Trial name
- NCT03200314
- Testing
- Measurment of blood recirculation
- Where
- Germany
- Volunteers
- 21 people
- Sponsor
- Charite University, Berlin, Germany
Coronavirus Infection, COVID
Cytokine Adsorption in Patients With Severe COVID-19 Pneumonia Requiring Extracorporeal Membrane Oxygenation
In December 2019 in the city of Wuhan in China, a series of patients with unclear pneumonia was noticed, some of whom have died of it.
- Conditions
- Coronavirus Infection, COVID, SARS-CoV 2, Respiratory Failure
- Trial name
- CYCOV-II (NCT04385771)
- Testing
- vv-ECMO + cytokine adsorption (Cytosorb adsorber), vv-ECMO only (no cytokine adsorption)
- Where
- 3 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Dr. Alexander Supady
Cardiogenic Shock
ExtraCorporeal Membrane Oxygenation in the Therapy of Cardiogenic Shock
Eligible patients with severe cardiogenic shock will be randomized to one of the two arms: immediate ECMO therapy or early conservative therapy.
- Trial name
- ECMO-CS (NCT02301819)
- Testing
- Veno-arterial extracorporeal membrane oxygenation (ECMO), Early conservative therapy according to standard practice
- Where
- 4 sites in Czechia
- Volunteers
- 122 people
- Sponsor
- Na Homolce Hospital
Acute Respiratory Distress Syndrome (ARDS)
Ultraprotective Lung Ventilation With Respiratory Extracorporeal Life Support for ARDS
Acute respiratory distress syndrome (ARDS) accounts for approximately 10% of all ICU admissions and 23% of patients requiring mechanical ventilation (MV).
- Trial name
- NOVAEOLIA (NCT07516665)
- Testing
- ECLS
- Volunteers
- 290 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Extracorporeal Membrane Oxygenation
The Effects of ECMO on the Pharmacokinetics of Hydromorphone
The purpose of this study was to establish a population pharmacokinetic (PPK) model of hydromorphone in patients under ECMO, and to recommend a dosing regimen when the target effective concentration was reached.
- Trial name
- NCT05565495
- Testing
- Hydromorphone
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Xiaobo Yang, MD
ARDS, Human, Extracorporeal Membrane Oxygenation Complication
Effects of Induced Moderate Hypothermia on ARDS Patients Under Venovenous ExtraCorporeal Membrane Oxygenation
Acute respiratory distress syndrome (ARDS) is a lesional pulmonary edema that occurs as a result of direct or indirect lung injury.
- Conditions
- ARDS, Human, Extracorporeal Membrane Oxygenation Complication, Hypothermia
- Trial name
- HypoLungECMO (NCT05306392)
- Testing
- Moderate Hypothermia, Normothermia
- Volunteers
- 30 people
- Sponsor
- Central Hospital, Nancy, France
Extracorporeal Membrane Oxygenation
Antithrombin Supplementation in ECMO
Bleeding is the most feared complication during extracorporeal membrane oxygenation (ECMO) and is associated with high dosing of heparin. There is no consensus on antithrombin (AT) supplementation during ECMO.
- Trial name
- NCT03208270
- Testing
- Antithrombin supplementation, No antithrombin supplementation
- Where
- Italy
- Volunteers
- 49 people
- Sponsor
- Policlinico Hospital
Acute Heart Failure
Pharmacokinetics of Levosimendan in Pediatric Intensive Care Units
To describe pharmacokinetics of levosimendan in neonates and children supported or not with extracorporeal circulation devices (ECMO, CRRT)
- Trial name
- PALMAréa (NCT03681379)
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Nantes University Hospital
Cardiogenic Shock
ECMOsorb Trial - Impact of a VA-ECMO in Combination With CytoSorb in Critically Ill Patients With Cardiogenic Shock
In the ECMOsorb study the impact of a veno-arterial -ECMO in combination with an extracorporeal cytokine hemadsorption system in critically ill patients with cardiogenic shock is to be examined
- Trial name
- ECMOsorb (NCT05027529)
- Testing
- CytoSorb, VA-ECMO only
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- Christian Schulze
Compartment Syndrome of Leg, Extracorporeal Membrane Oxygenation Complication
Continuous Compartment Pressure Monitoring for Compartment Syndrome in VA-ECMO Patients
Acute compartment syndrome (ACS) is a surgical emergency that can develop in patients on extracorporeal membrane oxygenation (ECMO).
- Conditions
- Compartment Syndrome of Leg, Extracorporeal Membrane Oxygenation Complication, Limb Ischemia, Limb Ischemia, Critical
- Trial name
- VA-ECMO (NCT05830721)
- Testing
- MY01 + Standard of Care, 14-Gauge Slit Catheter + Standard of Care, Standard of Care
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Johns Hopkins University
Cystic Fibrosis
ECMO for Lung Transplantation in Cystic Fibrosis Patients
Cystic fibrosis (CF) is the most common genetically inherited disease in the Caucasian population. Bilateral lung transplantation (LUTX) is a viable option for these patients.
- Trial name
- RetroLUTX (NCT03919604)
- Testing
- Extracorporeal Life Support
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Policlinico Hospital
Cardiogenic Shock
A Study on the Effects of Left Ventricular Unloading in the Setting of VA ECMO Support
REMAP ECMO is a registry based platform in which multiple response adaptive randomized clinical trials (trial domains) will be embedded.
- Trial name
- REMAP ECMO (NCT05913622)
- Testing
- Intra-aortic balloon pump
- Where
- 14 sites in Belgium, Netherlands
- Volunteers
- 430 people
- Sponsor
- Erasmus Medical Center