Clinical trials: Extracorporeal Circulation
Long-term Outcome, Extracorporeal Membrane Oxygenation
Long-term Outcome of Patients Treated With Extracorporeal Membrane Oxygenation
Outcomes and Long-term Quality-of-life of Patients Treated With Extracorporeal Membrane Oxygenation are not known in china.A cross-section survey will be performed to assess the long-term outcome of these patients.
- Trial name
- NCT03182023
- Where
- China
- Volunteers
- 83 people
- Sponsor
- Southeast University, China
Cardiac Surgery, Extracorporeal Circulation; Complications
Evaluation of Blood and Cardiac Protein O-GlcNAcylation Levels in Cardiac Surgery in Children
Cardiac surgery requires the use of extracorporeal circulation (ECC). Age-related differences in inflammatory response, the greater susceptibility of immature organ systems to injury and the larger ratio of extracorporeal…
- Conditions
- Cardiac Surgery, Extracorporeal Circulation; Complications, Metabolism, Low Cardiac Output
- Trial name
- CardiOGlcNAc (NCT06754709)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Nantes University Hospital
Acute Respiratory Distress Syndrome, COVID19
Ultraprotective Ventilation Without Extracorporeal Circulation During COVID 19 Pneumonia
Mortality of COVID-19 pneumonia with acute respiratory distress syndrome (ARDS) is extremely high in preliminary reports amounting to 50-60%.
- Conditions
- Acute Respiratory Distress Syndrome, COVID19, Sars-CoV2, Pneumonia
- Trial name
- VT4COVID (NCT04349618)
- Testing
- PROTECTIVE VENTILATION, ULTRAPROTECTIVE VENTILATION
- Where
- 11 sites in France
- Volunteers
- 220 people
- Sponsor
- Hospices Civils de Lyon
Hemorrhage
Albumin vs. Plasma for PEdiAtric pRiming Trial
This is a randomized controlled trial that compares two different priming composition (albumin vs. fresh frozen plasma) for extracorporeal circulation of pediatric patients under 10 kg of weight.
- Trial name
- APPEAR (NCT02738190)
- Testing
- Albumin, Fresh Frozen Plasma
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS Policlinico S. Donato
Coronary Artery Disease, Heart Valve Diseases
Nitric Oxide in Cardiopulmonary Bypass for Renal Protection in Cardiac Surgery
This prospective randomized study evaluates the nephroprotective effects of exogenous nitric oxide delivered to the extracorporeal circulation circuit during cardiac surgery with cardiopulmonary bypass.
- Conditions
- Coronary Artery Disease, Heart Valve Diseases, Cardiomyopathies, Acute Kidney Injury
- Trial name
- NephroNO (NCT03527381)
- Testing
- Nitric Oxide, Standard CPB
- Volunteers
- 96 people
- Sponsor
- Nikolay Kamenshchikov
Lung Transplant; Complications, Extracorporeal Circulation; Complications
Routine Versus Selective Intraoperative ECMO in Lung Transplant
Intraoperative hemodynamic management is vital in the success of lung transplantation. Significant intraoperative hemodynamic compromise and hypoxic episodes may contribute to an increase in severe postoperative complications…
- Conditions
- Lung Transplant; Complications, Extracorporeal Circulation; Complications, Postoperative Complications
- Trial name
- NCT05505422
- Testing
- Routine ECMO, On demand ECMO
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Microvascular Rarefaction, Heart Valve Diseases
Evaluation of Systemic Microcirculation of Patients Undergoing Heart Valve Surgery
The study aims to study the systemic microcirculation in adult patients hospitalized at a quaternary public hospital during the preoperative and immediate postoperative periods of heart valve surgery and correlations to their…
- Conditions
- Microvascular Rarefaction, Heart Valve Diseases, Extracorporeal Circulation
- Trial name
- NCT05728047
- Testing
- Evaluation of sublingual microcirculation with side-stream dark field imaging (cytocam)
- Where
- Brazil
- Volunteers
- 31 people
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Pulmonary Hypertension
Iloprost in High Risk Cardiac Surgical Patients
In this study effects of the intra operative, prophylactic inhalation of Iloprost (Ventavis) before and during extracorporal circulation on perioperative morbidity and outcome in high risk cardiac surgical patients is…
- Trial name
- Ilocard (NCT00927654)
- Testing
- Iloprost (Ventavis)
- Where
- 6 sites in Germany
- Volunteers
- 253 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Arteriovenous Fistula
Correlation Between Access Blood Flow and Extracorporeal Blood Flow
The purpose of this study is to determine if Effective Extracorporeal Blood Flow(eEBF) has correlation with Access Blood Flow (Qa), when eEBF adjusts with Dynamic Arterial Line Pressure (DALP) in patients with Arteriovenous…
- Trial name
- NCT00522704
- Testing
- Dynamic Arterial line Pressure (DALP)
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Acute Kidney Injury
Does MiECC Improve Outcome in Diabetic Patients Undergoing Elective Coronary Bypass Grafting?
The aim of this study was to prospectively evaluate MECC compared with conventional extracorporeal circulation of diabetic patients undergoing elective coronary revascularization procedures.
- Trial name
- NCT02672514
- Testing
- Minimally invasive extracorporeal circulation (MiECC), Conventional extracorporeal circulation (CECC)
- Volunteers
- 104 people
- Sponsor
- Herzzentrum Coswig
Cardiopulmonary Bypass Surgery, Aortic Valve Surgery
Methylene Blue-Enhanced Ultrafiltration Improves Outcomes After Cardiopulmonary Bypass
Introduction: Fluid overload and systemic inflammation are major contributors to postoperative complications in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB).
