Clinical trials: Eyes Dry Chronic
Dry Eye, Dry Eye Syndromes
Effect of Lifitegrast 5% on Tear Film Markers
The purpose of this study is to assess the duration of time (in weeks) for improvement in objective dry eye markers for people who are placed on lifitegrast 0.5% (Xiidra®), an FDA-approved therapy for dry eyes.
- Conditions
- Dry Eye, Dry Eye Syndromes, Dry Eyes Chronic
- Trial name
- NCT03952481
- Testing
- Lifitegrast 5% Ophthalmic Solution
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Dry Eye
Effect of UMSCs Derived Exosomes on Dry Eye in Patients With cGVHD
The purpose of this study is to determine whether Umbilical Mesenchymal Stem Cells (UMSCs) derived Exosomes could alleviate dry eye symptoms in patients with chronic Graft Versus Host Diseases (cGVHD).
- Trial name
- NCT04213248
- Testing
- Umbilical Mesenchymal Stem Cells derived Exosomes
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Dry Eye, Neuropathic Pain
Effect of Trigeminal Nerve Stimulation on Corneal Nerves and Chronic Ocular Pain
Individuals with dry eye tend to present with ocular pain which persists despite the use of topical treatment. This could be secondary to somatosensory impairment attributable to neuropathic pain.
- Conditions
- Dry Eye, Neuropathic Pain, Eye Pain
- Trial name
- NCT04648085
- Testing
- Trigeminal Nerve Stimulation
- Where
- Mexico
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Dry Eye, Eye Diseases
Impact of TRYPTYR on a Patient's Quality of Life and Ability to Perform Work
This 1-month, 3-visit study will be conducted at the Southern College of Optometry (Memphis, TN), Kannarr Eye Care, LLC (Pittsburg, KS) and Complete Eye Care of Medina (Minneapolis, MN).
- Conditions
- Dry Eye, Eye Diseases, Eyes Dry Chronic
- Trial name
- TRYPTYR ADL (NCT07266948)
- Testing
- Acoltremon
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Southern College of Optometry
Dry Eye
Clinical Efficacy of Topical Hydrocortisone 0.335% (Softacort®) in Patients With Chronic Dry Eye Disease and Associated Ocular Surface Inflammation
Dry eye disease (DED) is a highly prevalent ocular condition and induces a significant burden to the affected patients. Regardless of the underlying etiology, DED is associated with increased inflammation of the entire ocular…
- Trial name
- NCT03907865
- Testing
- Softacort
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna
Chronic Ocular Pain
Study of Efficacy and Safety of SAF312 Eye Drops in Subjects With Post-operative Corneal Induced Chronic Pain (CICP)
The study was designed to demonstrate the safety and efficacy of two dose concentrations of SAF312 eye drops (5 mg/mL and 15 mg/mL) in subjects with CICP persisting at least for 4 months after refractive or cataract surgery and…
- Trial name
- NCT04630158
- Testing
- SAF312
- Where
- 28 sites in United States, Japan and 1 more
- Volunteers
- 153 people
- Sponsor
- Novartis Pharmaceuticals
Age-Related (Dry) Macular Degeneration
Ocular Proteomics Testing In Chronic Atrophy
Study to evaluate the safety of routine diagnostic anterior chamber paracentesis (ACP) for proteomic profiling in patients with geographic atrophy (GA)
- Trial name
- OPTICA (NCT07298291)
- Testing
- AC Tap (anterior chamber paracenthesis)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- ClinOmicsAI
SCAD, Addison Disease
Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity
This case control study aims to determine whether spontaneous coronary artery dissection (SCAD) is associated with autoimmune diseases and to update the incidence of SCAD in a population-based cohort.
- Conditions
- SCAD, Addison Disease, Ankylosing Spondylitis, Antiphospholipid Antibody Syndrome
- Trial name
- NCT03941184
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Mayo Clinic
GVHD, Ocular Rosacea
IPL and Meibomian Gland Expression to Treat Ocular Rosacea Ocular GVHD
The purpose of this study was to see if Intense Pulsed Light (IPL) can be used safely and effectively to help treat dry eyes from ocular rosacea after chronic graft-versus-host disease (GVHD).
- Conditions
- GVHD, Ocular Rosacea, Dry Eye Syndrome
- Trial name
- NCT02066051
- Testing
- IPL, Meibomian Gland Expression
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Dry Eye
Clinical Characteristics of Patients Developing Chronic Dry Eye After Refractive Surgery
In recent years, many scholars have studied the ocular surface damage of patients with dry eye disease（DED）after FS-LASIK, but there has been a lack of comprehensive observation and research on the relationship and difference…
- Trial name
- NCT05600985
- Testing
- FS-LASIK
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Ocular Graft-versus-host Disease
Allogeneic Platelet Lysate Eye Drops for the Treatment of Severe Chronic Ocular Graft-versus-host Disease
The study evaluates the efficacy and safety of allogeneic platelet lysate eye drops in patients with severe ocular graft versus host disease refractory to conventional systemic and local treatments.
