Clinical trials: Eye Inflammation
Uveitis Posterior Non-Infectious, Inflammation Eye
Targeting Immunosuppressive Treatment for Non-infectious Uveitis Using Aqueous Humor Cytokine Profiles
This multicenter, prospective, interventional, non-pharmacological study aims to investigate whether the intraocular cytokine profile is associated with the therapeutic response to immunosuppressive drugs in patients with…
- Conditions
- Uveitis Posterior Non-Infectious, Inflammation Eye, Uveitis, Uveitis, Anterior
- Trial name
- PRIN_NIU (NCT07262437)
- Testing
- to improve clinical practice in treatment of non-infective uveitis
- Where
- 3 sites in Italy
- Volunteers
- 220 people
- Sponsor
- University of Milan
Cataracts Infantile
Clobetasol Propionate Ophthalmic Nanoemulsion, 0.05% in the Treatment of Inflammation After Cataract Surgery in Pediatric Population
Multicenter, randomized, evaluator-blinded clinical trial compared to Prednisolone acetate, 1% in the treatment of inflammation and pain after cataract surgery in pediatric population.
- Trial name
- CLOSE-3 (NCT05724446)
- Testing
- Clobetasol Propionate, Prednisolone acetate ophthalmic suspension, 1%
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Salvat
Nervous System Malformations, Arthropathy, Neurogenic
Anakinra to Treat Patients With Neonatal Onset Multisystem Inflammatory Disease
This study will evaluate the safety and effectiveness of anakinra (Kineret) for treating patients with neonatal-onset multisystem inflammatory disease (NOMID), also known as chronic infantile neurological, cutaneous and…
- Conditions
- Nervous System Malformations, Arthropathy, Neurogenic, Urticaria, Papilledema
- Trial name
- NCT00069329
- Testing
- anakinra
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Corneal Edema, Corneal Defect
Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Corneal Transplant Surgery
Assessing the efficacy and safety of DEXTENZA, sustained release dexamethasone 0.4 mg insert following corneal transplant surgery (PKP, DSEK, DMEK) as compared to topical prednisolone acetate 1%.
- Conditions
- Corneal Edema, Corneal Defect, Corneal Transplant, Penetrating KeratoPlasty
- Trial name
- NCT04521140
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, Prednisolone Acetate 1% Oph Susp
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Nicole Fram M.D.
Sepsis, Bronchopulmonary Dysplasia
Cysteine Supplementation in Critically Ill Neonates
Critically ill babies less than 1 month of age have deficient amounts of the antioxidant glutathione and a high incidence of disease associated with oxidative injury compared to healthy babies.
- Conditions
- Sepsis, Bronchopulmonary Dysplasia, Necrotizing Enterocolitis, Retinopathy of Prematurity
- Trial name
- NCT00254176
- Testing
- Parenteral cysteine-HCl supplementation
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of California, Los Angeles
Uveitis
An Open-label, Rollover Study Providing Continued Dosing of Gevokizumab in Order to Assess Long-term Gevokizumab Safety Data
The purpose of this study is to provide continued dosing of gevokizumab in order to obtain and assess long-term gevokizumab safety data.
- Trial name
- EYEGUARD™-E (NCT02258854)
- Testing
- Dose 2 gevokizumab
- Where
- 33 sites in United States
- Volunteers
- 69 people
- Sponsor
- XOMA (US) LLC
Dry Eye
Ocular Inflammation in Cataract Patients and Response to Treatment With Xiidra
To determine if the use of Xiidra® reduces ocular surface inflammation in preoperative and postoperative cataract patients.
- Trial name
- NCT04120987
- Testing
- Lifitegrast 5% Ophthalmic Solution
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bucci Laser Vision Institute
Rheumatoid Arthritis, Ankylosing Spondylitis
Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases
TRANSREG will assess the safety and biological efficacy of low-dose IL2 as a Treg inducer in a set of 14 autoimmune and auto-inflammatory diseases, with the aim to select diseases in which further therapeutic development will be…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Systemic Lupus Erythematosus, Psoriasis
- Trial name
- TRANSREG (NCT01988506)
- Testing
- Interleukin 2
- Where
- 11 sites in France
- Volunteers
- 81 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Glaucoma, Corneal Transplantation
Inflammatory Mediators of Glaucoma After Corneal Transplantation (AH-Tears)
Glaucoma is the most common threat to vision rehabilitation in patients with Boston keratoprosthesis type 1 (KPro) implantation.
- Conditions
- Glaucoma, Corneal Transplantation, Inflammation
- Trial name
- AH-Tears (NCT04339907)
- Testing
- Sampling of tears, Sampling of aqueous humor
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cataracts
Modified Intraocular Lens to Reduce Eye Inflammation After Cataract Surgery in Uveitis Patients
This study will test the effectiveness of an intraocular lens treated with heparin in reducing or preventing inflammation after cataract surgery in patients with uveitis.
- Trial name
- NCT00001311
- Testing
- heparin-surface modified intraocular lens
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Eye Institute (NEI)
Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder
Neurogenetics and Multi-omics of Neuroinflammatory Diseases in Multiplex Families to Improve Patients Health
The goal of this observational study is to learn why some families have several members with multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), or MOG antibody-associated disease (MOGAD).
