Clinical trials: Eye Disorders
Cataract
Comparison of Visual Outcomes With Mini-Monovision Between a Monofocal and an Adjustable Intraocular Lens
This study is a single center, multi-surgeon, prospective, randomized, comparative study of binocular corrected distance visual acuity (CDVA) after successful bilateral cataract surgery.
- Trial name
- NCT06122103
- Testing
- Clareon Monofocal, Light-Adjustable Lens
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Gainesville Eye Associates
Glaucoma
Smart Soft Contact Lenses for Monitoring Glaucoma
This study is exploring the effectiveness and safety of soft contact lenses with embedded sensors, called smart contact lenses. Smart contact lenses are used to measure the pressure inside the eye.
- Trial name
- NCT07224542
- Testing
- Bare Contact Lens, Experimental Smart Contact Lens, Commercially available smart contact lens
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Indiana University
Dry Eye
Effects of Topical Insulin on Levels of Tear Inflammatory Mediators
60 samples are take to determine the effects of topical insulin on tear inflammatory mediators interleukin 1a, interleukin 6 and matrix metalloprotenase 9 in diabetics with dry eye disease.
- Trial name
- NCT04877210
- Testing
- Topical Insulin
- Where
- Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Convergence Insufficiency
Non-invasive Brain Stimulation for Treating Symptomatic Convergence Insufficiency
The goal of this randomized controlled trial is to test the effectiveness of non-invasive brain stimulation in treating adults with symptomatic convergence insufficiency compared to vergence/accommodative therapy.
- Trial name
- NIBSCI (NCT05877560)
- Testing
- Anodal-Transcranial Direct Current Stimulation, Office-Based Vergence/Accommodative Therapy
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Midwestern University
Presbyopia
Clinical Outcomes of Femtosecond Laser Presbyopia Treatment in Monofocal IOLs
This study aimed to assess the safety and efficacy of treating presbyopia in eyes implanted with a mono focal IOL using a low-energy femtosecond laser.
- Trial name
- NCT07384182
- Testing
- Perfector
- Where
- Czechia
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Perfect Lens, LLC
Emergence Delirium, Strabismus
KETODEX for Emergence Delirium in Children Undergoing Outpatient Strabismus Surgery
Strabismus surgery for children is a very common procedure, with a high incidence of emergence delerium in the recovery room. A combination of intravenous ketamine/dexmedetomidine, or ketodex, has been previously shown to reduce…
- Trial name
- NCT03779282
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Corneal Edema Secondary to Corneal Endothelial Dystrophy
Early Experience With Descemet's Stripping Automated Endothelial Keratoplasty
The purpose of this study is to report the early clinical outcomes in patients undergoing Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) for corneal edema secondary to corneal endothelial cell dysfunction, and to…
- Trial name
- DSAEK (NCT00744796)
- Testing
- DSAEK, Anterior Segment Optical Coherence Topography (OCT), Best Spectacle Corrected Visual Acuity (BSCVA)
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Choroidal Neovascularization
Intraocular Pressure Immediately Following Intravitreous Injection of Ranibizumab
This study will quantify the intraocular pressure elevation in the immediate time period following intravitreous injection. With more widespread use of intravitreous injections in patients that may require several injections per…
- Trial name
- NCT00417703
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University Center for Health Sciences
Diabetes, Diabetic Retinopathy
Pivotal Trial of Automated Artificial Intelligence (AI) Based System for Early Diagnosis of Diabetic Retinopathy
In this pivotal trial, we aim to perform a prospective study to find the efficacy of iPredict-DR, an artificial intelligence (AI) based software tool on early diagnosis of Diabetic Retinopathy (DR) in the primary care and…
- Trial name
- NCT07151001
- Testing
- No intervention
- Where
- United States
- Volunteers
- 922 people, healthy volunteers welcome
- Sponsor
- iHealthScreen Inc
Ocular Surface Disease
Comparison Between Lathe Cut Versus Cast Molding Soft Contact Lens Technique on Ocular Surface Integrity
"Comparison between Lathe Cut versus Cast Molding Soft Contact Lens Technique on Ocular Surface Integrity" investigates the impact of two different manufacturing methods on the health and integrity of the ocular surface.
