Clinical trials: Extracellular Matrix Alteration
Critical Limb Ischemia, Extracellular Matrix Alteration
Matrix Metalloproteinases in Patients With Critical Limb Ischemia Undergoing Surgical Revascularization
In the present study the investigators will evaluate MMPs. serum levels variations in patients affected by critical limb ischemia, before and after lower limb surgical revascularization through venous or prosthetic bypass.
- Conditions
- Critical Limb Ischemia, Extracellular Matrix Alteration, Peripheral Revascularisation
- Trial name
- ROMAMETA (NCT02388867)
- Testing
- Polytetrafluoroethylene (PTFE) bypass grafting., Autogenous vein bypass grafting
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro
Postthrombotic Syndrome With Ulcer of Left Lower Extremity, Extracellular Matrix Alteration
Biomarkers in Post Thrombotic Syndrome
This study aims to deepen the investigators knowledge of Post Thrombotic Syndrome and MMPs (and other related molecules such as TIMPS, NGAL and cytokines) to find a predictive molecular system to better classify the risk of…
- Trial name
- BIPOSTO (NCT02376764)
- Testing
- Blood drawing (venipuncture)
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro
HEMORRHOIDS, Extracellular Matrix Alteration
Hemorrhoids and Metalloproteinases, Observational Study
An association between hemorrhoidal disease and matrix metalloproteinases (MMPs) has been described previously. MMPs regulate extracellular structural proteins and tissue remodeling.
- Trial name
- HeMe (NCT02358174)
- Testing
- Hemorrhoidectomy, blood sampling, tissue sampling
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro
Allergic Asthma, Airway Remodelling
Role of Extracellular Matrix in the Development of Airway Remodeling in Asthma
Asthma is a major noncommunicable chronic inflammatory disorder which is characterized by airway inflammation and related to pathological modifications of the bronchial wall structure so called airway remodeling.
- Conditions
- Allergic Asthma, Airway Remodelling, Extracellular Matrix Alteration
- Trial name
- ECMA (NCT03388359)
- Testing
- Bronchial challenge with allergen, Co-culture formation, Inhibition of Wnt and Smad signaling pathways
- Where
- Lithuania
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Incisional Hernia, Extracellular Matrix Alteration
Transcriptomic Analysis of Incisional Hernia Based on High-throughput Sequencing Technology
This study included patients who underwent surgical treatment for incisional hernia and non-hernia conditions. Surgical specimens were collected for transcriptome sequencing to obtain the gene expression list.
- Trial name
- NCT06366581
- Testing
- Transcriptomic analysis
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Fudan University