Clinical trials: Eye
Aphakia, Postcataract, Cataract; Eye Disease
Safety and Efficacy of a Trifocal Intraocular Lens (IOL) POD L GF in Comparison With a Multifocal and a Monofocal IOL
The objectives of the Post-Market Follow-up (PMCF) clinical investigation are to determine the safety and performance of a hydrophobic trifocal intraocular lens POD L GF in comparison with two comparator lenses: another…
- Trial name
- NCT04005651
- Testing
- POD L GF IOL, Symfony® IOL, AcrySof® IOL
- Where
- 5 sites in France, Germany and 1 more
- Volunteers
- 100 people
- Sponsor
- Beaver-Visitec International, Inc.
Obesity, Behavior, Health
Evaluation of Brain Activity Changes After a Behavior Change Weight Loss Intervention
The aim of this study is to compare brain changes in individuals with overweight or obesity enrolled in either the Noom Healthy Weight program or a matched control.
- Conditions
- Obesity, Behavior, Health, Weight Loss
- Trial name
- NCT04522245
- Testing
- Noom Healthy Weight; mobile behavior change program for weight loss., Matched Control
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Noom Inc.
Neuromyelitis Optica, Neuromyelitis Optica Spectrum Disorder
A Randomized Controlled Trial of Eculizumab in AQP4 Antibody-positive Participants With NMO (PREVENT Study)
The objectives of this time-to-event study were to assess the efficacy and safety of eculizumab as compared with placebo in participants with neuromyelitis optica spectrum disorder (NMOSD) who were anti-aquaporin-4 (AQP4)…
- Trial name
- NCT01892345
- Testing
- Eculizumab
- Where
- 70 sites in United States, Argentina and 16 more
- Volunteers
- 143 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Dry Eye Disease
Efficacy and Safety of BUFY02 Versus TRB02 in the Treatment of Dry Eye Disease
The goal of this interventional investigation is to compare BUFY02 with TRB02 in the treatment of patients with dry eye disease.
- Trial name
- BUSTON-02 (NCT05865457)
- Testing
- BUFY02 eye drops in single-dose containers, TRB02 eye drops in single-dose containers
- Where
- 6 sites in Austria, France
- Volunteers
- 80 people
- Sponsor
- TRB Chemedica International SA
Age Related Macular Degeneration
Mobile Clinic - a Cross-sectional Epidemiological Survey
The aim of the study is to find out prevalence of aged-related macular degeneration (AMD) in Slovak Republic. The outcome of the project will be epidemiology survey, prevalence of wet form of AMD in relation to demographic data…
- Trial name
- NCT02055612
- Where
- Slovakia
- Volunteers
- 3,278 people, healthy volunteers welcome
- Sponsor
- Novartis Slovakia, s.r.o.
Progressive Keratoconus
Study to Evaluate the Safety and Efficacy of Epi-on Corneal Cross-linking in Eyes With Progressive Keratoconus
To evaluate the safety and efficacy of epithelium-on corneal collagen cross-linking (CXL) in impeding the progression of, and/or reducing corneal curvature (Kmax) in eyes with progressive keratoconus.
- Trial name
- NCT03442751
- Testing
- Test Article A, Test Article B, KXL medical device system
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Glaukos Corporation
Ocular Inflammation
Loteprednol Etabonate in an Ophthalmic Base vs Vehicle for the Treatment of Inflammation Following Cataract Surgery
Evaluation of the clinical safety and efficacy of loteprednol etabonate in an ophthalmic base, when compared to vehicle for the treatment of inflammation following cataract surgery.
- Trial name
- NCT00699153
- Testing
- Loteprednol Etabonate, Vehicle of Ophthalmic Loteprednol Etabonate
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Bausch & Lomb Incorporated
Astigmatism
Clinical Comparison of Two Silicone Hydrogel Toric Lenses in the US
The purpose of this trial is to compare the performance of two different contact lenses for contact lens wearers with astigmatism.
- Trial name
- NCT01007812
- Testing
- Lotrafilcon B contact lens, Comfilcon A contact lens
- Volunteers
- 50 people
- Sponsor
- CIBA VISION
Dry Eye Syndrome
Clinical Trial to Assess the Effectiveness of I+Med's DayDrop Advanced Ophthalmic Drop
Clinical trial conducted with the aim of evaluating changes in the signs of dry eye through the change in the amount of tears produced, measured through the Schirmer test.
- Trial name
- NCT06732830
- Testing
- DayDrop Advanced ophthalmic drop
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- i+Med S.Coop.
Dry Eye Disease
NovaTears® Eye Drops Observational Study
This observational pilot-study is intended to collect outcome data from a cohort of 30 patients suffering from hyper-evaporative dry eye disease who are treated with the medical device NovaTears® eye drops for a duration of 5 to…
- Trial name
- NCT02111928
- Testing
- NovaTears® Eye Drops
- Where
- 2 sites in Germany
- Volunteers
- 30 people
- Sponsor
- Novaliq GmbH
Cataract
Intra-Operative Metrics With CENTURION® and INFINITI® Vision Systems
The purpose of this study is to evaluate intra-operative phacoemulsification machine metrics after phacoemulsification with the CENTURION® vision system configuration compared with the INFINITI® vision system configuration.
