Clinical trials: Eye Injury Trauma
Dystrophic Epidermolysis Bullosa, DEB - Dystrophic Epidermolysis Bullosa
A Study Comparing KB803 and Matched Placebo in Patients With Dystrophic Epidermolysis Bullosa
KB803-EYE-01 is a Phase 3 double-blind, randomized, placebo-controlled, crossover study to evaluate the safety and efficacy of KB803 versus matched placebo in pediatric and adult subjects with recurrent corneal abrasions due to…
- Conditions
- Dystrophic Epidermolysis Bullosa, DEB - Dystrophic Epidermolysis Bullosa, Recessive Dystrophic Epidermolysis Bullosa, Dominant Dystrophic Epidermolysis Bullosa
- Trial name
- IOLITE (NCT07016750)
- Testing
- KB803
- Where
- 5 sites in United States
- Volunteers
- 16 people
- Sponsor
- Krystal Biotech, Inc.
Mild Traumatic Brain Injury
The Use of the VOMS Tool With Military Personnel to Track mTBI Recovery and RTD Status
The purpose of the proposed project is to determine if the VOMS is an effective screening tool to identify and track recovery of vestibular and ocular motor impairment and symptoms following mTBI, that corpsman-level medical…
- Trial name
- NCT02634944
- Testing
- Vestibular Ocular Motor Screening Tool (VOMS)
- Where
- United States
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Concussion, Eye
The Effects of Concussion on Gait and Posture in Individuals With Peripheral Vision Loss
Changes in gait and balance often occur in individuals who have suffered a concussion. In addition, a subset of concussed individuals also experience peripheral vision loss.
- Trial name
- NCT05948501
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Gaylord Hospital, Inc
Tumor, Facial Fracture
A Post Market Clinical Follow-up Study on Biomet Microfixation HTR PEKK (Midface), Facial & Mandibular Plates.
This study will address medical devices manufactured by Biomet Microfixation (d.b.a. Zimmer Biomet) designed for fixation and stabilization of the facial and mandibular skeleton.
- Conditions
- Tumor, Facial Fracture, Mandibular Fractures, Fibrous Dysplasia
- Trial name
- NCT04931056
- Testing
- Titanium Facial Plates, Titanium Mandibular Plates, Add-on Condyle
- Where
- Argentina
- Volunteers
- 91 people
- Sponsor
- Zimmer Biomet
Mild Traumatic Brain Injury, Brain Concussion
Eyetracking and Neurovision Rehabilitation of Oculomotor Dysfunction in Mild Traumatic Brain Injury
The purpose of this single center, longitudinal, pilot study is to provide evidence for the use of an eye tracking system as an objective tool to identify mild traumatic brain injury (mTBI) related oculomotor dysfunction (OMD)…
- Conditions
- Mild Traumatic Brain Injury, Brain Concussion, Convergence Insufficiency, Accommodative Insufficiency
- Trial name
- NCT03319966
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Hennepin Healthcare Research Institute
Concussion, Mild, Concussion; Eye
EYE-SYNC Concussion Classification Study
The purpose of this study is to determine the sensitivity and specificity of an aid in assessment of concussion based on eye-tracking, in comparison to a clinical reference standard appropriate for sport-related concussion…
- Conditions
- Concussion, Mild, Concussion; Eye, Concussion, Brain, Concussion, Severe
- Trial name
- NCT04381767
- Testing
- EYE-SYNC
- Where
- United States
- Volunteers
- 1,303 people
- Sponsor
- Sync-Think, Inc.
Glaucoma, Blindness, Acquired
Implantable Intraocular Pressure Sensor for Glaucoma Monitoring in Patients With Boston Keratoprosthesis Type 1
The purpose of this study is to evaluate the safety and performance of the EYEMATE system in patients undergoing concomitant implantation of a BKPro type 1 and an EYEMATE sensor over the 24 months period beginning at implantation.
- Conditions
- Glaucoma, Blindness, Acquired, Keratitis, Herpetic, Ocular Cicatricial Pemphigoid
- Trial name
- BKPro (NCT03421548)
- Testing
- EyeMate
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Eye Injury Trauma
Adjunctive Steroid Combination in Ocular Trauma (ASCOT) Study
Eye trauma is a leading cause of blindness and visual impairment. Penetrating injuries of the eye are more likely to result in poor vision and the main cause of this is a scarring response on the retina (proliferative…
- Trial name
- ASCOT (NCT02873026)
- Testing
- Triamcinolone Acetonide
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Eye Trauma
Treatment of Corneal Wounds Emergencies During the COVID-19 Shutdown: Absorbable 10-0 Vicryl Sutures as a Valuable Strategy.
Vicryl (polyglactin) 10-0 resorbable suture is rarely used, little known to ophthalmologists but may offer therapeutic and practical advantages in eligible cases of corneal trauma, particularly during a COVID-19 pandemic.
- Trial name
- NCT04733846
- Testing
- data collection
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Head Trauma
Effect of Cervical Collar on the Optic Nerve Sheath Diameter in Minor Head Trauma
This is randomized, controlled and blinded study was performed in minor head trauma patients. Two sonographers measured optic nerve sheath diameters (ONSD) of each subjects' eyes separately for different time points.