- Conditions
- Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder, MOG Antibody-Associated Disease, Demyelinating Autoimmune Diseases, CNS
- Trial name
- NeuroDIP (NCT07902479)
- Testing
- Blood sampling and multi-omic profiling
- Where
- 5 sites in France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Graves Disease, Graves Ophthalmopathy
Systemic Inflammation, Thyroid Autoimmunity and Neuroretinal Changes in Graves Disease
This retrospective observational study aims to evaluate the relationship between systemic inflammatory parameters, thyroid autoimmunity markers, and neuroretinal structures in patients with Graves disease.
- Trial name
- NCT07480720
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Cataract, Pseudoexfoliation Syndrome
Bromfenac to Reduce Inflammation in Patients With Pseudoexfoliation Syndrome After Cataract Surgery
OBJECTIVE To evaluate the efficacy of bromfenac ophthalmic solution 0.09% for reducing postoperative inflammation in eyes with pseudoexfoliation syndrome (PEX) undergoing cataract surgery and receiving standard postoperative eye…
- Trial name
- REPEX (NCT02137161)
- Testing
- Dexamethasone+Tobramycin eye drop, Bromfenac eye drop
- Where
- Italy
- Volunteers
- 62 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Endophthalmitis
Nanopore Sequencing in Ophthalmology
In this pilot study, the feasibility of the Oxford Nanopore MinION to identify pathogens from vitrectomy samples in eyes with endophthalmitis shall be assessed.
- Trial name
- NCT05372861
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Graz
Diabetic Retinopathy
Anti-inflammatory Effect of Curcumin, Homotaurine, Vitamin D3 on Human Vitreous in Patients With Diabetic Retinopathy
Dosage of pro-inflammatory cytokines and soluble mediators (TNFα, IL6, IL2 and PDGF-AB) performed on 25 vitreous biopsies taken from patients with diabetic retinopathy and treated with increasing doses of curcumin (0.5uM and…
- Trial name
- NCT04378972
- Testing
- curcumin, homotaurine, vitamin D3, control
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- University of Molise
Post-Surgical Ocular Pain, Post-Surgical Ocular Inflammation
OTX-15:003: A Phase 3 Study Evaluating the Safety and Efficacy of OTX-DP for the Treatment of Ocular Inflammation and Pain After Cataract Surgery
The objective of the study was to evaluate the safety and efficacy of OTX-DP (dexamethasone insert) 0.4 mg for intracanalicular use when placed in the canaliculus of the eyelid for the treatment of post-surgical inflammation and…
- Trial name
- NCT02736175
- Testing
- Dexamethasone
- Volunteers
- 438 people
- Sponsor
- Ocular Therapeutix, Inc.
Dry Eye, Dry Eye Syndromes
The Effect of a Pre-cataract Surgical Ocular Hygiene Regime on Microbial Load, Tear Osmolarity, Dry Eye, and Inflammatory Markers
This study assesses the impact of two differing ocular hygiene regimens prior to cataract surgery. The first regimen includes an omega-3 supplement and the second without, and both include an at-home lid wipe and cleansing eye…
- Conditions
- Dry Eye, Dry Eye Syndromes, Cataract
- Trial name
- NCT05990712
- Testing
- Omega-3, Trehalose, Zocular Eyelid System Treatment
- Where
- Canada
- Volunteers
- 68 people
- Sponsor
- Uptown Eye Specialists
Uveitis
Impact of Humira® Therapy on Ocular Inflammation, Selected Health Care Resource Utilization and Patient Reported Outcomes in Patients With Active Non-infectious Intermediate, Posterior and Panuveitis in Routine Clinical Practice
This study aims at evaluating real life effectiveness of originator adalimumab (Humira®) participants with active non-infectious intermediate, posterior and panuveitis (NIIPPU) despite high-dose corticosteroid therapy; including…
- Trial name
- HOPE (NCT03155243)
- Where
- 28 sites in Austria, Colombia and 10 more
- Volunteers
- 155 people
- Sponsor
- AbbVie
Uveitis, Scleritis and Episcleritis
Demographics and Clinical Characteristics of Ocular Inflammatory Diseases in Singapore
This is a retrospective study analyzing demographics, clinical characteristics, treatment received, and outcomes of ocular inflammatory diseases that presented to the Singapore National Eye Centre (SNEC).
- Conditions
- Uveitis, Scleritis and Episcleritis, Endophthalmitis, Masquerade Syndromes
- Trial name
- NCT07176130
- Testing
- No Intervention: Observational Cohort
- Where
- Singapore
- Volunteers
- 200 people
- Sponsor
- Singapore National Eye Centre
Sarcoidosis, Tuberculosis
The Serum Angiotensin Converting Enzyme and Lysozyme Levels in Patients Non-infectious and Infectious Uveitis
This study evaluates the significance of differences in serum angiotensin converting enzyme and lysozyme levels of patients with ocular involvement of other autoimmune inflammatory and infectious diseases.
- Trial name
- uveitis (NCT02627209)
- Testing
- spectrophotometric assay, radial immunodiffusion
- Where
- Turkey (Türkiye)
- Volunteers
- 280 people
- Sponsor
- Ozlem Sahin