Clinical trials: Eye Manifestations
Retinitis Pigmentosa, Retinitis
Efficacy and Safety of MCO-010 Optogenetic Therapy in Adults With Retinitis Pigmentosa [RESTORE]
The purpose of the study is to evaluate the safety and efficacy of a single intravitreal injection of virally-carried Multi-Characteristic Opsin (MCO-010).
- Conditions
- Retinitis Pigmentosa, Retinitis, Retinal Diseases, Eye Diseases
- Trial name
- RESTORE (NCT04945772)
- Testing
- Gene Therapy Product-MCO-010
- Where
- 6 sites in United States, Puerto Rico
- Volunteers
- 27 people
- Sponsor
- Nanoscope Therapeutics Inc.
Amblyopia
Children's Eye Examination and Testing At Home Study
Repeated measures observational study of tablet-based children's visual acuity tests.
- Trial name
- CHEETAH (NCT06980415)
- Testing
- Kay Pictures iSight
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Hyperalgesia, Cataract Bilateral Nos
Gabapentin Pretreatment for Staged Bilateral Cataract Operations
To evaluate the effect of oral gabapentin premedication on hyperalgesia in elderly patients undergoing staged bilateral cataract operations under monitored anesthesia care
- Trial name
- NCT03826615
- Testing
- Gabapentin
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Seoul National University Hospital
Age Related Macular Degeneration
Second Line Therapy to Treat Age-related Macular Degeneration (AMD) for Patients Not Responding Well to Lucentis Therapy by Itself
The purpose of this study is to demonstrate that Visudyne-Lucentis-dexamethasone (V-L-D) triple therapy will give similar efficacy and safety results as Lucentis monotherapy.
- Trial name
- NCT00457678
- Testing
- Visudyne, Lucentis, Dexamethasone
- Sponsor
- Vitreous -Retina- Macula Consultants of New York
Skin Manifestations, Antioxidative Stress
Omegia Softgel Clinical Research Program
Evaluate the improvement of regulation of skin and blood index composition after consumption of Omegia® Softgel
- Conditions
- Skin Manifestations, Antioxidative Stress, Eye Strain, Vaginal Disease
- Trial name
- NCT05872178
- Testing
- Omegia® Softgel -B, Omegia® Softgel -A
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chia Nan University of Pharmacy ＆ Science
Eye Pain, Neuropathy, Optic
Alternating and Direct Current Stimulation for Neuropathic Eye Pain
The goal of this clinical intervention is to test if two forms of transcranial current stimulation, transcranial direct current stimulation (tDCS) or transcranial alternating current stimulation (tACS) can alleviate neuropathic…
- Conditions
- Eye Pain, Neuropathy, Optic, Cerebral Injury
- Trial name
- NCT05931250
- Testing
- DC-Stimulator Plus (NeuroConn GmbH, Germany), Sooma direct current stimulator (Sooma, Finland)
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Neil Lagali
Light Sensitivity
Eye Movement Behaviour and Pupil Size in Natural Outdoor and Indoor Scenes
In this study, the researchers will be using eye tracking and detailed lighting measurements to understand how different types of indoor and outdoor lighting affect the eye movements and pupil sizes of our participants.
- Trial name
- NCT05971238
- Testing
- Indoor vs. outdoor scenes
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Wet Macular Degeneration
OZURDEX in Age Related Macular Degeneration as Adjunct to Ranibizumab
In the Western World, Age Related Macular Degeneration (ARMD) is a leading cause of blindness. This disease was once thought to be a natural part of aging, but recent research has introduced effective treatments.
- Trial name
- STAR (NCT01243086)
- Testing
- Ranibizumab, OZURDEX
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- McMaster University
Progressive Supranuclear Palsy(PSP), Dementia With Lewy Bodies (DLB)
Digital Health Technologies for Progressive Supranuclear Palsy and Dementia With Lewy Bodies
Progressive supranuclear palsy (PSP), mild cognitive impairment with Lewy bodies (MCI-LB), and Dementia with Lewy Bodies (DLB) are severe neurodegenerative diseases that cause significant motor impairment impacting daily…
- Conditions
- Progressive Supranuclear Palsy(PSP), Dementia With Lewy Bodies (DLB), PSP, Lewy Body Dementia (LBD)
- Trial name
- NCT07240805
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- BioSensics
Vision Disorders
Pilot Clinical Evaluation of Approved Contact Lenses
This is a pilot evaluation to assess the feasibility of using novel imaging process to characterize lens edge and limbal epithelial thickness profile; lens movement with gaze and blink; and conjunctival microvasculature including…
- Trial name
- NCT02540122
- Testing
- Marketed Contact Lens 1, Marketed Contact Lens 2, Marketed Contact Lens 3
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Keratoconus, Crosslinking
Riboflavin at 4ºC for the Management of Pain After Crosslinking for Keratoconus Patients
Background: The objective of corneal collagen crosslinking (CXL) is to increase the binding of intrafibrillary and interfibrillary covalent bonds to improve the mechanical stability of the cornea and thus to stop the progression…
- Trial name
- NCT03760770
- Testing
- corneal collagen crosslinking
- Where
- Mexico
- Volunteers
- 90 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Amblyopia, Amblyopia Strabismic
Effectiveness of tDCS in Paediatric Amblyopia.
