Clinical trials: FEV1
Cystic Fibrosis
Host and Bacterial Mechanisms During Cystic Fibrosis Pulmonary Exacerbations
Cystic fibrosis pulmonary exacerbations (CF PEx) vary greatly in their severity, their pathogens, and their treatment responses.
- Trial name
- NCT04354038
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- National Jewish Health
Chronic Obstructive Pulmonary Disease (COPD)
Effect on Structural Changes in Airways, Measured by MSCT, of Twice Daily 60mg AZD9668 for 12 Weeks in Chronic Obstructive Pulmonary Disease (COPD) Patients
The primary objective of the study is to evaluate structural changes effected by AD9668 in the airways of adults with Chronic Obstructive Pulmonary Disease (COPD) by Multi-Slice Computed Tomography (MSCT)
- Trial name
- NCT01054170
- Testing
- AZD9668
- Where
- 9 sites in Canada, Denmark and 3 more
- Volunteers
- 52 people
- Sponsor
- AstraZeneca
Cardiac Disease
Dysphagia and VFMI in Cardiac Patients
The proposed study seeks to determine the incidence of dysphagia and vocal fold mobility impairment (VFMI) in individuals undergoing cardiothoracic surgical procedures.
- Trial name
- NCT03768739
- Testing
- Fiberoptic Endoscopic Evaluation of Swallowing
- Where
- 3 sites in United States
- Volunteers
- 207 people
- Sponsor
- University of Florida
Postpartum Fever, Ileus
Comparison of Extraperitoneal and Intraperitoneal Cesarean Technique
Cesarean section will performed via intraperitoneally and extraperitoneally. During postoperative period pain, need for analgesia, respiratory function tests, ileus, bowel movement, discharged time will be compared.
- Conditions
- Postpartum Fever, Ileus, Hemorrhage, Pain
- Trial name
- NCT02760290
- Testing
- Extraperitoneal cesarean section, Intraperitoneal cesarean section
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Effects of a 4-week Acu-Transcutaneous Electrical Nerve Stimulation (Acu-TENS) Program on Subjects With Stable Chronic Obstructive Pulmonary Disease (COPD)
The objectives of this study are to investigate the effectiveness of Acu-TENS (transcutaneous electrical nerve stimulation applied on acupoints) on lung functions and quality of life and to explore the associated underlying…
- Trial name
- NCT00971490
- Testing
- Acu-TENS (Transcutaneous electrical nerve stimulation)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The Hong Kong Polytechnic University
Obesity, Bariatric Surgery
Comparison of Epidural and Intravenous Analgesia in Laparoscopic Sleeve Gastrectomy Patients
This retrospective observational study aimed to compare the effects of epidural analgesia and intravenous analgesia on early postoperative pulmonary function in patients undergoing laparoscopic sleeve gastrectomy.
- Conditions
- Obesity, Bariatric Surgery, Laparoscopic Sleeve Gastrectomy
- Trial name
- EAvs IV in LSG (NCT07712224)
- Testing
- Epidural analgesia (0.125% bupivacaine/2mcg fentanyl solution), Intravenous analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people
- Sponsor
- Trabzon Kanuni Education and Research Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Efficacy and Safety of Twice Daily 60mg AZD9668 in COPD for 12 Weeks in Patients on Background Budesonide/Formoterol
The primary objective is to evaluate the efficacy of AZD9668 compared with placebo in symptomatic COPD patients by assessing the effects on lung function and symptoms of COPD
- Trial name
- NCT01023516
- Testing
- AZD9668
- Where
- 66 sites in Bulgaria, Czechia and 4 more
- Volunteers
- 615 people
- Sponsor
- AstraZeneca
COPD, Exposure Occupational
Characterization of Professional COPD Related to Exposure to Organic Dust - Mean Follow up at 6 Years
The main objective of the BALISTIC research program is to characterize COPD related to organic particles (of which the model is agricultural COPD) in comparison with tobacco-related COPD, at the clinical, functional (at rest and…
- Trial name
- BALISTIC 2 (NCT03468101)
- Testing
- Pulmonary Function Testing
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Pain
The cryoICE™ CryoAnalgesia Study For Pain Management in Post thoRacic Procedures Via intercOSTal Cryoanalgesia (FROST)
The investigators propose to assess whether intra-operative intercostal cryoanalgesia using the cryoICE® probe (AtriCure®, Inc., 7555 Innovation Way, Mason, Ohio) provides superior post-operative analgesic efficacy as compared to…
- Trial name
- FROST (NCT02922153)
- Testing
- Cryoanalgesia, Standard of Care
- Where
- 5 sites in United States
- Volunteers
- 84 people
- Sponsor
- AtriCure, Inc.
COPD, FEV1
Predictive Value of Inflammatory Biomarkers and FEV1 for COPD
This is a multi-center, prospective, cohort study. A total of 10,000 people aged 40～75 without lung disease will be recruited and followed for 3 years.
