Clinical trials: Extracorporeal Circulation
Blood Platelet Disorders, Cardiac Surgery
Observational Study of Platelet Dysfunction Assessed by Thromboelastography in Cardiovascular Surgery (DISPLATEG)
Perioperative bleeding requiring blood transfusion is common during cardiovascular surgery, especially in procedures requiring cardiopulmonary bypass. Adenosine diphosphate (ADP) plays a fundamental role in platelet function.
- Conditions
- Blood Platelet Disorders, Cardiac Surgery, Postoperative Bleeding
- Trial name
- DISPLATEG (NCT06961175)
- Where
- Spain
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Heart Transplant Failure, Determination of Death
Evaluation of Safety and Effectiveness of The SherpaPak in Donation After Circulatory Death Heart Transplantation
This is a prospective, pilot trial to evaluate the safety and effectiveness of The Paragonix SherpaPak™ Cardiac Transport System ("SherpaPak CTS") in transportation of cardiac allografts recovered from donors after circulatory…
- Conditions
- Heart Transplant Failure, Determination of Death, Outcomes Research, Extracorporeal Membrane Oxygenation
- Trial name
- NCT05038943
- Testing
- Paragonix SherpaPak Cardiac Transport System
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Nebraska
Pulmonary Valve Insufficiency
Pulmonary Valve Replacement in Large Right Ventricular Outflow Tract
The purpose of this study is to compare 2 techniques of pulmonary valve replacement in patients with a large right ventricular outflow tract: a standard surgical treatment using cardiopulmonary bypass versus a medico-surgical…
- Trial name
- NCT00259207
- Testing
- Pulmonary valve insertion, medical surgery hybride
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neurologic Manifestations
Cannulation of the Artery Axiliaris for Extracorporeal Circulation
Comparision of two different cannulation techniques on the neurological outcome in cardiac surcical procedures. Study hypothesis: Cannulation of the axilaris artery can reduce neurolocical side effects.
- Trial name
- NCT01615172
- Testing
- cannulation
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Heart Diseases, Lung Diseases
TandemHeart Experiences and MEthods (THEME Registry)
This study is intended to be a multicenter, prospective observation registry. By collecting prospective descriptive data, provide insight into disease defining characteristics resulting in the clinical decision to use…
- Trial name
- THEME (NCT02326402)
- Testing
- TandemHeart or LifeSPARC System
- Where
- 16 sites in United States
- Volunteers
- 365 people
- Sponsor
- CardiacAssist, Inc.
Vasoplegia, Endothelial Dysfunction
Evaluation of the Association Between Pre-existing Endothelial Dysfunction and the Onset of Vasoplegia During Cardiac Surgery With Cardiopulmonary Bypass
Cardiac surgery patients have many risk factors for endothelial dysfunction (hypertension, atherosclerosis, dyslipidemia, chronic renal failure ...).
- Trial name
- DYVA (NCT02965339)
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Coronary Artery Disease, Heart Valve Diseases
Removal of Cytokines During Extracorporeal Circulation in Cardiac Surgery
The aim of this study is to prove that using a CytoSorb(TM) filter in the cardiopulmonary circuit attenuates the inflammatory response to extracorporeal circulation in patients undergoing cardiac surgery.
- Trial name
- NCT02297334
- Testing
- CytoSorb device
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Long-term Outcome, Extracorporeal Membrane Oxygenation
Long Term Outcome of Extracorporeal Membrane Oxygenation Patients in China
Outcomes and Long-term Quality-of-life of Patients requiring Extracorporeal Membrane Oxygenation are not known in china. A prospective study survey will be performed to assess the long-term outcome of these patients.
- Trial name
- ECMO (NCT03345758)
- Testing
- outcome
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Southeast University, China
Cardiopulmonary Bypass
Heparin and Protamine Titration in Cardiac Surgery Under Minimal Invasive Extracorporeal Circulation
During a cardiac surgery under cardiopulmonary bypass it is essential that an appropriate level of anticoagulation is accomplished. To achieve this, the patient is administered heparin.
- Trial name
- NCT04215588
- Testing
- Hemostasis Management System Plus, Activated Coagulation Timer System Plus
- Where
- Greece
- Volunteers
- 134 people
- Sponsor
- Aristotle University Of Thessaloniki
Coronary Artery Bypass
Neurocognitive Outcome After Coronary Artery Bypass Surgery Using Minimal Versus Conventional Extracorporeal Circulation
The aim of this study is to assess the effect of minimal (MECC) versus conventional (CECC) extracorporeal circulation on neurocognitive function after elective coronary bypass grafting (CABG) as well as whether this can be…
- Trial name
- NCT01213511
- Testing
- Coronary artery bypass grafting with the use of minimal extracorporeal circulation, Coronary artery bypass grafting under conventional extracorporeal circulation
- Where
- Greece
- Volunteers
- 64 people
- Sponsor
- AHEPA University Hospital
Hemodialysis Complication, Air Embolism
Reduction of Microemboli of Air Using a New Developed Air Trap (EmbolessTM) During Haemodialysis
During hemodialysis (HD) the blood of the patient pass an extracorporeal circuit that contains a dialyzer for rinsing and a venous chamber (air trap) to prevent from air embolism through the return blood into the patient.
