Clinical trials: Extracellular Vesicles
Oral Premalignant Lesions
The Senstivity and Specificity of Using Salivary miRNAs in Detection of Malignant Transformation of Oral Lesions.
Due to cancer is a leading cause of death world wide , we will coduct the study to evaluate the diagnostic accuracy of using salivary miRNAs (412,512) from the salivary extracellular vesicles (index test) in detection of the…
- Trial name
- NCT04913545
- Testing
- using salivary miRNA (412,512)
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Cairo University
Breast Cancer, Colon Cancer
EXoPERT EMERALD Clinical Study
The purpose of this study is to establish a multi-center clinical repository of blood samples to support the development and evaluation of an artificial intelligence-based in vitro diagnostic software.
- Conditions
- Breast Cancer, Colon Cancer, Pancreatic Cancer, Ovarian Cancer
- Trial name
- NCT07186296
- Testing
- EXoPred
- Where
- 9 sites in United States
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- EXoPERT
Scalp Health, Alopecia
Evaluation of the Scalp Skin Care Effects of Premium Revitalizing Elixir and Topical 5% Minoxidil
The study aims to evaluate the efficacy of two formulations on human scalp skin against established standard treatment of 5% minoxidil and base formula (placebo).
- Conditions
- Scalp Health, Alopecia, Hair Condition, Hair Loss
- Trial name
- NCT07901426
- Testing
- Base formula only, Base formula plus Centella asiatica extracellular vesicles, IGF-1 & FGF-7, Base formula plus Centella asiatica and ginger extracellular vesicles, IGF-1 & FGF-7
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hungkuang University
Cardiovascular Diseases, Vesicle
Kinetics of cEVs Over the 24-hour Dosing Interval After Low-dose Aspirin Administration
Extracellular vesicles (EVs) are small vesicles deriving from all cell types during cell activation, involved in transcellular communication, and regarded as predictors of vascular damage and of cardiovascular events.
- Trial name
- NCT05584943
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Brain Tumor, Childhood Cancer
Biomarkers of Brain Injury in Children With Brain Tumors
The goal of this observational study is to identify biomarkers of treatment-induced brain injury in children treated for primary brain tumors.
- Conditions
- Brain Tumor, Childhood Cancer, Childhood Brain Tumor
- Trial name
- BiomarkCBT (NCT07381959)
- Where
- Sweden
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Huntington Disease
Extracellular Vesicles for HD
The primary objective of this study is to discover blood-based biomarker of brain Huntingtin (HTT) protein using extracellular vesicles to be used in evaluating target engagement in HTT lowering clinical trials.
- Trial name
- NCT06082713
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Glioblastoma
Tear Fluid for the Detection of Tumor-associated Extracellular Vesicles in Glioblastoma Patients
This clinical trial tests the impact of tear fluid in detecting tumor-associated extracellular vesicles (TEVs) in patients with glioblastoma.
- Trial name
- NCT07775534
- Testing
- Biospecimen Collection, Electronic Health Record Review, Questionnaire Administration
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Healthy Control Subjects, Schizophrenia Diagnosis
Understanding Lifespan Trajectories of Social Cognition, Brain Microstructure and Iron Dysregulation in Schizophrenia
This study aims to better understand how schizophrenia may affect social thinking, emotion regulation, brain function, and biological processes over time. Two groups will take part in the study: 1.
- Trial name
- NCT07856381
- Where
- Austria
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Obesity, Weight Loss
Adipocyte-Derived Extracellular Vesicles, Weight Loss, and Endothelial Function
Changes in adipose tissue biology are now recognized as a key factor underlying the increased risk of metabolic and cardiovascular disease with obesity.
- Trial name
- NCT06776081
- Testing
- Weight loss without pharmacotherapy
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Parkinson's Disease and Parkinsonism
Saliva and Extracellular Vesicles for Parkinson's Disease
Rehabilitation is crucial in the treatment of people with Parkinson's disease (PD) as it can ameliorate motor and non-motor impairments, improving their clinical profile and quality of life.
- Trial name
- RaSPiD (NCT05320250)
- Testing
- Single saliva collection, Saliva collection, longitudinal
- Where
- 4 sites in Italy
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Systemic Lupus Erythematosus Nephritis
Monitoring Lupus Nephritis Through Urinary Extracellular Vesicles
Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE) that can lead to irreversible kidney damage if not detected and managed promptly.
