Clinical trials: Eyelid Diseases
Sickle Cell Disease (SCD)
Self-administered Acupressure in Patients With Sickle Cell Disease
The proposed research is to determine the clinical efficacy and neurobiological mechanisms of acupressure analgesia in patients with sickle cell disease (SCD).
- Trial name
- NCT07875777
- Testing
- Verum Acupressure (using AcuWand)
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Cincinnati
Facial Paralysis, Sinkynesis
Eye Soft Surgery for Facial Sinkynesis
Facial synkinesis (FS) is a distressing sequela of facial palsy (FP) characterized by involuntary, simultaneous movements of facial muscles occurring during voluntary facial expressions.
- Trial name
- NCT06538103
- Testing
- Eye soft surgery, Physical Rehabilitation
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- University of Catania
Evaporative Dry Eye Disease
Effect of Thermal Pulsation System (Lipiflow) Treatment for Ocular Surface Disease Due to Meibomian Gland Dysfunction
Meibomian glands are a kind of sebaceous gland located in the tarsus of lower and upper lids and their function is to express lipids to the tear film.
- Trial name
- NCT03843983
- Testing
- Lipiflow® application
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Dry Eye, Evaporative Dry Eye Disease
Microbiome-Focused Food Supplement for Evaporative Dry Eye Due to Meibomian Gland Dysfunction
Dry eye disease (DED) is a common chronic condition characterized by ocular surface discomfort and tear film instability. Evaporative DED associated with meibomian gland dysfunction (MGD) is a frequent phenotype and is often…
- Conditions
- Dry Eye, Evaporative Dry Eye Disease, Meibomian Gland Dysfunction (Disorder)
- Trial name
- NCT07453212
- Testing
- Dietary Supplement: Microbiome-targeted oral supplement
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Varol TUNALI
Blepharospasm, Hemifacial Spasm
Testing the Effect of Zinc Supplementation to Improve the Treatment Effect of Botulinum Toxin for Oculofacial Spasm
The purpose of this study is to determine whether zinc supplements are effective in enhancing the treatment of oculofacial spasm disorders with botulinum toxin.
- Trial name
- NCT01546805
- Testing
- Zinc Supplement, Sugar pill
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Meibomian Gland Dysfunction
Study to Determine the Effect of Azasite on Corneal Surface Irregularity
The purpose of this study is to evaluate the effect of Azasite on patients with corneal surface irregularity (meibomian gland dysfunction).
- Trial name
- NCT01797107
- Testing
- Azasite
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Philadelphia Eye Associates
Lower Eyelid Steatoblepharon (Excess Eyelid Fat)
Phase 2 Study of XAF5 (XOPH5) Ointment for Reduction of Excess Eyelid Fat (Steatoblepharon)
This study will test whether XAF5 (XOPH5) ointment, applied once daily to the lower eyelids for 10 weeks, reduces the prominence of lower eyelid fat in adults with moderate to severe steatoblepharon (excess eyelid fat).
- Trial name
- NCT02230761
- Testing
- XOPH5 Ointment
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Topokine Therapeutics, Inc.
Down's Syndrome
Eyelash Line Resection for Entropion Associated With Down's Syndrome
Surgical outcome of entropion associated with Down's syndrome was evaluated. Grading scale of superficial punctate keratopathy and score of wearing glasses to correct refractive errors were measured.
- Trial name
- NCT01758718
- Testing
- Eyelash line resection
- Where
- Japan
- Volunteers
- 24 people
- Sponsor
- Kyorin University
Palpebral Pathologies, Ocular Surface Disease
Management of Eyelid Disorders by Ophthalmologists in Usual Medical Practice
The purpose of this study is to determine the incidence and characteristics of eyelid inflammatory disorders during general ophthalmological consultations and to demonstrate association between palpebral pathologies and ocular…
- Conditions
- Palpebral Pathologies, Ocular Surface Disease, Meibomian Gland Dysfunction
- Trial name
- MEIBUM (NCT01552174)
- Where
- 2 sites in Germany, Spain
- Volunteers
- 185 people
- Sponsor
- Laboratoires Thea
Dry Eye Syndromes
Estrogen and the Outer Eye in Women During Fertility Treatment
The purpose of this study is to determine the relation between estrogen and progesterone levels, and between dryness of the eyes, in women during their fertile years.
