Clinical trials: Facial Deformity, open to volunteers
Facial Wrinkles, Jawline Contour
Evaluation of SofWave Sofware-Guided Energy Delivery for Lower Face and Neck Rejuvenation
Non-randomized single-arm prospective clinical study.
- Conditions
- Facial Wrinkles, Jawline Contour, Skin Laxity
- Trial name
- NCT07723664
- Testing
- SofWave
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sofwave Medical LTD
Facial Injuries, Traumatic Wounds and Injuries
Human Craniomaxillofacial Allotransplantation
Background: The human face is critically important for breathing, eating, seeing, and speaking/ communicating, but its most important job may be to look like a human face.
- Conditions
- Facial Injuries, Traumatic Wounds and Injuries, Craniofacial Injuries, Craniofacial Defects
- Trial name
- NCT01889381
- Testing
- Bone marrow cell-based therapy & 1-drug immunosuppression.
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Pain and Anxiety in Children With MIH
Preemptive Analgesia for Pain and Anxiety Control in Children With MIH
This randomized, triple-blinded clinical trial aims to evaluate the effect of preemptive analgesia using ibuprofen on pain perception and anxiety during restorative treatment of first permanent molars in children diagnosed with…
- Trial name
- NCT07374354
- Testing
- ibuprofen 100mg/ml oral suspension syrup
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- October University for Modern Sciences and Arts
Epidermolysis Bullosa Dystrophica, Epidermolysis Bullosa Dystrophica, Recessive
A Natural History Study of Corneal Abrasions in Patients With Dystrophic Epidermolysis Bullosa (DEB)
This study is a non-interventional, observational study that will evaluate the natural history of corneal abrasions in patients with Dystrophic Epidermolysis Bullosa (DEB).
- Conditions
- Epidermolysis Bullosa Dystrophica, Epidermolysis Bullosa Dystrophica, Recessive, Epidermolysis Bullosa Dystrophica Dominans
- Trial name
- NCT06563414
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Krystal Biotech, Inc.
Romberg Disease, Craniofacial Microsomia
Efficacy of Preconditioned Adipose-Derived Stem Cells in Fat Grafting
The aim of this study is to evaluate the comparison of therapeutic potential of curcumin preconditioned adipose derived stem cells (ASCs) enrichment fat grafting, naïve ASCs enrichment fat grafting and conventional fat grafting…
- Conditions
- Romberg Disease, Craniofacial Microsomia, Burn Scar, Post-Traumatic Scar (Disorder)
- Trial name
- NCT05610878
- Testing
- Cultured ASCs enrichment fat grafting, Curcumin-preconditioned ASCs enrichment fat grafting, Conventional fat grafting
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- University of the Punjab
Hemifacial Microsomia, Mucormycosis
Clinical Evaluation of Patient-Specific 3D-Printed Titanium Implants for Facial Reconstruction.
This clinical study aims to evaluate the effectiveness of patient-specific 3D-printed titanium facial implants in the reconstruction and aesthetic correction of facial defects.
- Conditions
- Hemifacial Microsomia, Mucormycosis, Oral Squamous Cell Carcinoma, Microgenia
- Trial name
- 3DFACE (NCT07654647)
- Testing
- Patient-specific titanium implants for facial reconstruction
- Where
- Syria
- Volunteers
- 30 people
- Sponsor
- Latakia University
Facial Asymmetry
Assessment of the Accuracy of Patient Specific Plates for Correction of Maxillary Cant in Facial Asymmetry
The goal of this clinical trial is to learn how accurate patient-specific plates (PSPs) are for correcting a tilted upper jaw (maxillary cant) in people with facial asymmetry.
- Trial name
- NCT07001826
- Testing
- Virtual Surgical Planning (VSP) with Patient-Specific Plates (PSPs)
- Where
- Egypt
- Volunteers
- 8 people
- Sponsor
- Cairo University
Molar Incisor Hypomineralization, Hypersensitivity
Intraosseous vs Infiltration Anesthesia in Molar-Incisor Hypomineralization (MIH) Children
This study aims to compare the effectiveness of intraosseous and infiltration anesthesia techniques administered using a computer-assisted anesthesia device (SleeperOne® 5; Dental HiTec, France) during restorative treatments of…
- Trial name
- MIH (NCT07352813)
- Testing
- Intraosseous anaesthesia using a computerized system, Infiltration anaesthesia using a computerized system
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Skin Laxity (Submental and Neck), Facial Skin Laxity
Safety and Effectiveness Evaluation of the High-intensity Focused Ultrasound Device for Lifting Lax Submental and Neck Tissue
This is a prospective, multicenter, randomized, evaluator-blinded, parallel-controlled, non-inferiority clinical study designed to evaluate the safety and effectiveness of the ULTRAFORMER MPT PLUS, a high-intensity focused…
- Conditions
- Skin Laxity (Submental and Neck), Facial Skin Laxity, Submental Tissue Laxity
- Trial name
- NCT07229430
- Testing
- ULTRAFORMER MPT PLUS, Ulthera System
- Where
- 5 sites in United States
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- CLASSYS Inc.
Charcot Marie Tooth Disease, DIFGAN
Genotype/Phenotype Correlation of MORC2 Mutations
The Microrchidia CW-type zinc finger 2 (MORC2) gene encodes a protein expressed in all tissues and enriched in the brain. It is involved in Charcot-Marie-Tooth disease, with mire than 30 families presenting MORC2 mutations.