- Conditions
- Hemodialysis Complication, Air Embolism, Extracorporeal Circulation; Complications
- Trial name
- NCT06168539
- Testing
- Emboless, Standard
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Umeå University
Cardiac Surgery Requiring Extracorporeal Circulation
Heparin Antagonization by Protamine in Cardiac Surgery: Pharmacokinetic/Pharmacodynamic Study
Protamine is currently used during cardiac surgery to neutralize unfractionated heparin (UFH) at the end of extra-corporeal circulation (ECC).
- Trial name
- PICS (NCT04092868)
- Testing
- Blood samples PK/ PD protamine
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cardiac Surgery
Influence of Extracorporeal Circulation During Cardiac Surgery on the Development of Postoperative Thrombotic Thrombocytopenic Purpura (TTP)
The purpose of this study is to determine whether extracorporeal circulation during cardiac surgery has an influence on ADAMTS13-Activity.
- Trial name
- NCT01300117
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Inflammatory Response
Removal Of CytoKines With cytoSorbenTs After Inflammatory Response Reaction During Cardiac Surgery
Detailed knowledge about the association between systemic inflammation and endothelial progenitor cell (EPCs) activation during extracorporeal circulation (ECC) is lacking.
- Trial name
- ROCKSTAR (NCT06286280)
- Testing
- cytokine adsorber (CytoSorb®)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Giessen
Cardiac Surgery With Cardiopulmonary Bypass, Acute Mesenteric Ischemia
Perioperatively Assessed Biomarker I-FABP Level for Prediction of Acute Mesenteric Ischemia and Its Correlation With Acute Kidney Injury, Followed by Extracorporeal Circulation (aMIKI)
Acute mesenteric ischemia (AMI) is a severe condition that might occur after cardiovascular surgery. Several risk factors for AMI, such as multimorbidity, the use of vasopressors, and an increase in inflammatory markers have been…
- Conditions
- Cardiac Surgery With Cardiopulmonary Bypass, Acute Mesenteric Ischemia, Acute Kidney Injury, Non-Occlusive Mesenteric Ischaemia
- Trial name
- aMIKI (NCT06365827)
- Testing
- observational study
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University of Giessen
Coronary Artery Disease
Miniaturized Extracorporeal Circulation Study
Rationale: Contemporary coronary artery bypass grafting (CABG) continues to be associated with a significant risk of postoperative bleeding.
- Trial name
- NCT03216720
- Testing
- CABG, Miniaturized extracorporeal circulation, Conventional extracorporeal circulation
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Aarhus University Hospital Skejby
Aortic Valve Stenosis, Extracorporeal Circulation
Cerebral Embolic Load in Patients Undergoing Surgical Aortic Valve Replacement: A Comparison of the Conventional With the Minimized Extracorporeal Circulation Technique Using Transcranial Doppler Ultrasound
In this study, the investigators aim to compare cerebral embolic load in patients undergoing surgical aortic valve replacement using either the minimized extracorporeal circulation or the conventional extracorporeal circulation…
- Trial name
- AKE-MECC (NCT02308566)
- Testing
- Minimized Extracorporeal Circulation (MECC), Conventional Extracorporeal Circulation (CECC)
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Protamine Dose, Protamine Adverse Reaction
Impact of Protamine Dose Reduction on Platelet Aggregation After Extracorporeal Circulation for Minimally Invasive Aortic Valve Replacement Surgery
Determining the minimum effective dose of protamine after extracorporeal circulation for mini-sternotomy aortic valve replacement surgery.
- Trial name
- NCT06254404
- Testing
- Low dose protamine
- Volunteers
- 50 people
- Sponsor
- University of Liege
Cutaneous T-Cell Lymphoma, Unspecified, Chronic Graft Versus Host Disease in Skin
Modification of Extracorporeal Photopheresis in Cutaneous T-cell Lymphoma or Chronic Graft-versus-host Disease
Extracorporeal photopheresis (ECP), is commonly used for the treatment of cutaneous T-cell lymphoma (CTCL) and chronic graft-versus-host disease. ECP (cGVHD) is an immune modulating treatment.
- Trial name
- NCT03109353
- Testing
- ECP with 5-aminolevulinic acid
- Where
- Norway
- Volunteers
- 7 people
- Sponsor
- St. Olavs Hospital
Mechanical Circulatory Support
Cerebral Oximetry, Pulmonary Artery Catheter Parameters and ECMO Flow in Patients Supported With Veno-arterial ECMO
for patients connected to VA ECMO due to cardiogenic shock, monitoring: 1. Cerebral Oximetry 2. ECMO Parameters ECMO blood flow (L/min) every 12 hours. Sweep gas flow Cannulation configuration 3.
- Trial name
- ECMO (NCT07526181)
- Volunteers
- 30 people
- Sponsor
- Assiut University