Clinical trials: Eye Disorders
Dry Eye Syndromes
The Effects of BAK on the Blood Aqueous Barrier of Pseudophakic Patients
BAK is one of the most frequent preservatives in eye drops. BAK is a quaternary ammonium salt with surfactant qualities. It can be bacteriostatic or bactericidal depending on the concentrations used.
- Trial name
- NCT01280110
- Testing
- Hydroxypropylmethylcellulose, Carboxymethylcellulose
- Where
- Brazil
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Cataract
Galilei Lens Professional vs. Predicate Devices: a Comparison Study
Study question: How does the new GALILEI Lens Professional compare to predicate devices? Study hypothesis: The GALILEI Lens Professional achieves a better precision in the postoperative, calculated target refraction with cataract…
- Trial name
- NCT01961089
- Testing
- Galilei Lens Professional, IOLMaster, Lenstar
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ziemer Ophthalmic Systems AG
Macular Holes
Clinical Characteristics and Surgical Outcomes of Full-thickness Macular Hole Without Focal Vitreomacular Traction.
This multicenter, retrospective, observational comparative study. We occasionally encounter FTMHs in which PVD has not been achieved and VMT is absent.
- Trial name
- NCT06560710
- Testing
- vitrectimy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- St. Marianna University School of Medicine
Diabetic Retinopathy, Retinal Vein Occlusion
Computer Aided Diagnosis of Multiple Eye Fundus Diseases From Color Fundus Photograph
Blindness can be caused by many ocular diseases, such as diabetic retinopathy, retinal vein occlusion, age-related macular degeneration, pathologic myopia and glaucoma.
- Conditions
- Diabetic Retinopathy, Retinal Vein Occlusion, Retinal Artery Occlusion, Central Serous Chorioretinopathy
- Trial name
- NCT04723160
- Testing
- Software assisted imaging diagnosis
- Where
- 5 sites in China
- Volunteers
- 748 people, healthy volunteers welcome
- Sponsor
- Visionary Intelligence Ltd.
Allergic Conjunctivitis
A Six-Week Safety Study of an Investigational Ophthalmic Solution
The purpose of this study was to evaluate the ocular safety of an investigational ophthalmic solution in subjects 2 years of age and older with asymptomatic eyes when administered once daily in both eyes for up to 6 weeks.
- Trial name
- NCT01698814
- Testing
- AL-4943A Ophthalmic Solution, AL-4943A Ophthalmic Solution Vehicle
- Volunteers
- 518 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Exophthalmos, Graves Ophthalmopathy
Exophthalmometry With 3D Face Scanners
This study investigates diagnostic methods to measure eyeball protrusion with a smartphone face scanner compared to the traditional Hertel exophthalmometer.
- Conditions
- Exophthalmos, Graves Ophthalmopathy, Orbital Tumor, Orbital Fractures
- Trial name
- EX3D (NCT04704414)
- Testing
- Exophthalmos measurement
- Where
- Switzerland
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Thyroid Associated Ophthalmopathy
Establishment of Multiparametric Prediction Models for Moderate to SevereThyroid Associated Ophthalmopathy
Thyroid-associated ophthalmopathy (TAO) is an organ-specific autoimmune disease closely related to thyroid disease, which leads the incidence of orbital disease in adults and is the most common cause of diffuse toxic goiter…
- Trial name
- NCT06590220
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Glaucoma
To Evaluate the Effect of Ginkgo Biloba Extract on Optic Nerve Head Perfusion Examined Using OCTA
Glaucoma is defined as progressive neuropathy of the optic nerve. It is an important cause of irreversible blindness worldwide. Lowering the intraocular pressure is the only proven treatment for this neurodegenerative disease.
- Trial name
- GBE (NCT04846179)
- Testing
- Ginkgo biloba extract
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Glaucoma
Prevalence of Glaucoma in Belgium: a Multicenter National Trial
To screen for the presence of glaucoma in a Belgian population over 40 years old using an AI algorithm developed for the detection of glaucoma based on fundus pictures.
- Trial name
- BelGlaucoma (NCT05703724)
- Testing
- AI algorithm for the detection of glaucoma
- Where
- 8 sites in Belgium
- Volunteers
- 1,418 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Myopia, Environment
Environmental Factors and Myopia Prevalence Among Uyghur Students in Remote China
Ophthalmologic screening performs annually. Main information collected: gender, age, race, school, visual acuity, autorefractive results.