- Trial name
- NCT03742427
- Testing
- ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Marmara University
Mild Traumatic Brain Injury, Concussion, Rehabilitation
Wearable Technology to Characterize and Treat mTBI Subtypes: Biofeedback-Based Precision Rehabilitation
Current clinical assessment tools are often not sensitive enough to detect and treat some subtle (yet troubling) problems after mTBI.
- Conditions
- Mild Traumatic Brain Injury, Concussion, Rehabilitation, Balance Impairment
- Trial name
- SuBTyPE (NCT06381674)
- Testing
- Vestibular therapy for mTBI augmented with audio and visual real-time biofeedback, Vestibular therapy for mTBI
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Oregon Health and Science University
Working Memory, Consolidation/Recconsolidation Memory
Theories of Working Memory and Consolidation/RECOnsolidation in the Process of Resorption of Post-traumatic Symptoms.
EMDR is a psychotherapeutic approach recommended by the World Health Organization (WHO) for the treatment of disorders such as post-traumatic stress disorder, anxiety, depression and, more generally, psychological distress.
- Conditions
- Working Memory, Consolidation/Recconsolidation Memory, Eye Movement Desensitization and Reprocessing, Alterning Bilateral Stimulation
- Trial name
- NCT06469333
- Testing
- Eye movements (EM), Auditory stimulations, Tactile stimulations
- Where
- France
- Volunteers
- 154 people
- Sponsor
- University of Lorraine
Orbital Fractures, Strabismus
Factors Associated With Postoperative Strabismus After Floor Fracture Repair
In patients suffered from floor fractures, there are 21.9% complaining about diplopia before fracture repair surgery and 20.8% after operation. Even after 6 months, there still are 16.4% had similar conditions.
- Trial name
- NCT02736461
- Testing
- Floor repair surgery
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Alkaptonuria
Long-Term Study of Nitisinone to Treat Alkaptonuria
This 3-year study will examine the safety and effectiveness of long-term use of nitisinone (Orfadin) for treating joint problems in patients with alkaptonuria, an inherited disease in which a compound called homogentisic acid…
- Trial name
- NCT00107783
- Testing
- Nitisinone (NTBC)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Eye Injuries
Treatment of Radiation Retinopathy With Open-Label Anecortave Acetate Sterile Suspension (15 mg)
Radiation retinopathy is a disease of the retina. It occurs in people who have received or been exposed to radiation near the eyes. The blood vessels are abnormal and may grow which lead to scarring and a loss of central vision.
- Trial name
- NCT00211367
- Testing
- Anecortave Acetate
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Manhattan Eye, Ear & Throat Hospital
Pterygium, Ocular Surface Disease
Autologous ex Vivo Conjunctival Epithelial Cell Expansion for Ocular Surface Transplantation
To evaluate the use of cultivated conjunctival epithelial equivalents for the treatment of ocular diseases
- Conditions
- Pterygium, Ocular Surface Disease, Stevens Johnson Syndrome, Chemical Injury
- Trial name
- NCT00346450
- Testing
- Cultivated conjunctival transplantation
- Where
- Singapore
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Severe Mental Disorder, Psychological Trauma
EMDR in Psychiatric Inpatients With Severe Mental Disorder
The study of psychological trauma has become increasingly important in the field of mental health research due to the strong negative impact it has on the course and prognosis of psychiatric pathologies.
- Trial name
- NCT03664713
- Testing
- Eye Movement Desensitization and Reprocessing (EMDR) Therapy
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Parc de Salut Mar
Corneal Abrasion
Short Term Topical Tetracaine is Safe and Highly Efficacious for the Treatment of Pain Caused by Corneal Abrasions
The objective of this study was to show that patients with corneal abrasions would experience more pain relief with short term topical tetracaine than placebo, have similar complication rates, and take less hydrocodone for…
- Trial name
- NCT04187417
- Testing
- topical tetracaine hydrochloride 1%
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- INTEGRIS Southwest Medical Center
Posttraumatic Stress Disorder
A Randomized Controlled Trial of Metacognitive Therapy and EMDR for Posttraumatic Stress Disorder
Posttraumatic stress disorder (PTSD) is a frequently occurring and often debilitating anxiety disorder resulting from exposure to trauma.
- Trial name
- NCT01955590
- Testing
- Metacognitive therapy, EMDR, Treatment as usual
- Where
- Norway
- Volunteers
- 96 people
- Sponsor
- Norwegian University of Science and Technology
Post Traumatic Stress Disorder PTSD
EMDR vs. CBT for PTSD
This study compares two evidence-based therapies, Eye Movement Desensitization and Reprocessing (EMDR) and Cognitive Behavioral Therapy (CBT), in reducing symptoms of post-traumatic stress disorder (PTSD) among adults affected by…
- Trial name
- EARTH-PTSD (NCT06758362)
- Testing
- Eye Movement Desensitization and Reprocessing (EMDR), Cognitive Behavioral Therapy (CBT)
- Where
- Turkey (Türkiye)
- Volunteers
- 89 people
- Sponsor
- Istanbul Nisantasi University