Clinical trials: Eye
Eye, Astigmatism
P1 Toric Vs. Max 1day
This study aims to determine if participants who are currently wearing Max1day contact lenses can successfully be refit into P1 for astigmatism contact lenses.
- Conditions
- Eye, Astigmatism, Contact Lenses
- Trial name
- NCT07914959
- Testing
- , silicone hydrogel (lehfilcon A) soft contact lens (CL) with SMARTSURFACE Technology and UV protection
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Southern College of Optometry
Eye Diseases, Healthy Volunteers
Adaptive Optics Retinal Imaging
Background: By the time diseases of the retina are detected, serious damage has often already been done. Researchers want to find better ways of viewing the retina. One way called adaptive optics may help detect problems earlier.
- Trial name
- NCT02317328
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Malignant Neoplasm of Breast, Malignant Neoplasms of Digestive Organs
Pembrolizumab With Intratumoral Injection of Clostridium Novyi-NT
Some tumors are difficult to treat with chemotherapy or radiation. One of the reasons is that areas of the tumor do not have many blood vessels, which makes it difficult for drugs to reach those areas.
- Conditions
- Malignant Neoplasm of Breast, Malignant Neoplasms of Digestive Organs, Malignant Neoplasms of Eye Brain and Other Parts of Central Nervous System, Malignant Neoplasms of Female Genital Organs
- Trial name
- NCT03435952
- Testing
- Pembrolizumab, Clostridium Novyi-NT, Doxycycline
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- M.D. Anderson Cancer Center
Dry Eye Syndrome
LacriFill Canalicular Occlusion for Dry Eye After LASIK
This study is a single-site, prospective, randomized (2:1) controlled study of subjects aged 18-39 who are candidates for bilateral LASIK and have dry eye symptoms (OSDI ≥13).
- Trial name
- NCT07911930
- Testing
- LacriFill Canalicular Filler
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Mann Eye Institute
Meibomian Gland Dysfunction, Dry Eye Disease
Clinical Study Evaluating Nordlys™ SWT IPL for Dry Eye Disease (DED) Due to MGD
Clinical Study Evaluating Nordlys™ System with Selective Waveband Technology (SWT)® Intense Pulsed Light (IPL) Applicators for Dry Eye Disease (DED) due to Meibomian Gland Dysfunction (MGD).
- Trial name
- NCT06064071
- Testing
- Nordlys SWT IPL, Meibomian Gland Expression (MGX)
- Where
- 3 sites in United States, Argentina
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Candela Corporation
Digital Eye Strain (DES)
Lactic Acid Bacteria for Reducing Blue Light-Induced Eye Fatigue
With the widespread use of digital devices and prolonged screen exposure, digital eye strain (DES), also known as computer vision syndrome, has become a global public health concern.
- Trial name
- NCT07737938
- Testing
- BL531_low dose, BL531_high dose, LR1349_low dose
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Synbio Tech Inc.
Dry Eye
20-20-20 Rule Plus Artificial Tears for Dry Eye
This study is for anyone struggling with dry, tired, or uncomfortable eyes, especially from long hours on screens. Investigators all know that feeling after staring at a laptop or phone too long.
- Trial name
- NCT07896395
- Testing
- Artificial Tears (AT), 20/20/20 rule
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Zagazig University
Dry Eye
a Novel siRNA Eyedrops for DED Treatment
A single-center, randomized, double-blind, placebo-controlled, cross-over clinical trial designed to evaluate the effectiveness and safety of a novel siRNA eye drops for the treatment of dry eye syndrome
- Trial name
- NCT07908251
- Testing
- Low dose Arm, High dose Arm
- Volunteers
- 30 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Diabetic Macular Edema (DME)
A Phase 3 Trial for Intravitreal Injection of 4D-150 in Adults With Diabetic Macular Edema (DME).
A Phase 3, Randomized, Double-Masked, Active-Controlled Trial to Evaluate the Safety, Efficacy, and Durability of a Single Intravitreal Injection of 4D-150 versus Aflibercept in Adults with Diabetic Macular Edema (4SIGHT)
- Trial name
- 4SIGHT (NCT07867080)
- Testing
- 4D-150 IVT (3x10^10 vg), EYELEA ® (aflibercept) Injection 2 mg (0.05mL)
- Where
- 87 sites in United States, China and 1 more
- Volunteers
- 514 people
- Sponsor
- 4D Molecular Therapeutics
Eye Diseases
Screening for Research Participants
This study will allow National Eye Institute (NEI) doctors the opportunity to examine people with eye disease, whether the diagnosis is known or not, to determine if they are eligible for other NEI research studies.