- Trial name
- NCT07119723
- Where
- China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University Eye Hospital
Dry Eye Disease
Comparison of Mucin Levels at the Ocular Surface of Visual Display Users With and Without Dry Eye Disease
The study aimed to evaluate 1) if levels of the glycocalyx membrane mucins, including MUC1, MUC4, MUC16 and MUC20, are altered in conjunctival cells of visual display users With and Without Dry Eye Disease, and 2) if mucin levels…
- Trial name
- NCT05604651
- Testing
- no intervention
- Where
- China
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Allergic Conjunctivitis
To Evaluate the Efficacy of AL-38583 in the Reduction of Tear Eosinophil Count Following Conjunctival Allergen Challenge
The purpose of the study is to determine whether Al38583 Ophthalmic Solution is safe and effective in reducing tear eosinophil levels at 5-8 hours after Conjunctival Allergen Challenge (CAC).
- Trial name
- NCT00881673
- Testing
- AL38583 Ophthalmic Solution, Maxidex, Vehicle
- Volunteers
- healthy volunteers welcome
- Sponsor
- Alcon Research
Ametropia
Evaluation of Enfilcon A Soft Contact Lens When Compared to Galyfilcon A Soft Contact Lens
The primary objective of thes study is to confirm that the ocular response to the Test lenses are similar to those of the Control lenses when used in a 1 week planned replacement, daily wear modality over a 1-month period.
- Trial name
- NCT01706770
- Testing
- enfilcon A, galyfilcon A
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Behcet Syndrome
Assessment of Disease Activity in Behcet by Complete Blood Count
To determine platelet to lymphocyte ratio (PLR), lymphocytes to monocytes ratio (LMR), mean platelet volume (MPV) and neutrophile lymphocyte ratio (NLR), levels in Behçet's disease (BD) To investigate their correlation with…
- Trial name
- NCT03747354
- Testing
- blood samples
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Eye Strain, Eye Fatigue
The Effects of Blackcurrant Supplementation on Eye Health
The purpose of this study is to evaluate the potential for supplementation with black currant to support eye health among otherwise healthy adult women who spend 6+ hours per day using digital screens.
- Trial name
- NCT04775654
- Testing
- Blackcurrant
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Nutraceuticals Research Institute
Age Factor, Age-related Macular Degeneration
Flicker Fusion Thresholds Between Young and Old Subjects at Various Luminance Levels
The objective of this study is to determine which luminance levels yield maximum differences in critical flicker fusion (CFF) scores between younger and older normal subjects.
- Trial name
- NCT03079570
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- ORA, Inc.
Primary Open-angle Glaucoma
Effects of Primary Open-angle Glaucoma on Visual-motor Coordination
Commonly used visual function assessments in glaucoma diagnosis and treatment-such as visual acuity, visual field, and contrast sensitivity-do not directly capture the impact of the disease on patients' daily abilities.
- Trial name
- NCT06692205
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Central Serous Chorioretinopathy
Short-Term Oral Mifepristone for Central Serous Chorioretinopathy
The goal of the study is to assess the efficacy and safety of mifepristone 300 or 900-mg once-daily dosing by mouth for 4 weeks in patients with central serous chorioretinopathy.
- Trial name
- STOMP-CSC (NCT02354170)
- Testing
- Mifepristone
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Roger Goldberg, M.D., MBA
Myopia
The Influence of Atropine on Choroidal Thickness
Atropine eye drops are increasingly prescribed for the management of progressive myopia or short-sightedness. A previous study suggested that the back of the eye or choroid may be a part of the mechanism by which it induces its…
- Trial name
- NCT03158142
- Testing
- Atropine Sulfate 1% Oph Soln
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- State University of New York College of Optometry
Dry Eye
Safety and Efficacy of Optive in Contact Lens Wearers With Dry Eyes
The purpose of this study is to determine if Optive®eye drops are safe for people who wear contact lenses and have dry eyes. The second goal of the study is to determine if using Optive®eye drops can improve my dry eye scores on…
- Trial name
- NCT00469573
- Testing
- 1. Optive
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Innovative Medical