Clinical trials: Eye
Dry Eye Disease
A Study to Determine the Safety and Tolerability of Escalating Doses of INS365 Ophthalmic Solution
The purpose of this study is to evaluate the safety and tolerability of INS365 Ophthalmic Solution when applied topically as eyedrops in patients with mild to moderate dry eye disease.
- Trial name
- NCT00680108
- Testing
- diquafosol tetrasodium (INS365) ophthalmic solution
- Volunteers
- 62 people
- Sponsor
- Merck Sharp & Dohme LLC
Corneal Ulcer
ACRO Biocornea Clinical Trial in Taiwan
The goal of this clinical trial is to investigate the safety and clinical performance of ABCcolla Collagen Ophthalmic Matrix used for anterior lamellar keratoplasty in patients suffering from corneal ulcer.
- Trial name
- NCT04054817
- Testing
- Lamellar keratoplasty-ABCcolla® Collagen Ophthalmic Matrix
- Where
- 3 sites in Taiwan
- Volunteers
- 6 people
- Sponsor
- ACRO Biomedical Co. Ltd
Refractory Glaucoma
The Vizio Clinical Study
Evaluate the Safety and Efficacy of the Vizio Aqueous Microshunt for the Treatment of Refractory Glaucoma
- Trial name
- NCT06591117
- Testing
- Vizio Aqueous Microshunt
- Where
- El Salvador
- Volunteers
- 50 people
- Sponsor
- Ocumedex
Thyroid Eye Disease
A Study of IBI3031 in Participants With Thyroid Eye Disease
This is a multicenter, randomized, double-masked, placebo-controlled, single/multiple-dose-escalation trial conducted in Chinese participants with Thyroid Eye Disease (TED), aiming to evaluate the safety and tolerability of…
- Trial name
- NCT07622368
- Testing
- IBI3031
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
High Myopia, Axial Length
Repeated Low-Level Red-Light Therapy Shortens Axial Length
The purpose of this clinical trial is to investigate the incidence and magnitude of axial length shortening after repeated low-level red-light therapy in high myopia children and teenagers.
- Conditions
- High Myopia, Axial Length, Eye Diseases
- Trial name
- NCT05768152
- Testing
- RLRL
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Second People's Hospital of Foshan
Primary Open Angle Glaucoma
Clinical Study Evaluating the Safety and Performance of the MIST Device for Intraocular Pressure Reduction in Patients With Primary Open-Angle Glaucoma
It is an interventional study for the treatment of Primary Open-Angle Glaucoma (POAG) using the Hexiris Microinvasive Scleral Trephine (MIST) system. This medical device includes a sclerectomy punch and injector assembly.
- Trial name
- NCT07358650
- Testing
- Hexiris Microinvasive Scleral Trephine (MIST)
- Where
- 5 sites in Canada
- Volunteers
- 25 people
- Sponsor
- Hexiris Inc
Macular Degeneration
Managing Neovascular (Known as "Wet") Age-related Macular Degeneration Over 2 Years Using Different Treatment Schedules of 2 mg Intravitreal Aflibercept Injected in the Eye
This study aims to evaluate the optimal use, efficacy, and safety of a Treat-and-Extend regimen with aflibercept in subjects with nAMD.
- Trial name
- ARIES (NCT02581891)
- Testing
- Eylea (Intravitreal Aflibercept, VEGF Trap-Eye, BAY86-5321)
- Where
- 39 sites in Australia, Canada and 6 more
- Volunteers
- 287 people
- Sponsor
- Bayer
Progressive Supranuclear Palsy
Study About Safety and Efficacy of Coenzyme Q10 in Progressive Supranuclear Palsy
Study hypothesis: A 6-week p.o treatment with 5 mg/Kg Coenzyme Q10 is safe and tolerable,increases the brain's metabolism and ameliorates clinical symptoms in patients with PSP.
- Trial name
- NCT00328874
- Testing
- Coenzyme Q10
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- German Parkinson Study Group (GPS)
Behçet Disease, Behcet Syndrome
Erectile Dysfunction in Patients With Non Ocular Behçet's Disease
It was aimed to demonstrate whether erectile dysfunction is affected by BH pathogenesis and whether there is a relationship between erectile dysfunction and BD pathogenesis by assessing both sexual function and retinal…
- Conditions
- Behçet Disease, Behcet Syndrome, Erectile Dysfunction
- Trial name
- NCT04386824
- Testing
- Erectil dysfunction
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Antalya Training and Research Hospital
Normal Eyes, Eyes With Glaucoma
OCT Agreement and Precision Study
To demonstrate clinical substantial equivalence of 3D OCT-1 Maestro as comparable to the commercially available iVue and NW-300.
- Conditions
- Normal Eyes, Eyes With Glaucoma, Eyes With Retinal Disease
- Trial name
- NCT02045823
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Topcon Medical Systems, Inc.
Giant Cell Arteritis (GCA)
oPtic Nerve Sheath Evaluation in gianT Cell aRtheritis by UltraSound
The purpose of this study is to evaluate whether the measure of the optic nerve sheath is a reliable diagnostic marker for giant cell arteritis
- Trial name
- PETRUS (NCT07001059)
- Testing
- orbital ultrasound
- Where
- 9 sites in France
- Volunteers
- 190 people
- Sponsor
- Hôpital NOVO
Keratitis, Pterygium
Robotic Surgery of the Ocular Surface
The introduction of surgical robots in the OR revolutionized a number of specialties (i. e. urology, gynecology, digestive surgery).
- Conditions
- Keratitis, Pterygium, Corneal Opacity Corneal Thinning, Corneal Perforation
- Trial name
- NCT02116062
- Testing
- 1. Amniotic membrane transplantation on the cornea with the Da Vinci Si HD© robot (Inlay or overlay technique), Pterygium removal and autograft of the conjunctiva with the Da Vinci Si HD© robot (Kenyon technique), Penetrating keratoplasty using Baron trephine and nylon stitches with the Da Vinci Si HD© robot
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Strasbourg, France
Antibody-mediated Rejection, NMO Spectrum Disorder
Biorepository and Registry for Plasma Exchange Patients
Patients who have immune mediated diseases commonly undergo plasma exchange (PLEX) procedures to remove pathological substances, typically believed to be antibodies.
- Conditions
- Antibody-mediated Rejection, NMO Spectrum Disorder, TTP, CIDP
- Trial name
- NCT05004493
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Charles M Knudson
GLAUCOMA 1, OPEN ANGLE, D (Disorder)
Comparing XEN®-63 Gel Stent and PRESERFLO® MicroShunt
The goal of this randomized controlled clinical trial is to learn whether two minimally invasive bleb-forming glaucoma implants can effectively treat adult patients with open-angle glaucoma who require surgical lowering of…
- Trial name
- MINI-BATTLE (NCT07359547)
- Testing
- XEN®-63 Gel Stent, PRESERFLO™ MicroShunt
- Where
- 3 sites in Belgium, Germany and 1 more
- Volunteers
- 166 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Smith-Lemli-Opitz Syndrome, Cone-Rod Dystrophy
Cholesterol and Antioxidant Treatment in Patients With Smith-Lemli-Opitz Syndrome (SLOS)
Patients with biochemically confirmed SLOS are being treated with cholesterol supplementation and antioxidant medication. They are carefully monitored with visits to clinic, laboratory testing including cholesterol and…
- Conditions
- Smith-Lemli-Opitz Syndrome, Cone-Rod Dystrophy, Hearing Loss
- Trial name
- NCT01773278
- Testing
- Antioxidants, Cholesterol
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Glaucoma, Hypertension
Know Your Pressures NYC
Dr. Lisa A. Hark (PI and Study Chair) and an interdisciplinary team have designed "Know Your Pressures NYC" to conduct blood pressure (BP)/glaucoma screenings in adults age 40+ to identify undiagnosed and/or uncontrolled…
- Conditions
- Glaucoma, Hypertension, Glaucoma, Suspect, Elevated Blood Pressure
- Trial name
- NCT05992415
- Testing
- Virtual Automated Navigator Intervention with Health Education, Usual Care
- Where
- United States
- Volunteers
- 7,085 people, healthy volunteers welcome
- Sponsor
- Columbia University
Glaucoma and Ocular Hypertension
Prospective,Randomized,Controlled Study to Assess Efficacy,Safety, and Tolerability of SLT vs. PLT in Patients With POAG
A prospective, randomized, controlled study to assess efficacy, safety, and tolerability of selective laser trabeculoplasty vs. pattern laser trabeculoplasty in patients with open-angle glaucoma.
- Trial name
- NCT02231515
- Testing
- Selective laser trabeculoplasty (SLT), Pattern laser trabeculoplasty (PLT)
- Where
- Switzerland
- Volunteers
- 29 people
- Sponsor
- University Hospital, Geneva
Optic Nerve Sheath Diameter
Anesthesia on Optic Nerve Sheath Diameter
Different amounts of anesthetic gas can be used in the obstetric gynecological surgery operations to be performed with open method.
- Trial name
- NCT04407715
- Testing
- The Effect Of Minimal and High Flow Anesthesia on Optic Nerve Sheath Diamater
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Retinitis Pigmentosa, Choroideremia
Pilot Study of a Suprachoroidal Retinal Prosthesis
This study will be an initial proof of concept study, to evaluate safety and efficacy of a prototype suprachoroidal retinal implant
- Trial name
- NCT01603576
- Testing
- Prototype wide view suprachoroidal retinal prosthesis
- Where
- 2 sites in Australia
- Volunteers
- 3 people
- Sponsor
- Center for Eye Research Australia
Myopia, Intraocular Lens Complication
Trifocal Intraocular Lens in High Myopic Patients With Different Meta-PM Grading
Study the postoperative visual quality and safety of trifocal intraocular lenses implanted in patients with different levels of myopic maculopathy stages according to Meta-PM staging (stage 0-2).
- Trial name
- NCT05718076
- Testing
- cataract surgery
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Aier School of Ophthalmology, Central South University
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