Clinical trials: Eye
Cataract, Astigmatism
Post-Approval Study of the TECNIS® Toric Extended Cylinder Range Intraocular Lens (IOL)
This study is a prospective, multicenter, bilateral, non-randomized, open-label, clinical study conducted at up to 20 sites in the USA.
- Trial name
- NCT02649842
- Testing
- TECNIS Toric Models ZCT450, ZCT525 or ZCT600
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Abbott Medical Optics
Myopia, Astigmatism
1-Week Dispensing Evaluation of Kalifilcon A Toric Contact Lenses Compared to Ultra for Astigmatism
This single-site, randomized, double-masked (participant and investigator), 2-way crossover, repeated-measures dispensing study evaluated the visual performance of kalifilcon A daily disposable toric (LD213001) contact lenses…
- Trial name
- NCT05320042
- Testing
- kalifilcon A daily disposable toric contact lenses, Ultra for Astigmatism (samfilcon A) contact lenses
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Dry Eye Syndrome, Healthy
Non-invasive Ocular Surface Measurements Before and After Interventions
Objectively evaluate the ocular surface (pre-corneal tear film) of individuals prior to and after an intervention (such as a dry eye treatment, environmental change, artificial tear use, or contact lens wear) in a…
- Trial name
- NCT01228929
- Testing
- Environmental Chamber Condition Change Intervention
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Dry Eye
Comparing Treatment of Dry Eye With Intracanalicular Dexamethasone, Restasis, and/or Lotemax
This 6 month study seeks to compare the use of Intracanalicular Dexamethasone in conjunction with Restasis (cyclosporine ophthalmic emulsion) for the treatment of signs and symptoms of dry eye disease as compared to Restasis with…
- Trial name
- NCT04555694
- Testing
- Cyclosporine, Loteprednol Etabonate, Dexamethasone Ophthalmic 0.4 Mg Ophthalmic Insert
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Thomas Chester, OD
Eyelid Droop
The Effect of Lumify™ Eyedrops on Eyelid Position
The purpose of the research is to see if Lumify™ has an effect on eyelid position.
- Trial name
- NCT03782701
- Testing
- Brimonidine tartrate ophthalmic solution 0.025%, Sterile balanced saline solution
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Miami
Glaucoma, Vision Disorder
Virtual Reality for Enhancement of Vision
This project aims to evaluate the use of Virtual Reality (VR) based visual stimulation for the treatment of blindness arising from Glaucoma and other retinal diseases or disorders of the visual system, through regeneration of…
- Trial name
- VR (NCT07071129)
- Testing
- Virtual Reality Stimulation
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Stanford University
Refractive Error
Corneal Staining Associated With Daily Disposable Beauty Contact Lenses
Limbal ring contact lenses enhance the look of the eye by adding pigmentation in a ring pattern to the contact lens. The purpose of this investigation is to determine if corneal staining increase is dependent upon the lens…
- Trial name
- NCT01882465
- Testing
- etafilcon A, 2-HEMA, EGDMA Non-ionic, hefilcon A
- Where
- Hong Kong
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Strabismus
Mobile Medical Application for Cost-effective Strabismus Screening
Develop and evaluate a new smartphone based app to screen for and measure eye misalignment (strabismus). The investigators will validate the app against simulated strabismus of known magnitude and common clinical tests.
- Trial name
- NCT03450980
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Visual Acuity
Clinical Investigation of Visual Acuity in Contact Lens Wearers After Instillation of a Lipid- Based Lubricating Eye Drop
This is a single visit, randomized, double masked, bilateral, non-dispensing, 2×2 crossover study to assess visual acuity.
- Trial name
- NCT06131476
- Testing
- Blink® Tears eye drops, Investigational lipid eye drops
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Myopia
Silicone Hydrogel Soft Contact Lens 7-Day Extended Wear Basis
The objective of this study is to evaluate the safety and effectiveness of the Bausch + Lomb samfilcon A soft (hydrophilic) contact lens, a new silicone hydrogel contact lens, compared to the Bausch + Lomb PureVision® soft…
- Trial name
- NCT02939950
- Testing
- Bausch + Lomb Samfilcon A Soft Contact Lens, Bausch + Lomb Pure Vision Soft Contact Lens
- Where
- United States
- Volunteers
- 816 people, healthy volunteers welcome
- Sponsor
- Bausch Health Americas, Inc.
