Clinical trials: Eye
Thyroid-Associated Ophthalmopathy
Sirolimus vs Corticosteroids in Treatment of Thyroid Eye Disease
The purpose of this study is to determine whether Sirolimus is more effective and burdened with less side effects than conventional treatment with corticosteroids in patients with active thyroid eye disease.
- Trial name
- NCT04936854
- Testing
- Sirolimus 1 mg Oral Tablet, Methylprednisolone
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Haukeland University Hospital
Glaucoma
Comparing SD-tVEP and PERG Tests Between Patients With Glaucoma, Patients With High Eye Pressure and "Normal" Patients
Wills Eye Hospital Glaucoma Research Center will conduct a 1-year prospective study to assess the ability of a Short Duration Transient Visual Evoked Potential (SD- tVEP) and a Steady-State Pattern electro-retinogram (PERG)…
- Trial name
- NCT02604953
- Testing
- Short Duration Transient Visual Evoked Potential (SDtVEP), Pattern electroretinogram (PERG)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Raised Intracranial Pressure
Effect of Intravenous Administration of Mannitol on ONSD in Patients With Raised ICP
Osmotherapy with mannitol has been a common practice in patients with raised ICP. Monitoring its effect on ICP can be performed invasively and non-invasively.
- Trial name
- NCT04188353
- Testing
- Optic nerve sheath diameter measurement, Mannitol
- Where
- Nepal
- Volunteers
- 40 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Fuchs' Endothelial Dystrophy, Cataract
Netarsudil Use After Descemetorhexis Without Endothelial Keratoplasty
Primary aim of the study is to determine whether a rho kinase inhibitor, Netarsudil, can speed corneal clearance after DWEK. Secondary aim of the study is to investigate whether patient factors, such as baseline age, pachymetry…
- Trial name
- NCT04057053
- Testing
- Netarsudil 0.02% Ophthalmic Solution
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Eye Cancer, Retinoblastoma
A Prospective International Multicenter Clinical Trial for Eyes With Relapsed Retinoblastoma
While 95% of patients with retinoblastoma can be cured nowadays, treatment of relapse remains challenging, ending often in enucleation and/or radiotherapy.
- Trial name
- EuRbG2018 (NCT04455139)
- Testing
- Topotecan, Melphalan
- Where
- Switzerland
- Volunteers
- 2 people
- Sponsor
- Prof. Beck Popovic Maja
Melanoma, Carcinoma, Non-Small- Cell Lung
A Study of SEA-CD40 Given With Other Drugs in Cancers
This trial is being done to see if an experimental drug (SEA-CD40) works when it's given with other cancer drugs to treat some types of cancer. It will also study side effects from the drug. There are 2 parts in this trial.
- Trial name
- NCT04993677
- Testing
- SEA-CD40, pembrolizumab (KEYTRUDA®), pemetrexed
- Where
- 29 sites in United States, Canada and 4 more
- Volunteers
- 77 people
- Sponsor
- Seagen Inc.
Myopia
A Prospective, Contralateral, Eye to Eye Comparison of SMILE Surgery to LASIK Surgery
Subjects will undergo SMILE surgery in one eye and LASIK surgery in their other eye to correct myopia.
- Trial name
- NCT03067077
- Testing
- SMILE, LASIK
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cataract
Visual Quality of Cataract Patients with High Myopia After Implantation of Different Intraocular Lenses
This prospective study aims to compare the visual outcomes following the implantation of two different types of multifocal intraocular lenses (IOLs) in highly myopic patients.
- Trial name
- NCT06892470
- Testing
- No intervention
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Wenzhou Medical University
Age Related Macular Degeneration
Study of WA-NG (NG-IMT) Telescope Prosthesis in Patients With End-stage Age-related Macular Degeneration
The purpose of this study is to evaluate the safety of the updated Model WA-NG telescope prosthesis (hereafter WA-NG telescope), an injectable telescope device, in patients with bilateral moderate to profound central vision…
- Trial name
- NCT04468373
- Testing
- WA-NG (NG-IMT) Telescope Prothesis
- Where
- 2 sites in Ireland, Spain
- Volunteers
- 9 people
- Sponsor
- VisionCare, Inc.
Macular Degeneration
Study of the Efficacy and Safety of the Ranibizumab Port Delivery System for Sustained Delivery of Ranibizumab in Patients With Subfoveal Neovascular Age-Related Macular Degeneration
This is a Phase II multicenter, dose-ranging, randomized, active treatment (monthly ITV injection)-controlled study to evaluate the efficacy, safety, and pharmacokinetics of ranibizumab delivered through the Implant using three…
- Trial name
- LADDER (NCT02510794)
- Testing
- Ranibizumab
- Where
- 50 sites in United States
- Volunteers
- 225 people
- Sponsor
- Genentech, Inc.
