Clinical trials: Eye Infections, Bacterial
Trachoma, Chlamydia
Trachoma Elimination Follow-up
The WHO has initiated a program to eliminate blinding trachoma by the year 2020, in large part by mass oral azithromycin distributions. It is not clear how frequently or for how long these treatments are necessary.
- Trial name
- TEF (NCT00221364)
- Testing
- Mass treatment with oral azithromycin to an entire village
- Where
- Ethiopia
- Volunteers
- 20,000 people
- Sponsor
- University of California, San Francisco
Trachoma
Partnership for Rapid Elimination of Trachoma
Trachoma, an ocular infection caused by C. trachomatis, is the second leading infectious cause of blindness worldwide. Years of repeated infection with C.
- Trial name
- PRET (NCT00792922)
- Testing
- Azithromycin
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Conjunctivitis, Bacterial, Keratitis Bacterial
Microbiologic Alterations of the Conjunctiva of Hot Tub-soaking Ophthalmologists
The purpose of this study is to determine if there are microbiologic alterations of the ocular surface after hot tub exposure. The study will evaluate the number of microbes before and after hot tub use in order to find out…
- Trial name
- MACHO (NCT03987178)
- Testing
- Dunk, Exposure to Hot Tub
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Trichiasis
Identification of TT Cases by Community Treatment Assistants: An Assessment
To achieve the goal of trachoma control as mandated by the World Health Organization, countries must reduce the backlog of trichiasis surgery cases to less than 1/1,000 of their population.
- Trial name
- SIMBA (NCT01783743)
- Testing
- TT Training Program and TT Screening Card
- Where
- United States
- Volunteers
- 27,473 people
- Sponsor
- Johns Hopkins University
Corneal Ulcer, Eye Infections, Bacterial
Steroids for Corneal Ulcers Trial
The purpose of this study is to determine whether adding topical steroids improves the outcomes of bacterial corneal ulcers, especially visual acuity.
- Trial name
- SCUT (NCT00324168)
- Testing
- Antibiotics, Topical corticosteroid
- Where
- 5 sites in United States, India
- Volunteers
- 500 people
- Sponsor
- Thomas M. Lietman
Trachomatous Trichiasis, Trachoma
A Trial of Non-absorbable Versus Absorbable Sutures for Trichiasis Surgery
Trachoma is the leading infectious cause of blindness worldwide. Recurrent infection by Chlamydia trachomatis causes in-turning of the eyelids / lashes (trichiasis), leading to corneal damage and blindness.
- Trial name
- NCT00522860
- Testing
- Trichiasis surgery with absorbable sutures, Trichiasis surgery with non-absorbable sutures
- Where
- Ethiopia
- Volunteers
- 1,300 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Primary Sjögren Syndrome, Vaginitis Candida
Sjögren and Gynecologic Considerations
Sjögren's syndrome is an autoimmune disorder characterized by glandular and extra-glandular manifestations. It is called primary Sjögren's syndrome (pSS) in absence of another connective tissue disease.
- Conditions
- Primary Sjögren Syndrome, Vaginitis Candida, Vaginitis, Sexual Dysfunction
- Trial name
- NCT05670535
- Testing
- Visual analogue scale (VAS) for dyspareunia, Visual analogue scale (VAS) for vaginal dryness, The European League Against Rheumatism Sjögren's Syndrome Disease Activity Index (ESSDAI)
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people
- Sponsor
- Ankara City Hospital Bilkent
Conjunctival Bacterial Flora
Effectiveness of Topical 0.5% Levofloxacin to Reduce the Conjunctival Bacterial Flora Before Intraocular Surgery
The purpose of this study is to determine whether additional topical application of 0.5% levofloxacin is more effective in reducing the load of the conjunctival bacterial flora in patients scheduled for intraocular surgery than…
- Trial name
- NCT00491049
- Testing
- 0.5% levofloxacin eye drops
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Sarcoidosis, Tuberculosis
The Serum Angiotensin Converting Enzyme and Lysozyme Levels in Patients Non-infectious and Infectious Uveitis
This study evaluates the significance of differences in serum angiotensin converting enzyme and lysozyme levels of patients with ocular involvement of other autoimmune inflammatory and infectious diseases.
