Clinical trials: Eye
Glaucoma, Suspect, Aberration, Corneal Wavefront
Ocular Changes With Alpha-2 Receptor Agonist.
selective alpha-2 receptor agonists cause changes in intraocular pressure and pupillary size thus may affect patient quality of life.
- Trial name
- NCT05670015
- Testing
- Low dosage selective alpha-2 receptor agonists topical eyedrop, High dosage selective alpha-2 receptor agonists topical eyedrop
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Benha University
Dry Eye
Intracanalicular Dexamethasone Insert for the Treatment of Inflammation and Discomfort in Dry Eye Disease (DEcIDED)
This prospective, single-center, randomized, double-masked, parallel comparison, sponsored study seeks to investigate the efficacy of Intracanalicular dexamethasone Insert (IDI) on ameliorating the signs and symptoms of dry eye…
- Trial name
- DEcIDED (NCT04527887)
- Testing
- Dextenza (IDI) (Sustained Release Dexamethasone), (0.4 mg), ProLong™ collagen plugs
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Tufts Medical Center
Progressive Supranuclear Palsy
Rehabilitation in Patients With Progressive Supranuclear Palsy
The investigators evaluate whether an aerobic, intensive, goal based and multidisciplinary rehabilitation treatment, previously conceived for Parkinson's disease, is effective for patients with progressive supranuclear palsy and…
- Trial name
- PSP-MIRTLoko (NCT02109393)
- Testing
- MIRT, MIRT+Lokomat
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Intraocular Inflammation
Intraocular Fluid Detection in Endophthalmitis
Endophthalmitis is also called vitreous inflammation. Broadly speaking, it refers to all kinds of serious intraocular inflammation, such as vitreitis, anterior chamber empyema and eye pain caused by intraocular infection…
- Trial name
- NCT04914884
- Testing
- intraocular fluid detection
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Central Retinal Artery Occlusion
Safety and Efficacy After Selective Intra-arterial Thrombolysis for Central Retinal Artery Occlusion
Central retinal artery occlusion (CRAO) is an ophthalmic emergency which leads to devastating visual function defects and poor prognosis.
- Trial name
- NCT05562284
- Testing
- intra-arterial thrombolysis, conservative treatments
- Where
- China
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Glaucoma, Narrow Angle
Intraocular Pressure Control After Anterior Segment Laser - Comparison Between 2 Drugs
The purpose of this study is to compare the intra-ocular (IOP) control efficacy between brimonidine 0.1% vs. 0.2% after laser peripheral iridotomy (LPI).
- Trial name
- NCT01417858
- Testing
- YAG laser peripheral iridotomy
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Universidade Federal do Paraná
Cataract
Clinical Application Comparison of Two Femtosecond Laser Systems
The goal of this clinical trial is to compare the perioperative parameters of femtosecond laser-assisted cataract surgery (FLACS) using two laser systems.
- Trial name
- NCT06754358
- Testing
- LenSx, Z8
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Age-related Macular Degeneration
Genetic Load and Phenotype in Aggressive AMD
Patients with AMD will provide cheek cell samples to determine if their is a correlation between genotype (DNA markers) and phenotype (the type of AMD the patient has).
- Trial name
- RPED Genetics (NCT01650948)
- Testing
- RetnaGene AMD LDT
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Sequenom, Inc.
Myopia, Refractive Errors
School-based Myopia Control Trial for Children With Premyopia or Myopia
This is a prospective, school-based randomized controlled trial designed to evaluate auricular acupressure combined with defocus spectacle lenses for myopia control in primary school students with premyopia or myopia.
- Trial name
- SPARK (NCT07746778)
- Testing
- Defocus Spectacle Lenses, Auricular Acupressure
- Where
- China
- Volunteers
- 358 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Glaucoma
A Study About the Safety of ASP2767 and Whether it Helps People With Glaucoma-Related Optic Nerve Damage
Open-angle glaucoma is the most common type of glaucoma, a disease that damages the nerves in the eye and can lead to vision loss. Current treatments include eye drops, laser treatment, and surgery that help lower eye pressure.