Normal Tension Glaucoma
Systemic Glutathione Level in Normal Tension Glaucoma
The purpose of this study is to evaluate whether systemic glutathione level is decreased in patients with normal tension glaucoma.
- Trial name
- NCT00570362
- Where
- South Korea
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Dry Eye
The Effect of Xiidra on Comfort and Dryness in Symptomatic Contact Lens Wearers
The purpose of this study to evaluate changes in comfort and dryness in symptomatic contact lens (CL) wearers after using Xiidra (lifitegrast 5.0% ophthalmic solution) for 12 weeks.
- Trial name
- COLLIE (NCT04297618)
- Testing
- Xiidra
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Presbyopia
A Single-Center, Double-Masked Evaluation of the Efficacy and Safety of PRX-100 in the Treatment of Early to Moderate Presbyopia
To evaluate the safety and efficacy of PRX-100 compared with aceclidine alone and vehicle in the treatment of early to moderate presbyopia.
- Trial name
- NCT03201562
- Testing
- Aceclidine+tropicamide combination, Aceclidine, Vehicle
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- LENZ Therapeutics, Inc
Age-Related Macular Degeneration
Alpha Lipoic Acid in Geographic Atrophy
Because of its iron-chelating and antioxidant properties, alpha lipoic acid may be a treatment for geographic atrophy (GA) secondary to age-related macular degeneration.
- Trial name
- ALA (NCT02613572)
- Testing
- alpha lipoic acid
- Where
- 5 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Visual Disorder
A Clinical Trial to Evaluate Investigational Silicone Hydrogel Contact Lenses Worn Continuously for One Week
This study is a prospective, randomized, double-masked, bilateral, dispensing, parallel-group clinical trial design. All subjects will participate in a 2-week daily disposable contact lens adaptation period prior to being…
- Trial name
- NCT02543528
- Testing
- Investigational Lens 1, Investigational Lens 2, Investigational Lens 3
- Where
- India
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Myopia, Hyperopia
Multicenter Dispensing Study of Biofinity Lenses in Extended Range
To obtain subjective and objective feedback on the clinical performance of Biofinity lenses after at least two weeks daily wear in existing contact lens wearers compared with their habitual lenses.
- Trial name
- NCT02060539
- Testing
- Biofinity XR
- Where
- 4 sites in United States, Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Eye Dryness
Comparison of Two Marketed Lenses in a Controlled Environment
This study is comparing two silicone hydrogel contact lenses in a controlled environment for identification of characteristics associated to vision.
- Trial name
- NCT02212301
- Testing
- senofilcon A, lotrafilcon B
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Vision Disorders
Study of A New Contact Lens Cleaning and Disinfecting Solution
The objective of this study is to evaluate the safety and efficacy of a new investigational cleaning and disinfecting solution (Test) compared to Clear Care cleaning and disinfecting solution (Control) when used by contact lens…
- Trial name
- NCT01318577
- Testing
- Investigational Cleaning & Disinfecting Solution, Clear Care Solution
- Where
- United States
- Volunteers
- 444 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Allergic Conjunctivitis
Effect of Olopatadine on Allergic Tear Mediators
The purpose of the research is to determine which inflammatory substances are involved in causing allergic symptoms in the eye. Allergic conjunctivitis is a common problem with symptoms of temporary redness, itching, tearing, and…
- Trial name
- NCT00609128
- Testing
- olopatadine
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Vitreoretinopathy, Coats' Disease
DEXTENZA in Pediatric Patients Following Retinal Surgery or Laser Treatment Under Anesthesia
The Tender Study is a prospective, open-label, single-center, randomized, investigator-initiated clinical study seeks to investigate the safety and efficacy of the DEXTENZA insert in pediatric patients following retinal surgery…
- Conditions
- Vitreoretinopathy, Coats' Disease, Exudative Retinopathy, Lattice Degeneration
- Trial name
- NCT05620901
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, Pred Forte
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Lejla Vajzovic, MD, FASRS