- Trial name
- NCT06642402
- Testing
- Kidney biopsy, Urinary extracellular vesicle testing, Autoimmunity in plasma
- Where
- 4 sites in Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kolding Sygehus
Atherosclerosis Cardiovascular Disease, Obesity
Deciphering the Effect of Moderate Wine Consumption on Healthy Aging Through Postprandial Extracellular Vesicles.
This study aims to investigate how moderate wine consumption influences circulating extracellular vesicles (EVs) in healthy adults.
- Conditions
- Atherosclerosis Cardiovascular Disease, Obesity, Metabolic Syndrome, Metabolic Disorders
- Trial name
- (WINEVOME) (NCT07361887)
- Testing
- White Wine, Red Wine, Water
- Where
- Spain
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Seville
Dengue (Virus); Fever, Sandfly, Sickle Cell Disease
Molecular and Cellular Basis of Severe Forms of Dengue in Sickle Cell Patients
Dengue virus (DENV) belongs to the genus of Flavivirus transmitted by the mosquito Aedes aegypti and is responsible for an infectious disease associated with different forms and severities such as dengue hemorrhagic fever or…
- Trial name
- DREPADENGUE (NCT07000747)
- Where
- Guadeloupe
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Primary Myelofibrosis
Role of Mesenchymal Stromal Cell Derived Extracellular Vesicles of Primary Myelofibrosis Patients on CD34+ Cells
The aim of this study is to demonstrate that, in patients with myelofibrosis (PMF), a chronic neoplastic disease of the bone marrow, some of the cells that form the bone marrow microenvironment (mesenchymal stromal cells, MSCs)…
- Trial name
- NCT06896344
- Testing
- In vitro culture
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Traumatic Brain Injury
Application of Circulating Extracellular Vesicles in Early Disease Assessment and Prognosis After Traumatic Brain Injury
The purpose of this study was to observe the relationship between the changes of circulating extracellular vesicles and disease development and outcome in patients with traumatic brain injury, and to find early serum markers and…
- Trial name
- NCT05279599
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Obesity
Differences in Extracellular Vesicles From Adipose Tissue of Individuals With Obesity.
Our society is characterized by a strong increase in the prevalence of obesity, which often causes the development of cardiovascular and metabolic diseases such as type 2 diabetes.
- Trial name
- EVO (NCT06444646)
- Testing
- Adipose tissue biopsy, Blood sampling, Questionnaire
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Caesarean Delivery
Regenerative Effects of Birth Material Derived Extracellular Vesicles
Stem cells offer great hope for a wide range of disorders, including age-related brain disease such as dementia. Mesenchymal stem cells (MSCs) are special types of adult stem cells found in various tissues like the umbilical…
- Trial name
- ReGAIN (NCT06866184)
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Essential Thrombocythemia (ET), Myelofibrosis (MF)
Unraveling the Role of Extracellular Vesicles-driven Senescence in Myeloproliferative Neoplasms
In this study the aim is to investigate the pathogenetic role of extracellular vesicles and senescence in Myeloproliferative Neoplasms.
- Conditions
- Essential Thrombocythemia (ET), Myelofibrosis (MF), Polycythemia Vera (PV)
- Trial name
- NCT06798805
- Where
- 5 sites in Italy
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Myocardial Infarction
Antiplatelet Therapy Effect on Extracellular Vesicles in Acute Myocardial Infarction
Platelet activation and aggregation leads to myocardial infarction. Platelet P2Y12 receptors are essential for platelet activation.
- Trial name
- AFFECT EV (NCT02931045)
- Testing
- Ticagrelor, Clopidogrel
- Where
- 2 sites in Netherlands, Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Wild-type ATTR Amyloidosis, Amyloidosis Cardiac
ATTR Amyloid Cardiomyopathy: Characterization of Extracellular Vesicles as Potential Disease Stratifiers and Prognostic Biomarkers
This study explores whether extracellular vesicles (EVs) tiny particles released into the bloodstream by cells can serve as early and minimally invasive biomarkers for transthyretin amyloid cardiomyopathy (ATTR-CM).
- Conditions
- Wild-type ATTR Amyloidosis, Amyloidosis Cardiac, Amyloidosis, Hereditary, Amyloidosis Transthyretin
- Trial name
- EV-ATTR (NCT07314268)
- Where
- Brazil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital