Clinical trials: Extracorporeal Membrane Oxygenation Support
Cardio-Respiratory Failure, Extracorporeal Membrane Oxygenation Complication
Safety and Performance of the Novalung Ultimate Kit and Xenios 2.0 During Stationary Use in Hospital and Ground-based Transport of Patients on Extracorporeal Life Support (ECLS)
This prospective observational study will evaluate the safety and performance of the Novalung ultimate kit in combination with the Xenios 2.0 and the MultiSupport Ground during stationary use in hospital and ground-based…
- Conditions
- Cardio-Respiratory Failure, Extracorporeal Membrane Oxygenation Complication, Acute Lung Injury
- Trial name
- Transport+ (NCT07156669)
- Testing
- Novalung ultimate kit, Xenios 2.0, and MultiSupport Ground (MSG)
- Where
- 3 sites in Germany
- Volunteers
- 20 people
- Sponsor
- Xenios AG
Cardiac Arrest, Cardiopulmonary Resuscitation
Cardiac Arrest Extra Corporeal Oxygenation Membrane
French guidelines for Cardio Pulmonary Resuscitation (CPR) consider Extra-Corporeal Life Support (ECLS) as one option in Refractory out-of hospital Cardiac Arrest (ROHCA) patients with a no-flow less than five minutes and absence…
- Conditions
- Cardiac Arrest, Cardiopulmonary Resuscitation, Advanced Cardiac Life Support, Extracorporeal Life Support
- Trial name
- CAREECMO (NCT03352999)
- Testing
- Fast track access to vaECMO
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
Lung Transplantation
Heparin-free Extracorporeal Membrane Oxygenation Support During Clinical Lung Transplantation
The aim of this investigation is to compare two different anti-coagulation strategies in clinical lung transplantation where lung implantations are all routinely done on veno-arterial (VA) extracorporeal membrane oxygenation…
- Trial name
- zero-hep (NCT05697692)
- Testing
- Heparin sodium
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Medical University of Vienna
Acute Hypoxemic Respiratory Failure, Mechanical Ventilation
Safety and Efficacy of Low-Flow ECMO in a Multi-modal Cohort of Adults in Respiratory Failure
The current standard of care (SOC) for treatment of patients with acute respiratory distress syndrome (ARDS), inhalation injury, volume overload, and/or pulmonary dysfunction is mechanical ventilation (MV).
- Conditions
- Acute Hypoxemic Respiratory Failure, Mechanical Ventilation, Acute Respiratory Distress Syndrome (ARDS)
- Trial name
- NCT06938217
- Testing
- Low-flow ECMO
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Institute for Extracorporeal Life Support
Extracorporeal Life Support, Extracorporeal Membrane Oxygenation
Quality Improvement to Reduce Mortality or Severe Intracranial Hemorrhage in Neonatal Extracorporeal Life Support
This is a three-year pre- and post- interventional study to assess the effectiveness of collaborative quality improvement interventions on reducing mortality and severe intracranial hemorrhage (ICH) for neonates receiving…
- Conditions
- Extracorporeal Life Support, Extracorporeal Membrane Oxygenation, Quality Improvement, Intracranial Hemorrhage
- Trial name
- NCT05075486
- Testing
- Collaborative quality improvement
- Sponsor
- Children's Hospital of Fudan University
Cardiopulmonary Arrest, Fungal Infection
Pharmacokinetics/Pharmacodynamics (PK/PD) of Fluconazole in Children on Extracorporeal Membrane Oxygenation (ECMO)
Extracorporeal membrane oxygenation (ECMO) is a form of heart-lung bypass used to support children who suffer heart or lung failure until whatever illness caused that failure can be treated and reversed.
- Trial name
- NCT01169402
- Testing
- Fluconazole
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Michael Cohen-Wolkowiez
Extracorporeal Life Support, Hypotension
Hypotension During Extracorporeal Circulatory Support Indicated for Cardiogenic Shock
The cardiogenic shock is characterized by an alteration of organs function following a decrease in cardiac output linked to an impairment of cardiac performance. The prognosis remains poor with mortality between 40 and 50%.
- Conditions
- Extracorporeal Life Support, Hypotension, Vasoplegia
- Trial name
- RetroECMO-VP (NCT03968926)
- Testing
- Arterial pressure management during circulatory support by VA-ECMO
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Montpellier
Sepsis, Critical Illness
Exploring and Establishment of Combined Extracorporeal Life Support(CELS) in Critically Ill Children
Multiple organ failure (MODS) is still the leading cause of death in children in ICU. The treatment of MODS is mainly organ function monitoring and organ replacement therapy.
- Conditions
- Sepsis, Critical Illness, MODS
- Trial name
- CELS (NCT03654287)
- Testing
- Treatment
- Where
- China
- Sponsor
- Guoping Lu
Myocardial Infarction, Shock, Cardiogenic
Comparison of Standard Treatment Versus Standard Treatment Plus Extracorporeal Life Support (ECLS) in Myocardial Infarction Complicated With Cardiogenic Shock
Cardiogenic shock is currently the main cause of death after myocardial infarction and 50% of deaths occur within the first 48 hours.
- Trial name
- NCT00314847
- Testing
- Extra-Corporeal Life Support -Impella 2.5
- Where
- 13 sites in France
- Volunteers
- 19 people
- Sponsor
- University Hospital, Caen
Extracorporeal Membrane Oxygenation Complication, Critical Care
Evaluation of Long-term Quality of Life in Children Supported with ExtraCorporeal Membrane Oxygenation (ECMO)
The main objective of this prospective transversal comparative study is to describe the quality of life of children supported by ECMO.
