Clinical trials: Eye
Dry Eye, Graft-versus-host-disease
Topical Fibrinogen-Depleted Human Platelet Lysate in Patients With Dry Eye Secondary to Graft vs. Host Disease
The purpose of this Phase 1/2 study is to compare the safety and tolerability of four times a day (QID) dosing of a non-preserved topical ocular drop formulation of 10 vol/vol % and 30 vol/vol % of FD hPL to vehicle control eye…
- Conditions
- Dry Eye, Graft-versus-host-disease, Ocular Discomfort
- Trial name
- NCT03414645
- Testing
- CAM-101 10%, Vehicle Control, CAM-101 30%
- Where
- 6 sites in United States
- Volunteers
- 64 people
- Sponsor
- Cambium Bio Limited
Myopia
Silicone Hydrogel Soft Contact Lens 7-Day Extended Wear Basis
The objective of this study is to evaluate the safety and effectiveness of the Bausch + Lomb samfilcon A soft (hydrophilic) contact lens, a new silicone hydrogel contact lens, compared to the Bausch + Lomb PureVision® soft…
- Trial name
- NCT02939950
- Testing
- Bausch + Lomb Samfilcon A Soft Contact Lens, Bausch + Lomb Pure Vision Soft Contact Lens
- Where
- United States
- Volunteers
- 816 people, healthy volunteers welcome
- Sponsor
- Bausch Health Americas, Inc.
Myopia
Evaluation Of One Silicone Hydrogel Contact Lens and Two Hydrogel Lenses in Daily Wear
To evaluate the comparative clinical performance of the fanfilcon A silicone hydrogel lens used in daily wear and to compare this with competitive hydrogel lens products.
- Trial name
- NCT04050618
- Testing
- fanfilcon A test lens, ocufilcon D control lens, etafilcon A control lens
- Where
- 6 sites in United States
- Volunteers
- 114 people
- Sponsor
- CooperVision, Inc.
Retinal Vein Occlusion
Vascular Endothelial Growth Factor (VEGF) Levels in Retinal Vein Occlusion (RVO) During Anti-VEGF Treatment
The purpose of this study is to treat patients with retinal vein occlusion with standard of care anti-vascular endothelial growth factor therapy and to correlate levels of vascular endothelial growth factor in the anterior…
- Trial name
- NCT04707625
- Testing
- Aflibercept Ophthalmic
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Wake Forest University Health Sciences
Cataracts
Clinical Investigation of AcrySof® IQ ReSTOR® +2.5 D Multifocal Intraocular Lens (IOL) Model SN6AD2 [SV25T0]
The purpose of this study is to compare the safety and efficacy of an investigational multifocal intraocular lens (IOL) to an FDA-approved monofocal IOL.
- Trial name
- NCT01510717
- Testing
- AcrySof® IQ ReSTOR® +2.5 D Multifocal IOL Model SN6AD2 [SV25T0], AcrySof® IQ Monofocal IOL Model SN60WF
- Volunteers
- 409 people
- Sponsor
- Alcon Research
Dry Eye
Study of Brimonidine Tartrate Nanoemulsion Eye Drop Solution in the Treatment of Dry Eye Disease (DED)
This study evaluates the use of Brimonidine tartrate nanoemulsion eye drop solution in the treatment of Dry Eye Disease (DED). Half of participants will receive Brimonidine and half will receive ophthalmic buffered saline…
- Trial name
- NCT03785340
- Testing
- Brimonidine Tartrate
- Where
- 16 sites in United States
- Volunteers
- 252 people
- Sponsor
- Ocugen
Choroidal Melanoma
Lucentis as an Adjuvant Therapy With TTT-ICG Based in Choroidal Melanoma
To report preliminary results on safety and tolerability of intravitreal injection of Ranibizumab (Lucentis) combined with Transpupillary Thermotherapy (TTT)+ Indocyanine Green (ICG)-based photodynamic therapy (PDT) in the…
- Trial name
- NCT00680225
- Testing
- Ranibizumab injection and TTT - ICG based
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- New England Retina Associates
Cataracts
DisCoVisc Comparative Evaluation
A comparison of the ability of DisCoVisc to that of other Opthalmic Viscosurgical Devices (OVDs) (DuoVisc®, BioVisc®, Healon5®, or Amvisc PLUS) regarding endothelial protection and anterior chamber space maintenance during…
- Trial name
- NCT00732225
- Testing
- DisCoVisc, DuoVisc, BioVisc
- Where
- United States
- Volunteers
- 173 people
- Sponsor
- Alcon Research
Myopia
Assessment of Measurement Variability Across Automated Biometry Devices
This is a non-interventional prospective, comparative study of white-to-white, corneal thickness, and anterior chamber depth measurements as taken on the Orbscan II compared to the IOL Master 700 (Zeiss), IOL Master 500 (Zeiss)…
- Trial name
- NCT06045325
- Testing
- Orbscan II, IOL Master 700, IOL Master 500
- Where
- United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Berkeley Eye Center
Bacterial Conjunctivitis
Clinical and Microbial Efficacy of ISV403 in Bacterial Conjunctivitis
To evaluate the clinical and microbial efficacy of ISV-403 administered three times a day (TID) for 5 days compared to vehicle three times a day for 5 days in the treatment of bacterial conjunctivitis
- Trial name
- NCT00622908
- Testing
- ISV-403, Vehicle
- Volunteers
- 270 people
- Sponsor
- Bausch & Lomb Incorporated
Optic Neuritis
Atacicept in Subjects With Optic Neuritis
This study was intended to evaluate the efficacy, safety and tolerability of atacicept compared to placebo and to explore the neuroprotective effect of atacicept as assessed by OCT in subjects with ON as CIS.