The goal of this randomized, double-blind clinical trial is to determine whether transcranial direct current stimulation (tDCS) can effectively and safely improve vision in children aged 4-14 years with strabismic or…
- Conditions
- Amblyopia, Amblyopia Strabismic, Visual Acuity, Stereoscopic Vision
- Trial name
- tDCS (NCT07547670)
- Testing
- tDCS
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Universidad de Murcia
Chronic Venous Insufficiency, CVI, Chronic Venous Insufficiency C2 or Higher
Reducing Skin Tone Inequities in Chronic Venous Insufficiency
The aim of this project is to define assessment criteria for chronic venous insufficiency (CVI) in people with dark skin tones. It will inform future interventions and modifications to practice for the assessment of CVI in people…
- Conditions
- Chronic Venous Insufficiency, CVI, Chronic Venous Insufficiency C2 or Higher, Chronic Venous Disease of Lower Limbs, Venous Leg Ulcer (VLU)
- Trial name
- NCT06798766
- Where
- 2 sites in United Kingdom
- Volunteers
- 51 people
- Sponsor
- King's College London
Fresnel Prism
Fresnel Prism in Low Vision Patients With Homonymous Hemianopia Defect in Cipto Mangunkusumo Hospital
Background: Homonymous hemianopia is a visual field defect that causes functional disabilities, such as decreased self-confidence, limited mobility, and increased risk of falls.
- Trial name
- NCT07531667
- Testing
- Fresnel prism
- Where
- Indonesia
- Volunteers
- 25 people
- Sponsor
- Universitas Indonesia
Low Back Pain, Visual Impairment
Development of a Tele-Physiotherapy Tool for the Early Management of Muskuloskeletal Pain in People With Visual Impairement (TeleEDxPhysio)
Chronic NonSpecific Low Back Pain (CNSLBP) is a common musculoskeletal condition often resulting in physical inactivity and disability.
- Trial name
- TeleEDxPhysio (NCT05478200)
- Testing
- physical exercise, Manual therapy
- Where
- 2 sites in Spain
- Volunteers
- 128 people
- Sponsor
- Escuela Universitaria de Fisioterapia de la Once
CLN3-related Disorders, Non-CLN3 Related Low Vision
Optic-to-Audio Device in a Pediatric Cohort With CLN3-related Conditions or Low Vision
Background: CLN3 involves vision loss observed around the preschool years, with eventual progression to blindness within 1-3 years.
- Trial name
- NCT04974307
- Testing
- OrCam MyEye 2
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Facial Paralysis, Sinkynesis
Eye Soft Surgery for Facial Sinkynesis
Facial synkinesis (FS) is a distressing sequela of facial palsy (FP) characterized by involuntary, simultaneous movements of facial muscles occurring during voluntary facial expressions.
- Trial name
- NCT06538103
- Testing
- Eye soft surgery, Physical Rehabilitation
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- University of Catania
Diabetic Macular Edema, Visual Impairment
Evaluation of Serum- and OCT Biomarkers in Patients With DME Treated With Anti-VEGF or Dexamethasone Implant
This study aims to investigate the association between serum biomarkers and clinical response to anti-VEGF or dexamethasone implant by assessing OCT-biomarkers in patients with diabetic macular edema, DME, and to compare these…
- Conditions
- Diabetic Macular Edema, Visual Impairment, Diabetes Mellitus, Hyperglycaemia (Diabetic)
- Trial name
- BiomarkerOCT (NCT06984822)
- Testing
- Anti-VEGF treatment, Dexamethasone implant, Treatment with intravitreal anti-VEGF OR Dexamethasone implant
- Where
- 2 sites in Sweden
- Volunteers
- 150 people
- Sponsor
- Vastra Gotaland Region
Pediatric Migraine
Randomized Study in Children and Adolescents With Migraine: Acute Treatment
The purpose of this study is to test the safety and efficacy of BHV-3000 versus placebo in the acute treatment of moderate or severe migraine in children and adolescents.
- Trial name
- NCT04649242
- Testing
- Rimegepant/BHV3000
- Where
- 246 sites in United States, Canada and 7 more
- Volunteers
- 2,100 people
- Sponsor
- Pfizer
Refractive Errors
Clinical Evaluation of Acuity 200 (Fluoroxyfocon A) RGP Contact Lens
The objective of this clinical investigation is to collect valid scientific safety and effectiveness data on the Acuity 200 (fluoroxyfocon A) Rigid Gas Permeable Contact Lens, manufactured from a newly developed rigid gas…
- Trial name
- Acuity 200 (NCT03971227)
- Testing
- Acuity 200 (Fluoroxyfocon A) contact lens, Acuity 100 (Hexafocon A) contact lens
- Where
- 3 sites in United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Acuity Polymers, Inc.
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