Clinical trials: Eye
Glaucoma
Determining the Clinical Utility of Using Virtual Reality Headsets to Assess Visual Function in Those With Glaucoma.
To validate a new virtual reality (VR) based visual field test against the gold standard clinical perimetry test (Humphrey Visual field test 24-2).
- Trial name
- NCT04273438
- Testing
- Visual field testing using Oculus Rift and Humphrey Visual Field Perimeter, Visual Field Testing using HUmphrey 24-3 Perimeter
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- Queen's University, Belfast
Myopia
Multi-Centre Clinical Evaluation Of Two Daily Disposable Contact Lenses
The purpose of this study is to compare the subjective performance for handling of two daily disposable contact lenses, stenfilcon A and etafilcon A.
- Trial name
- NCT01707238
- Testing
- etafilcon A, stenfilcon A
- Where
- 7 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- CooperVision, Inc.
Healthy, Multiple Sclerosis
Normal Chinese Lifespan Brain Charts Initiative (NCLBCI)
Major brain diseases (including neuroimmune diseases, neurodegenerative diseases, and cerebrovascular diseases) are leading causes of death and disability in humans.
- Conditions
- Healthy, Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, Neurodegenerative Diseases
- Trial name
- NCT06643858
- Testing
- No intervention
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Intraocular Inflammation, Retinal Vascular Occlusion
Analysis of Imaging Features From Patients Treated With Brolucizumab in the Post-marketing Setting With Reports of Retinal Vasculitis and/or Retinal Vascular Occlusion
This non-interventional descriptive study was undertaken to better understand the most common imaging features associated with inflammation arising in the post-marketing setting when brolucizumab was prescribed in routine…
- Trial name
- NCT05657158
- Testing
- Brolucizumab
- Where
- Switzerland
- Volunteers
- 198 people
- Sponsor
- Novartis Pharmaceuticals
Postural Balance
Posturography as Biomarker of Oculomotor and Postural Control Integration
Determine the effects looking in certain direction or moving the eyes in a certain way have on the ability of a subject to maintain equilibrium in different circumstances (eyes open/closed, and standing on hard or compliant…
- Trial name
- NCT02733055
- Testing
- posturographic evaluation
- Where
- 2 sites in United States, Australia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Carrick Institute for Graduate Studies
Diabetic Retinopathy
Loss to Follow-up in PDR Patients
This study determined the clinical impact and causes of loss to follow-up (LTFU) from the patients' perspective in individuals with proliferative diabetic retinopathy (PDR) who received panretinal photocoagulation (PRP) and/or…
- Trial name
- NCT04018326
- Volunteers
- 467 people
- Sponsor
- Assiut University
Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor
Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Rare Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Bone marrow transplantation may allow doctors to give higher doses of chemotherapy and kill more tumor cells.
- Conditions
- Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Head and Neck Cancer, Kidney Cancer
- Trial name
- NCT00002515
- Testing
- filgrastim, carboplatin, thiotepa
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Severe Nonproliferative Diabetic Retinopathy, Diabetic Retinopathy
PRP vs PRP+IVC for Severe nPDR
The randomized clinical trial aims to compare the therapeutic effects between panretinal photocoagulation(PRP) and PRP combined with intravitreal conbercept (IVC) injection in severe nPDR with/without diabetic macular edema…
- Conditions
- Severe Nonproliferative Diabetic Retinopathy, Diabetic Retinopathy, Diabete Mellitus
- Trial name
- NCT03863535
- Testing
- Conbercept, Panretinal coagulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Ruijin Hospital
Presbyopia, Low Vision
Ocular Biomarkers for Successful Premium Trifocal Intra-ocular Lenses Implantation
The purpose of this study is to identify ocular biomarkers that can predict the success of phacoemulsification with bilateral AT LISA try 839MP (Carl Zeiss Meditec AG) implantation to achieve satisfactory post-post-operativly…
- Trial name
- NCT05863247
- Testing
- Patient Reported Outcomes / Biometric data revision
- Where
- Portugal
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Hospital dos Lusíadas
Amblyopia, Strabismus
The Use of Interactive Binocular Treatment (I-BiT) for the Management of Anisometropic, Strabismic and Mixed Amblyopia in Children Aged 3.5 - 12 Years
Around one child in fifty has a lazy eye (termed amblyopia) where the eye is structurally normal but the vision fails to develop correctly.
- Trial name
- I-BiT Plus (NCT02810847)
- Testing
- I-Bit plus
- Volunteers
- 182 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Age-Related Macular Degeneration
Combined Therapy in Age-Related Macular Degeneration (ARMD)
The purpose of this study is to investigate the efficacy of combined intravitreal therapy with or without prior photodynamic therapy in patients with wet age-related macular degeneration (AMD).