- Trial name
- NCT00655096
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Genetic Eye Disease
Whole Exome and Whole Genome Sequencing for Genotyping of Inherited and Congenital Eye Conditions
Objective: The objective of this study is to identify genetic causes of inherited eye conditions through whole exome or whole genome sequencing (referred to as exome sequencing and genome sequencing in the remainder of the…
- Trial name
- NCT02077894
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- National Eye Institute (NEI)
Genetic Eye Disease
Genetics of Inherited Eye Disease
Background: Research has identified some of the genes involved in inherited eye diseases. But for many of these diseases, the genes are not yet known. Researchers want to try to find these genes.
- Trial name
- NCT02471287
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Retinitis Pigmentosa, Eye Diseases
Rate of Progression in EYS Related Retinal Degeneration
The overall goal of this project funded by the Foundation Fighting Blindness is to characterize the natural history of disease progression in patients with EYS mutations in order to accelerate the development of outcome measures…
- Trial name
- Pro-EYS (NCT04127006)
- Where
- 19 sites in United States, Canada and 5 more
- Volunteers
- 103 people
- Sponsor
- Jaeb Center for Health Research
Presbyopia, Near Vision
Phase 3 Efficacy Study of LNZ100 & LNZ101 for the Treatment of Presbyopia
Phase 3 Efficacy Study to evaluate the Safety and Efficacy of LNZ100 \& LNZ101 for the Treatment of Presbyopia
- Conditions
- Presbyopia, Near Vision, Refractive Error, Eye Diseases
- Trial name
- CLARITY 2 (NCT05728944)
- Testing
- Aceclidine+Brimonidine combination ophthalmic solution, Aceclidine ophthalmic solution, Vehicle
- Where
- 17 sites in United States
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- LENZ Therapeutics, Inc
Dry Eye Disease
Efficacy and Safety of BUFY01 Versus SVS20 in the Treatment of Dry Eye Disease
The goal of this interventional investigation is to compare BUFY01 with SVS20 in the treatment of patients with dry eye disease.
- Trial name
- BUSTON-01 (NCT05865379)
- Testing
- BUFY01 eye drops in single-dose containers, SVS20 eye drops in single-dose containers
- Where
- 3 sites in Belgium, France
- Volunteers
- 80 people
- Sponsor
- TRB Chemedica International SA
Meibomian Gland Dysfunction (Disorder)
TearCare in Young Adults
This study is a non-randomized, open-label, interventional trial of TearCare® eyelid warming and manual meibomian gland expression in young adults with clinically significant meibomian gland dysfunction (MGD).
- Trial name
- NCT07579156
- Testing
- TearCare®
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Alabama at Birmingham
Computer Vision Syndrome, Asthenopia
Yogic Eye Exercises for Computer Vision Syndrome in Female Design Students
Computer vision syndrome (CVS) is a cluster of eye and musculoskeletal complaints - dryness, redness, blurred vision, foreign body sensation, excessive tearing, and neck, shoulder or back pain - that arises from prolonged work at…
- Conditions
- Computer Vision Syndrome, Asthenopia, Eye Strain, Dry Eye
- Trial name
- NCT07816419
- Testing
- Yogic eye exercise programme
- Where
- Saudi Arabia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- King Saud University
Keratitis, Autoimmunity
A Clinical Study to Evaluate the Safety and Effectiveness of MSCohi-O Lens in the Treatment of Immune-related Ocular Surface Diseases.
Immune-related ocular surface diseases are a kind of non-infectious eye disease pedigree, which is mediated by abnormal immune system function and characterized by ocular surface tissue damage.
- Conditions
- Keratitis, Autoimmunity, Dry Eye Disease (DED)
- Trial name
- NCT07902687
- Testing
- MSCohi-O lens
- Volunteers
- 20 people
- Sponsor
- Guangdong ProCapZoom Biosciences Co., Ltd.
Dry Eye Disease (DED), Contact Lens Discomfort (CLD)
Treating Contact Lens Discomfort With Cyclosporine 0.1% Ophthalmic Solution
Of the 140 million contact lens (CL) wearers worldwide, most wear soft contact lenses. Despite major improvements in contact lens care, nearly 20% of wearers stop using lenses, with contact lens discomfort (CLD) being the main…
- Trial name
- NCT07904728
- Testing
- Cyclosporine 0.1% Ophthalmic Solution
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ocular Aesthetics, LLC dba Ocular Clinical Trials
Stevens-Johnson Syndrome, Graft Versus Host Disease in Eye
Evaluation of Tangible Boost for Patients With Stevens Johnson Syndrome, Sjogren's Syndrome, and Graft Vs Host Disease
The goal of this research is to determine if the Tangible Boost system adequately replenishes the Hydra-PEG coating on the surface of a rigid contact lens.
- Conditions
- Stevens-Johnson Syndrome, Graft Versus Host Disease in Eye, Sjogren's Syndrome, Dry Eye
- Trial name
- NCT04313725
- Testing
- Tangible Boost
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Tangible Science