Clinical trials: Extubation
Gas Exchange
High-Flow Nasal Cannula Versus Conventional Oxygen Therapy After Extubation in Liver Transplantation
Humidified oxygen therapy via high-flow nasal cannula (HFNC) is a recently available technique delivering heated and humidified high flow oxygen through simple nasal prongs.
- Trial name
- NCT03441854
- Testing
- HFNC group
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Post-extubation Dysphagia
High-frequency Repetitive Transcranial Magnetic Stimulation for Patients With Dysphagia After Extubation
Post-extubation dysphagia (PED) is characterized by a range of clinical manifestations, including absence of visible swallowing effort, coughing or choking following liquid intake, and post-swallowing dysarthria.
- Trial name
- Dysphagia (NCT07381946)
- Testing
- Swallowing training, a bilateral high-frequency repetitive transcranial magnetic stimulation, No intervention
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Wuhan University
Oxygen Deficiency
HFNC vs Two Nare HFNC in Extubated Patients
High flow nasal cannula (HFNC) are introduced to clinical practice to improve oxygenation. Our group were the first to report the use of HFNC in extubated patients that showed comparable delivery of oxygen and improved comfort.
- Trial name
- HFNC (NCT06398951)
- Testing
- Two nare high flow nasal cannula
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- Peninsula Health
Dysphagia
Nutritional Therapy in Patients With Post-extubation Dysphagia
The aim of this study is to evaluate the impact of the prescription of two doses of protein on the amount in kilograms of muscle mass and on the clinical evolution (time until safe swallowing, time until removal of the feeding…
- Trial name
- NCT06511284
- Testing
- High protein dose, Usual protein dose
- Where
- Mexico
- Volunteers
- 128 people
- Sponsor
- National Institute of Respiratory Diseases, Mexico
Myelomeningocele, Extubation Time
Operating Room Extubation and Postoperative Outcomes in Neonates With Meningomyelocele
Meningomyelocele is one of the most common neural tube defects requiring surgical repair in the neonatal period. Postoperative respiratory complications and the need for prolonged mechanical ventilation are important causes of…
- Conditions
- Myelomeningocele, Extubation Time, Neonatal
- Trial name
- MEROX (NCT07465055)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gaziantep City Hospital
Weaning Failure, Mechanical Ventilation Complication
Comparison of Two Extubation Techniques in Critically Ill Adult Patients
Orotracheal extubation consists in the removal of the endotracheal tube (ETT) when it is no longer required. This procedure may carry a considerable risk of complications and extubation failure.
- Trial name
- ExtubAR (NCT03918811)
- Testing
- Positive Pressure Extubation Technique, Traditional Extubation Technique
- Where
- Argentina
- Volunteers
- 725 people
- Sponsor
- Hospital Donación Francisco Santojanni
Intensive Care Units, Neonatal, Misadventures to Patients During Surgical and Medical Care
SEPREVEN: a Stepped-wedge Randomised Controlled Trial
Adverse events are frequent in Neonatal Intensive Care Units' (NICU) patients and account for a high morbidity and mortality. Possible severe adverse events are central line associated bloodstream infections (CLABSI), ventilator…
- Conditions
- Intensive Care Units, Neonatal, Misadventures to Patients During Surgical and Medical Care, Catheter-related Bloodstream Infection (CRBSI) Nos, Quality of Healthcare
- Trial name
- SEPREVEN (NCT02598609)
- Testing
- Education program for NICU caregivers
- Where
- 12 sites in France
- Volunteers
- 8,000 people
- Sponsor
- Dr Caeymaex Laurence
Extubation Readiness, Respiratory Failure With Hypoxia
Identifying the Best Flow Setting Strategy for High-Flow Nasal Cannula
The goal of this randomized trial is to compare four different flow-setting approaches for post-extubation use of high-flow nasal cannula (HFNC).
- Trial name
- NCT07007715
- Testing
- Flow of 40L/min, Peak tidal inspiratory flow (PTIF) guided, PaO2/FiO2 ratio guided
- Where
- Taiwan
- Volunteers
- 480 people
- Sponsor
- National Taiwan University Hospital
Critically Ill, Extubation
Does Tracheal Suction During Extubation in Intensive Care Unit Decrease Functional Residual Capacity
Little is known about the procedure of extubation of patients admitted in Intensive Care Units (ICU). In particular, effects of tracheal suction during extubation have never been evaluated.
