Clinical trials: Extremity Fracture Lower
Lower Extremity Fracture
Atropine Versus Glycopyrrolate in Preventing Spinal Anesthesia Induced Hypotension in Lower Limb Surgeries
A study to compare between intravenous atropine and glycopyrrolate in preventing spinal anesthesia induced hypotension in patients undergoing major lower limb orthopedic surgeries.
- Trial name
- NCT03580889
- Testing
- Atropine, Glycopyrrolate, Normal Saline Flush, 0.9% Injectable Solution
- Where
- Nepal
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- B.P. Koirala Institute of Health Sciences
Myocardial Injury
Sufentanil in Patients With Lower Extremity Fracture Surgery Myocardial Damage Function Study
1. To analyze the association of different doses of opioids on myocardial injury/protection through BMP-6/SMAD pathway. 2. To observe the effect of different doses of opioids on the expression of BMP-6 in bone marrow. 3.
- Trial name
- Sipwlefsmdfs (NCT06808841)
- Testing
- Sufentanil injection
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Second Hospital of Shanxi Medical University
Fracture of Lower Limb
Comparing Heavy Levobupivacaine With Enantiomeric Excess of 50% and Heavy Racemic Bupivacaine.
The purpose of this study is to compare the non-inferiority between Heavy Levobupivacaine with Enantiomeric Excess of 50% and Heavy Racemic Bupivacaine During Spinal Anesthesia for Orthopedic Procedures in the Lower Limbs.
- Trial name
- NCT01308047
- Testing
- Bupivacaine
- Where
- 2 sites in Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- Cristália Produtos Químicos Farmacêuticos Ltda.
Lower Extremity Fractures
Insole Sensor to Determine Optimal Limb Loading
The purpose of this study is to use a novel load monitoring technology to correlate limb loading to OTA type 42IIIB and IIIC tibial fracture outcomes.
- Trial name
- NCT02170493
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Utah
Nonunion of Fracture
Evaluation the Treatment of Nonunion of Long Bone Fracture of Lower Extremities (Femur and Tibia) Using Mononuclear Stem Cells From the Iliac Wing Within a 3-D Tissue Engineered Scaffold
Because the rate of non union of long bone in lower extremities specially in tibia in this two last decade due to malnutrition and smoking and other risk factors was increased, so many patient in our country suffer from non…
- Trial name
- NCT01958502
- Testing
- surgical treatment of non union with mesenchymal stem cells with BMP2 within a 3-D tissue engineered scaffold
- Where
- Iran
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Emdadi Kamyab Hospital
Educational Problems, Simulation of Physical Illness
Learning Management of Open Fractures on Virtual Patient
A novel virtual world programme with over 240 multiple choice questions was developed to assess the competencies in managing an open fracture of the lower limb according to the British Orthopaedic Association Standards for Trauma…
- Conditions
- Educational Problems, Simulation of Physical Illness, Fractures, Bone, Emergencies
- Trial name
- NCT04605380
- Testing
- Virtual reality online world
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
Wound Healing
Efficacy of Early Postoperative ON101 Application for Lower-extremity Fracture Incisions: a Prospective Evaluator-blinded Controlled Study of Scar Quality and Digital-clinical Concordance
Background: Postoperative scars after lower-extremity fracture fixation endure high tension, where excessive scarring can restrict periarticular mobility.
- Trial name
- ON101 Efficacy (NCT07854470)
- Testing
- ON101
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- LIN Kai-Cheng
Procedural Sedation
Low-Dose Intravenous Ketamine Bolus Versus Conventional Technique
Abstract Background: Ketamine has been introduced as one of the most common drugs, administered to sedate children for different painful procedures in the emergency department (ED) but administration in higher dosage causes some…
- Trial name
- NCT03499886
- Testing
- Ketamine Hydrochloride 50Mg/1mL Solution for Injection, Ketamine Hcl 50Mg/Ml Inj
- Where
- 2 sites in Iran
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Osteoporosis, Arthroplasty Complications
Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity Arthroplasty
The goal of this clinical trial is to observe the impact of a surgeon-driven bone health referral pathway following lower extremity arthroplasty.
- Conditions
- Osteoporosis, Arthroplasty Complications, Fragility Fracture
- Trial name
- NCT05845021
- Testing
- Surgeon-Initiated Bone Health Referral Pathway
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Osteoarthritis, Spinal Diseases
The Effect of AposTherapy on the Level of Pain, Function and Quality of Life in Patients With Neuro-muscular and Neurological Disorders
The purpose of the study is to examine the effect of a new biomechanical device and treatment methodology (AposTherapy) on gait patterns, pain, function and quality of life of patients with musculoskeletal and neurological…
- Conditions
- Osteoarthritis, Spinal Diseases, Ligament Rupture, Lower Extremity Fracture
- Trial name
- NCT01266382
- Testing
- AposTherapy
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg
A Comparison of Two Injection Locations in Obese Patients Having Lower Leg/Foot Surgery
One technique for the nerve block involves injecting the numbing medicine where the nerve is together (higher up in the back of the thigh).
