Clinical trials: Eye
Eye Diseases, Retinitis Pigmentosa
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosomes for NAION
This trial will study the safety and efficacy of intranasal delivery of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes for the treatment of non-arteritic ischemic optic neuropathy
- Conditions
- Eye Diseases, Retinitis Pigmentosa, Diabetic Retinopathy, Macular Degeneration
- Trial name
- NCT05147701
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes
- Where
- 2 sites in United States, Greece
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Suicide, Suicide, Attempted
Brief Cognitive Behavioral Therapy for People With Physical Disabilities
The purpose of this study is to examine the effectiveness of a psychotherapy (non-medication) treatment, Brief Cognitive Behavioral Therapy for Suicide Prevention, in reducing suicide ideation and attempts for people with…
- Conditions
- Suicide, Suicide, Attempted, Suicidal Ideation, Disability Physical
- Trial name
- NCT05695430
- Testing
- Brief Cognitive Behavioral Therapy for People with Physical Disabilities
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ohio State University
Working Memory, Consolidation/Recconsolidation Memory
Theories of Working Memory and Consolidation/RECOnsolidation in the Process of Resorption of Post-traumatic Symptoms.
EMDR is a psychotherapeutic approach recommended by the World Health Organization (WHO) for the treatment of disorders such as post-traumatic stress disorder, anxiety, depression and, more generally, psychological distress.
- Conditions
- Working Memory, Consolidation/Recconsolidation Memory, Eye Movement Desensitization and Reprocessing, Alterning Bilateral Stimulation
- Trial name
- NCT06469333
- Testing
- Eye movements (EM), Auditory stimulations, Tactile stimulations
- Where
- France
- Volunteers
- 154 people
- Sponsor
- University of Lorraine
Leber Hereditary Optic Neuropathy
RESCUE and REVERSE Long-term Follow-up
The goal of this clinical trial is to assess the long-term safety and efficacy of GS010, a gene therapy, and assess the quality of life in subjects with LHON due to the G11778A ND4 mitochondrial mutation and who were treated in…
- Trial name
- RESTORE (NCT03406104)
- Testing
- GS010
- Where
- 7 sites in United States, France and 3 more
- Volunteers
- 62 people
- Sponsor
- GenSight Biologics
Thyroid Associated Ophthalmopathies
Treatment of Soft Tissue Expansion in Inactive Thyroid Eye Disease Patients Using Drops of Prostaglandin Analogues
Prostaglandin analogues eye drops are common and effective treatment for decreasing Intra-Ocular Pressure (IOP) in Glaucoma patients.
- Trial name
- NCT02155049
- Testing
- bimatoprost 0.03%
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Rabin Medical Center
Myopia
The Effect of +3.00ADD on Myopia Progression in Chinese Children
The purpose of this study is to evaluate the effect of +3.00ADD vs single vision spectacle on the progression of myopia in children.
- Trial name
- NCT03242226
- Testing
- two spectacles, single vision spectacles
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Myasthenia Gravis (MG), Myasthenia Gravis, Generalized
AXIS MG Patient Registry
The goal of the AXIS Autoimmune Neurology Registry is to learn about the experiences of adults living with autoimmune neurological disorders, starting with myasthenia gravis (MG), over time.
- Conditions
- Myasthenia Gravis (MG), Myasthenia Gravis, Generalized, Myasthenia Gravis, Ocular, Myasthenia Gravis Crisis
- Trial name
- AXIS (NCT07761026)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Autoimmune Neurology Alliance
Behcet Syndrome
Zinc Supplementation and Behçet's Syndrome
To study the effects of zinc gluconate supplementation on patients with Behçet's syndrome, 50 patients will be randomly allocated to two groups: placebo group or zinc group (one tablet of 30 mg/day elemental zinc) for 12 weeks.
- Trial name
- NCT05098678
- Testing
- Zinc gluconate
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Tabriz University of Medical Sciences
Presbyopia
Volumetric Visual Fields at Different Distances in Presbyopic Patients Using Occupational (PC-133 and PC-200) and General-Purpose Progressive Addition Lenses
This single-center, randomized, double-blind, crossover clinical trial aims to compare the volumetric visual fields provided by two occupational progressive addition lenses (OPLs) optimized for intermediate and near vision in…
- Trial name
- CIVIUS2026PAL (NCT07870785)
- Testing
- OPAL PC 133 assessment, OPAL PC 200 assessment, PAL assessment
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- University of Seville
Diabetic Retinopathy, Vitreous Hemorrhage
Use of Intravitreal Ranibizumab in the Treatment of Vitreous Hemorrhage
Primary Objective: To investigate the effectiveness of intravitreal applications of 0.5 mg Lucentis (ranibizumab) in patients with vitreous hemorrhage due to proliferative diabetic retinopathy.
