Clinical trials: Eye Manifestations
Chronic Venous Insufficiency, CVI
Structured Home-Based Exercise and Education for Chronic Venous Insufficiency
The goal of this clinical trial is to learn whether a structured home-based exercise and education program can improve quality of life and leg symptoms in adults with chronic venous insufficiency.
- Trial name
- NCT07777978
- Testing
- Structured Home-Based Exercise and Education Program, Standard Care (in control arm)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Abant Izzet Baysal University
Visual Impairment
Causes of Visual Impairment Among Patients Applying for the Visually Disability Certification
Causes of Visual Impairment Among Patients Applying for the Visually Disability Certification in Upper Egypt: A Retrospective Study
- Trial name
- NCT06518148
- Testing
- 1- uncorrected and best corrected visual acuity (UCVA and BCVA) by Snellen's-chart.2-slit lamp bio microscopy (Haag-Streit, USA).3-IOP measurements (Goldmann Applanation tonometer)
- Where
- Egypt
- Volunteers
- 2,000 people
- Sponsor
- New Valley University
Facial Paralysis, Peripheral, Bell's Palsy
The Efficacy of Intradermal Acupuncture for Ocular Surface Diseases After Intractable Facial Paralysis
The purpose of this study is to explore the clinical efficacy of intradermal acupuncture in the treatment of ocular surface diseases after Intractable Facial Paralysis, and to seek effective and convenient treatment for ocular…
- Conditions
- Facial Paralysis, Peripheral, Bell's Palsy, Ocular Surface Disease
- Trial name
- NCT07537426
- Testing
- Intradermal acupuncture treatment
- Where
- China
- Volunteers
- 78 people
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
Visual Impairment
Telerehabilitation for Visually Impaired
the purpose of the study is to evaluate the software usability and patient's adherence from five vision rehabilitation centres. In addition, the effect and benefits of a customizable telerehabilitation program were tested.
- Trial name
- NCT05772793
- Testing
- Telerehabilitation
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Amore Filippo
Suicide Attempt
Treating Suicidality Remotely
Background: Practical and psychological barriers make it difficult for people with Suicidal Thoughts and Behaviors (STBs) to get professional help.
- Trial name
- TREASURE (NCT06370104)
- Testing
- Brief Cognitive Behavioral Therapy for Suicide Prevention, Living under control
- Where
- Netherlands
- Volunteers
- 364 people
- Sponsor
- 113 Suicide Prevention
Diabetic Macular Edema, Macular Edema, Cystoid
Effect of Intravitreal Long Acting Dexamethasone Implant, Ozurdex in Patients With Diabetic Macular Edema
This study is undertaken to determine the effect of intravitreal long acting dexamethasone implant,(Ozurdex®)in patients with diabetic macular edema.Diabetic macular edema is important cause of visual impairment in patients with…
- Conditions
- Diabetic Macular Edema, Macular Edema, Cystoid, Vision Disorders, Clinically Significant Macular Edema
- Trial name
- NCT01698749
- Testing
- long acting intravitreal dexamethasone implant
- Where
- India
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Vision, Low, Mobility Limitation
Evaluating Stairway Designs for Individuals With Vision Impairment
The goal of this study is to learn if contrast frequency on step tread-edges influences foot clearance measures, a marker of fall risk, in older adults with and without visual impairments.
- Trial name
- NCT07337317
- Testing
- Frequency of contrast marking on stair steps
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- The University of Alabama in Huntsville
Gait Disorders, Neurologic, Gait Disorders in Old Age
ExerG: Video Game-based Physical Cognitive Training for Patients: a Usability Study
Video game-based training programs, in the following referred to as "exergames" are an innovative digital training approach to simultaneously train physical and cognitive functions and increase training motivation for various…
- Conditions
- Gait Disorders, Neurologic, Gait Disorders in Old Age, Gait Disorder, Sensorimotor, Balance; Distorted
- Trial name
- ExerGetic (NCT05967078)
- Testing
- ExerG
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Frank Behrendt
Leukodystrophy, White Matter Disease
LeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for Leukodystrophies
Leukodystrophies, and other heritable disorders of the white matter of the brain, were previously resistant to genetic characterization, largely due to the extreme genetic heterogeneity of molecular causes.
- Conditions
- Leukodystrophy, White Matter Disease, 4H Syndrome, Adrenoleukodystrophy
- Trial name
- NCT02699190
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Children's Hospital of Philadelphia
Neovascular Age-related Macular Degeneration
Study of Innovative Multimodal Imaging Biomarkers to Predict Anatomical Outcome in Naive Patients With wAMD Treated With Brolucizumab.
