Clinical trials: Eye Hemorrhage
Eyelid Diseases, Periorbital Disorder
The Role of Local Tranexamic Acid on Periorbital Oculoplastic Surgery
This study investigates the effect of tranexamic acid, a medication that helps reduce bleeding, in patients undergoing surgeries around their eyes.
- Conditions
- Eyelid Diseases, Periorbital Disorder, Hemorrhage, Surgical Blood Loss
- Trial name
- NCT05672407
- Testing
- Tranexamic acid
- Sponsor
- University of Miami
Proliferative Diabetic Retinopathy
Bevacizumab and Long Acting Gas in Diabetic Vitrectomy
Persistent or recurrent vitreous hemorrhage after vitrectomy for diabetic retinopathy complications is a common occurrence with an incidence of 12% to 63%.
- Trial name
- NCT00656435
- Testing
- Bevacizumab
- Where
- Taiwan
- Volunteers
- 16 people
- Sponsor
- National Taiwan University Hospital
Vitrectomy, Epiretinal Membrane
Performance Comparison of the 25 Gauge 20,000cpm HYPERVIT Dual Blade vs. 10,000cpm ULTRAVIT Vitrectomy Cutter
This prospective randomised controlled trial will be conducted to investigate that increasing the vitrectomy cutting rate from 10,000 cut/min to 20,000 cut/min will result more efficiency and shorter core vitrectomy time, and it…
- Conditions
- Vitrectomy, Epiretinal Membrane, Macular Hole, Vitreous Hemorrhage
- Trial name
- NCT05710458
- Testing
- 25 gauge 20,000 cpm Hypervit Dual Blade, 25 gauge 10,000 cpm Ultravit Vitrectomy Cutter
- Where
- Hong Kong
- Volunteers
- 72 people
- Sponsor
- The University of Hong Kong
Lymphoma
Revlimid® Capsules Drug Use-results Surveillance (Relapsed or Refractory ATLL)
To understand the safety and efficacy of Revlimid® Capsules 2.5 mg and 5 mg (hereinafter referred to as Revlimid) under actual conditions of use in patients with relapsed or refractory adult T-cell leukemia lymphoma (hereinafter…
- Trial name
- NCT03098589
- Testing
- Revlimid
- Where
- Japan
- Volunteers
- 1,149 people
- Sponsor
- Celgene
Spontaneous Vitreous Hemorrhage, Retinal Break
Early VItrectomy in DENse Spontaneous Vitreous HEmorrhage
The aim of the protocol is to compare the ocular outcomes after spontaneous vitreous hemorrhage treated with an early vitrectomy versus ultrasound monitoring with late vitrectomy.
- Conditions
- Spontaneous Vitreous Hemorrhage, Retinal Break, Retinal Detachment
- Trial name
- EVIDENSE (NCT04676256)
- Testing
- Early vitrectomy
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Systemic Lupus Erythematosus, Idiopahic Inflammatory Myopathies
A Study of CD19 UCAR-T Cells in Subjects With Autoimmune Diseases
The purpose of this study is to assess the safety and efficacy of CD19 UCAR-T cell therapy in Subjects with autoimmune diseases.
- Conditions
- Systemic Lupus Erythematosus, Idiopahic Inflammatory Myopathies, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Sjögren's Syndrome
- Trial name
- ET-902-AID01 (NCT07212322)
- Testing
- CD19 UCAR-T cells
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Intracranial Hypertension, Acute Brain Injury
Non-Invasive Triage for Intracranial Hypertension in Prehospital Care
This study tests whether two non-invasive tools can help paramedics detect dangerously high pressure inside the skull in patients with a sudden brain injury, such as stroke or head trauma, before they reach the hospital.
- Conditions
- Intracranial Hypertension, Acute Brain Injury, Stroke, Traumatic Brain Injury
- Trial name
- B4C-APH (NCT07747636)
- Testing
- Brain4care non-invasive intracranial pressure monitor, Optic nerve sheath diameter ultrasound
- Volunteers
- 180 people
- Sponsor
- Juliana Caldas
Vascular Retinopathy of Left Eye (Disorder), Vascular Retinopathy of Right Eye (Disorder)
Intraoperative Application of Fluorescein Sodium Angiography in Vascular Retinopathy
The study used a new surgical technique: intraoperative fluorescence imaging,In the 1980s, some scholars proposed the concept of intraoperative fluorescein angiography.During vitrectomy, intraoperative fluorescein angiography…
- Conditions
- Vascular Retinopathy of Left Eye (Disorder), Vascular Retinopathy of Right Eye (Disorder), Diabetic Retinopathy, Retinal Vein Occlusion
- Trial name
- NCT06343961
- Testing
- Intraoperative Fluorescein Angiography
- Volunteers
- 80 people
- Sponsor
- Jie Zhong
Giant Cell Arteritis, Takayasu Arteritis
Biologics in Refractory Vasculitis: A Trial of Biologic Therapy for Refractory Primary Non-ANCA Associated Vasculitis
Vasculitis occur when the body's immune system, rather than protecting the body, attacks blood vessels, causing injury to the vessel and the part of the body it supplies with blood.
- Conditions
- Giant Cell Arteritis, Takayasu Arteritis, Cogan Syndrome, Relapsing Polychondritis
- Trial name
- BIOVAS (NCT05168475)
- Testing
- Rituximab, Infliximab, Tocilizumab
- Where
- 5 sites in United Kingdom
- Volunteers
- 22 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Proliferative Diabetic Retinopathy
Endolaserless Vitrectomy With Intravitreal IAI for PDR-Related VH
This is a phase I/II open label, randomized, interventional clinical trial. Study eyes will receive one preoperative intravitreal aflibercept injection (IAI) <21 days but >7 days prior to vitrectomy and one intraoperative IAI at…
- Trial name
- LASERLESS (NCT02976012)
- Testing
- Aflibercept, Endolaserless Vitrectomy
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Southeast Retina Center, Georgia
Retinal Hemorrhage, Bilateral, Retinal Hemorrhage, Left Eye
Retinal Imaging Study of Children That Might be at Risk of Having Retinal Hemorrhages
This is a clinical trial in which we will learn about the retinal findings in three clinical groups of children, who might be at risk of having retinal hemorrhages (RH).
- Conditions
- Retinal Hemorrhage, Bilateral, Retinal Hemorrhage, Left Eye, Retinal Hemorrhage, Right Eye
- Trial name
- RISC (NCT05576285)
- Testing
- ophthalmoscopy and fundus photography through dilated pupills
- Where
- Sweden
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Diabetic Retinopathy, Retinal Detachment
Ranibizumab for Diabetic Traction Retinal Detachment
The purpose of this study was to assess the effect of ranibizumab in reducing intraoperative vitreous haemorrhage during pars plana vitrectomy, thus facilitating surgery and improving its anatomical and functional results in…
- Trial name
- RANITRA (NCT01201161)
- Testing
- Ranibizumab
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- University of Sao Paulo
Antiphospholipid Syndrome (APS), Bullous Pemphigoid (BP)
Phase 1b Trial of RAY121 in Immunological Diseases (RAINBOW Trial)
This Phase 1b basket trial will investigate the safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity and preliminary efficacy of RAY121, a inhibitor of classical complement pathway, after multiple dose…
- Conditions
- Antiphospholipid Syndrome (APS), Bullous Pemphigoid (BP), Behçet's Syndrome (BS), Dermatomyositis (DM)
- Trial name
- NCT06371417
- Testing
- RAY121
- Where
- 77 sites in United States, Australia and 18 more
- Volunteers
- 144 people
- Sponsor
- Chugai Pharmaceutical
Ocular Trauma
Application of tPA in Suprachoroidal and Subretinal Hemorrhage
Severe ocular rupture may be accompanied by suprachoroidal hemorrhage, or subretinal hemorrhage, or with suprachoroidal hemorrhage and subretinal hemorrhage. The suprachoroidal hemorrhage needs to be drained as soon as possible.
- Trial name
- NCT05736757
- Testing
- Tissue Plasminogen Activator
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Diabetic Retinopathy, Vitreous Hemorrhage
Use of Intravitreal Ranibizumab in the Treatment of Vitreous Hemorrhage
Primary Objective: To investigate the effectiveness of intravitreal applications of 0.5 mg Lucentis (ranibizumab) in patients with vitreous hemorrhage due to proliferative diabetic retinopathy.
- Trial name
- NCT01824043
- Testing
- intravitreal ranibizumab injections
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Hospital Regional de São José - Dr. Homero de Miranda Gomes
Polypoidal Choroidal Vasculopathy
Intravitreal Aflibercept Injection for Polypoidal Choroidal Vasculopathy With Hemorrhage or Exudation
To evaluate the efficacy and safety of intravitreal aflibercept injection in the treatment of PCV
- Trial name
- EPIC (NCT01871376)
- Testing
- Intravitreal aflibercept injection 2.0mg
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Gregg T. Kokame, MD
Proliferative Diabetic Retinopathy, Diabetic Traction Retinal Detachment
Prospective Randomized Controlled Study of Intravitreal Injection of Bevacizumab for Proliferative Diabetic Retinopathy
We hypothesized that to reduce the adverse effects of intravitreal bevacizumab on ocular tissue and whole body, intravitreal injection of a low concentration of bevacizumab and conducting vitrectomy shortly after the injection is…
- Conditions
- Proliferative Diabetic Retinopathy, Diabetic Traction Retinal Detachment, Vitreous Hemorrhage
- Trial name
- NCT01854593
- Testing
- Bevacizumab, Vitrectomy
- Where
- Japan
- Volunteers
- 69 people
- Sponsor
- Nihon University
Epiretinal Membrane, Macular Hole
UNITY VCS Vitreoretinal Surgery
This purpose of this study is to compare the safety and effectiveness of two eye surgery systems-UNITY VCS and CONSTELLATION-in treating adults with vitreoretinal diseases or disorders.
- Conditions
- Epiretinal Membrane, Macular Hole, Visually Significant Vitreous Floater, Vitreomacular Traction
- Trial name
- NCT07054281
- Testing
- UNITY Vitreoretinal Cataract System (VCS), CONSTELLATION Vision System, Vitreoretinal ophthalmic surgery
- Where
- 8 sites in United States
- Sponsor
- Alcon Research
Vitreous Hemorrhage
Aflibercept Injection for Proliferative Diabetic Retinopathy
To evaluate the ocular and systemic safety of intravitreal aflibercept injection in patients undergoing Pars Plana Vitrectomy for Proliferative Diabetic Retinopathy.
- Trial name
- NCT01805297
- Testing
- Intravitreal Aflibercept Injection, Standard Vitrectomy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Oklahoma
Eye Diseases, Macular Degeneration, Wet
Vitrectomy, Subretinal Tissue Plasminogen Activator (TPA) and Intravitreal Gas for Submacular Haemorrhage Secondary to Exudative (Wet) Age-related Macular Degeneration (TIGER).
The centre of the retina (macula) at the back of the eye contains cells that give us our central vision that we use for reading and recognising faces.
- Conditions
- Eye Diseases, Macular Degeneration, Wet, Sub-Macular Hemorrhage
- Trial name
- TIGER (NCT04663750)
- Testing
- Pars plana vitrectomy, Intravitreal 2 mg aflibercept will be injected at baseline then monthly for two further doses, then 2-monthly until month 12, subretinal injection of recombinant TPA (Alteplase) up to a maximum of 25 micrograms in 0.2 mls
- Where
- 42 sites in Germany, Ireland and 5 more
- Volunteers
- 210 people
- Sponsor
- King's College Hospital NHS Trust