- Trial name
- NCT01824043
- Testing
- intravitreal ranibizumab injections
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Hospital Regional de São José - Dr. Homero de Miranda Gomes
Anterior Ischemic Optic Neuropathy
PDE5 Inhibitor Use and Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)
The primary objective of this study is to determine whether the use of PDE5 inhibitors (vardenafil, sildenafil, or tadalafil) increases the risk for the development of NAION.
- Trial name
- NCT00867815
- Testing
- Diagnostic procedures
- Where
- 13 sites in United States, Australia and 1 more
- Volunteers
- 10 people
- Sponsor
- Bayer
Dry Eye
The Prophylactic Use of Topical Cyclosporine A 0.05% to Prevent Graft Versus Host Disease Related Dry Eye
The purpose of this study is to determine whether Restasis is an effective treatment for preventing the occurrence and progression of dry eye syndrome in patients who have recently received a bone marrow transplant and are at…
- Trial name
- NCT00553735
- Testing
- Cyclosporine A 0.05%, Arificial Tear
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Glaucoma, Glaucoma, Open-Angle
The Effect of Lumify™ on Ocular Redness, Intraocular Pressure, and Eyelid Position in Glaucoma Patients
Glaucoma represents a group of conditions that cause damage to the optic nerve and can lead to irreversible vision loss. Current treatments are aimed at lowering intraocular pressure while minimizing medication side effects.
- Conditions
- Glaucoma, Glaucoma, Open-Angle, Glaucoma; Drugs, Droopy Eyelid
- Trial name
- NCT04007276
- Testing
- brimonidine tartrate ophthalmic solution 0.025%, sterile balanced saline solution
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Tulane University
Progressive Supranuclear Palsy, Parkinson's Disease
Postural Instability in Progressive Supranuclear Palsy
The purpose of this study is to better understand why individuals with Progressive Supranuclear Palsy (PSP) fall. Understanding the mechanism of gait and balance dysfunction in individuals with PSP may provide us with important…
- Trial name
- NCT01563276
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
AMD
the Blood-Aqeous Barrier During Anti-Angiogenic Therapy in Exudative Age-Related Macular Degeneration
To evaluate the status of the blood-aqueous barrier by objectively measuring protein concentration in the aqueous humor using laser flare photometry (LFP) in patients with exudative age-related macular degeneration (AMD)…
- Trial name
- BABAMD (NCT07375901)
- Testing
- laser flare photometry before intravitreal injection
- Where
- Ukraine
- Volunteers
- 30 people
- Sponsor
- The Filatov Institute of Eye Diseases and Tissue Therapy
Strabismus, Nystagmus, Congenital
Genetic Studies of Strabismus, Nystagmus, and Associated Disorders
Strabismus (misalignment of the eyes) often runs in families. In this study, the investigators are looking for genetic variants associated with strabismus and nystagmus.
- Trial name
- NCT04770519
- Testing
- whole genome sequencing or whole exome sequencing
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Boston Children's Hospital
Visual Function
A Performance Study Comparing the EyeMirage (Test Device) to Standard of Care (Reference Device) in Patients 18 to 65 Years of Age Undergoing Standard Eye Examinations Such as Visual Acuity, Visual Field, Color Vision, and Self-Paced Saccade for Various Conditions
This study will assess the effectiveness and accuracy of results of a new device for eye function testing. This will be done by comparing results of four eye tests that are done through the current standard used in eye clinics…
- Trial name
- NCT06908967
- Testing
- EyeMirage device
- Where
- 4 sites in Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Neuroptek Corporation Inc.
Acanthamoeba Keratitis
Parasitic Ulcer Treatment Trial Pilot
This is a study of optimal treatments for acanthamoeba keratitis. In the first part of the study, participants will be randomized to chlorhexidine monotherapy or chlorhexidine plus povidone iodine.
- Trial name
- NCT03484507
- Testing
- Chlorhexidine, Povidone-Iodine, Prednisolone Sodium Phosphate
- Where
- 2 sites in India
- Volunteers
- 49 people
- Sponsor
- University of California, San Francisco
Glaucoma, Open-Angle
A Study of the Rate of Progression of Glaucoma During a Follow-up Period of Two Years
This is an epidemiological, non-interventional, prospective study to collect data on glaucoma progression in a routine setting. Patients may receive treatment at the discretion of their physician per local standard of care.
- Trial name
- NCT01629407
- Testing
- Standard of Care
- Where
- Spain
- Volunteers
- 315 people
- Sponsor
- Allergan
Cataract, Presbyopia
Clinical Trial With PRECIZON Presbyopic
The purpose of this clinical trial is to evaluate the effectiveness of the PRECIZON Presbyopic.
- Trial name
- NCT02409771
- Testing
- PRECIZON Presbyopic
- Where
- 6 sites in Belgium, Germany and 3 more
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ophtec BV
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