- Trial name
- NCT01848288
- Testing
- CENTURION® Vision System (CVS), INFINITI® Vision System (IVS)
- Volunteers
- 112 people
- Sponsor
- Alcon Research
Dry Eye Disease
Evaluation of the Efficacy of OC-01 Nasal Spray on Signs and Symptoms of Dry Eye Disease
The objective of this study is to evaluate the safety and effectiveness of OC-01 Nasal Spray as compared to placebo on signs and symptoms of dry eye disease
- Trial name
- NCT03636061
- Testing
- OC-01 (varenicline) nasal spray
- Where
- 3 sites in United States
- Volunteers
- 182 people
- Sponsor
- Oyster Point Pharma, Inc.
Wet Macular Degeneration
Real Life of Aflibercept in France in Patients Refractory to Ranibizumab: Observational Study in Wet AMD
The aim of the TITAN study is to describe the clinical practices of a cohort of patients with wAMD refractory to ranibizumab (persistence of intra-retinal and/or subretinal fluid) who switch to aflibercept after less than 12…
- Trial name
- TITAN (NCT02321241)
- Testing
- Aflibercept (EYLEA, BAY-86-5321)
- Where
- France
- Volunteers
- 236 people
- Sponsor
- Bayer
Healthy
Engineering Evaluation of an Eye Movement Monitor Device
The objective of the engineering evaluation is to verify and validate the design of an eye movement monitor device, the Retitrack, for recording, viewing, measuring, and analyzing temporal characteristics of fixation and saccadic…
- Trial name
- NCT05222022
- Testing
- Retitrack
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- C. Light Technologies, Inc.
Open Angle Glaucoma, Ocular Hypertension
A Long Term Study of STN1012600 in Subjects With Open Angle Glaucoma or Ocular Hypertension
To evaluate safety and the ocular hypotensive effect of STN1012600 ophthalmic solution 0.002% alone or in combination with Timolol ophthalmic solution 0.5% for 52 weeks in subjects with open angle glaucoma or ocular hypertension.
- Trial name
- NCT05503901
- Testing
- STN1012600 ophthalmic solution 0.002%, STN1012600 ophthalmic solution 0.002% and Timolol ophthalmic solution 0.5%
- Where
- 18 sites in Japan
- Volunteers
- 131 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Glaucoma, Open-Angle
Early Evaluation of the Beacon Aqueous Microshunt in Patients Refractory to Drug Therapy in the European Union
This is prospective, non-randomized, single-arm study to assess the safety and effectiveness of lowering intraocular pressure with the Beacon Aqueous Microshunt. A total of 65 subjects will be enrolled at five centers.
- Trial name
- EARLY BIRD EU (NCT03634319)
- Testing
- Beacon Aqueous Microshunt
- Where
- 2 sites in Germany
- Volunteers
- 10 people
- Sponsor
- MicroOptx
Cataract
Long-term (3 Months) Safety of Femtosecond-laser Assisted Cataract Surgery
This clinical study is a prospective, post-market-clinical-follow-up study to investigate the long-term (3 months) safety of femtosecond laser assisted cataract surgery as a study follow-up extension to the Study #1304 titled as…
- Trial name
- NCT02023437
- Testing
- Femtosecond laser cataract surgery, Manual cataract surgery
- Where
- 2 sites in Czechia, India
- Volunteers
- 132 people
- Sponsor
- Technolas Perfect Vision GmbH
Acquired Blepharophimosis
LIDRISE Study: A Phase 3 Study on the Efficacy and Safety of STN1013800 (Oxymetazoline HCl 0.1% Eye Drops, Single Dose) in the Treatment of Acquired Blepharoptosis.
A Randomised, Double-Masked, Placebo-Controlled Phase 3 Study on the Efficacy and Safety of STN1013800 (Oxymetazoline HCl 0.1% Eye Drops) used twice daily (BID) in the Treatment of Acquired Blepharoptosis
- Trial name
- NCT06514612
- Testing
- STN1013800 (0.1% Oxymetazoline Hydrochloride) eye drops in single dose containers
- Where
- 36 sites in Czechia, France and 7 more
- Volunteers
- 234 people
- Sponsor
- Santen SAS
Progressive Supranuclear Palsy
RT001 in Patients With Progressive Supranuclear Palsy (PSP) PROGRESSIVE SUPRANUCLEAR PALSY
This is a randomized, placebo-controlled trial of RT001 in patients with PSP.
- Trial name
- NCT04937530
- Testing
- RT001
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Biojiva LLC
Contact Lens Wettability
Effect of FID 114675A on Lens Wettability
The purpose of this study is to evaluate lens wettability of contact lenses when used with an investigational multi-purpose disinfecting solution.
- Trial name
- NCT01342107
- Testing
- FID 114675A multi-purpose disinfecting solution (MPDS), Soft contact lens, Blister pack solution
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Alcon Research
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