Clinical trials: Eye
Cytomegalovirus Retinitis, HIV Infections
A Study of Cidofovir in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS
Incomplete Closed Protocol
- Trial name
- NCT00002384
- Testing
- Cidofovir
- Sponsor
- Gilead Sciences
Retinal Vein Occlusion
Retrospective Data Analysis of Patients Treated for Macular Edema Due to Central Retinal Vein Occlusion
The objective of this retrospective chart review is to evaluate drug utilization, usage patterns and indication of effectiveness Eylea in the routine clinical (real-life) management of patients who suffer from ME (Macular Edema)…
- Trial name
- RETRO CRVO (NCT02645747)
- Testing
- Aflibercept (Eylea, BAY86-5321)
- Where
- Belgium
- Volunteers
- 126 people
- Sponsor
- Bayer
Keratitis
Effect of IKERVIS® Eye Drops Once Daily on the Quality of Vision in Dry Eye Disease Patients With Severe Keratitis
The proposed 3-month study is a prospective, open-label, multicentre, phase IV, proof of concept study. The study is designed to assess the effect on the quality of vision of IKERVIS® (1mg/mL ciclosporin) eye drops administered…
- Trial name
- FAST (NCT03237936)
- Testing
- 1mg/mL ciclosporin
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Santen SAS
Colorectal Cancer, Adenoma
G-Eye Advanced Colonoscopy For Increased Polyp Detection Rate-randomized Tandem Study With Different Endoscopist
The purpose of this study is to compare the adenoma detection rate of G-EYE™ high definition colonoscopy with that of standard high definition colonoscopy.
- Trial name
- NCT02066064
- Testing
- Standard Colonoscopy, G-EYE(TM) Colonoscopy
- Where
- Germany
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Smart Medical Systems Ltd.
Presbyopia
Study Assessing the Efficacy and Safety of STN1013600 Ophthalmic Solution 0.1% and 0.3% Compared With Placebo in Subjects With Presbyopia
This is a Phase IIa study to assess efficacy and safety of STN1013600 ophthalmic solution (0.1%, and 0.3 %), twice daily when compared to Placebo in subjects diagnosed with presbyopia.
- Trial name
- OPSIS (NCT05665387)
- Testing
- 0.1% STN1013600 ophthalmic solution, 0.3% STN1013600 ophthalmic solution
- Where
- 12 sites in United States
- Volunteers
- 79 people
- Sponsor
- Santen Inc.
All Conditions, All
Measurement of Ocular Microtremor With the iTremor Device in a Diverse US Cohort
To evaluate the reliability of using the iTremor device to accurately measure Ocular Microtremor (OMT) across a diverse cohort, representative of the US population, with a view to establishing this as a standard measurement tool…
- Trial name
- NCT07858214
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Head Diagnostics
Myopia
A Clinical Comparison of Two Daily Disposable Contact Lenses.
The objective of this study is to evaluate the clinical performance of two daily disposable contact lenses.
- Trial name
- NCT00775021
- Testing
- etafilcon A, nelfilcon A
- Where
- United Kingdom
- Volunteers
- 123 people
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Dry Eye Syndrome (DES)
Evaluation of a Novel Ocular Lubricating Eye Drop
The objective of this 2-part study is to assess the safety and tolerability of the new ocular lubricating drop ABR2 during short-term use in subjects for the temporary relief of ocular discomfort due to dryness of the eye.
- Trial name
- DRAGON (NCT07593404)
- Testing
- Part 2 ABR2 At least twice a day for 28 days, Part 1: ABR2 single dose in one eye
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Pleryon Therapeutics (Hangzhou) Limited
Melanoma
Compassionate Use Program to Access Trametinib and Dabrafenib for Patients With BRAF Mutation-positive Metastatic Melanoma
The purpose of this Cohort Treatment Plan is to allow access to trametinib (monotherapy or in combination) and dabrafenib (monotherapy or in combination) for eligible patients diagnosed with metastatic melanoma BRAF…
- Trial name
- NCT04489433
- Testing
- Dabrafenib and Trametinib, Dabrafenib, Trametinib
- Sponsor
- Novartis Pharmaceuticals
Astigmatism
The Clinical Study of Silicone Hydrogel Daily Disposable Stenfilcon A Toric Lens
The aim of this study is to evaluate the clinical performance of stenfilcon A toric lenses compared with etafilcon A toric lenses for astigmatism.
- Trial name
- NCT02801006
- Testing
- stenfilcon A, etafilcon A
- Where
- 2 sites in Japan
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Myopia, Cornea
Euclid Phoenix Lens Design Trial
The "first fit" success rate of the current Euclid orthokeratology "MAX" lens design will be compared to that of the new Euclid orthokeratology MAX "Phoenix" lens design in 30 children.