- Trial name
- NCT02072122
- Volunteers
- 30 people
- Sponsor
- Meir Medical Center
Meibomian Gland Dysfunction
Intraductal Meibomian Gland Probing Trial
In this research study, the investigators are looking at the effects of Meibomian Gland Probing (MGP) versus a sham (fake) procedure in patients with refractory MGD who have already tried traditional management with no success in…
- Trial name
- MGP (NCT02256969)
- Testing
- Blephamide, GenTeal PM Night-Time, Meibomian Gland Probing
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Joseph B. Ciolino, MD
Eyelid Diseases
Functional Changes After Upper Blepharoplasty
Upper blepharoplasty is a common eyelid procedure. It associated with visual, cosmetic and functional changes .Investigator will evaluate outcome of this procedure.
- Trial name
- NCT04201925
- Testing
- upper blepharoplasty
- Where
- United Arab Emirates
- Volunteers
- 50 people
- Sponsor
- Benha University
Entropion
Cicatricial Upper Eyelid Entropion Management
Suture-less technique will be used in treatment for cicatricial upper eyelid entropion to detect its long-term efficacy
- Trial name
- NCT05371626
- Testing
- Suture-less surgical procedure
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Minia University
Ocular Surface Disease
Analysis of Videodermatoscopic Parameters of Ocular, Periocular, Conjunctival and Palpebral Neoformations
ANALYSIS OF VIDEODERMATOSCOPIC PARAMETERS OF OCULAR, PERIOCULAR, CONJUNCTIVAL AND PALPEBRAL NEOFORMATIONS
- Trial name
- NCT06714799
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Dryness, Dry Eye Syndromes
Prevalence of Different Etiologies of Ocular Dryness in Patients Previously Diagnosed With Dry Eye Disease in A Sample of Egyptian Patients
Proposed Study Title: Prevalence of Different Etiologies of Ocular Dryness in Patients Previously Diagnosed with Dry Eye
- Conditions
- Dryness, Dry Eye Syndromes, Meibomian Gland Dysfunction
- Trial name
- NCT05598437
- Testing
- Dry eye device
- Where
- 2 sites in Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Roweis adel youssef
Blepharitis, Conjunctivitis
Safety/Efficacy of Antibiotic Steroid Combination in Treatment of Blepharitis and/or Keratitis and/or Conjunctivitis
Safety and efficacy of antibiotic steroid combination compared with individual administration in the treatment of bacterial ocular inflammation and infection (blepharitis and/or keratitis and/or conjunctivitis).
- Conditions
- Blepharitis, Conjunctivitis, Keratitis
- Trial name
- BRA-07-02 (NCT00732446)
- Testing
- Moxifloxacin and Dexamethasone combined, Moxifloxacin, Dexamethasone
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Federal University of São Paulo
Ptosis, Eyelid
Effect of Eyelid Patching After Ptosis Surgery
The goal of this randomized, controlled, observer-blinded study is to compare the effect of compression dressing after ptosis surgery.
- Trial name
- NCT05770973
- Testing
- Compression dressing (build by Kompressen, gauze swabs, Nobamed Paul Danz AG, Wetter, Germany and NOBALUMENAL® - steril, eye pad, Nobamed Paul Danz AG, Wetter, Germany
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Augenklinik LMU
Meibomian Gland Dysfunction, Demodex Infestation of Eyelid
Effect of an Exploratory Vehicle on Meibomian Gland Dysfunction in Patients With Demodex
The purpose of this study is to evaluate and compare the effect of two dosing regimens, BID versus TID dosing, of an Exploratory Vehicle (EV) on meibomian gland dysfunction (MGD) in patients with Demodex lid infestation.
- Conditions
- Meibomian Gland Dysfunction, Demodex Infestation of Eyelid, Blepharitis, Demodectic Blepharitis
- Trial name
- Rhea (NCT06054217)
- Testing
- Vehicle of TP-03
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Tarsus Pharmaceuticals, Inc.
Xanthelasma Palpebrarum
Topical 2% Simvastatin for Xanthelasma Palpebrarum
This study is evaluating whether a topical cream containing 2% simvastatin can improve xanthelasma palpebrarum, a common condition that causes yellow cholesterol deposits on the eyelids.
- Trial name
- STAT-LID (NCT07662785)
- Testing
- Topical Simvastatin 2% Cream, Vehicle cream
- Volunteers
- 30 people
- Sponsor
- Klira Skin
Ectropion
Hyaluronic Acid Gels for Lower Lid Retraction
Lid retraction is a difficult problem encountered in oculofacial plastic surgery. It can result from previous surgery, radiotherapy or cicatrizing disease or it may be idiopathic.
- Trial name
- NCT01838252
- Testing
- Hyaluronic acid, Saline
- Where
- United States
- Sponsor
- University of California, Los Angeles