- Conditions
- Cardiopulmonary Bypass Surgery, Aortic Valve Surgery, Mitral Valve Surgery, Myocardial Revascularization Surgery With Extracorporeal Circulation
- Trial name
- NCT07212842
- Testing
- Methylene Blue, Conventional ultrafiltration, Zero-balance ultrafiltration
- Where
- Brazil
- Volunteers
- 124 people
- Sponsor
- University of Sao Paulo
Out-Of-Hospital Cardiac Arrest
Rapid Response VA-ECMO in Refractory Out-of-hospital Cardiac Arrest
A selected group of patients with refractory cardiac arrest may benefit from inhospital treatment and this may warrant transfer to the hospital with ongoing CPR.
- Trial name
- RESuSCITATe (NCT03658759)
- Testing
- Extracorporeal Cardiopulmonary Resuscitation
- Where
- Netherlands
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Pulmonary Embolism and Thrombosis, Extracorporeal Membrane Oxygenation
Mechanical Respiratory/circulatory Support in Patients with Pulmonary Thrombectomy
Pulmonary embolism (PE) results from embolization of venous thrombi in the branches of the pulmonary arteries. Although anticoagulation is usually the preferred method of treatment, patients with high-risk and/or…
- Conditions
- Pulmonary Embolism and Thrombosis, Extracorporeal Membrane Oxygenation, Percutaneous Pulmonary Thrombectomy
- Trial name
- NCT06525480
- Testing
- Percutaneous pulmonary thrombectomy
- Where
- Spain
- Volunteers
- 77 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Intensive Care Unit
Effect of Ketamine Assisted Analgesia on Oxygen Supply and Oxygen Consumption in Patients After Cardiac Surgery
After cardiopulmonary bypass heart surgery, with the rewarming of body temperature, the metabolic capacity of the body is enhanced, the microcirculation is opened, and tissue perfusion is increased.
- Trial name
- NCT04906915
- Testing
- Ketamine
- Where
- China
- Volunteers
- 112 people
- Sponsor
- First People's Hospital of Chenzhou
Extracorporeal Membrane Oxygenation Complication, Cerebral Circulatory Failure
Monitoring of Cerebral Blood Flow in Patients on Extracorporeal Membrane Oxygenation
Venovenous extracorporeal membrane oxygenation (VV-ECMO) is a supportive therapy, indicated in case of severe, possibly reversible pulmonary failure, refractory to conventional therapies.
- Trial name
- NOTICE (NCT05303363)
- Testing
- VV-ECMO
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Extracorporeal Circulation; Complications, Air Embolism
Comparing Air Embolic Load in Two Venous Cannulation Methods, 40 Patients Undergoing Elective Valve Surgery.
The goal of this single center prospective controlled observational and interventional trial is to investigate and compare origin of air emboli when different venous cannulation methods is used in patients undergoing cardiac…
- Trial name
- NCT05820828
- Testing
- Volume control
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Petronella Torild
Extracorporeal Circulation
Anticoagulation Management in Complex Cardiac Surgery
The goal of this clinical trial is to compare the anticoagulation management with or without heparin concentration level guidance, in patients undergoing valve or complex cardiac surgery during cardiopulmonary bypass using…
- Trial name
- NCT05944107
- Testing
- Activated Clotting Time measurements combined with heparin concentration monitoring, Activated Clotting Time
- Where
- Greece
- Volunteers
- 65 people
- Sponsor
- Aristotle University Of Thessaloniki
Cardiac Diseases, Cardio-pulmonary Bypass
A Monitoring System Based on the Multifactorial Dynamic Perfusion Index to Predict and Prevent the Onset of Postoperative Acute Kidney Injury After Cardiac Surgery, Based on a Dynamic Collection of Hemodynamic and Clinical Parameters During Cardiopulmonary Bypass
This project is based on a predictive alghorithm (Multifactorial Dynamic Perfusion Index-MDPI) already published and covered by a patent.
- Conditions
- Cardiac Diseases, Cardio-pulmonary Bypass, Acute Kidney Injury, Adult Cardiac Surgery
- Trial name
- PEQUOD 2 (NCT06786416)
- Testing
- PEQUOD
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- IRCCS Policlinico S. Donato
Respiratory Insufficiency, Circulatory Failure
Comparing Anticoagulation Strategies Using UFH, Argatroban and LMWH for ECMO Support
A three-arm randomized controlled non-inferiority pilot study comparing anticoagulation strategies using unfractionated heparin, argatroban and enoxaparin for extracorporeal membrane oxygenation support conducted as an…
- Conditions
- Respiratory Insufficiency, Circulatory Failure, Thromboembolism, Bleeding
- Trial name
- CASUAL-ECMO (NCT06442267)
- Testing
- Enoxaparin Injectable Solution, Argatroban, 1 Mg/mL Intravenous Solution, Unfractionated heparin
- Where
- Austria
- Volunteers
- 90 people
- Sponsor
- Medical University of Vienna
Anemia, Cognitive; Disorder, Due to General Medical Condition
Haemo-autologous Antegrade Repriming (HAR) as Minimum Impact Perfusion Strategy for Cardiopulmonary Bypass
Haemo-autologous Antegrade Repriming (HAR) is a procedure based in the combination of evidence proven measures designed to reduce the haemodilution caused by establishing the cardiopulmonary bypass (CPB) during cardiac surgery.
- Conditions
- Anemia, Cognitive; Disorder, Due to General Medical Condition, Embolism, Air, Transfusion
- Trial name
- HARjbm1 (NCT03720184)
- Testing
- HAR
- Where
- Spain
- Volunteers
- 116 people
- Sponsor
- Juan Blanco Morillo