- Trial name
- PIFCOPD (NCT03532893)
- Testing
- No intervention
- Where
- 10 sites in China
- Volunteers
- 10,385 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
COPD
Dose Ranging Study of RPL554 in Chronic Obstructive Pulmonary Disease (COPD) Patients
The study investigates the effect of 4 weeks of twice daily treatment of four different doses of RPL554 (a phosphodiesterase [PDE]3/4 inhibitor) or placebo in patients with moderate to severe chronic obstructive pulmonary disease…
- Trial name
- NCT03443414
- Testing
- RPL554 suspension
- Where
- 49 sites in Bulgaria, Czechia and 4 more
- Volunteers
- 405 people
- Sponsor
- Verona Pharma, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA
Dyspnea, Respiratory Rate
Evaluating the Effectiveness of Incentive Spirometry
Post-operative pulmonary complications (PPCs) have a major impact on patients and healthcare expenses. The goal of perioperative respiratory therapy is to improve airway clearance, increase lung volume, and mitigate atelectasis.
- Conditions
- Dyspnea, Respiratory Rate, Oxygen Saturation, Oxygen Requirements
- Trial name
- NCT02952027
- Testing
- Use-recording, patient-reminder alarm for incentive spirometry
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Lifespan
Asthma
Study to Investigate the Effect of PBF-680 on Forced Expiratory Volume in 1 Second (FEV1) in Asthmatic Patients
The present trial is an exploratory study aiming at evaluating the safety, tolerability, and efficacy of a 15-day, once daily administration of 10 mg PBF-680 in subjects with persistent, mild-to-moderate atopic asthma.
- Trial name
- ADENOASMA (NCT03774290)
- Testing
- PBF-680
- Where
- Spain
- Volunteers
- 107 people
- Sponsor
- Palobiofarma SL
Pediatric Asthma
Bronchoreversibility Test in Asthmatic Children and Correlation With Diagnostic Criteria Proposed by the GINA Guidelines
Since 2015, GINA (Global INitiative on Asthma) guidelines were modified and adapted to better fit the pediatric population. Asthma diagnosis is mainly based on the results of PFT (Pulmonary Function Tests) and…
- Trial name
- VERI-VEMS (NCT03814018)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Montpellier
Pulmonary Disease, Chronic Obstructive
Comparative Study of Umeclidinium/Vilanterol (UMEC/VI) in a Fixed Dose Combination With Indacaterol Plus Tiotropium
This is a Phase IIIb multicentre, randomised, blinded, triple dummy, parallel group study to evaluate the efficacy and safety of UMEC/VI inhalation powder (62.5/25 microgram [mcg] Once daily [QD]) when administered via ELLIPTA®…
- Trial name
- NCT02257385
- Testing
- UMEC/VI, Tiotropium, Indacaterol
- Where
- 84 sites in Argentina, Chile and 10 more
- Volunteers
- 967 people
- Sponsor
- GlaxoSmithKline
Pneumoperitoneum
Influence of Posture and Gas Insufflation on Perioperative Lung Function
Perioperative airway resistance and lung function are evaluated perioperatively in patients, who undergo surgical procedures in different postures and with or without gas insufflation into the peritoneal cavity.
- Trial name
- NCT00948571
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Kliniken Essen-Mitte
Chronic Obstructive Pulmonary Disease (COPD)
Multi-centre Study to Assess the Efficacy and Safety of AZD5423 in COPD Patients on a Background Therapy of Formoterol
The purpose of the study is to assess the efficacy and safety of two staggered dose levels of inhaled once daily AZD5423 or twice daily budesonide for 12 weeks in COPD patients on a background therapy of formoterol.
- Trial name
- NCT01555099
- Testing
- AZD5423, Budesonide
- Where
- 44 sites in Bulgaria, France and 6 more
- Volunteers
- 353 people
- Sponsor
- AstraZeneca
Osteoporotic Vertebral Compression Fractures, Lung Function
Osteoporotic Vertebral Compression Fractures: Can Kyphoplasty Improve Lung Function? A Prospective Evaluation
Patients with vertebral fractures often have problems to straighten and as a consequence of impaired lung ventilation that leads to a impaired lung function.
- Trial name
- NCT01609712
- Testing
- Radiofrequency Kyphoplasty
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bonn
Cystic Fibrosis
Mechanisms for Vascular Dysfunction and Exercise Tolerance in CF
Cystic fibrosis has many health consequences. A reduction in the ability to perform exercise in patients with CF is related to greater death rates, steeper decline in lung function, and more frequent lung infections.
- Trial name
- CF-AOX (NCT02690064)
- Testing
- Acute Antioxidant, Chronic Antioxidant
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Augusta University
Bronchial Hyperreactivity
Methacholine Challenge Testing: Comparison of FEV1 and IOS Parameters in Adult Asthma Patients
A classic methacholine challenge test is considered positive when forced expiratory volumen after one second (FEV1) decrease 20%.
- Trial name
- NCT06034145
- Testing
- No intervention
- Volunteers
- 500 people
- Sponsor
- Allergi- og Lungeklinikken, Elsinore