- Trial name
- uveitis (NCT02627209)
- Testing
- spectrophotometric assay, radial immunodiffusion
- Where
- Turkey (Türkiye)
- Volunteers
- 280 people
- Sponsor
- Ozlem Sahin
Age-Related Macular Degeneration, Allergies
Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives
To collect, preserve, and/or distribute annotated biospecimens and associated medical data to institutionally approved, investigator-directed biomedical research to discover and develop new treatments, diagnostics, and…
- Conditions
- Age-Related Macular Degeneration, Allergies, Alpha-Gal Syndrome, Alzheimer Disease
- Trial name
- NCT05635266
- Testing
- Specimen sample
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Trachoma
Trachoma Elimination Study by Focused Antibiotic (TESFA)
The study population consists of all households residing in eligible kebeles (sub-districts) within districts in Amhara National Regional State which are identified as having a high prevalence of trachoma and infection measured…
- Trial name
- NCT03523156
- Testing
- Azithromycin mass treatment, Azithromycin targeted treatment
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Trichiasis, Trachoma
Fluorometholone as Ancillary Therapy for TT Surgery
The investigators aim to evaluate a new potentially cost-effective approach to improving trichiasis surgery outcomes, perioperative topical anti-inflammatory therapy.
- Conditions
- Trichiasis, Trachoma, Bilamellar Tarsal Rotation
- Trial name
- NCT01949454
- Testing
- Fluorometholone 0.1% ophthalmic solution
- Where
- Ethiopia
- Volunteers
- 154 people
- Sponsor
- University of Pennsylvania
Keratitis Bacterial, Corneal Ulcer (Diagnosis)
Fluorometholone Study
The investigators seek to determine whether adjunctive topical fluorometholone (FML) improves best-corrected visual acuity (BCVA) at 3 months in patients with bacterial corneal ulcers compared with standard topical antibiotic…
- Trial name
- NCT07308938
- Testing
- Adjunctive Topical Fluorometholone (FML) 0.1%, Standard Topical Antibiotic Therapy
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- Vishal Jhanji
Bacterial Conjunctivitis
A Study of the Safety and Efficacy of Gatifloxacin in Patients With Bacterial Conjunctivitis
The study will determine the safety and efficacy of gatifloxacin eye drops in patients with bacterial conjunctivitis
- Trial name
- NCT00509873
- Testing
- Gatifloxacin 0.5% eye drops
- Where
- United States
- Volunteers
- 578 people
- Sponsor
- Allergan
Conjunctivitis, Bacterial
Systemic Pharmacokinetics of BOL-303224-A
This is a multi-center, open-label, single dose/multiple dose, pharmacokinetic study in participants with bacterial conjunctivitis.
- Trial name
- NCT00407589
- Testing
- BOL-303224-A
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Bausch & Lomb Incorporated
Bacterial Conjunctivitis
Besifloxacin Ophthalmic Suspension Verses Gatifloxacin Ophthalmic Solution in Neonates With Bacterial Conjunctivitis
The objective of this study is to evaluate the safety and efficacy of Besivance (besifloxacin 0.6%) ophthalmic suspension compared to gatifloxacin 0.3% ophthalmic solution when administered three times daily (TID) for seven days…
- Trial name
- NCT01330355
- Testing
- Besivance, Gatifloxacin
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Bausch & Lomb Incorporated
Bacterial Conjunctivitis
Topical Treatment of Bacterial Conjunctivitis and Its Effect on Microbial Flora
Topical Treatment of Bacterial Conjunctivitis and its Effect on Microbial Flora
- Trial name
- NCT00312338
- Testing
- VIGAMOX
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Alcon Research
Bacterial Conjunctivitis
A Study to Evaluate the Safety and Efficacy of Gatifloxacin for the Treatment of Bacterial Conjunctivitis
This is a 7 day study to evaluate the safety and efficacy of topical gatifloxacin ophthalmic solution for the treatment of bacterial conjunctivitis in subjects from birth to 31 days of age
- Trial name
- NCT00464438
- Testing
- gatifloxacin, moxifloxacin 0.5% eye drops
- Where
- 2 sites in United States, Canada
- Volunteers
- 171 people
- Sponsor
- Allergan
Child Development
Antibiotic Resistance and Microbiome in Children Aged 6-59 Months in Nouna, Burkina Faso
The use of antibiotics has saved millions of human lives, however consumption of antibiotics can select for antibiotic resistant organisms and may lead to changes in commensal microbiome.
- Trial name
- ARMCA (NCT03187834)
- Testing
- Azithromycin, Amoxicillin, Cotrimoxazole
- Where
- 2 sites in United States, Burkina Faso
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
COVID-19, Mucormycosis
Ocular Manifestation and Related Risk Factors of Covid-19 Associated Mucormycosis: a Multicenter Study in Iran
Coronavirus disease 2019 (COVID-19) infection caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may manifest as a variety of disease patterns, ranging from mild to life-threatening pneumonia.
- Trial name
- NCT05097664
- Where
- Iran
- Volunteers
- 250 people
- Sponsor
- Isfahan University of Medical Sciences