Clinical trials: Eye Manifestations
Antiphospholipid Syndrome (APS), Bullous Pemphigoid (BP)
Phase 1b Long-term Extension Trial of RAY121 in Immunological Diseases (RAINBOW-LTE Trial)
This is a long-term extension trial of RAY121 in patients with immunological diseases such as antiphospholipid syndrome (APS), bullous pemphigoid (BP), Behçet's Syndrome (BS), dermatomyositis (DM), immune-mediated necrotizing…
- Conditions
- Antiphospholipid Syndrome (APS), Bullous Pemphigoid (BP), Behçet's Syndrome (BS), Dermatomyositis (DM)
- Trial name
- NCT06723106
- Testing
- RAY121
- Where
- 62 sites in Australia, Austria and 17 more
- Volunteers
- 144 people
- Sponsor
- Chugai Pharmaceutical
Smith-Lemli-Opitz Syndrome, Cone-Rod Dystrophy
Cholesterol and Antioxidant Treatment in Patients With Smith-Lemli-Opitz Syndrome (SLOS)
Patients with biochemically confirmed SLOS are being treated with cholesterol supplementation and antioxidant medication. They are carefully monitored with visits to clinic, laboratory testing including cholesterol and…
- Conditions
- Smith-Lemli-Opitz Syndrome, Cone-Rod Dystrophy, Hearing Loss
- Trial name
- NCT01773278
- Testing
- Antioxidants, Cholesterol
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Corticobasal Syndrome(CBS), Primary Progressive Aphasia(PPA)
Neuroinflammation in FTLD
The goal of this observational study is to investigate the role of neuroinflammation in frontotemporal lobar degeneration (FTLD). The main aims of this study are: 1.
- Conditions
- Corticobasal Syndrome(CBS), Primary Progressive Aphasia(PPA), Progressive Supranuclear Palsy(PSP), Behavioral Variant Frontotemporal Dementia (bvFTD)
- Trial name
- NCT06870838
- Testing
- 7T MRI scan, CSF, Blood withdrawal
- Where
- 2 sites in Netherlands
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Cataract, Cataract (Post-operative Cataract Surgery Follow-up)
Randomized Controlled Trial of the STEIN Protocol: A Neuroplastic Pain Education and Guided Breathing Intervention During Awake Cataract Surgery
This randomized controlled trial evaluates whether a standardized perioperative neuroplastic intervention: the STEIN Protocol (Strategies and Techniques for Enhancing Integration and Neuroplasticity), consisting of pain…
- Trial name
- SLin (NCT07715591)
- Testing
- Music and Guided Imagery, Control, Music Only
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of California, Los Angeles
Corneal Edema, Corneal Defect
Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Cataract Surgery
Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Cataract Surgery
- Conditions
- Corneal Edema, Corneal Defect, Anterior Chamber Inflammation, Ocular Pain
- Trial name
- NCT05626478
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, Prednisolone Acetate 1% Oph Susp, Prolensa 0.07% Ophthalmic Solution
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Nicole Fram M.D.
Obstructive Sleep Apnoea, Primary Open Angle Glaucoma
PAIR Study-PAP And IOP Relationship: Study 1
Lowering of the pressure in the eye (intraocular pressure, IOP) is the only proven treatment for Primary Open-angle Glaucoma (POAG).
- Trial name
- PAIR (NCT03127813)
- Testing
- Application of continuous positive airway pressure (CPAP)
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Papworth Hospital NHS Foundation Trust
Cataract, Anterior Chamber Inflammation
Iontophoretic Delivery of EGP-437 in Patients Who Have Undergone Cataract Surgery
Phase 2b trial evaluating the safety and efficacy of EGP-437, versus placebo using the EyeGate® II Drug Delivery System (EGDS) in patients having undergone cataract surgery with implantation of a monofocal posterior chamber…
- Conditions
- Cataract, Anterior Chamber Inflammation, Pain, Postoperative
- Trial name
- NCT03180255
- Testing
- Dexamethasone phosphate
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Eyegate Pharmaceuticals, Inc.
Cataract, Traffic Accident
Validation of Mesopic and Photopic Contrast Vision Tests With Respect to Nighttime Driving Ability
A) The main purposes of this study are (i) to develop a related virtual reality (VR) environment in order to judge the nighttime driving ability under mesopic and under glare conditions (ophthalmologically healthy subjects and…
- Conditions
- Cataract, Traffic Accident, Vision Disorders, Driving Impaired
- Trial name
- ContrastVal (NCT03169855)
- Testing
- Slit lamp (LOCS III Score)
- Where
- Germany
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Aalen University
Retinitis Pigmentosa, Usher Syndromes
Prospective Open Clinical and Genetic Study of Patients With Retinitis Pigmentosa
This study is aimed to characterize Russian population of Retinitis Pigmentosa
- Trial name
- RU-RP (NCT03901391)
- Testing
- Whole Exome Sequencing
- Where
- 2 sites in Russia
- Volunteers
- 130 people
- Sponsor
- Sensor Technology for Deafblind
Vestibular Schwannoma, Visual Impairment
Consequence of Unilateral Vestibular Loss on Visual Abilities
Unilateral vestibular lesions are frequent and disabling pathologies causing a set of oculomotor, postural and perceptual symptoms. These symptoms reduce over time according to a vestibular compensation.