- Conditions
- Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg, Crushing Injury of Lower Leg, Fracture Malunion - Ankle and/ or Foot
- Trial name
- NCT01550094
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jose Soberon, MD
Pediatric Fractures, Lower Extremity Fractures
Loss of Parental Workforce in Paediatric Fractures
Childhood fractures are frequently encountered in orthopaedic practice. 40-64% of boys and 25-40% of girls have at least one fracture by the age of 16.
- Conditions
- Pediatric Fractures, Lower Extremity Fractures, Upper Extremity Fractures
- Trial name
- NCT06891027
- Where
- Turkey (Türkiye)
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Osteoporosis
Balance and Muscle Strength as Indicators of Fracture Risk in Postmenopausal Women
The study is designed as a cross-sectional clinical study. A total of 156 postmenopausal women who visited the Physical Therapy and Rehabilitation outpatient clinic at Beylikdüzü State Hospital and have had Dual X-ray…
- Trial name
- NCT06645600
- Testing
- Fracture risk
- Where
- Turkey (Türkiye)
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Beylikduzu State Hospital
Automobile Driving With an Aircast Walker, Automobile Driving With a Walking Cast
Effects of Right Lower Limb Orthopedic Immobilization on Braking Function
Research on the implications of orthopedic injury and surgery on automobile driving ability has been limited. Only a handful of orthopedic issues have been studied to date, especially the safe postoperative resumption of driving.
- Trial name
- NCT01171287
- Testing
- Driving with an Aircast Walker, Driving with a walking cast, Driving with a running shoe
- Where
- 2 sites in Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Lower Limb Fracture
Effect of Early Versus Delayed Postoperative Feeding in Lower Limb Fracture Surgery
The treatment of lower limb fracture accounting one third of total fracture is a complex problem for the surgical and rehabilitation team.
- Trial name
- NCT05823649
- Testing
- Early feeding/intervention group
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Armed Police Force Hospital, Nepal
Arthroscopic Knee Surgery, Lower Limb Fractures
Comparison of Gait Parameters Between Floor and Sponge Surfaces and Special Shoes
This study compares the gait pattern of individuals with weight bearing difficulties walking on the floor, a soft surface, or with special shoes (Kyboot).
- Conditions
- Arthroscopic Knee Surgery, Lower Limb Fractures, Back Pain and Asymmetric Gait, Complex Regional Pain Syndrome
- Trial name
- NCT02742376
- Testing
- Soft surface, Floor, Kyboot shoes
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg
Onset Time of Nerve Block: A Comparison of Two Injection Locations in Patients Having Lower Leg/ Foot Surgery
The purpose of this study is to compare injecting local anesthetic (numbing medication) in different patterns around a major nerve in the leg.
- Conditions
- Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg, Crushing Injury of Lower Leg, Fracture Malunion - Ankle and/or Foot
- Trial name
- NCT01542840
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Closed Multiple Fractures of Upper and Lower Limbs
Is Analgesic Effect of Low Dose Ketamine-midazolam the Same as Morphine
the investigators assessed the effects of low-dose IV ketamine-midazolam versus morphine on pain control in trauma patients with closed limb fracture(s); and also compared the incidence of adverse events (mainly cardio pulmonary…
- Trial name
- NCT01807429
- Testing
- Ketamine-midazolam, Morphine
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Prevention of Postspinal Shivering
the Use of Magnesium Sulfate for Prevention of Postspinal Shivering
Shivering is an unpleasant experience after spinal anesthesia. Shivering is defined as an involuntary, repetitive activity of skeletal muscles.
- Trial name
- NCT04249804
- Testing
- Magnesium Sulfate 1000 MG
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cairo University
Stroke, Acute, Parkinson Disease
Assessment of the Rehabilitative Effects of Curved-walking Training in Stroke, Parkinson and Orthopaedic Populations
The recovery of walking ability is crucial to promote independence in daily living and is one of the major goal of neuromotor rehabilitation.
- Conditions
- Stroke, Acute, Parkinson Disease, Femur Fracture
- Trial name
- NCT03545477
- Testing
- Novel locomotion treatment: curved-walking training, Standard locomotion treatment: straight-walking training, Standard physical therapy
- Where
- Italy
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA