Clinical trials: Extremity Fracture Lower, open to volunteers
Patients With Fractures
Osteogenon in Orthopedics and Traumatology
The aim of this study was to evaluate the supportive effect of the ossein-hydroxyapatite complex in fracture healing. The investigators hypothesized that the ossein-hydroxyapatite complex would positively impact fracture healing…
- Trial name
- Osteogenon (NCT07210281)
- Testing
- received an ossein-hydroxyapatite complex
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- University of Opole
Infections, Infected Wound
PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation
This is a Phase III clinical randomized control trial to investigate differences between patient with an infected nonunion treated by PO vs. IV antibiotics.
- Conditions
- Infections, Infected Wound, Nonunion of Fracture, Injury Leg
- Trial name
- POvIV2 (NCT05699174)
- Testing
- Standard of Care PO (oral) antibiotics, Standard of Care Intravenous (IV) antibiotics
- Where
- 13 sites in United States
- Volunteers
- 250 people
- Sponsor
- Major Extremity Trauma Research Consortium
Myocardial Injury
Sufentanil in Patients With Lower Extremity Fracture Surgery Myocardial Damage Function Study
1. To analyze the association of different doses of opioids on myocardial injury/protection through BMP-6/SMAD pathway. 2. To observe the effect of different doses of opioids on the expression of BMP-6 in bone marrow. 3.
- Trial name
- Sipwlefsmdfs (NCT06808841)
- Testing
- Sufentanil injection
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Second Hospital of Shanxi Medical University
Tibial Fracture
Blood Flow Restriction Therapy to Optimize Muscle Size and Strength in Recovery From Lower Limb Fractures
This study will assess the feasibility and effectiveness of blood flow restriction therapy in patients with tibia fractures (or lower leg bone).
- Trial name
- BOOST (NCT07103252)
- Testing
- Blood Flow Restriction Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Pseudarthrosis, Ununited Fracture
Tuebingen Register of Union Failure After Fractures of the Upper and Lower Extremities
TRUFFLE is a register of clinical patient data of failed bone healing and bone non-union after fracture. All patients suffering from a long bone delayed or non-union after fracture and undergoing revision surgery are registered…
- Trial name
- TRUFFLE (NCT06098157)
- Where
- Germany
- Volunteers
- 850 people
- Sponsor
- Department of Trauma and Reconstructive Surgery at Eberhard Karls University Tuebingen, BG Klinik Tu
Lower Extremity Fractures, Pelvis
PROactive HEALing in High-Risk Pelvic and Non-hip Lower Extremity Fragility Fractures (PRO HEAL Pilot)
Fragility fractures are common in older adults with weakened bone. At least 1 in 3 females and 1 in 5 males will sustain a fragility fracture in their lifetime, and over 80% of fractures in Canadians aged 50 years and older are…
- Conditions
- Lower Extremity Fractures, Pelvis, Acetabulum
- Trial name
- PRO HEAL Pilot (NCT06303284)
- Testing
- subcutaneous Teriparatide injection
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- University of Calgary
Tibial Shaft Fracture, Tibial Plateau Fracture
Gene Expression in Lower Extremity Acute Traumatic Compartment Syndrome
The purpose of this study is to evaluate both genotypic differences and differences in local gene expression in individuals who develop acute traumatic compartment syndrome relative to control patients with at-risk lower…
- Trial name
- NCT05521958
- Testing
- Acute injury without compartment syndrome, Acute injury with compartment syndrome, Exertional compartment syndrome
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Utah
Fracture Arm, Fracture Closed of Lower End of Forearm, Unspecified
A Clinical Trial on the Use of Lidocaine Infusion During Surgery for Pediatric Upper Extremity Fractures and Its Impact on Total Perioperative Opioid Requirements
This study is a prospective, randomized, double-blind clinical trial evaluating whether intraoperative intravenous lidocaine infusion (IVLI) reduces opioid requirements and improves postoperative pain control in children…
- Conditions
- Fracture Arm, Fracture Closed of Lower End of Forearm, Unspecified, Fracture Elbow, Fracture Fixation
- Trial name
- NCT07552766
- Testing
- Lidocaine Infusion, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Nemours Children's Clinic
Lower Extremity Fracture
Perioperative Nutrition Optimization for Reducing Complications After Surgical Fracture Fixation
The objective of this multi-center, prospective, placebo-controlled, randomized study is to compare oral conditionally essential amino acid (CEAA) supplementation for decreasing the key postoperative complications of…
- Trial name
- NCT07155447
- Testing
- CEAA supplementation
- Volunteers
- 1,000 people
- Sponsor
- University of Minnesota
Fracture Femur, Fracture Tibia
Oral Supplementation With a Formulation Based on Cetylated Fatty Acids for Post-fracture Long Bone Healing
This clinical study aims to evaluate the potential benefits of a formulation based on Cetylated Fatty Acids in improving fracture healing of long bones in the lower limbs.
- Trial name
- CETIULTRA-BONE (NCT07299851)
- Testing
- CFA-based food supplement
- Where
- 6 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- Pharmanutra S.p.a.
