Clinical trials: Eye Disorders
Retinopathy of Prematurity, Neurodevelopmental Abnormality
Analysis of Ocular and Neurodevelopmental Function for Retinopathy of Prematurity
The goal of this research project is to identify the long-term outcome of neurodevelopment in patients with retinopathy of prematurity(ROP) and the treatment of anti-vascular endothelial growth factor (VEGF) such as intravitreal…
- Trial name
- NCT05186155
- Testing
- Severe ROP
- Where
- Taiwan
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Myopia, Ear Acupressure Pellets
Effects of Auricular Point Pressing With Pellets in Children With Insufficient Hyperopia Reserve
This project aims to address the trend of early onset and high myopia among children in China by focusing on insufficient hyperopia reserve, a key early warning indicator for myopia.
- Conditions
- Myopia, Ear Acupressure Pellets, Hyperopia Reserve, Low-concentration Atropine Eye Drops
- Trial name
- NCT07475585
- Testing
- Ear acupoint pressure pellet intervention group, Atropine intervention group, Joint intervention Group
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Fangbiao Tao
Dry Eye
A Study Evaluating the Efficacy and Safety on Moderate to Severe Dry Eye
The purpose of this study is to compare the efficacy and safety of HBM9036 Ophthalmic Solution versus placebo in the treatment of dry eye
- Trial name
- NCT04092907
- Testing
- HBM9036 0.25% Ophthalmic Solution
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Harbour BioMed (Guangzhou) Co. Ltd.
Glaucoma
Efficacy and Safety of iStent in Reducing Intraocular Pressure in Open-angle Glaucoma
To evaluate the efficacy and safety of istent inject W in reducing intraocular pressure in Chinese adult patients with open-angle glaucoma complicated with cataract.
- Trial name
- NCT07354009
- Testing
- PHACO+PC-IOL+iStent, PHACO+PC-IOL
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Glaucoma, Healthy Subjects
mRNA Expression in Lymphocytes of Glaucoma Patients
The aim of the study is to compare messenger ribonucleic acid (mRNA) expression of various genes in lymphocytes between glaucoma patients and sex and age-matched healthy subjects.
- Trial name
- NCT00327509
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Cataract
A Prospective, Randomized, Subject and Vision-assessor Masked, Multicenter Study Comparing Bilateral Clareon PanOptix, Bilateral Clareon PanOptix Pro, and Mixed Clareon PanOptix Pro/Vivity Intraocular Lens Implantation in Cataract Subjects
Prospective, randomized, multicenter, multi-arm, subject and vision-assessor-masked, two stage study with Stage 1 as a three-arm initial enrollment period, followed by Stage 2 as a head-to-head study refined based on the Stage 1…
- Trial name
- NCT06922084
- Testing
- Clareon PanOptix, Clareon PanOptix PRO, Mix-and-Match PanOptix/Vivity
- Where
- 2 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Berkeley Eye Center
Cannabis Intoxication
Evaluation of an Eye Tracking Sensor to Detect Cannabis Impairment
The purpose of this study is to determine if an eye tracking impairment sensor can detect cannabis-induced impairment after using cannabis.The overall objective is to correlate measures collected from the eye tracking sensor with…
- Trial name
- NCT03994926
- Testing
- Virtual Reality Eye Tracking after smoking Cannabis - HTC Vive Pro-Eye, Cannabis cigarette - 4.0% THC
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Battelle Memorial Institute
Primary Open Angle Glaucoma
The Effects of Caffeinated Coffee on Intraocular Pressure
High intraocular pressure (IOP) is a known risk factor for developing primary open-angle glaucoma (POAG). There is controversy in the literature regarding the degree to which caffeine influences IOP, with some studies reporting…
- Trial name
- NCT01364207
- Testing
- Caffeinated Coffee, Decaffeinated Coffee
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Uveitis
Uveitis Gene-Expression Profiling
Uveitis is a group of troublesome diseases that collectively represent a cause of blindness comparable to diabetes. Most forms of uveitis are either infectious or immune-mediated.
- Trial name
- NCT00874471
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Refractive Errors
Measurment of Optic Disc Parameters, RNFL Thickness and Ganglion Cell Complex in Myopic, Hypermetropic and Emmetropic Patients Using OCT and Axial Length Measurments
To evaluate the optic disc parameters, thickness of ganglion cell complex (GCC), and thickness of peripapillary retinal nerve fiber layer (RNFL) in myopic and hyperopic and emmetrop patients using optical coherence tomography…
- Trial name
- NCT07241806
- Testing
- OCT
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Assiut University
Uveitis, Diabetic Retinopathy
Biomarkers of Common Eye Diseases
To identify biomarkers of common eye diseases based on single-cell sequencing technologies using PBMC samples. These diseases include uveitis, diabetic retinopathy, age-related macular degeneration and polypoid choroidal…
- Conditions
- Uveitis, Diabetic Retinopathy, Age-related Macular Degeneration, Polypoidal Choroidal Vasculopathy
- Trial name
- NCT04101604
- Testing
- Collection of blood samples
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Healthy Volunteer, Sjogren's Syndrome
Characterization of Diseases With Salivary Gland Involvement
Background: Salivary glands in and around the mouth and throat make saliva. Salivary gland disorders can affect a person s quality of life.
- Conditions
- Healthy Volunteer, Sjogren's Syndrome, Salivary Gland Disease
- Trial name
- NCT02327884
- Where
- United States
- Volunteers
- 1,150 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Age-related Macular Degeneration
QA102 Phase 1 Study in Healthy Young and Older Adult Subjects
This will be a double masked, randomized, placebo controlled, single and multiple oral dose study conducted in 3 parts. The safety and tolerability of single and multiple ascending oral doses of QA102 in healthy young and older…
- Trial name
- NCT04894071
- Testing
- QA102
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Smilebiotek Zhuhai Limited
Child Development
Antibiotic Resistance and Microbiome in Children Aged 6-59 Months in Nouna, Burkina Faso
The use of antibiotics has saved millions of human lives, however consumption of antibiotics can select for antibiotic resistant organisms and may lead to changes in commensal microbiome.
- Trial name
- ARMCA (NCT03187834)
- Testing
- Azithromycin, Amoxicillin, Cotrimoxazole
- Where
- 2 sites in United States, Burkina Faso
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Retinal Disease, AMD
Cell Collection to Study Eye Diseases
Background: Best Vitelliform Dystrophy (Best disease), Late-Onset Retinal Degeneration (L-ORD), and Age-Related Macular Degeneration (AMD) all affect the retina, the light sensing area at the back of the eye.
- Conditions
- Retinal Disease, AMD, Retinal Degeneration, Retinitis Pigmentosa
- Trial name
- NCT01432847
- Where
- United States
- Volunteers
- 930 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Traumatic Brain Injury
Integrated Eye Tracking and Neural Monitoring for TBI: Optimization
Traumatic brain injury (TBI) is one of the most frequent injuries affecting service members. Unfortunately, current neurocognitive assessment tools are unable to reliably detect mild TBI more than a few days post- injury.
- Trial name
- NCT03451058
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Cerebral Palsy (CP), CP (Cerebral Palsy)
Immersive AOT: Multisensory Stimulation and Neurophysiological Correlates in Children With Cerebral Palsy and Typical Development - A Pilot Study
The discovery of the Mirror Neuron System (MNS) has promoted the development of rehabilitation techniques such as Action Observation Treatment (AOT) and Motor Imagery (MI).
- Conditions
- Cerebral Palsy (CP), CP (Cerebral Palsy), Motor Imagery, Action Observation
- Trial name
- ImmersiveAOT (NCT07369193)
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- IRCCS Fondazione Stella Maris
Cataract
Individual vs Cohort Long Distance Advising for Mental Care for Congenital Cataract Guardians
Nowadays, doctors put mental health at a prior place and pay more attention to the psychological problems of ill kids' parents. In our research, we try to find a new modern and efficient psychological counseling mode to improve…
- Trial name
- NCT03216655
- Testing
- phone call, wechat group
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Glaucoma, Glaucoma, Angle-Closure
Macular Pigment Optical Density in Primary Angle-closure Disease
Glaucoma is the leading cause of irreversible blindness in the world, and primary angle-closure glaucoma (PACG) is the most important type of glaucoma in Asia.
- Conditions
- Glaucoma, Glaucoma, Angle-Closure, Macular Pigment Optical Density
- Trial name
- NCT05251792
- Testing
- Ocular examination
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Retinal Dystrophies
EyeConic: Qualification for Cone-Optogenetics
This study aims to prepare for the first-in-human clinical trial of cone optogenetics vision restoration. As a first step, this worldwide multicenter ocular imaging study (EyeConic Study) is performed to identify eligible…
- Trial name
- NCT05294978
- Testing
- Optical coherence tomography (OCT)
- Where
- 9 sites in United States, China and 5 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Institute of Molecular and Clinical Ophthalmology Basel
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