The purpose of this study was to identify innovative early imaging parameters as predictors of the long-term clinical response to brolucizumab in terms of fluid resolution in patients with wet Age-related Macular Degeneration…
- Trial name
- IMAGINE (NCT04774926)
- Testing
- Brolucizumab
- Where
- 20 sites in Italy
- Volunteers
- 122 people
- Sponsor
- Novartis Pharmaceuticals
Eye Diseases Hereditary, Retinal Disease
Inherited Retinal Degenerative Disease Registry
The My Retina Tracker® Registry is sponsored by the Foundation Fighting Blindness and is for people affected by one of the rare inherited retinal degenerative diseases studied by the Foundation.
- Conditions
- Eye Diseases Hereditary, Retinal Disease, Achromatopsia, Bardet-Biedl Syndrome
- Trial name
- MRTR (NCT02435940)
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Foundation Fighting Blindness
Wet Age-related Macular Degeneration, Neovascular Age-related Macular Degeneration
ADVM-022 Intravitreal Gene Therapy for Wet AMD
ADVM-022 (AAV.7m8-aflibercept) is a gene therapy product developed for the treatment of neovascular (wet) age-related macular degeneration (wet AMD).
- Trial name
- OPTIC (NCT03748784)
- Testing
- ADVM-022
- Where
- 11 sites in United States
- Volunteers
- 30 people
- Sponsor
- Adverum Biotechnologies, Inc.
Loss of Visual Contrast Sensitivity, Near Vision
Visual Performance Following Implantation of Presbyopia Correcting IOLs
The purpose of the current study was to compare the visual performance after bilateral implantation of the Panoptix IOL , or the AT LISA IOL or Tecnis Symfony IOL .
- Conditions
- Loss of Visual Contrast Sensitivity, Near Vision, Visual Impairment
- Trial name
- NCT04907955
- Testing
- phacoemulsification with implantation of presbyopia correcting IOL
- Where
- Kuwait
- Volunteers
- 50 people
- Sponsor
- Dar Al Shifa Hospital
Sjogren-Larsson Syndrome
ADX-629 Therapy for Sjogren-Larsson Syndrome
This research study will determine whether orally administered ADX-629 is safe and has biochemical efficacy in participants with Sjögren-Larsson syndrome (SLS), a rare inherited disorder of fatty aldehyde metabolism The disease…
- Trial name
- NCT05443685
- Testing
- ADX-629
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Nebraska
Progressive Supranuclear Palsy
A 6 Month, Open-Label, Pilot Futility Clinical Trial of Oral Salsalate for Progressive Supranuclear Palsy
This is a multi-center, open label, pilot futility clinical trial of the safety, tolerability, pharmacodynamics and preliminary efficacy of oral salsalate in up to 10 patients with PSP.
- Trial name
- NCT02422485
- Testing
- Salsalate
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Adam Boxer
Pituitary Adenoma, Visual Impairment
Clinical Study of Structural and Functional Evaluation of the Visual Pathway
Sellar area tumors such as pituitary adenoma, craniopharyngioma and meningioma, etc, commonly lead to visual impairment symptoms.
- Conditions
- Pituitary Adenoma, Visual Impairment, Sellar Tumor, Neuroimaging
- Trial name
- NCT03591315
- Testing
- resting state fMRI, visual tasking state fMRI, diffusion tensor imaging
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Parkinson Disease, Multiple System Atrophy
Diagnostic and Prognostic Biomarkers in Parkinson Disease
The overall goal of PROBE is to evaluate the feasibility and potential utility of three markers (alpha-synuclein, transcriptomic profiles and olfactory function) to determine the risk or prognosis of PD.
- Conditions
- Parkinson Disease, Multiple System Atrophy, Progressive Supranuclear Palsy
- Trial name
- PROBE (NCT00653783)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Parkinson Study Group
Vertigo, Unsteadiness
Accuracy of a Diagnostic Algorithm for the Differential Diagnosis of Vertigo in the ED: the STANDING.
This study evaluate the diagnostic accuracy of a simplified clinical algorithm (STANDING) for the differential diagnosis of acute vertigo in the emergency department.
- Trial name
- STANDING (NCT02782962)
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Progressive Supranuclear Palsy, PSP
AMX0035 and Progressive Supranuclear Palsy
A35-009 (ORION) is a Phase 2b/3 trial to evaluate the efficacy and safety of AMX0035 in participants with Progressive Supranuclear Palsy (PSP), consisting of randomized, double blind placebo controlled phases, followed by an…
- Conditions
- Progressive Supranuclear Palsy, PSP, Neurodegenerative Diseases, Atypical Parkinsonism
- Trial name
- ORION (NCT06122662)
- Testing
- AMX0035
- Where
- 62 sites in United States, France and 3 more
- Volunteers
- 139 people
- Sponsor
- Amylyx Pharmaceuticals Inc.
Visual Impairment
Virtual Assistance for Daily Living: Neurophysiological and Functional Effects in Low Vision
This study aims to investigate how visual impairment affects neurophysiological and biomechanical responses during real-world navigation and daily activities, with a focus on the rehabilitative feasibility and impact of assistive…
- Trial name
- NCT07442461
- Testing
- VIS4ION Platform
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
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