Clinical trials: Eye
Open Angle Glaucoma (OAG), Ocular Hypertension (OH)
Evaluate Efficacy, Safety, Tolerability and Biodegradation of PA5346 Ocular Implant in Patients With Open-Angle Glaucoma or Ocular Hypertension
The goal of this clinical study is to learn how effective and safe is a single administration of PA5346 Ocular Implant for the reduction of intraocular pressure in adult patients with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT06964061
- Testing
- PA5436 Ocular Implant, 115mcg
- Where
- 2 sites in Australia
- Volunteers
- 12 people
- Sponsor
- PolyActiva Pty Ltd
Corneal Ulcer
Village Integrated Eye Workers Trial
VIEW is a community-randomized trial designed to determine whether it is possible to prevent corneal ulcers on a large scale. The study compares the incidence of corneal ulceration between villages in which volunteers are trained…
- Trial name
- VIEW (NCT01969786)
- Testing
- Corneal ulcer prevention program
- Where
- Nepal
- Volunteers
- 223,671 people
- Sponsor
- University of California, San Francisco
Ocular Hypertension
IOP Patterns in Ocular Hypertensive Patients Newly Converted to Glaucoma vs Stable Ocular Hypertensive Patients
The purpose of the study is to assess the relationship between IOP pattern as recorded over 24 hours by using Triggerfish and quantified by acrophase scored dichotomously, and conversion to glaucoma in OHT patients (conversion…
- Trial name
- NCT02030886
- Testing
- Sensimed Triggersfish® (TF)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Sensimed AG
Cystoid Macular Edema, Diabetes Mellitus
Assessing Diabetes Mellitus on Cytokine Analysis and Macular Edema Following FLACS
The purpose of this study is to assess the effects of diabetes mellitus (DM) on anterior chamber cytokine production and postoperative macular edema in patients undergoing femtosecond laser-assisted cataract surgery (FLACS).
- Conditions
- Cystoid Macular Edema, Diabetes Mellitus, Cataract
- Trial name
- NCT04856670
- Testing
- Cataract surgery
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Uptown Eye Specialists
Myopia
Clinical Evaluation of the Long-Term Effects of Contact Lens Care Systems
The purpose of this study is to compare two marketed contact lens care solutions in regards to comfort and ocular health.
- Trial name
- NCT00813761
- Testing
- O2Optix contact lens, Proclear contact lens, ReNu MultiPlus Multi-Purpose Solution
- Where
- 26 sites in United States, United Kingdom
- Volunteers
- 473 people
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Strabismus, Reflex, Oculocardiac
Hydroxyzine Dihydrochloride Premedication is a Necessity for Strabismus Surgery
Oculocardiac reflex (OCR) is usually happening in pediatric strabismus surgery and observed just when the surgent pulls the ocular muscles.
- Conditions
- Strabismus, Reflex, Oculocardiac, Hydroxyzine, Bradycardia Sinus
- Trial name
- NCT03806270
- Testing
- Midazolam, Hydroxyzine Dihydrochloride
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Yeditepe University
Cataract, Bilateral Senile Cataract
Cataract Monitored Anesthesia Care (MAC) Feasibility Pilot Study
The goal of this pilot clinical trial comparing two different sedation approaches for cataract surgery is to assess the feasibility, completeness, and distribution of data in measuring patient satisfaction, the quality of…
- Conditions
- Cataract, Bilateral Senile Cataract, Anesthesia, Patient Satisfaction
- Trial name
- CaTNAPS-1 (NCT06506669)
- Testing
- Oral sedation
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Diabetic Macular Edema
Relating Retinal Structural and Functional Parameters to Visual Acuity in Eyes Undergoing Treatment for Diabetic Macular Edema
This longitudinal interventional case series will utilize the patients at the University of Michigan W.K. Kellogg Eye Center scheduled to begin treatment for diabetic macular edema.
- Trial name
- NCT02088229
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Michigan
Diabetes Mellitus, Type 2, Macular Edema
Effects of Adding Triamcinolone Acetonide to Conbercept Treatment for Refractory Diabetic Macular Edema (CONTE)
This study aimed to compare intravitreous conbercept alone with conbercept plus intravitreous triamcinolone acetonide in DME eyes which showed limited response to anti-VEGF treatment after one injection.
- Trial name
- CONTE (NCT04627402)
- Testing
- Conbercept and TA, Conbercept
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Thyroid-associated Ophthalmopathy, Dry Eye Syndrome
The Effect of Intravenous Glucocorticoids on the Tearfilm in Eyes With Thyroid-associated Ophthalmopathy
Thyroid-associated ophthalmopathy (TAO), also called Graves' ophthalmopathy or thyroid eye disease, is a common orbital disease in adults.