Lower Extremity Fracture, Surgical Fracture Repair
Pre-Incision Peripheral Nerve Blocks for Lower Extremity Fracture Surgery in Older Adults
Fractures of the lower leg are especially difficult for older adults. They are more likely to have serious complications, require longer healing times, and have a higher risk of death This occurs because their bodies cannot…
- Conditions
- Lower Extremity Fracture, Surgical Fracture Repair, Orthopaedic Trauma, Orthogeriatric Fractures
- Trial name
- NCT07217626
- Testing
- Local anesthesia injections
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Maryland, Baltimore
Fracture Healing, Treatment Duration
Smart Crutch Tips for Guided Weight-Bearing in Patients Recovering From Extra-Articular Distal Tibia Fractures
The goal of this clinical trial is to learn whether personalized weight-bearing prescriptions using Smart Crutch Tips™ can improve recovery after surgery for extra-articular distal tibia fractures.
- Conditions
- Fracture Healing, Treatment Duration, Distal Tibia Fracture
- Trial name
- NCT07138066
- Testing
- Smart Crutch Tips™, Finite Element Analysis (FEA), Iterative walking
- Where
- 18 sites in Ukraine
- Volunteers
- 30 people
- Sponsor
- Comeback Mobility Inc
Osteoporosis, Arthroplasty Complications
Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity Arthroplasty
The goal of this clinical trial is to observe the impact of a surgeon-driven bone health referral pathway following lower extremity arthroplasty.
- Conditions
- Osteoporosis, Arthroplasty Complications, Fragility Fracture
- Trial name
- NCT05845021
- Testing
- Surgeon-Initiated Bone Health Referral Pathway
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Femoral Shaft Fracture, Tibial Shaft Fractures
Rehabilitation After Lower Extremity Nailing Trial
The goal of this clinical trial is to learn if outpatient physical therapy (PT) results in differing functional outcomes compared to a self-guided home exercise program (HEP) in tibial or femoral nail patients.
- Trial name
- ReLENT (NCT07783568)
- Testing
- Formal Physical Therapy (PT), Home Exercise Program (HEP)
- Volunteers
- 80 people
- Sponsor
- University of Chicago
Ceserean Section, Lower Limb Fractures
Infection Prevention for "Bellwether" Surgery in Ethiopia
The study examines surgical site infections and antimicrobial resistance following life-saving surgeries like C-sections and leg fracture repairs in Ethiopia.
- Conditions
- Ceserean Section, Lower Limb Fractures, Surgical Site Infection (SSI)
- Trial name
- NCT07647796
- Testing
- Surgical Site Infection Prevention and Control (IPC) Bundle
- Where
- Ethiopia
- Volunteers
- 1,000 people
- Sponsor
- Karolinska Institutet
Periprosthetic Fracture of the Upper or Lower Limb, Peri-implant Fracture of the Upper or Lower Limb
Peri-Implant and Peri-Prosthetic Fractures: Epidemiology, Morbidity, Mortality, Treatment and Outcome Analysis
This study supports Spanish data collection and analysis on Periprosthetic and Peri-implant fractures of the upper and lower limb. Treatment and clinical management of this fractures are complex and goes along with complications.
- Conditions
- Periprosthetic Fracture of the Upper or Lower Limb, Peri-implant Fracture of the Upper or Lower Limb, Periprosthetic Fractures, Peri-implant Fracture
- Trial name
- PIPPAS (NCT04663893)
- Where
- 7 sites in Spain
- Volunteers
- 2,500 people
- Sponsor
- Hospital Clínico Universitario de Valladolid
Depression in Old Age, Fragility Fracture
Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following Fragility Fractures
The goal of this pilot study is to learn about the feasibility about prescribing anti-depressants at discharge in patients aged 50 years and older with a lower extremity fragility fracture.
- Trial name
- SNRI (NCT05851898)
- Testing
- Duloxetine 30 mg
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University Health Sciences
Open Tibia Fracture, Open Dislocation of Ankle
Accelerated Flap Coverage Versus Standard Timing in the Treatment of Severe Lower Extremity Musculoskeletal Injuries
The goal of this randomized controlled trial is to determine if accelerated flap coverage compared to standard flap coverage timing leads to improved infection-related complications in patients with open fractures and/or…
- Conditions
- Open Tibia Fracture, Open Dislocation of Ankle, Extremity Fracture Lower, Extremity Injuries Lower
- Trial name
- FLAP ATTACK (NCT07828613)
- Testing
- Accelerated Flap Coverage Surgery, Standard of Care Flap Timing
- Where
- 31 sites in United States
- Volunteers
- 356 people
- Sponsor
- Johns Hopkins University
Treatment Duration, Fracture Healing
Smart Crutch Tips for Guided Weight-Bearing in Patients Recovering From Extra-Articular Proximal Tibia Fractures
The goal of this clinical trial is to learn whether personalized weight-bearing prescriptions using Smart Crutch Tips™ can improve recovery after surgery for extra-articular proximal tibia fractures.
- Conditions
- Treatment Duration, Fracture Healing, Extra-articular Proximal Tibia Fractures
- Trial name
- NCT07134257
- Testing
- Smart Crutch Tips™, Finite Element Analysis (FEA), Iterative walking
- Where
- 18 sites in Ukraine
- Volunteers
- 30 people
- Sponsor
- Comeback Mobility Inc
Fracture Arm, Fracture Leg
Accuro XV Ultrasound Imaging System for BoneEnhance and Fracture Detection Algorithms
The Accuro XV is a cart-based, bedside ultrasound instrument that incorporates new signal processing-based technologies for enhanced bone and soft-tissue imaging.
- Conditions
- Fracture Arm, Fracture Leg, Wrist Injury, Ankle Injury
- Trial name
- NCT07853768
- Testing
- Accuro XV Ultrasound Imaging System
- Where
- 10 sites in United States
- Volunteers
- 25,000 people
- Sponsor
- Rivanna Medical, Inc.