- Trial name
- NCT07770685
- Testing
- ASP2767, Prophylactic Regimen A, Prophylactic Regimen B
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Neck Pain, Eye Strain
Effectiveness of an Eye-Cervical Re-education Program in Chronic Neck Pain
The aim of the present study is to value the effectiveness of an Eye-Cervical Re-education Program (ECRP) to decrease pain and increase mobility in the cervical area compared to a Combined Physiotherapy Protocol (CPP) in patients…
- Trial name
- NCT03197285
- Testing
- EYE-CERVICAL RE-EDUCATION PROGRAM, Combined Physiotherapy Protocol
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- University of Cadiz
Myopia
Multicenter Evaluation of Near Vision and Outdoor Time in Kids Study
Currently, optical and pharmacological interventions have been developed to prevent the progression of childhood myopia. However, no myopia control strategy has been shown to have complete efficacy in controlling myopia…
- Trial name
- MENOK (NCT06119243)
- Testing
- Vivior
- Where
- 5 sites in United States, Australia
- Volunteers
- 230 people
- Sponsor
- The University of New South Wales
Viral Conjunctivitis
Viral Conjunctivitis Treatment Study
The objective of this study is to determine the efficacy Avenova® (0.01% hypochlorous acid) in the treatment of viral conjunctivitis.
- Trial name
- NCT03861728
- Testing
- 0.01% Hypochlorous acid
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Miami
Glaucoma, Angle-Closure
Effect of Peripheral Laser Iridotomy Placement on Post-operative Visual Function
To evaluate the influence of superior versus temporal laser peripheral iridotomy location on post-operative visual acuity and contrast sensitivity.
- Trial name
- NCT03352492
- Testing
- Superior laser peripheral iridotomy, Temporal laser peripheral iridotomy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of the Incarnate Word
Retinal Vein Occlusion
Minocycline to Treat Central Retinal Vein Occlusion
Background: Central retinal vein occlusion (CRVO) is a blockage of the main vein that carries blood away from the retina in the back of the eye.
- Trial name
- NCT01468844
- Testing
- Minocycline, Bevacizumab
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 6 people
- Sponsor
- National Eye Institute (NEI)
Dry Eye Syndromes
Feasibility of IPL for Reducing Dry Eye Symptoms Caused by MGD
The purpose of this study is to evaluate if, in patients with meibomian gland dysfunction (MGD), treatment with the Lumenis M22 Intense Pulsed Light (IPL) system causes a reduction in dry eye symptoms post-treatment, compared to…
- Trial name
- NCT02621593
- Testing
- M22-IPL
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- Lumenis Be Ltd.
Retinal Detachment
Short Term Postoperative Tamponade Using Perfluorocarbon Liquid for Giant Retinal Tears
The purpose of the article is, to investigate the efficacy and safety of perfluorocarbon liquid (PFCL) ,as a short term postoperative tamponade for treating retinal detachment ,associated with giant retinal tears.
- Trial name
- NCT01604616
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ziv Hospital
Cutaneous Melanoma, Uveal Melanoma
A Study of RO7293583 in Participants With Unresectable Metastatic Tyrosinase Related Protein 1 (TYRP1)-Positive Melanomas
This is a first-in-human, multi-center clinical study to determine the safety, Maximum Tolerated Dose (MTD) and/or Optimal Biological Dose (OBD) as well as the optimal schedule for intravenous (IV) and/or subcutaneous (SC)…
- Conditions
- Cutaneous Melanoma, Uveal Melanoma, Mucosal Melanoma
- Trial name
- NCT04551352
- Testing
- RO7293583, Tocilizumab, Obinutuzumab
- Where
- 14 sites in United States, Australia and 4 more
- Volunteers
- 20 people
- Sponsor
- Hoffmann-La Roche
Dry Eye Disease
Study to Assess Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of Palovarotene Ophthalmic Solution in Healthy Adult Subjects
Dry eye disease (DED) is a keratoconjunctive disorder that "is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage…
- Trial name
- NCT04762355
- Testing
- Palovarotene, Vehicle
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Clementia Pharmaceuticals Inc.
Primary Open Angle Glaucoma, Intraocular Pressure
Effects of Forskolin on Intraocular Pressure in Glaucomatous Patients Under Maximum Tolerated Medical Therapy
Elevated intraocular pressure is still the main risk factor for development and progression of glaucoma. Several drugs exist on the market that may decrease IOP in glaucomatous patients.
- Trial name
- NCT00864578
- Where
- Italy
- Sponsor
- Sooft Italia
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