- Trial name
- ECMOQoL (NCT05721105)
- Testing
- Quality of life assessment using questionnaires
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Nantes University Hospital
Out-of Hospital Cardiac Arrest
Hyperinvasive Approach in Cardiac Arrest
Prague out-of Hospital Cardiac Arrest (OHCA) study is a prospective randomized multicenter clinical study comparing use of prehospital intraarrest hypothermia, mechanical chest compression device, extracorporeal life support…
- Trial name
- NCT01511666
- Testing
- Prehospital mechanical compressions, intraarrest cooling and in hospital ECLS, Standard care
- Where
- Czechia
- Volunteers
- 256 people
- Sponsor
- Charles University, Czech Republic
Cardiogenic Shock
The Effect of Simultaneous Renal Replacement Therapy on Extracorporeal Membrane Oxygenation Support for Cardiogenic Shock Patients
Extracorporeal membrane oxygenation (ECMO) is a temporary mechanical circulatory support device for cardiogenic shock (CS) patients.
- Trial name
- NCT02870946
- Testing
- Simultaneous RRT, Standard care
- Where
- China
- Volunteers
- 262 people
- Sponsor
- Beijing Anzhen Hospital
MERS-CoV Infection, Refractory Hypoxemia
Saudi Outcomes of ECMO-treated MERS-CoV Patients
A highly pathogenic human coronavirus causing respiratory disease emerged in Saudi Arabia in 2012. This viral infection termed Middle East respiratory syndrome coronavirus (MERS-CoV) is associated with high mortality rate in…
- Trial name
- NCT02627378
- Testing
- Extracorporeal Membrane Oxygenation, Non Extracorporeal Membrane Oxygenation
- Where
- Saudi Arabia
- Volunteers
- 35 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Death, Sudden, Cardiac, HEART ARREST
Blood Management During ECMO for Cardiac Support
Extracorporeal membrane oxygenation (ECMO) is a lifesaving procedure used to treat severe forms of heart and/or lung failure. It works by the principal of replacing the function of these organs by taking blood from the patient…
- Conditions
- Death, Sudden, Cardiac, HEART ARREST, Shock, Cardiogenic, Arrhythmias, Cardiac
- Trial name
- OBLEX (NCT03714048)
- Where
- Australia
- Volunteers
- 561 people
- Sponsor
- St Vincent's Hospital, Sydney
Respiratory Failure
Lung Transplantation in Respiratory Failure Patients
Survival after cadaveric lung transplantation in recipients depended on ventilation support prior to transplantation has been reported to have relative high surgical mortality and morbidity rate.
- Trial name
- NCT00854165
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- National Taiwan University Hospital
Critical Illness, Respiratory Failure (Pediatric Patients)
Ventilator Settings and Outcomes in Pediatric Patients on ECMO for Severe Respiratory Failure
This study aims to describe the effects of ECMO initiation on the intensity of ventilation in the first 24 hours after ECMO initiation and to explore associations between changes in ventilation intensity and hospital mortality in…
- Trial name
- NCT06899009
- Where
- Netherlands
- Volunteers
- 750 people
- Sponsor
- University Medical Center Groningen
Residual Cardiac Output During PVA-ECMO
Use of Exhaled Carbon Dioxyde for Monitoring the Native Cardiac Function During Mechanical Circulatory Support With Venoarterial By-pass in Intensive Care Unit
Cardiogenic shock, the most severe form of acute heart failure, is a critical situation where the body cells lack of oxygen because of cardiac dysfunction.
- Trial name
- CAPNOECMO (NCT03323268)
- Testing
- PetCO2 monitoring
- Where
- France
- Volunteers
- 39 people
- Sponsor
- University Hospital, Montpellier
Bleeding Disorder, Extra Corporeal Life Support
Extracorporeal Life Support and Modification of Hemostasis
To evaluate change in coagulation tests during a 48-h period after initiation VV-ECMO and VA-ECMO. (ECMO= Extra Corporeal Membrane Oxygenator) Assessment of bleeding during Veno-Venous Extracoporeal Membrane Oxygenator (VV-ECMO)…
- Conditions
- Bleeding Disorder, Extra Corporeal Life Support, Thrombosis
- Trial name
- ELMOH (NCT04912336)
- Testing
- Standard coagulation profile, Specific coagulation tests, Bleeding Scores
- Where
- 6 sites in Belgium, Germany
- Volunteers
- 43 people
- Sponsor
- University Hospital, Ghent
Acute Decompensated Heart Failure
Interest of Levosimendan in Reducing Weaning Failures of ExtraCorporeal Life Support - ECLS
Extracorporeal life support (ECLS) is a circulatory cardio supplementation technique; it therefore makes it possible to compensate for a defective cardiac or cardio-respiratory function.
- Trial name
- Weanilevo (NCT04158674)
- Testing
- Levosimendan, Cernevit
- Where
- France
- Volunteers
- 82 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
VV ECMO, Bleeding
Incidence of Bleeding, Thrombosis and Transfusion Requirements in ICU Patients With COVID-19 Supported With Veno-venous Extracorporeal Membrane Oxygenation
The investigators aim to assess the risk of bleeding and thrombo-embolic complications as well as benefit and harm of blood product transfusion and anticoagulation therapy in adult ICU patients with COVID-19 supported with V-V…
- Conditions
- VV ECMO, Bleeding, Thrombosis, Transfusion Adverse Reaction
- Trial name
- NCT07352072
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet