Clinical trials: Eye
Primary Open Angle Glaucoma, Ocular Hypertension
Ph2 Placebo-Controlled Study for Safety & Ocular Efficacy of SBI-100 Ophthalmic Emulsion in Pts w/ Elevated Eye Pressure
The goal of this clinical trial is to test in patients with glaucoma and elevated pressure in the eye. The main questions it aims to answer are: • ability to lower pressure in the eye • safety in the eye and the body of patients…
- Trial name
- NCT06144918
- Testing
- SBI-100 Ophthalmic Emulsion, 0.5%, SBI-100 Ophthalmic Emulsion, 1.0%
- Where
- 3 sites in United States
- Volunteers
- 56 people
- Sponsor
- Skye Bioscience, Inc.
Glaucoma, Ocular Hypertension
6-Week Proof-of-Concept Study of Travoprost/Brinzolamide Ophthalmic Suspension in Subjects With Open-Angle Glaucoma or Ocular Hypertension
The purpose of this study is to evaluate Travoprost/Brinzolamide fixed combination (Trav/Brinz) administered twice daily as compared to each of its marketed components (TRAVATAN Z® solution and AZOPT® suspension) and to the…
- Trial name
- NCT02140060
- Testing
- Dose Level A / Brinzolamide 1% ophthalmic suspension, Dose Level B / Brinzolamide 1% ophthalmic suspension, Dose Level C / Brinzolamide 1% ophthalmic suspension
- Volunteers
- 327 people
- Sponsor
- Alcon Research
Cataract
Presbyopia-Correcting Intraocular Lenses (IOLs)
The purpose of this study is to prospectively evaluate postoperative visual and refractive parameters in a series of subjects bilaterally implanted with Presbyopia-Correcting Intraocular Lenses (IOLs).
- Trial name
- NCT00963560
- Testing
- ReSTOR +3, Crystalens HD, Crystalens AO
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Alcon Research
Scleritis, Orbital Disease
Rituximab in the Treatment of Scleritis and Non-Infectious Orbital Inflammation
The purpose of this study is to assess the safety and tolerability of Rituximab in refractory scleritis and non-infectious orbital inflammation.
- Trial name
- NCT00415506
- Testing
- Rituximab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Oregon Health and Science University
Exudative Macular Degeneration
Wet Macular Degeneration Study to Compare Ranibizumab or Bevacizumab to Aflibercept
This study will examine the use of Aflibercept in patients with exudative macular degeneration requiring intravitreal injections. Patients will be followed for 24 months. The follow up phase will be completed at month 36.
- Trial name
- NCT01617148
- Testing
- Aflibercept
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Rishi Singh
Refractive Error
Clinical Comparison of Two Silicone-Hydrogel Contact Lenses
The objective of this study is to evaluate the clinical performance of two silicone-hydrogel contact lenses.
- Trial name
- NCT00762385
- Testing
- galyfilcon A, comfilcon A
- Volunteers
- 97 people
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Metastatic Melanoma, Mucosal Melanoma
Nab-Paclitaxel and Bevacizumab or Ipilimumab as First-Line Therapy in Treating Patients With Stage IV Melanoma That Cannot Be Removed by Surgery
This randomized phase II trial studies how well nab-paclitaxel and bevacizumab or ipilimumab works as first-line therapy in treating patients with stage IV melanoma that cannot be removed by surgery.
- Conditions
- Metastatic Melanoma, Mucosal Melanoma, Stage IV Cutaneous Melanoma AJCC v6 and v7, Stage IV Uveal Melanoma AJCC v7
- Trial name
- NCT02158520
- Testing
- Bevacizumab, Ipilimumab, Laboratory Biomarker Analysis
- Where
- 13 sites in United States
- Volunteers
- 24 people
- Sponsor
- Academic and Community Cancer Research United
Blindness, Spinal Cord Injury
Use of "Smart Wheelchairs" to Provide Independent Mobility to Visual and Mobility Impairments
The goal of this project is to evaluate the Smart Wheelchair Component System (SWCS) for power wheelchairs and the Smart Power Assistance Module (SPAM) for manual wheelchairs in realistic indoor environments with target users…
- Trial name
- NCT00333762
- Testing
- Smart Power Assistance Module (SPAM), Smart Wheelchair Component System (SWCS)
- Where
- 2 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cataracts
Comparison of Tetracaine 0.5% and Lidocaine 2% Jelly for Topical Phacoemulsification Cataract Surgery
The purpose of this study is to determine if there is a difference on the penetration of betadine 5% when using lidocaine 2% jelly versus topical tetracaine 0.5% in topical cataract surgery.
- Trial name
- NCT00827073
- Testing
- tetracaine 0.5%, Lidocaine 2% Jelly
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hermann Eye Center
Hyperopia, Astigmatism
A Study to Evaluate the Safety and Effectiveness of the Technols 217z Zyoptix System for Hyperopia
A study to demonstrate the safety and effectiveness of wavefront laser refractive surgery treatments for hyperopia and astigmatism.
- Trial name
- NCT00348205
- Testing
- Technolas 217z Zyoptix Laser
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Bausch & Lomb Incorporated
Keratoconjunctivitis Sicca
Phase 3 Study of OTX-101 in the Treatment of Keratoconjunctivitis Sicca
This is a randomized, double-masked, vehicle-controlled study of the safety and efficacy of OTX-101 (0.09% cyclosporine nanomicellar solution) in the treatment of keratoconjunctivitis sicca to be conducted at approximately 50…
- Trial name
- Emerald (NCT02688556)
- Testing
- cyclosporine, vehicle of OTX-101
- Where
- 3 sites in United States
- Volunteers
- 745 people
- Sponsor
- Sun Pharmaceutical Industries Limited
Hyperopia
Safety and Effectiveness of Wavefront-Guided LASIK Correction of Hyperopic Refractive Errors
Demonstrate that wavefront-guided LASIK using measurements from the iDesign System is safe and effective for the treatment of Hyperopia.
- Trial name
- NCT01675479
- Testing
- LASIK correction of hyperopic refractive errors
- Where
- 9 sites in United States
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Abbott Medical Optics
Childhood Choroid Plexus Tumor, Childhood Medulloblastoma
Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer
This randomized phase III trial studies flexible administration of filgrastim after combination chemotherapy to see how well it works compared to fixed administration of filgrastim in decreasing side effects of chemotherapy in…
- Conditions
- Childhood Choroid Plexus Tumor, Childhood Medulloblastoma, Childhood Pineoblastoma, Childhood Soft Tissue Sarcoma
- Trial name
- NCT01987596
- Testing
- filgrastim
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Allergic Conjunctivitis
Study of Two Marketed Ocular Anti-Allergy Medications in Subjects With Allergic Conjunctivitis
The purpose of this study is to compare the effects of two marked ocular anti-allergy medications in cat sensitive subjects with allergic conjunctivitis.
- Trial name
- NCT00534794
- Testing
- Elestat, Pataday
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Merck Sharp & Dohme LLC
Myopia, Refractive Errors
DD T2 Daily Disposable Registration Trial
The purpose of this study is to evaluate the performance of the investigational verofilcon A contact lens compared to the commercially available delefilcon A contact lens, by assessing visual acuity as the primary variable.
- Trial name
- NCT03305770
- Testing
- verofilcon A contact lenses, delefilcon A contact lenses
- Where
- 6 sites in United States
- Volunteers
- 107 people
- Sponsor
- Alcon Research
Dry Eye Disease
Study to Evaluate the Safety, Tolerability, and Efficacy of OTX-CSI in Subjects With Dry Eye Disease.
To assess the safety, tolerability and efficacy of a single dose of OTX-CSI, a sustained release cyclosporine drug product, in subjects with dry eye disease.
- Trial name
- NCT04362670
- Testing
- OTX-CSI
- Where
- 15 sites in United States
- Volunteers
- 153 people
- Sponsor
- Ocular Therapeutix, Inc.
Dry Eye
Clinical Outcomes Following Treatment With SYSTANE® BALANCE
The purpose of this study is to evaluate the clinical effectiveness of SYSTANE® BALANCE compared to REFRESH OPTIVE® Advanced in subjects with lipid-deficient dry eye.
- Trial name
- NCT02776670
- Testing
- Propylene glycol, 0.6% eye drops, Lubricant eye drops
- Volunteers
- 308 people
- Sponsor
- Alcon Research
Presbyopia
A Single-Center, Double-Masked Evaluation of the Efficacy and Safety of PRX-100 in the Treatment of Early to Moderate Presbyopia
To evaluate the safety and efficacy of PRX-100 compared with aceclidine alone and vehicle in the treatment of early to moderate presbyopia.
- Trial name
- NCT03201562
- Testing
- Aceclidine+tropicamide combination, Aceclidine, Vehicle
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- LENZ Therapeutics, Inc
Hemianopia, Homonymous, Hemianopsia, Homonymous
VR System for Cross-modal Rehabilitation of Hemianopia
The purpose of this research study is to investigate the effectiveness of a new rehabilitation for visual hemianopia. The study team believes a cross-modal rehabilitation technique delivered by a virtual reality system can help…
- Trial name
- NCT04230486
- Testing
- Cross-model Visual Auditory Rehabilitation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Wake Forest University Health Sciences
Myopia
An Evaluation of the Effectiveness of Dual Focus Soft Contact Lenses in Slowing Mypoia Progression
The purpose of this study is to determine whether a new type of soft contact lens with a unique optical design (dual focus) is effective at slowing the progression of myopia (near-sightedness) in children.
- Trial name
- NCT01729208
- Testing
- Dual Focus Soft Contact Lens, Single Vision Soft Contact Lens
- Where
- 4 sites in Canada, Portugal and 2 more
- Volunteers
- 144 people
- Sponsor
- CooperVision, Inc.
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.