- Conditions
- Vestibular Schwannoma, Visual Impairment, Vestibular Meniere Syndrome
- Trial name
- SVorthoptie (NCT03581331)
- Testing
- orthoptic balance
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Cortical Blindness, Stroke Ischemic
Mechanisms of Visual Restoration After Occipital Stroke
This project will collect brain imaging data to quantify the effects of early visual cortex damage and visual training interventions on the structure and function of the residual visual system.
- Conditions
- Cortical Blindness, Stroke Ischemic, Vision Loss Partial, Visual Fields Hemianopsia
- Trial name
- MOVROS (NCT07134777)
- Testing
- MRI
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Acute Stroke, Visual Field Loss
Fluoxetine for Visual Recovery After Ischemic Stroke
The purpose of this study is to determine whether fluoxetine, a selective serotonin reuptake inhibitor commonly used for depression, enhances visual recovery after an acute ischemic stroke.
- Trial name
- FLUORESCE (NCT02737930)
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Bogachan Sahin
Congenital Muscular Dystrophy With ITGA7 (Integrin Alpha-7) Deficiency, Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy and Abnormal Glycosylation of Dystroglycan With Severe Epilepsy)
Congenital Muscle Disease Study of Patient and Family Reported Medical Information
The Congenital Muscle Disease Patient and Proxy Reported Outcome Study (CMDPROS) is a longitudinal 10 year study to identify and trend care parameters, adverse events in the congenital muscle diseases using the Congenital Muscle…
- Conditions
- Congenital Muscular Dystrophy With ITGA7 (Integrin Alpha-7) Deficiency, Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy and Abnormal Glycosylation of Dystroglycan With Severe Epilepsy), Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy With Fatty Liver and Infantile-onset Cataract Caused by TRAPPC11 Mutations), Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy With Hypoglycosylation of Dystroglycan)
- Trial name
- CMDPROS (NCT01403402)
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- Cure CMD
Deafness
Word Learning in Deaf Children Using Eye-tracking and Behavioral Measures
Mutual exclusivity is a word learning constraint in which the learner assumes that a given word refers to only one category of objects.
- Trial name
- NCT05993832
- Testing
- input cue
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Boston University Charles River Campus
Postoperative Pain, Retinal Detachment
Postoperative Pain After Vitreoretinal Surgery
Postoperative pain (POP) is frequently underestimated in general and little data are available particularly for POP after vitreoretinal surgery (VRS).
- Trial name
- NCT03538847
- Testing
- Numerical rating scale
- Volunteers
- 800 people
- Sponsor
- University of Florence
Amblyopia
Patching for Lazy Eye: Trial to Evaluate Daily Patching Amounts
Amblyopia ('lazy eye') is the commonest visual disorder of childhood and is caused by an interruption to visual development. Occlusion of the better eye by patching is the mainstay of treatment, so forcing use, of the affected…
- Trial name
- NCT00274664
- Testing
- 6 hours occlusion by patching, 12 hours occlusion by patching
- Where
- 2 sites in United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- City, University of London
Idiopathic Intracranial Hypertension
Safety and Effectiveness of 11b-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) to Treat Idiopathic Intracranial Hypertension.
Assessing the safety and effectiveness of a 11-βhydroxysteroid dehydrogenase type 1 inhibitor (AZD4017), in a placebo controlled trial, in acute idiopathic intracranial hypertension (IIH) IIH is a condition of young, overweight…
- Trial name
- IIH:DT (NCT02017444)
- Testing
- AZD4017
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- University of Birmingham
Diabetes Mellitus, Diabetes Complications
Diabetes Complications and Hearing Loss
Observation study, shows the relation between diabetes, its neurological and optical complication and hearing loss, by asking participants questions about there age,BMI,job,the history of any cataract,diabetes retinopathy or…
- Conditions
- Diabetes Mellitus, Diabetes Complications, Hearing Loss
- Trial name
- NCT06190938
- Where
- Syria
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Syrian Private University
Dystonia
Neurophysiological Markers in Patients With Craniofacial Dystonia and Their Relatives
This study will use a technique called blink reflex to study and compare how the brain controls muscle movement in patients with craniofacial dystonia, their first-degree relatives, and healthy, normal volunteers.
- Trial name
- NCT00082615
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Chronic Neck Pain
Eye-cervical Re-education and Motor Control Training Program in Chronic Neck Pain
The study was conducted to determine the comparative effects of an eye-cervical re-education and motor control training program on pain, range of motion and functional disability in chronic neck pain
- Trial name
- NCT07438548
- Testing
- Eye-cervical Re-education Program, Motor Control Training Program, Standardized Physiotherapy Treatment
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- Riphah International University
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