- Trial name
- NCT00624468
- Testing
- Atacicept
- Where
- 28 sites in United States, Australia and 9 more
- Volunteers
- 34 people
- Sponsor
- EMD Serono
Glaucoma
Human Optokinetic Contrast Device (HOCD) to Measure Visual Function and Identify Patients With and Without Glaucoma
The purpose of this study is to determine if an optokinetic contrast detection device is sufficient to measure contrast sensitivity and to distinguish between patients with and without glaucoma.
- Trial name
- HOCD (NCT02014597)
- Testing
- HOCD
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Benjamin Frankfort, MD, PhD
Dry Eye
Safety and Efficacy Study on Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease (PROTEGO-1 Study)
Primary objectives To compare the efficacy of cenegermin vs vehicle in Schirmer I test (without anaesthesia) >10mm/5min at Week 4 by testing the superiority.
- Trial name
- NCT05133180
- Testing
- Oxervate, Vehicle
- Where
- 10 sites in United States, Italy
- Volunteers
- 104 people
- Sponsor
- Dompé Farmaceutici S.p.A
Central Retinal Vein Occlusion
Assessing the Efficacy and Safety of Brolucizumab Versus Aflibercept in Patients With Visual Impairment Due to Macular Edema Secondary to Central Retinal Vein Occlusion
The purpose of this study was to evaluate the efficacy and safety of brolucizumab in treatment of patients with macular edema (ME) secondary to central retinal vein occlusion (CRVO).
- Trial name
- RAVEN (NCT03810313)
- Testing
- Brolucizumab 6 mg, Aflibercept 2 mg
- Where
- 120 sites in United States, Australia and 18 more
- Volunteers
- 493 people
- Sponsor
- Novartis Pharmaceuticals
Astigmatism
Pseudophakic Astigmatic Reduction With Verion-LenSx Arcuate Incisions
To assess the effectiveness of the Verion-LenSx guided arcuate incision technique to reduce astigmatism in a pseudophakic population.
- Trial name
- NCT02763124
- Testing
- Verion-LenSx
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Gainesville Eye Associates
Hyperopia, Hyperopic Astigmatism
Safety and Efficacy of Corneal Collagen Cross-linking Following LASIK for Treatment of Hyperopia and Hyperopic Astigmatism
The objectives of this study are to evaluate the safety and efficacy, with regards to regression of refractive outcome, as measured by manifest refraction spherical equivalent (MRSE), of two treatment regimens for hyperopic and…
- Trial name
- NCT01893359
- Testing
- riboflavin ophthalmic solution, 0% dextran, UVA Irradiation (30 mW/cm2 for 2 minutes continuous UVA), UVA Irradiation (30 mW/cm2 for 3 minutes pulsed UVA with an on/off cycle of 2 seconds UVA on/1 second UVA off)
- Where
- 5 sites in United States
- Volunteers
- 2 people
- Sponsor
- Glaukos Corporation
Keratoplasty, Grafting, Corneal
Descemet Endothelial Thickness Comparison Trial
The purpose of this study is to compare visual acuity outcomes of two types of endothelial keratoplasty: 1) Ultrathin Descemet's Stripping Endothelial Keratoplasty (DSAEK) or 2) Descemet's Membrane Endothelial Keratoplasty…
- Conditions
- Keratoplasty, Grafting, Corneal, Transplantation, Corneal, Transplantation, Cornea
- Trial name
- DETECT (NCT02373137)
- Testing
- DSAEK, DMEK, Endoserter
- Where
- 3 sites in United States
- Volunteers
- 38 people
- Sponsor
- Oregon Health and Science University
Dry Eye Syndrome
SYSTANE® Family - Meibomian Deficiency
The purpose of this study was to assess the efficacy of the SYSTANE® family of products (SYSTANE® Lid Wipes, SYSTANE® BALANCE Lubricant Eye Drops, and SYSTANE® Vitamins) on meibomian gland functionality in subjects with lipid…
- Trial name
- M-12-077 (NCT01733745)
- Testing
- SYSTANE® Lid Wipes, SYSTANE® BALANCE, SYSTANE® Vitamins
- Volunteers
- 26 people
- Sponsor
- Alcon Research
Cataract
Visual Outcomes of Subjects Bilaterally Implanted With ReSTOR Aspheric +4 vs. Tecnis or Acri.LISA
This is a study to compare visual outcomes of subjects bilaterally implanted w/ReSTOR to subjects bilaterally implanted with the Tecnis Multifocal Intraocular Lens (IOL) or Acri.LISA IOL
- Trial name
- NCT00721253
- Testing
- ReSTOR, Tecnis, Acri.LISA
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Presbyopia
Safety and Effectiveness Study of the AcuFocus Corneal Inlay ACI 7000PDT in Presbyopes
The purpose of this study is to determine if the AcuFocus Corneal Inlay ACI 7000PDT will provide an effective method for the correction of presbyopia in patients who have normal distance vision but need a correction such as…
- Trial name
- ACI (NCT00850031)
- Testing
- AcuFocus Corneal Inlay
- Where
- 8 sites in Australia, Austria and 4 more
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- AcuFocus, Inc.
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