Rhegmatogenous Retinal Detachment
Pneumatic Retinopexy Versus Vitrectomy for Retinal Detachment in Patients With Extended Criteria
Objective: To compare outcomes of retinal detachment repair following pneumatic retinopexy (PnR) versus pars plana vitrectomy in terms of anatomical success, functional success and patient quality of life in patients with…
- Trial name
- NCT02871531
- Testing
- Pneumatic retinopexy, Vitrectomy
- Where
- 2 sites in Canada
- Volunteers
- 178 people
- Sponsor
- Unity Health Toronto
Cataract, Dry Eye
Clinical Evaluation of Reproducibility of Keratometric Measurements and Influencing Factors in Cataract Patients
The investigational device is an approved biometry device to perform biometric measurements preoperatively to calculate the needed IOL power. First, two native measurements at the IOL Master will be performed.
- Trial name
- KerSty (NCT04196621)
- Testing
- High viscous artificial tears, Low viscous artificial tears
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Medical University of Vienna
Bietti's Crystalline Dystrophy
Safety and Tolerability of ZVS101e in Patients With Bietti 's Crystalline Dystrophy
The purpose of the study is to evaluate the safety and tolerability of an adeno-associated virus vector expressing CYP4V2 in patients with Bietti's crystalline dystrophy (BCD).
- Trial name
- NCT05714904
- Testing
- ZVS101e
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Peking University Third Hospital
Diabetic Retinopathy, Diabetes Mellitus, Type 2
Confronting Unequal Eye Care in Pennsylvania
Pt. 1 Diabetic retinopathy is a common eye condition among diabetic adults and can lead to severe vision impairment and even blindness.
- Conditions
- Diabetic Retinopathy, Diabetes Mellitus, Type 2, Glaucoma
- Trial name
- NCT01179555
- Testing
- Behavioral Activation, Supportive Therapy
- Where
- 3 sites in United States
- Volunteers
- 206 people
- Sponsor
- Wills Eye
Dislocated Lens, Pars Plana Vitrectomy
Effectiveness and Safety of 25-Gauge Needle-Assisted Phacoemulsification of Dislocated Intravitreal Lens Nucleus
The goal of this observational study is to learn about the effects of 25-gauge (G) needle-assisted phacoemulsification to remove dislocated intravitreal lens nuclei.
- Conditions
- Dislocated Lens, Pars Plana Vitrectomy, Phacoemulsification, Needle
- Trial name
- NCT06709378
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Changzhou No.2 People's Hospital
Cataract, Pseudophakia
Wavefront Analisys and Contrast Sensitivity of Spherical and Aspherical Intraocular Lenses
Purpose:To compare visual performance, total and high order wavefront aberrations (coma, spherical aberration and other terms) and contrast sensitivity in eyes implanted with one monofocal aspheric intraocular lens (IOL) and two…
- Trial name
- NCT00347243
- Testing
- phacoemulsification (cataract surgery)
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Abnormal Vitreous Humor Morphology, Abnormal Choroid Morphology
Accuracy of the Red Reflex Test in the Pediatric Population
This study is designed to investigate the sensitivity and specificity of the Red Reflex Test (RRT), with and without dilation, for early detection of ocular abnormalities in children and newborns.
- Conditions
- Abnormal Vitreous Humor Morphology, Abnormal Choroid Morphology, Optic Nerve Diseases, Retinal Disease
- Trial name
- NCT04125043
- Testing
- Direct ophthalmoscope
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Behçet Disease, Physiopathology
Understanding the Role of Oral Microbiota in Behçet's Disease (BEHCETBIOT)
Behçet's disease (BD) is a systemic vasculitis that affects, especially, young people. Although its etiology remains unexplained, data suggest that the inflammatory response during BD results from a disruption of the homeostasis…
- Conditions
- Behçet Disease, Physiopathology, Microbiota, Oral Microbiota
- Trial name
- BEHCETBIOT (NCT04959435)
- Testing
- biological samples collection
- Where
- 2 sites in France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Clermont-Ferrand
Age-related Macular Degeneration
A Study of Ranibizumab Administered Monthly or on an As-needed Basis in Patients With Subfoveal Neovascular Age-related Macular Degeneration (HARBOR)
This is a Phase III, multicenter, randomized, double-masked, dose-comparison study of the efficacy and safety of ranibizumab injection administered intravitreally to patients with choroidal neovascularization (CNV) secondary to…
- Trial name
- HARBOR (NCT00891735)
- Testing
- Ranibizumab
- Where
- 99 sites in United States
- Volunteers
- 1,097 people
- Sponsor
- Genentech, Inc.
Open-angle Glaucoma
Subjects With Open-angle Glaucoma, Pseudoexfoliative Glaucoma, or Ocular Hypertension Naïve to Medical and Surgical Therapy, Treated With Two Trabecular Micro-bypass Stents (iStent Inject) or Travoprost
Evaluation of the intraocular pressure (IOP) lowering effect of two iStent inject devices versus medical therapy in eyes of subjects with primary open-angle glaucoma, pseudoexfoliative glaucoma, or ocular hypertension naïve to…
- Trial name
- NCT01444040
- Testing
- iStent inject, Travoprost
- Where
- Armenia
- Volunteers
- 196 people
- Sponsor
- Glaukos Corporation
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