Clinical trials: Eye Manifestations
Anisocoria
Anisocoria in the Intensive Care Unit (AICU Study)
This retrospective single-center cohort study aims to determine the prevalence of acute "new onset" pupillary abnormalities in adult intensive care unit patients, assess their clinical impact, identify the contexts leading to…
- Trial name
- NCT06964997
- Where
- Switzerland
- Volunteers
- 920 people
- Sponsor
- University Hospital, Basel, Switzerland
Macular Holes, Microperymetry
The Application of M-charts and Microperimetry for the Assessment of Visual Function in Patients After Vitrectomy Due to the Full Thickness Macular Hole.
To examine the relationship between morphological and functional results in eyes after vitrectomy due to the full thickness macular hole (FTMH).
- Conditions
- Macular Holes, Microperymetry, Vitrectomy, M-charts
- Trial name
- NCT03701542
- Testing
- Microperymetry, M-charts
- Volunteers
- 22 people
- Sponsor
- Medical University of Lublin
Keratitis
Tolerance to Light for Patients Suffering From Keratitis
In order to develop an innovative device to study infectious keratitis, we need to illuminate the cornea of patients suffering from an infectious keratitis with red or near-infrared light.
- Trial name
- EBLOUI (NCT03586505)
- Testing
- Light exposure
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Ocular Motility Disorder
Evaluation and Treatment of Pediatric Eye Diseases
This study offers evaluation and treatment for patients with pediatric eye diseases, particularly amblyopia and strabismus. The protocol is not designed to test new treatments; rather, patients will receive current standard of…
- Trial name
- NCT00006422
- Testing
- current standard of care treatments
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Eye Institute (NEI)
Visual Field Defect, Peripheral, Stroke
Improving Visual Field Deficits With Noninvasive Brain Stimulation
This is a randomized, pilot interventional study in participants with visual field deficit (VFD) caused by cortical lesion. Damage to the primary visual cortex (V1) causes a contra-lesional, homonymous loss of conscious vision…
- Conditions
- Visual Field Defect, Peripheral, Stroke, Visual Impairment, Hemianopsia
- Trial name
- NCT05085210
- Testing
- transcranial random noise stimulation (tRNS), Computer Based Visual Training, Virtual Reality Based Visual Training
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Beth Israel Deaconess Medical Center
Dry Eye Disease, Dry Eye
Neurological Dry Eye Study Stimulating Both Lacrimal and Vagus Nerves
This is a study on neurological dry eye disease, focusing on a patented over-the-counter supplement supporting tear production neurologically, including the lacrimal and vagus nerves.
- Trial name
- NCT06271005
- Testing
- NeuroTears
- Volunteers
- 75 people
- Sponsor
- Genetic Disease Investigators
Neurodegenerative Disorders
Development of IPS from Donated Somatic Cells of Patients with Neurological Diseases
Human fibroblasts and possibly other human somatic cells may be reprogrammed into induced pluripotent stem (iPS) cells by the forced expression of transcription factors (1-5).
- Trial name
- NCT00874783
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Hemianopia, Hemianopsia
Rehabilitating Visual Deficits Caused by Stroke
This research aims to understand the efficacy of a visual training task to improve visual loss after stroke, also known as hemianopia.
- Conditions
- Hemianopia, Hemianopsia, Quadrantanopia, Stroke Induced Vision Loss
- Trial name
- NCT04878861
- Testing
- Training in the blind field
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Oxford
Facial Paralysis, Bell Palsy
Artificial Eye Blinking Stimulation Following Paralysis of the Facial Nerve
Artificial eye blinking stimulation following damage to the facial nerve. Group 1 - Patients with a persistent unilateral facial paralysis (palsy) that underwent an operation for facial reanimation Group 2 - Patients with…
- Trial name
- Bioniceye (NCT04153916)
- Testing
- Neurotrigger eye blinking stimulator
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Neurotrigger Ltd
Macular Polypoidal Choroidal Vasculopathy (PCV)
Study Assessing the Efficacy and Safety of a Personalized Monotherapy Regimen of Brolucizumab in Patients With Symptomatic Macular Polypoidal Choroidal Vasculopathy
This study is a 60-week, two-arm, randomized, open-label, active-controlled, multi-center study in patients with Polypoidal choroidal vasculopathy (PCV) who have not previously received anti-Vascular endothelial growth factor…
- Trial name
- PROUD (NCT05666804)
- Testing
- Brolucizumab 6mg
- Where
- 15 sites in South Korea
- Volunteers
- 148 people
- Sponsor
- Novartis Pharmaceuticals
PSP - Progressive Supranuclear Palsy
Study Evaluating the Effect of Transcranial Direct Current Stimulation (tDCS) Targeting the Right Inferior Frontal Gyrus on Inhibitory Control in Patients With PSP
Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease with a prevalence estimated at 6 per 100,000 in France and a rapidly progressive course.