- Conditions
- Critically Ill, Extubation, Intensive Care Unit
- Trial name
- NCT03681626
- Testing
- no tracheal suction, tracheal suction
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Hypoxemia
'Optiflow + Duet' Interface' vs 'Standard' High Flow Nasal Cannula
High-flow nasal cannula (HFNC) therapy is increasingly used in the management of acute respiratory failure. Its clinical application has been largely investigated in chronic obstructive pulmonary disease (COPD) patients but only…
- Trial name
- OPTIMARF (NCT05838326)
- Testing
- Symmetrical high flow nasal cannula (HFNO), Asymmetrical high flow nasal cannula (DUET HFNO)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Padova
Airway Extubation, Weaning Mechanical Ventilation
One-Hour Positive Pressure Ventilation After a Pressure Support Spontaneous Breathing Trial
This is a randomized, open, multicenter, pragmatic, adaptive clinical trial with intention-to-treat analysis. The study will compare two weaning strategies from mechanical ventilation in critically ill patients admitted to…
- Conditions
- Airway Extubation, Weaning Mechanical Ventilation, Extubation Failure
- Trial name
- NCT07324460
- Testing
- One-hour positive pressure ventilation, Immediate extubation
- Volunteers
- 4,000 people
- Sponsor
- Hospital do Coracao
Behavioral Monitoring in ICU, Prediction of Accidental Events Using AI-Assisted Video Analysis
Exploring the Use of AI-Assisted Video Monitoring to Predict Accidental Events in ICU Patients
This study aims to improve the safety and care of patients in the Intensive Care Unit (ICU) by using artificial intelligence (AI) to analyze video monitoring.
- Conditions
- Behavioral Monitoring in ICU, Prediction of Accidental Events Using AI-Assisted Video Analysis, ICU Patient Safety and Early Warning System
- Trial name
- AIME-ICU (NCT07307521)
- Testing
- AI-Assisted Video Monitoring
- Volunteers
- 300 people
- Sponsor
- Shanghai Zhongshan Hospital
Postoperative Pain, ICU Hospitalization
The Effect of Parasternal Block on Postoperative Pain in Patients Undergoing Coronary Artery Bypass Graft Surgery
Objective: This study aims to investigate the effects of intraoperative parasternal block on postoperative analgesia in patients undergoing elective coronary artery bypass graft surgery.
- Conditions
- Postoperative Pain, ICU Hospitalization, Extubation Time
- Trial name
- NCT06893601
- Testing
- Parasternal block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Aydin Adnan Menderes University
Prematurity, Respiratory Failure
Non-invasive Neurally Adjusted Ventilatory Assist Versus Nasal Intermittent Positive Pressure Ventilation for Preterm Infants After Extubation
Non-invasive respiratory support has been emerging in the management of respiratory distress syndrome (RDS) in preterm infants to minimise the risk of lung injury.
- Conditions
- Prematurity, Respiratory Failure, Ventilator Lung; Newborn
- Trial name
- NCT03388437
- Testing
- NI-NAVA, NIPPV
- Where
- Saudi Arabia
- Volunteers
- 36 people
- Sponsor
- King Fahad Armed Forces Hospital
Neurosurgery, Mechanical Ventilation
Lung and Heart USG for Predicting Weaning in Neurosurgical Patients
Ultrasonography is a commonly used diagnostic and procedural adjunctive modality in intensive care. Weaning of neurosurgical patients off ventilatory support is a critical procedure, fraught with risks of hypoxia and hypercapnia.
- Conditions
- Neurosurgery, Mechanical Ventilation, Extubation
- Trial name
- NCT03580993
- Testing
- Lung Ultrasound
- Where
- India
- Volunteers
- 27 people
- Sponsor
- National Institute of Mental Health and Neuro Sciences, India
Nausea, Vomiting
The Effect on Thirst, Nausea-Vomiting and Comfort Levels of Menthol Lozenge Applied After Extubation
It is reported that approximately 17.5 million people die worldwide each year due to cardiovascular diseases, including ischemic heart disease, cerebrovascular disease and rheumatic heart disease.
- Conditions
- Nausea, Vomiting, Thirst
- Trial name
- NCT04994262
- Testing
- Menthol Lozenge
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Drug Usage
EC95 of Remifentanil for Preventing Cough
The investigator designed this study to investigate remifentanil effect-site concentration in 95% of patients (EC95) for preventing cough after laryngomicrosurgery from propofol anesthesia.
- Trial name
- NCT02973724
- Testing
- Remifentanil, Propofol anesthesia
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Ajou University School of Medicine
Respiratory Failure, Weaning Failure
HVNI for Successful Weaning in Respiratory Failure
The goal of this randomized active-controlled study is to investigate the role of high velocity nasal insufflation (HVNI) in the immediate post-extubation period and compare it with non-invasive positive pressure ventilation…
- Trial name
- REVIVER (NCT05855213)
- Testing
- High Velocity Nasal Insufflation, Non-invasive positive pressure ventilation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alexandria University
Post-extubation Dysphagia
Clinical Application of Comprehensive Intervention for PED Based on Neuroregulatory Mechanism
This study aims to establish a practical comprehensive intervention program for dysphagia after extubation in adult ICU patients based on the best evidence of its assessment and intervention, through expert panel discussion and…
- Trial name
- NCT06386159
- Testing
- Comprehensive Intervention or Comprehensive Intervention Combined with Electrical vagus nerve stimulation
- Where
- China
- Volunteers
- 69 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pulmonary Atelectasis
Ventilation Strategy Reduces Postoperative Atelectasis
Atelectasis is common during and after general anesthesia. The investigators hypothesized that a ventilation strategy with a combination of 1) continuous positive airway pressure (CPAP) or positive end-expiratory pressure (PEEP)…
- Trial name
- NCT01911923
- Testing
- No CPAP/PEEP and 100 % oxygen, CPAP/PEEP and 30 % oxygen
- Where
- Sweden
- Sponsor
- Region Västmanland