Clinical trials: Extracellular Alteration
Postthrombotic Syndrome With Ulcer of Left Lower Extremity, Extracellular Matrix Alteration
Biomarkers in Post Thrombotic Syndrome
This study aims to deepen the investigators knowledge of Post Thrombotic Syndrome and MMPs (and other related molecules such as TIMPS, NGAL and cytokines) to find a predictive molecular system to better classify the risk of…
- Trial name
- BIPOSTO (NCT02376764)
- Testing
- Blood drawing (venipuncture)
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro
Diabetic Kidney Disease, Extracellular Matrix Alteration
The Influence of the Thickening of Bowman's Capsule on the Clinical Prognosis of Patients With Diabetic Kidney Disease
Diabetic kidney disease (DKD) is the leading cause for renal replacement therapy in developed country. DKD is also the primary cause of ESKD among middle-aged and elderly people in China.
- Trial name
- NCT06049550
- Testing
- no intervention
- Volunteers
- 250 people
- Sponsor
- RenJi Hospital
HEMORRHOIDS, Extracellular Matrix Alteration
Hemorrhoids and Metalloproteinases, Observational Study
An association between hemorrhoidal disease and matrix metalloproteinases (MMPs) has been described previously. MMPs regulate extracellular structural proteins and tissue remodeling.
- Trial name
- HeMe (NCT02358174)
- Testing
- Hemorrhoidectomy, blood sampling, tissue sampling
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro
Extracellular Fluid Alteration, Corona Virus Infection
Extracellular Water in Covid 19 Pneumonia
According to various studies Covid 19 pneumonia has a very similar clinical course to Acute Respiratory Distress Syndrome (ARDS) which has clarified by Berlin definition.
- Trial name
- NCT04416009
- Testing
- NİCaS
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Metabolic Acidosis, Nephrolithiasis
Alkalinization by Urologists & Nephrologists
Metabolic acidosis recovers a wide range of diseases in which an oral alkalinization could be useful. This therapeutic intervention has been said to increase extracellular volume leading to rising blood pressure.
- Conditions
- Metabolic Acidosis, Nephrolithiasis, Extracellular Alteration, Blood Pressure
- Trial name
- AlcalUN (NCT03035812)
- Testing
- Alkali
- Where
- 18 sites in France
- Volunteers
- 156 people
- Sponsor
- Jean-Philippe Bertocchio
Critical Limb Ischemia, Extracellular Matrix Alteration
Matrix Metalloproteinases in Patients With Critical Limb Ischemia Undergoing Surgical Revascularization
In the present study the investigators will evaluate MMPs. serum levels variations in patients affected by critical limb ischemia, before and after lower limb surgical revascularization through venous or prosthetic bypass.
- Conditions
- Critical Limb Ischemia, Extracellular Matrix Alteration, Peripheral Revascularisation
- Trial name
- ROMAMETA (NCT02388867)
- Testing
- Polytetrafluoroethylene (PTFE) bypass grafting., Autogenous vein bypass grafting
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro
Incisional Hernia, Extracellular Matrix Alteration
Transcriptomic Analysis of Incisional Hernia Based on High-throughput Sequencing Technology
This study included patients who underwent surgical treatment for incisional hernia and non-hernia conditions. Surgical specimens were collected for transcriptome sequencing to obtain the gene expression list.
- Trial name
- NCT06366581
- Testing
- Transcriptomic analysis
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Fudan University
Statin, Aneurysm
Influence of Statins in Artery Aneurysms
The altered balance between the proteinases and their tissue inhibitors (TIMPS) is one of the pathogenetical mechanism of the aneurysmatic connective tissue degeneration.
- Conditions
- Statin, Aneurysm, Extracellular Matrix Alteration
- Trial name
- INSTANT (NCT03061487)
- Testing
- Open Surgical Treatment of Aneurysm (Aneurysmectomy)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Catanzaro
Anorectal Fistula, Extracellular Matrix Alteration
Ligation of Intersphincteric Fistula Tract (LIFT) Versus LIFT-plug Procedure for Anal Fistula Repair
The purpose of this study is to validate the effect of Ligation of Intersphincteric Fistula Tract (LIFT) Versus LIFT-plug procedure for Anal Fistula Repair.
- Trial name
- LIFT-plug (NCT01478139)
- Testing
- LIFT-plug, LIFT
- Where
- 5 sites in China
- Volunteers
- 240 people
- Sponsor
- Zhen Jun Wang
Allergic Asthma, Airway Remodelling
Role of Extracellular Matrix in the Development of Airway Remodeling in Asthma
Asthma is a major noncommunicable chronic inflammatory disorder which is characterized by airway inflammation and related to pathological modifications of the bronchial wall structure so called airway remodeling.
- Conditions
- Allergic Asthma, Airway Remodelling, Extracellular Matrix Alteration
- Trial name
- ECMA (NCT03388359)
- Testing
- Bronchial challenge with allergen, Co-culture formation, Inhibition of Wnt and Smad signaling pathways
- Where
- Lithuania
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
ESRD, Extracellular Fluid Alteration
Using Intradialytic Blood Pressure Slopes to Guide Ultrafiltration
This study is an open label randomized clinical trial that comparing intradialytic blood pressure slope-based ultrafiltration prescriptions to standard care in the chronic fluid management of maintenance hemodialysis patients.
- Conditions
- ESRD, Extracellular Fluid Alteration, Hypertension
- Trial name
- IBPS (NCT03303391)
- Testing
- Intradialytic Blood Pressure Slope Based Ultrafiltration
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Texas Southwestern Medical Center
Pulmonary Infection, COVID-19
MMP-9, TIMP-9 in Lung Imaging and Functional of COVID-19
This study aims to determine the role of the extracellular matrix in lung abnormalities in COVID-19 patients. Anatomical abnormalities of the lungs can be observed by the presence of abnormalities on a chest x-ray that is scored…
- Conditions
- Pulmonary Infection, COVID-19, Extracellular Matrix Alteration
- Trial name
- NCT05844215
- Testing
- MMP-9 and TIMP-1
- Where
- Indonesia
- Volunteers
- 78 people
- Sponsor
- Universitas Airlangga
Cardiac Disease, Covid19
Validation of Quantitative Myocardial Tissue Characterization Through Non-gated CT
The main aim is to validate non-gated 5-min computed tomography myocardial relative enhancement (CT-MRE), which can be readily estimated via contrast-enhanced non-gated chest CT, as a tool for estimating myocardial extracellular…
- Conditions
- Cardiac Disease, Covid19, Cardiotoxicity, Extracellular Space Alteration
- Trial name
- NCT04880317
- Testing
- Cardiac Magnetic Resonance, Additional CT acquisition, Blood tests
- Where
- Italy
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Muscle Loss, Extracellular Fluid Alteration
Ultrasound Detection of Body Composition in Critical Care
Objective assessment of the Changes in body composition of critically ill patients is very valuable. Ultrasound stands as a solution due to its portability, bedside availability, and radiation-free technology.
- Conditions
- Muscle Loss, Extracellular Fluid Alteration, Critical Illness, Pregnancy Complications
- Trial name
- NCT06728722
- Testing
- ultrasound detection of body composition
- Where
- Egypt
- Volunteers
- 121 people
- Sponsor
- Ain Shams University