- Trial name
- NCT00805649
- Testing
- Low fluorescence Photodynamic therapy, core pars plana vitrectomy, dexamethasone
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Conjunctival Bacterial Flora
Effectiveness of Topical 0.5% Levofloxacin to Reduce the Conjunctival Bacterial Flora Before Intraocular Surgery
The purpose of this study is to determine whether additional topical application of 0.5% levofloxacin is more effective in reducing the load of the conjunctival bacterial flora in patients scheduled for intraocular surgery than…
- Trial name
- NCT00491049
- Testing
- 0.5% levofloxacin eye drops
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Angle Closure Glaucoma
Comparing Nd:YAG Laser and Sequential Double Frequency YAG-Nd:YAG Laser Iridotomy
No single type of laser or set of laser parameters is appropriate for all type of irides. Pure Nd:YAG laser iridotomy is very effective in the light color irides. It was considered as the gold standard for iridotomy.
- Trial name
- NCT02474238
- Testing
- The sequential technique, The pure Nd:YAG laser technique
- Where
- Thailand
- Volunteers
- 82 people
- Sponsor
- Prince of Songkla University
Glaucoma and Ocular Hypertension
Study Evaluating the Safety and Intraocular Pressure (IOP) Lowering Response of Brimonidine Tartrate Ophthalmic Solution in Subjects With Open Angle Glaucoma or Ocular Hypertension
The purpose of this study is to determine the intraocular Pressure (IOP) lowering response and evaluate the safety of brimonidine tartrate 0.025% ophthalmic solution in adult subjects with open angle glaucoma or ocular…
- Trial name
- NCT01687426
- Testing
- Brimonidine Tartrate 0.025%, Vehicle
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Eye Therapies, LLC
Eye Disease
Analysis of Human Tear Proteins in Children
The significance of our study is in the importance of understanding the quality and quantity of proteins in the human tear film, and any unique aspects of tears in children.
- Trial name
- NCT00473278
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Optic Nerve Sheath Diameter
Changes of Optic Nerve Sheath Diameter Between Obese and Non-obese Patients Undergoing Laparoscopic Gynecological Surgery
This study aims to compare the change of optic nerve sheath diameter in obese and non-obese patients undergoing laparoscopic gynecological surgery in a steep Trendelenburg position.
- Trial name
- NCT04427085
- Testing
- Ultrasound assessment of optic nerve sheath diameter
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- SMG-SNU Boramae Medical Center
Dry Eyes, Sjogren's Disease With Dry Eyes
Treating Dry Eyes and Corneal Ulcers With Fingerprick Autologous Blood
To investigate if fresh finger prick autologous blood (FAB) instead of serum from venesection, is a safe and effective treatment for dry eyes and corneal ulcers/ epithelial defects.
- Conditions
- Dry Eyes, Sjogren's Disease With Dry Eyes, Persistent Corneal Epithelial Defects, Chronic Corneal Ulcers
- Trial name
- FAB (NCT02153515)
- Testing
- Your own ( autologous) finger prick of blood produced with a diabetic lancet
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Bedford Hospital NHS Trust
Neovascular Age-related Macular Degeneration
A Randomized, Double-masked, Multicenter, Controlled Study of Intravitreal KH902 in Patients With Neovascular AMD
This study is designed to access the safety and efficacy of multiple injections of KH902 at variable dosing regimens in patients with CNV due to neovascular AMD.
- Trial name
- AURORA (NCT01157715)
- Testing
- intravitreal injection of KH902
- Where
- 9 sites in China
- Volunteers
- 122 people
- Sponsor
- Chengdu Kanghong Biotech Co., Ltd.
Corneal Diseases, Effectiveness of Microdrops
Efficacy of Nanodropper-mediated Topical Anesthetic
The goal of this clinical trial is to compare the onset and duration of numbness of the surface of the eye following the administration of numbing drops, called proparacaine, using either a standard eye drop bottle or a…
- Trial name
- NCT06636708
- Testing
- Nanodropper and Proparacaine HCl 0.5%, Standard Eye Drop Bottle with Proparacaine HCl 0.5%
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Columbia University
Maculopathy
Ozonized Oil as Dietary Supplement in Macular Degeneration
Macular degeneration, also called age-related macular degeneration (AMD), is a leading cause of visual impairment and severe vision loss. AMD is a disease with a multifactorial etiology.
- Trial name
- NCT06351033
- Testing
- High ozonide (HOO) ozonated oil
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Alba Di Pardo
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