- Trial name
- NCT06389916
- Testing
- Euclid orthokeratology MAX (current design), Euclid orthokeratology MAX Phoenix (new design)
- Where
- 5 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Euclid Systems Corporation
Dry Eye
Clinical Evaluation of Systane® Gel Drops in Dry Eye Subjects
The purpose of this study is to evaluate the efficacy and safety of Systane® Gel Drops in dry eye subjects following 90 days of QID (4 times/day) dosing.
- Trial name
- NCT02380248
- Testing
- Polyethylene Glycol, 0.4%, Propylene Glycol, 0.3% eye drops
- Where
- India
- Volunteers
- 207 people
- Sponsor
- Alcon Research
Astigmatism, Presbyopia
Comparing Biofinity Toric Multifocal to Ultra Multifocal for Astigmatism
The objective of the study was to compare the handling and performance of Biofinity Toric Multifocal to Ultra Multifocal for Astigmatism.
- Trial name
- NCT04404725
- Testing
- comfilcon A, Samfilcon A
- Where
- 7 sites in United States, Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Allergic Conjunctivitis, Rhinoconjunctivitis
Ocular Allergy Treatment Practical Impact Trial
To study the impact of alcaftadine in patients treated with other opthalmic ocular agents (or specific topical opthalmic treatment) in an allergy subspecialist outpatient setting.
- Trial name
- (OAT-PIT) (NCT01808768)
- Testing
- Alcaftadine
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Starx Research Center, LLC
Open Angle Glaucoma or Ocular Hypertension
DE-111 Ophthalmic Solution in Patients With Open Angle Glaucoma or Ocular Hypertension
Safety and IOP (intraocular pressure) lowering effect of DE-111 ophthalmic solution will be evaluated in open-angle glaucoma or ocular hypertension patients, in an open-label, multicenter study.
- Trial name
- NCT01343082
- Testing
- DE-111 ophthalmic solution
- Where
- Japan
- Volunteers
- 148 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Healthy Subject
A Clinical Trial to Evaluate Tolerability and Pharmacokinetics of HL217 Eye Drop in Healthy Male Subjects
The purpose of this study is to evaluate the safety, tolerability and PK parameters in healthy subjects.
- Trial name
- NCT03650608
- Testing
- Cohort 1: HL217 Ophathalmic Solution QD, Cohort 2: HL217 Ophathalmic Solution BID, Cohort 3: HL217 Ophthalmic Solution QID
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hanlim Pharm. Co., Ltd.
Myasthenia Gravis
A Phase 1b/2 Study of IM-101 in Adult Participants With Generalized Myasthenia Gravis and Ocular Myasthenia Gravis
The goal of this clinical trial is to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and potential efficacy of IM-101 in adult participants with AChR antibody-positive gMG.
- Trial name
- Synergy-MG (NCT07250750)
- Testing
- IM-101 Part A, IM-101 Part B
- Where
- 25 sites in United States, Bulgaria and 4 more
- Volunteers
- 96 people
- Sponsor
- ImmunAbs Inc.
Glaucoma
Optical Coherence Tomography (OCT) Data Collection Study
Collect OCT data to evaluate the range and age trend of ocular measurements.
- Trial name
- NCT01641835
- Where
- Canada
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Wet Age Related Macular Degeneration
Phase 3 Study of Intravitreal OLN324 in Adults With Neovascular (Wet) Age-related Macular Degeneration (nAMD) (OLN324-CP-04)
This is a Phase 3 study of an investigational drug called OLN324, which is being developed by Ollin Biosciences as a treatment for patients with neovascular (wet) age-related macular degeneration (nAMD).
- Trial name
- MOJAVE (NCT07816315)
- Testing
- OLN324, Aflibercept
- Volunteers
- 500 people
- Sponsor
- Ollin Biosciences, Inc.
Inflammation and Pain Associated With Cataract Surgery
2nd Study to Assess ISV-305 Compared to Vehicle for Treatment of Inflammation and Pain Associated With Cataract Surgery
The purpose of this study is to evaluate the ocular safety, tolerability, and efficacy of ISV-305 (Dexamethasone in DuraSite® 2) compared to Vehicle in the treatment of inflammation and pain associated with cataract surgery.
- Trial name
- ISV-305 (NCT03192150)
- Testing
- ISV-305, Vehicle
- Where
- United States
- Volunteers
- 246 people
- Sponsor
- Sun Pharmaceutical Industries Limited
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