- Conditions
- Charcot Marie Tooth Disease, DIFGAN, Developmental Delay (Disorder), Impaired Growth
- Trial name
- PhenoMORC2 (NCT07038239)
- Testing
- Skin biopsy, Blood sample
- Where
- 12 sites in France
- Volunteers
- 45 people
- Sponsor
- Hospices Civils de Lyon
Facial Aging, Skin Laxity
Quantified Evaluation of Noninvasive System Delivering Microwave Energy for Unwanted Fat Reduction and Skin Tightening in Asians.
The goal of this observational study is to evaluate the effectiveness and safety of microwave-assisted heating technology in facial fat reduction and skin tightening in Asians. The main questions it aims to answer are: 1.
- Conditions
- Facial Aging, Skin Laxity, Cheek Wrinkles
- Trial name
- NCT06925074
- Where
- Taiwan
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Chang Chang Cheng
Lymphatic Malformation, Pediatric
Efficacy of Rapamycin in the Treatment of Cervico-facial Lymphatic Malformations
To evaluate the efficacy of Rapamycin in extended cervicofacial lymphatic malformations in pediatric patients. Rapamycin is administered oral for a 6 month period.
- Trial name
- RAPAMALYMPH (NCT03243019)
- Testing
- rapamycin, MRI, Rapamycin dosage
- Where
- 2 sites in France
- Volunteers
- 28 people
- Sponsor
- University Hospital, Lille
Face Injuries, Hand Injuries
Craniomaxillofacial and Upper Extremity Allotransplantation
The purpose of this study is to evaluate functional and aesthetic outcomes of combined facial and upper extremity composite tissue allografts on patients who have not achieved functional and aesthetic outcomes with conventional…
- Conditions
- Face Injuries, Hand Injuries, Craniofacial Injuries, Upper Extremity Injuries
- Trial name
- NCT04057638
- Testing
- Combined Craniomaxillofacial and Upper Extremity Allotransplantation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- NYU Langone Health
Volume Deficiency in the Mid-Face, Skin Laxity
A Study to Characterize Human Skin Changes From Biostimulator Treatments Via Non-invasive Imaging
Adult subjects with moderate-to-severe cheek wrinkles will be treated with Sculptra for correction of fine lines and wrinkles in the cheek area.
- Conditions
- Volume Deficiency in the Mid-Face, Skin Laxity, Photo-aged Skin
- Trial name
- NCT07399028
- Testing
- Sculptra®
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Galderma R&D
Neonatal Complication, Neonatal Asphyxia
Face Mask vs Laryngeal Mask in Neonatal Resuscitation
The goal of this single-centre interventional study without medication neither device (for procedure) is to improve training of health care personnel (physicians, nurses, and midwives) on neonatal resuscitation through manikin…
- Trial name
- ManiMask2025 (NCT06952088)
- Testing
- Training on Neonatal Resuscitation
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Atopic Dermatitis
A Study of Lebrikizumab in Adults and Adolescents With Face and Neck Atopic Dermatitis
The main aim of the study is to evaluate the efficacy and safety of lebrikizumab treatment for up to 32 weeks in participants with moderate-to-severe face and neck atopic dermatitis (FNAD) who also have moderate-to-severe AD…
- Trial name
- ADface (NCT07873801)
- Testing
- Lebrikizumab
- Volunteers
- 230 people
- Sponsor
- Almirall, S.A.
Skin Laxity (Submental and Neck), Skin Lifting and Tightening
Safety and Efficacy of a 2,910 nm Fractional Ablative Fiber Laser (UltraClear®) for Improvements of Skin Laxity and Lifting of the Lower Face, Submental, and Neck Treatment Areas
This study evaluates the safety and effectiveness of the UltraClear® 2,910 nm fractional ablative fiber laser for improving skin laxity and tissue lifting in the lower face, submental, and neck areas.
- Trial name
- UC 29-2026 (NCT07759817)
- Testing
- 2910 nm fiber laser (UltraClear®)
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- FA Corporation
Wrinkle, Scar
Pre-marketing Trial to Assess Safety and Efficacy of 'Volumizing Filler Based on Hyaluronic Acid and Recombinant Collagen'
Study to validate the safety and efficacy of the Hyaluronic Acid +Collagen filler 40 patients will undergo through 3 visits one to asses the health and apply the filler one after 4 weeks to check the results one after 16 weeks…
- Conditions
- Wrinkle, Scar, Laxity; Skin
- Trial name
- NCT06336044
- Testing
- Karisma
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Taumedika s.r.l.
Hemophilia, Chronic Pain
Multimodal Telerehabilitation Versus Face-to-Face Care for Adults With Hemophilia and Chronic Pain
Hemophilia is an inherited bleeding disorder that is commonly associated with chronic joint pain, reduced physical function, and decreased quality of life.
- Trial name
- HEMO-TELE (NCT07682519)
- Testing
- other, Exercise
- Where
- Chile
- Volunteers
- 24 people
- Sponsor
- University of Chile
Obesity Prevention, Pediatric Obesity
Relationship Between Eating Patterns, Body Composition and the Detection of Fatty Liver in Children and Adolescents With Trisomy 21: LiverTy Project
Childhood obesity is a growing public health issue affecting millions of children worldwide, increasing the risk of metabolic and cardiovascular diseases in adulthood.
- Conditions
- Obesity Prevention, Pediatric Obesity, Trisomy 21, Down Syndrome (Trisomy 21)
- Trial name
- LiverTy (NCT06888570)
- Testing
- To evaluate fat liver content in the cases/controls population.
- Where
- Spain
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- IMDEA Food