- Trial name
- NCT01579539
- Testing
- Methylprednisolone, Esomeprazole
- Where
- Austria
- Volunteers
- 18 people
- Sponsor
- Medical University of Vienna
Hydration, Cataract Surgery
Posterior Flap Hydration of Clear Corneal Incisions in Cataract Surgery: Influence on Corneal Wound Tightness and Architecture
Sutureless clear corneal incision (CCI) is the most commonly used technique for creating an entrance wound in cataract surgery. Corneal incision hydration enhances wound tightness and reduces postoperative fluid suction from the…
- Trial name
- CCI hydration (NCT07581366)
- Testing
- Patient with visible central wound gap of the CCI
- Where
- Czechia
- Volunteers
- 53 people
- Sponsor
- University Hospital Pilsen
Dry Eye Syndromes
Evaluation of Dry Eye Disease's Signs in Patients Who Were Administered Intravitreal Anti-VEGF Injections
The goal of this interventional, monocentric, prospective, single-masked, case-control study is to evaluate the efficacy of Thealoz Duo (artificial tear containing trehalose 3 g and hyaluronic acid 0.15 g) in comparison to a…
- Trial name
- DRYEYE-IVT (NCT06317922)
- Testing
- Thealoz Duo;
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Francesco Bandello
Polypoidal Choroidal Vasculopathy
Aqueous Humor Level of Cytokines in Polypoidal Choroidal Vasculopathy and Change of Cytokines After Photodynamic Therapy
This is a prospective, comparative control analysis. The investigators want to evaluate the aqueous humor levels of vascular endothelial growth factor in polypoidal choroidal vasculopathy and the effect of photodynamic therapy…
- Trial name
- NCT01360151
- Testing
- ranibizumab(Lucentis), verteporfin(Visudyne)
- Where
- South Korea
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Seoul St. Mary's Hospital
Glaucoma, Glaucoma, Open-Angle
Longitudinal Study on Glaucoma Surgery Using XEN® Gel Stent
To evaluate the safety and efficacy of the XEN® Gel Stent in mild to moderate glaucoma patients undergoing glaucoma surgery.
- Conditions
- Glaucoma, Glaucoma, Open-Angle, Glaucoma, Angle-Closure, Glaucoma, Primary Open Angle
- Trial name
- NCT03151577
- Testing
- XEN® Gel Stent implantation
- Volunteers
- 150 people
- Sponsor
- Swiss Vision Network
Astigmatism
Rotation Stability of Toric Intraocularlens (IOL) Compared Sitting Against Lying After Cataract Operation
To assess the rotation stability of toric intraocular lenses between sitting or routine settings (sitting, going around) after cataract operation.
- Trial name
- NCT04776057
- Testing
- catarct surgery with toric intra ocular lenses
- Where
- Austria
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Prim. Prof. Dr. Oliver Findl, MBA
Keratoconus, Cornea Ectasia
Safety and Efficacy of Corneal Crosslinking Using the PXL-Platinum 330 for Eyes With Corneal Ectatic Conditions
To evaluate the safety and effectiveness of the PXL Platinum 330 device for performing Corneal Crosslinking in patients with corneal thinning conditions.
- Trial name
- NCT04240457
- Testing
- Epithelial-on Corneal Crosslinking with the PXL 330 Platinum system.
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Arbor Center for Eye Care
Diabetic Retinopathy
Severe Proliferative Diabetic Retinopathy
The purpose of this study is to examine and compare, prospectively, best corrected visual acuity (BCVA) outcomes and complications of a cohort of patients with Proliferative Diabetic Retinopathy and Tractional Retinal Detachment…
- Trial name
- NCT01115257
- Testing
- vitrectomy, panretinalphotocoagulation
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- University of Catania
Lysosomal Storage Disease, Lung Diseases
Biomarker for Maroteaux-Lamy Disease (BioMaroteaux)
Development of a new MS-based biomarker for the early and sensitive diagnosis of Maroteaux-Lamy disease from blood
- Conditions
- Lysosomal Storage Disease, Lung Diseases, Obstructive Sleep Apnoea, Macroglossia
- Trial name
- BioMaroteaux (NCT01458613)
- Where
- 5 sites in Egypt, Germany and 2 more
- Sponsor
- CENTOGENE GmbH Rostock
Optic Neuritis
Evaluation of Optic Neuritis Using Synthetic Quantitative MRI
Inflammatory optic neuropathy (optic neuritis) is an acute condition that can affect the optic nerve along its entire course. It is a rare event, with a prevalence of up to 5 cases per 100,000 people per year, predominantly…
- Trial name
- QUESTION (NCT06916182)
- Testing
- MRI sequence
- Volunteers
- 100 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Oesophageal Cancer
Laser Speckle Contrast Imaging, Surgical Eye & ICG Fluorescence Imaging for Perfusion Assessment of the Gastric Conduit
Rationale Globally, esophageal cancer is the seventh most common cancer type, with over half a million cases reported in 2020. The survival of gastroesophageal cancer is poor and the prognosis is primarily determined by the…
- Trial name
- CONDOR-I (NCT05685862)
- Testing
- Laser Speckle Contrast Imaging using the PerfusiX-Imaging device
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Frisius Medisch Centrum
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