Clinical trials: Extraesophageal Reflux
Extraesophageal Symptoms, Gastroesophageal Reflux Disease (GERD)
A Study on the Effectiveness of Laparoscopic Fundoplication on Extraesophageal Manifestations of Gastroesophageal Reflux Disease (GERD)
Available data regarding the effectiveness of laparoscopic antireflux surgery on extraesophageal symptoms of gastroesophageal reflux disease (GERD) are scarce and mostly controversial.
- Trial name
- NCT01324986
- Testing
- Laparoscopic anti-reflux surgery
- Where
- Austria
- Sponsor
- General Public Hospital Zell am See
Extraesophageal Reflux
Extraesophageal Reflux - Feasibility of Measurement of Pepsin in Saliva as a Diagnostic Option
The diagnostics of extraesophageal reflux (EER) is challenging. Currently, 24-h dual-probe esophageal pH monitoring or impedance is considered the best diagnostic method for EER.
- Trial name
- NCT03904758
- Testing
- Pepsin in saliva test
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- University Hospital Ostrava
Gastroesophageal Reflux Disease
The Proton Pump Inhibitor (PPI) Test for the Extraesophageal Manifestation of GERD
PPI test;empirical trial with high-dose proton-pump inhibitors (PPIs) has been shown to be a sensitive tool for diagnosing patients with GERD.
- Trial name
- NCT00539786
- Testing
- Proton pump inhibitor (rabeprazole)
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Nasal Diseases, Nasal Polyps
The Diagnostics of Extraesophageal Reflux With the Restech System
The aim of the project is to define the frequency with which EER is present in patient with chronic rhinosinusitis (CHR). The measurement will be carried out with a 24-hour monitoring of the pH using the Restech system.
- Conditions
- Nasal Diseases, Nasal Polyps, Laryngopharyngeal Reflux
- Trial name
- NCT01819454
- Testing
- pH monitoring (Restech)
- Where
- Czechia
- Volunteers
- 90 people
- Sponsor
- University Hospital Ostrava
Postnasal Drainage
Post-nasal Drainage as an Extraesophageal Manifestation of Reflux
Objectives of this study are: To quantitatively evaluate the relationship between extraesophageal manifestations of gastroesophageal reflux (EER) and postnasal drainage(PND)in a group of patients without radiographic or…
- Trial name
- NCT00199953
- Testing
- Rabeprazole 20 mg twice a day for 90-day period treatment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Medical College of Wisconsin
Otitis Media With Effusion, Laryngopharyngeal Reflux
Three Methods Used in the Diagnosis of EER in Children With OME
Detection of extraesophageal reflux (EER) in children with chronic otitis media with effusion (OME) using three different diagnostic methods and selection of the group of patients with severe EER who could potentially benefit…
- Trial name
- NCT02183961
- Testing
- Restech, Peptest, Detection of pepsin in adenoid specimen
- Where
- Czechia
- Volunteers
- 24 people
- Sponsor
- University Hospital Ostrava
Laryngopharyngeal Reflux
Treatment of Extraesophageal Reflux With the Reza Band UES Assist Device
The purpose of the study is to determine the safety and effectiveness of non-invasive Reza Band UES Assist Device for the treatment of esophagopharyngeal reflux with extra-esophageal symptoms (chronic cough, choking, aspiration…
- Trial name
- NCT01857713
- Testing
- Reza Band UES Assist Device
- Where
- 5 sites in United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Somna Therapeutics, L.L.C.
Recurrent Respiratory Papillomatosis, Extra Oesophageal Reflux
Recurrent Respiratory Papillomatosis and Extraesophageal Reflux
The purpose of the study was to determine, whether patients with recurrent respiratory papillomatosis (RRP) suffer from extra oesophageal reflux more often than patients with laryngeal cyst (control group).
- Conditions
- Recurrent Respiratory Papillomatosis, Extra Oesophageal Reflux, Laryngeal Cyst
- Trial name
- NCT02592902
- Testing
- Surgical collection of histology specimen, Performance of immunohistochemical analysis
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- University Hospital Ostrava
Laryngopharyngeal Reflux (LPR), Extraesophageal Reflux
Positive Predictive Value of the Dx-pH Probe for Predicting PPI Response in LPR
The purpose of this research study is to better understand whether information obtained from a pH probe can help physicians predict whether a patient will respond to the medication that is prescribed for laryngopharyngeal reflux…
- Conditions
- Laryngopharyngeal Reflux (LPR), Extraesophageal Reflux, Reflux Laryngitis, Posterior Laryngitis
- Trial name
- NCT01755221
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Northwestern University
Chronic Cough, Extraesophageal Reflux
Individualized Diagnosis and Treatment of Extraesophageal Reflux in Patients With Chronic Cough
Chronic cough is a very unpleasant symptom, significantly reduces the patient's quality of life, and bothers the neighborhood. A very common cause or co-factor of chronic cough is extraesophageal reflux (EER).