- Trial name
- NCT05311514
- Testing
- Allogeneic platelet lysate eye drops
- Where
- Russia
- Volunteers
- 38 people
- Sponsor
- St. Petersburg State Pavlov Medical University
Dry Eye Disease, Dry Eye
Phase III Study of Topical Fibrinogen-Depleted Human Platelet Lysate Compared to Placebo for Moderate to Severe Dry Eye
Prospective, multicenter, randomized, vehicle-controlled, double-masked, study of CAM-101 topical ophthalmic solution compared to vehicle control followed by crossover to long-term follow-up open-label treatment with CAM-101 for…
- Conditions
- Dry Eye Disease, Dry Eye, Dry Eyes Chronic, Dry Eye Syndromes
- Trial name
- CAMOMILE-2 (NCT06903611)
- Testing
- CAM-101, Vehicle Control
- Volunteers
- 475 people, healthy volunteers welcome
- Sponsor
- Cambium Bio Limited
Inflammatory Disorder of Immune System, Spondylitis, Ankylosing
Effects of Phytocannabinoids on Immune Response and Autophagy During Chronic Immune-mediated Inflammatory Diseases
Cannabis, in addition to its psychotropic properties, could have anti-inflammatory and immunomodulatory effects. Phytocannabinoids (pCBs) are a group of molecules naturally secreted by the cannabis plant.
- Conditions
- Inflammatory Disorder of Immune System, Spondylitis, Ankylosing, Arthritis, Rheumatoid, Arthritis, Psoriatic
- Trial name
- pCB-IMIDs (NCT06842316)
- Testing
- 1 blood sample, 40 mL (collection during a blood test, part of the standard of care for this disease)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Graft Versus Host Disease in Eye
Evaluation of 0.05% CsA and 0.1% FK506 Eye Drops in Ocular GVHD Treatment
It is planned to explore the efficacy and safety of local 0.05% cyclosporine eye drops in the treatment of chronic graft-versus-host eye disease.
- Trial name
- NCT05294666
- Testing
- Cyclosporine, tacrolimus
- Where
- China
- Volunteers
- 89 people
- Sponsor
- Peking University Third Hospital
Meibomian Gland Dysfunction, Eyes Dry Chronic
iLux Treatment for Meibomian Gland Dysfunction
Summary: Purpose: To compare the safety and efficacy of eyelid treatment with the ILux®-MGD Treatment System in one session versus five sessions of mechanical meibomian gland expression (MMGE) in patients with moderate to severe…
- Trial name
- MGD (NCT06278584)
- Testing
- iLUX Treatment System
- Where
- Colombia
- Volunteers
- 130 people
- Sponsor
- Clínica de Oftalmología de Cali S.A
Dry Eyes Chronic
Clinical Efficacy of Amniotic Membrane Extract Eye Drops in Dry Eye Treatment
This prospective longitudinal study aims at evaluating the clinical efficacy of human amniotic fluid extract eye drops in the treatment of dry eye disease.
- Trial name
- NCT05169931
- Testing
- RegenerEyes
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Autoimmune Diseases, Lupus Erythematosus, Systemic
Comparative Autoantibody and Immunologic Cell Marker Study
The purpose of this study is to compare immune phenotype, function, and specificity of B lymphocytes from different developmental stages in autoimmune patients to B cells from infectious disease patients and healthy controls.
- Conditions
- Autoimmune Diseases, Lupus Erythematosus, Systemic, Communicable Diseases
- Trial name
- NCT02422875
- Where
- 3 sites in United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Emory University
Dry Eye Disease
Exploratory Study Comparing Signs and Symptoms in Patients With Ocular Hypertension or Glaucoma Using Xalatan R® or Travatan Z®
The purpose of this study is to determine if there is a difference in the ocular signs and symptoms of subjects' eyes using Xalatan® 0.005% versus Travatan Z® 0.004% based on the outcome of subject assessment and clinical…
- Trial name
- NCT00799682
- Testing
- Xalatan, Travatan Z
- Where
- 5 sites in United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Ophthalmic Consultants of Long Island
Sjogren's Syndrome, Interstitial Lung Disease
Sjogren's Lung Study
Lung involvement in Sjögren's syndrome is common and causes reduced quality of life and increased mortality. Sjögren's syndrome-related lung diseases (SS-RLD) are classified and treated as the primary lung diseases they resemble.
- Conditions
- Sjogren's Syndrome, Interstitial Lung Disease, Primary Pulmonary Lymphoma (Disorder), Chronic Bronchiolitis
- Trial name
- NCT04843345
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Stanford University
Rheumatic Diseases, Adult Onset Still Disease
Rheumatology Patient Registry and Biorepository
To facilitate clinical, basic science, and translational research projects involving the study of rheumatic diseases.
- Conditions
- Rheumatic Diseases, Adult Onset Still Disease, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- NCT04402086
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Yale University