Clinical trials: Extracorporeal Membrane Oxygenation Support
Respiratory Insufficiency, Circulatory Failure
Comparing Anticoagulation Strategies Using UFH, Argatroban and LMWH for ECMO Support
A three-arm randomized controlled non-inferiority pilot study comparing anticoagulation strategies using unfractionated heparin, argatroban and enoxaparin for extracorporeal membrane oxygenation support conducted as an…
- Conditions
- Respiratory Insufficiency, Circulatory Failure, Thromboembolism, Bleeding
- Trial name
- CASUAL-ECMO (NCT06442267)
- Testing
- Enoxaparin Injectable Solution, Argatroban, 1 Mg/mL Intravenous Solution, Unfractionated heparin
- Where
- Austria
- Volunteers
- 90 people
- Sponsor
- Medical University of Vienna
Carbon Dioxide
Validation of Continuous Transcutaneous Carbon Dioxide Monitoring in VA-ECMO Patients
Carbon dioxide in patients on veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is eliminated via respirator as well as via the oxygenator's membrane of the ECMO machine.
- Trial name
- NCT04445909
- Testing
- VA-ECMO
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Acute Respiratory Distress Syndrome (ARDS)
Ultraprotective Lung Ventilation With Respiratory Extracorporeal Life Support for ARDS
Acute respiratory distress syndrome (ARDS) accounts for approximately 10% of all ICU admissions and 23% of patients requiring mechanical ventilation (MV).
- Trial name
- NOVAEOLIA (NCT07516665)
- Testing
- ECLS
- Volunteers
- 290 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiogenic Shock
A Study on the Effects of Left Ventricular Unloading in the Setting of VA ECMO Support
REMAP ECMO is a registry based platform in which multiple response adaptive randomized clinical trials (trial domains) will be embedded.
- Trial name
- REMAP ECMO (NCT05913622)
- Testing
- Intra-aortic balloon pump
- Where
- 14 sites in Belgium, Netherlands
- Volunteers
- 430 people
- Sponsor
- Erasmus Medical Center
Acute Respiratory Distress Syndrome, Cardiogenic Shock
Closed Loop Mechanical Ventilation and ECMO
Mechanical ventilation and ECMO are both technologies interacting on gas exchange. Nevertheless, besides a consensus paper, no evidence-based guidelines regarding protective lung ventilation on ECMO exist to date.
- Trial name
- NCT04925518
- Testing
- Closed Loop Mechanical Ventilation, Conventional Mechanical Ventilation
- Volunteers
- 62 people
- Sponsor
- University of Zurich
Extracorporeal Membrane Oxygenation Complication
EUROSETS ECMO Study in Clinical Extracorporeal Life Support Applications
This is a prospective single-center study designed for evaluation of safety and performance of the Conformitè Europëenne (CE)-marked EUROSETS ECMOLIFE SYSTEM, composed by: ECMOLIFE console, ECMO TUBING SET, ECMO OXYGENATOR and…
- Trial name
- NCT05163925
- Testing
- Eurosets ECMO Life System
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Eurosets S.r.l.
Extracorporeal Membrane Oxygenation Complication, Cardiopulmonary Bypass
Evaluation Of The Pharmacokinetics Of Antithrombin III In Neonates And Infants Undergoing CPB And ECMO Support
The potential role of ATIII in achieving and maintaining adequate anticoagulation in pediatric patients on the heart-lung machine has recently taken on increased importance as caregivers strive to mitigate the risk for clinically…
- Trial name
- NCT02631174
- Testing
- Antithrombin III
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Extracorporeal Membrane Oxygenation Complication
Bivalirudin vs Heparin in ECMO Patients
This is an open label, randomized study comparing the clinical outcomes of unfractionated Heparin and Bivalirudin for anticoagulation in adult subjects requiring ECMO support.
- Trial name
- NCT03707418
- Testing
- Heparin Sodium, Bivalirudin Injection [Angiomax]
- Where
- United States
- Sponsor
- Johns Hopkins University
Extracorporeal Membrane Oxygenation, Platelet Activation
Platelet Function During Extracorporeal Membrane Oxygenation in Adult Patients
The primary aim is to describe platelet function in adult patients treated with extracorporeal membrane oxygenation (ECMO). A clarification of the platelet function in these critically ill patients contributes to an understanding…
- Conditions
- Extracorporeal Membrane Oxygenation, Platelet Activation, Platelet Aggregation, Platelet Function Tests
- Trial name
- NCT03355625
- Where
- 2 sites in Denmark
- Volunteers
- 33 people
- Sponsor
- Aarhus University Hospital
Critically Ill Patients With ECMO
Imipenem in Critically Ill Patients
Extracorporeal membrane oxygenation (ECMO) has become increasingly used for lifesaving respiratory and/or cardiac failure support in critically ill patients, including those with life-threatening severe infections.
- Trial name
- NCT03776305
- Testing
- Imipenem
- Where
- Thailand
- Volunteers
- 12 people
- Sponsor
- Prince of Songkla University
Acute Myocardial Infarction, Cardiogenic Shock
Extracorporeal Life Support in Cardiogenic Shock
The aim of the study is to examine whether treatment with extracorporeal life support (ECLS) in addition to revascularization with percutaneous coronary intervention (PCI) or alternatively coronary artery bypass grafting (CABG)…
- Trial name
- ECLS-SHOCK (NCT03637205)
- Testing
- ECLS insertion, Revascularisation and optimal medical treatment
- Where
- 46 sites in Germany, Slovenia
- Volunteers
- 420 people
- Sponsor
- Helios Health Institute GmbH
Microcirculation, Extracorporeal Membrane Oxygenation
Effects of Microcirculation-assisted Adjustment of Blood Flow of VA-ECMO on Prognosis
One of the key factors of survival of patients with extra-corporeal membrane oxygenation (ECMO) life support system is whether the blood flow supplied by ECMO can meet the need of perfusion of each organ.
- Trial name
- NCT03470792
- Testing
- Microcirculation examination
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Cardiac Arrest (CA), ExtraCorporeal Life Support (ECLS)
Search for Prognostic Factors Associated With Better Survival in Refractory Cardiac Arrest
Through this retrospective observational study (over 4 years; period analysed: 1st January 2011 to 31st December 2014), we looked for prognostic factors associated with better survival in refractory cardiac arrest by: assessing…
- Trial name
- Pro-ACR (NCT03261232)
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Mechanical Circulatory Support
Cerebral Oximetry, Pulmonary Artery Catheter Parameters and ECMO Flow in Patients Supported With Veno-arterial ECMO
for patients connected to VA ECMO due to cardiogenic shock, monitoring: 1. Cerebral Oximetry 2. ECMO Parameters ECMO blood flow (L/min) every 12 hours. Sweep gas flow Cannulation configuration 3.
- Trial name
- ECMO (NCT07526181)
- Volunteers
- 30 people
- Sponsor
- Assiut University
Heart Failure, Respiratory Failure
Reduced Anticoagulation Targets in ECLS (RATE)
The objective of the RATE-trial is to study if reduced anticoagulation targets during ECLS diminish bleeding complications without an increase in thromboembolic complications or a negative impact on outcome.
- Conditions
- Heart Failure, Respiratory Failure, Extracorporeal Membrane Oxygenation, Bleeding
- Trial name
- RATE (NCT04536272)
- Testing
- Heparin, LMWH
- Where
- 8 sites in Netherlands
- Volunteers
- 330 people
- Sponsor
- University Medical Center Groningen
Extracorporeal Life Support, Neurodevelopment
A Follow-up Study of Neonates Receiving Extracorporeal Life Support in China
Descriptive study of two-year follow-up outcomes of surviving neonates who are enrolled in the Chinese Neonatal Extracorporeal Life Support Registry (Chi-NELS) from 2022 to 2024.
- Conditions
- Extracorporeal Life Support, Neurodevelopment, Neonate, Mortality
- Trial name
- NCT05045092
- Sponsor
- Children's Hospital of Fudan University
Heart Arrest
Evaluation of Drainable Volume Measurements During VA-ELS
Veno-arterial extracorporeal life support (VA-ELS) is used to support patients with acute cardiac failure. In that context, sufficient drainable venous volume is crucial for reliable and adequate support.
- Trial name
- NCT02326506
- Testing
- VA-ELS pump speed variations
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Maastricht University Medical Center
Cardiogenic Shock, Heart Failure
Veno-arterial Extracorporeal Membrane Oxygenation Prior to Left Ventricular Assist Device Implantation.
Cardiogenic shock is an uncommun pathology with a high mortatily rate around 45%. Veno arterial extracorporeal membrane oxygenation (VA-ECMO) is a temporary extracorporeal assist device which restore an adequate blood flow when a…
- Conditions
- Cardiogenic Shock, Heart Failure, Extracorporeal Membrane Oxygenation, Left Ventricular Assist Device
- Trial name
- LVAD-ECMO (NCT03583970)
- Testing
- Left Ventricular Assist Device Implantation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
Extracorporeal Life Support
Optic Nerve Sheath Diameter and the Duration of Extracorporeal Life Support During Newborn Cardiac Surgery
Mortality rates for newborns with congenital heart disease (CHD) have dramatically decreased thanks to surgical methods and medical treatment improvements.
- Trial name
- NCT05930691
- Testing
- Optic nerve sheath diameter measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Konya City Hospital
Cardiogenic Shock, Cardiac Arrest
China Extracorporeal Life Support Registry
Extracorporeal life support (ECLS), also known as extracorporeal membrane oxygenation (ECMO), is an extracorporeal technique of providing effective cardiac and respiratory support to patients with lungs and/or heart failure.
- Conditions
- Cardiogenic Shock, Cardiac Arrest, Heart Failure, Acute Respiratory Distress Syndrome
- Trial name
- NCT04158479
- Testing
- ECMO
- Where
- China
- Volunteers
- 20,000 people
- Sponsor
- Beijing Anzhen Hospital