- Conditions
- Chronic Cough, Extraesophageal Reflux, Laryngopharyngeal Reflux, Allergy
- Trial name
- NCT04984304
- Testing
- Lifestyle modifications and Antireflux diet, Extraesophageal reflux diagnostic
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- University Hospital Ostrava
Extraesophageal Symptoms, Cough
Screening for Barrett's Esophagus in Otolaryngology Patients
The purpose of this project is to develop an accurate method to identify patients that suffer from acid reflux, but may not present with classic reflux symptoms (such as heart burn).
- Conditions
- Extraesophageal Symptoms, Cough, Throat Clearing, Hoarseness
- Trial name
- SCE (NCT00695227)
- Testing
- Screening for Barrett's Esophagus
- Where
- United States
- Volunteers
- 295 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Gastroesophageal Reflux Disease
A Cross-sectional Study on the Prevalence and Extraesophageal Symptoms of Gastroesophageal Reflux Disease(GERD) in Patients With Upper GI Symptoms, Visiting the Outpatient Departments of Peripheral Hospitals in Greece
The present study has been designed to provide current data on GERD prevalence in several regional areas of Greece outside the two major urban centres (Athens and Thessaloniki), to measure the treatment response in GERD patients…
- Trial name
- GERDQ-XS (NCT01215305)
- Where
- 19 sites in Greece
- Volunteers
- 600 people
- Sponsor
- AstraZeneca
Laryngopharyngeal Reflux
Predictive Value of Subjective and Objective Measurement Tools for Extraesophageal Reflux
Acid reflux can cause many symptoms in the throat, including discomfort or pain, and difficulty with breathing and voice problems.
- Trial name
- NCT01829074
- Volunteers
- 150 people
- Sponsor
- Respiratory Technology Corporation
Extra-esophageal Reflux
Sleep Position May Reduce Acid Reflux Symptoms at Night
This study is designed to determine if the addition of the MedclineTM Sleep Assist Device will decrease night-time gastroesophageal reflux disease events.
- Trial name
- NCT02320968
- Testing
- MedclineTM Sleep Assist Pillow
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University Medical Center
Bronchial Asthma, Gastroesophageal Reflux
Improvement in Bronchial Asthma in Patients With Extraesophageal Reflux After Acid Suppression
The purpose of this study is to determine if 20mg BID of Rabeprazole is effective in controlling GERD in patients with concomitant bronchial asthma and to assess improvement in asthma after reflux control.
- Trial name
- NCT00234117
- Testing
- Rabeprazole
- Where
- Puerto Rico
- Volunteers
- 40 people
- Sponsor
- Ponce Gastroenterology Research
Nasal Polyps, Gastroesophageal Reflux
Investigation of the Association Between Nasal Polyposis and Extraesophageal Reflux Disease
Although nasal polyposis has been recognized as an inflammatory process for many years, the true etiology of nasal polyposis mainly unknown.
- Trial name
- NCT00215787
- Testing
- lansoprazole
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Head and Neck Surgery Associates
Inferior Nasal Turbinate Hypertrophy, Extraesophageal Reflux
Effect of Extraesophageal Reflux on Inferior Nasal Turbinates Hypertrophy
The study examines the severity of extraesophageal reflux using oropharyngeal pH monitoring in patients with varying degrees of lower turbinates hypertrophy.
- Trial name
- NCT04581174
- Testing
- 24-hour monitoring of oropharyngeal pH by Restech, RYAN scores upright and supine, and pH values <5.5 will be evaluated
- Where
- 3 sites in Czechia, Slovakia
- Volunteers
- 160 people
- Sponsor
- University Hospital Ostrava
Extraesophageal Reflux, Laryngopharyngeal Reflux
Comprehensive Analysis of the Swallowing Mechanism Using High-resolution Manometry With Impedance
The aim of this project is to perform a detailed evaluation of upper esophageal sphincter function and the swallowing mechanism in patients with swallowing disorders or suspected extraesophageal reflux using high-resolution…
- Conditions
- Extraesophageal Reflux, Laryngopharyngeal Reflux, Dysphagia, Chronic Cough
- Trial name
- NCT07365046
- Testing
- High resolution oesophageal manometry with impedance, 24-hour pH metry
- Where
- Czechia
- Volunteers
- 160 people
- Sponsor
- University Hospital Ostrava