- Trial name
- TinPSP (NCT07818733)
- Testing
- tDCS, or transcranial direct current stimulation
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Nantes University Hospital
Diabetic Retinopathy
A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer Compared With Sham Treatment in Participants With Diabetic Retinopathy (DR)
This study will demonstrate that tarcocimab 5 mg is superior to sham treatment in participants with DR.
- Trial name
- GLOW2 (NCT06270836)
- Testing
- Tarcocimab
- Where
- 39 sites in United States, Puerto Rico
- Volunteers
- 255 people
- Sponsor
- Kodiak Sciences Inc
Strabismus
Comparison of Propofol 1mg/kg and Propofol 0.5mg/kg for Prevention of Emergence Agitation in Children Undergoing Strabismus Surgery During Sevoflurane Anesthesia
The occurrence of emergence agitation (EA) in pediatric patients who have received sevoflurane anesthesia is a common postoperative problem.
- Trial name
- NCT02152787
- Testing
- Injection of propofol 1.0mg/kg, propofol 0.5mg/kg, normal saline
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Yonsei University
Visual Impairment
Quality of Life in Italian Visually Impaired Patients
Clinical register of visual rehabilitation activity and observational study on the validation of the VA LV VFQ questionnaire in the Italian context
- Trial name
- SOPIITA (NCT05752214)
- Testing
- WEB Register
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Amore Filippo
NMO Spectrum Disorder, Spasticity, Muscle
A Phase IIb Study of Nabiximols for Spasticity Due to Neuromyelitis Optica Spectrum Disorders
The goal of this clinical trial is to evaluate the safety and efficacy of nabiximols, a cannabinoid spray, for the treatment of moderate to severe spasticity in adult patients with AQP4-IgG positive and antibody-negative NMOSD.
- Trial name
- SENS-NMO (NCT05974293)
- Testing
- Nabiximols
- Where
- United States
- Sponsor
- Michael, Levy M.D.,Ph.D.
Visual Impairment, Healthy
Touching the World With a Cane: Cognitive and Neural Processes
The use of tools is ubiquitous in our lives and allows us to expand the sensorimotor capacities of our body. Much research has been done on the subject in sighted people over the past decades.
- Trial name
- TOOL_TOUCH (NCT05199896)
- Testing
- Behavioral protocol, EEG protocol, fMRI protocol
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Keratoconus, Crosslinking
Riboflavin at 4ºC for the Management of Pain After Crosslinking for Keratoconus Patients
Background: The objective of corneal collagen crosslinking (CXL) is to increase the binding of intrafibrillary and interfibrillary covalent bonds to improve the mechanical stability of the cornea and thus to stop the progression…
- Trial name
- NCT03760770
- Testing
- corneal collagen crosslinking
- Where
- Mexico
- Volunteers
- 90 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Blindness, Blindness, Acquired
Advanced Spatiomotor Rehabilitation for Navigation in Blindness & Visual Impairment
One of the most challenging tasks for blind and visually impaired individuals is navigation through a complex environment. The goal of the present multidisciplinary study is to increase spatial-cognition abilities in people who…
- Conditions
- Blindness, Blindness, Acquired, Low Vision, Blindness, Complete
- Trial name
- NCT05377853
- Testing
- Cognitive-Kinesthetic Navigational Training
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Smith-Kettlewell Eye Research Institute
Erythema
Tegaderm vs. EyeGard for Eye Protection
This study compares TegadermTM and EyeGard® in general anesthesia.
- Trial name
- NCT03549429
- Testing
- Medical tapes: TegadermTM and EyeGard®
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Low Vision, Orientation
SmartHMD for Improved Mobility
The National Eye Institute estimated about 3 million people over age 40 in the US had low vision in 2010 and projects an increase to nearly 5 million in 2030 and 9 million in 2050.
- Conditions
- Low Vision, Orientation, Mobility Limitation, Navigation, Spatial
- Trial name
- NCT03781583
- Testing
- SmartHMD version 1, SmartHMD version 2, SmartHMD version 3
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- James Weiland
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