- Trial name
- NCT06495112
- Testing
- Soft contact lens with lathe cut technique Lathe, Soft contact lens with cast molding technique
- Where
- Pakistan
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Superior University
Intracranial Pressure Increase
Effect of Acetazolamide on Optic Nerve Sheath Diameter in Laparoscopic Donor Nephrectomies
The purpose of the trial is to study the effect of acetazolamide administered via Ryle's tube on optic nerve sheath diameter in laparoscopic live donor nephrectomy patients.
- Trial name
- NCT03005665
- Testing
- Acetazolamide, Normal Saline
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Essential Tremor
Pathophysiology of Tremor-modulating Mechanisms of Propranolol and Primidone in Essential Tremor
Pathophysiology of tremor-modulating mechanisms of propranolol and primidone in essential tremor (ET) will be studied using accelerometry with electromyography (EMG), transcranial magnetic stimulation (TMS), and eyeblink…
- Trial name
- NCT04692844
- Testing
- Propranolol, Primidone
- Where
- Slovenia
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Glaucoma, Cataract Senile
Effect of Presbyopic Correction Lens on Humphrey Visual Field Testing in Patients With Multifocal Intraocular Lens
Purpose of this study was to evaluate the effect of presbyopic correction lens on Humphrey visual field (HVF) testing in patients with 2 models of multifocal intraocular lens (MIOL) both with and without glaucoma.
- Trial name
- NCT05220007
- Testing
- Humphrey visual field testing
- Where
- Thailand
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Siriraj Hospital
Ophthalmological Agent Toxicity, Bacterial Conjunctivitis
Study to Evaluate the Safety and Tolerability of PRO-231 Versus VIGAMOXI® on the Ocular Surface of Healthy Subjects
This is a phase I clinical study evaluating the safety and tolerability of PRO-231 ophthalmic solution through the incidence of unexpected adverse events, incidence of conjunctival hyperemia and chemosis, changes in Best…
- Trial name
- NCT06363292
- Testing
- PRO-231, VIGAMOXI®
- Where
- Mexico
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Postoperative Delirium, Strabismus
Does Preoperative Sleep Quality Affect the Postoperative Emergence Delirium in Children Undergoing Strabismus Surgery
Sleep is important in maintaining the physiological function of the human body. Recently several studies have reported that preoperative sleep quality is associated with postoperative emergence delirium (ED) The ED is a common in…
- Conditions
- Postoperative Delirium, Strabismus, Sleep Disorder
- Trial name
- NCT03332407
- Where
- South Korea
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Myopia
Change in Choroidal Thickness of Myopic Eyes With a Myopia Control Contact Lens
In this study, the direct effect of the MiSight contact lens (Cooper Vision), a daily disposable contact lens recently approved in Germany for the treatment of myopia, will be investigated.
- Trial name
- NCT06636019
- Testing
- Myopia control contact lens
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital Augsburg
Hyperopia, Presbyopia
The VIS Opti-K Low Vision Aid Device Provides Vision Improvement.
The VIS Opti-K Low Vision Aid device will be used to provide vision improvement to patients with refractive disorders (hyperopia and presbyopia).
- Trial name
- Opti-K Pres (NCT06597292)
- Testing
- Vision improvement
- Where
- 2 sites in United States, Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- VIS, Inc.
Branch Retinal Vein Occlusion
Assessment Of Peri-papillary Retinal Nerve Fiber Layer Thickness In Patients With Unilateral Branch Retinal Vein Occlusion
Several studies have indicated a relation between the development of RVO and elevated intraocular pressure (IOP) and glaucoma [9].
- Trial name
- NCT06146309
- Testing
- aflibercept (2mg/0.05ml)
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Accommodation Disorder, Keratoconus
Clinical Investigation for a Multifunction Ophthalmic Measurement Device
The purpose of this clinical investigation is to evaluate the clinical utility of a multifunctional measuring device for Ophtalmology.
- Conditions
- Accommodation Disorder, Keratoconus, Dry Eye, Refractive Errors
- Trial name
- NCT06565091
- Testing
- Measurements of physiological parameters of the anterior chamber, Measurements of the Axial biometry
- Where
- France
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Essilor International
Mild Cognitive Impairment (MCI), Alzheimer Disease (AD)
Remote Digital Assessments for Cognitive Disorders
Memory and thinking problems in older adults, including mild cognitive impairment (MCI) and Alzheimer's disease (AD), can be difficult to assess promptly because evaluation often depends on in-person specialist visits.
- Trial name
- MonitorCog-AI (NCT07883746)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
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