Clinical trials: Facial Injuries and Disorders, open to volunteers
Bone Loss, Jaw, Edentulous
Effectiveness of 3D-printed Patient-specific Resorbable Scaffolds for Maxillary Bone Regeneration
The objective of this study is to test the bone formation capacity of a 3D printed scaffold with a plastic material called Polycaprolactone (PCL), compared to the use of synthetic bone grafts, for bone formation in the maxilla or…
- Conditions
- Bone Loss, Jaw, Edentulous, Edentulous Mouth, Jaw Fractures
- Trial name
- OSTEOPRINT (NCT06773923)
- Testing
- PCL Scaffold, PTFE + Bio-Oss®
- Where
- Chile
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universidad Austral de Chile
Facial Injuries, Traumatic Wounds and Injuries
Human Craniomaxillofacial Allotransplantation
Background: The human face is critically important for breathing, eating, seeing, and speaking/ communicating, but its most important job may be to look like a human face.
- Conditions
- Facial Injuries, Traumatic Wounds and Injuries, Craniofacial Injuries, Craniofacial Defects
- Trial name
- NCT01889381
- Testing
- Bone marrow cell-based therapy & 1-drug immunosuppression.
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Pain Management
Local Anesthesia for Facial Fractures
The study is a double-blind randomized, placebo controlled trial examining the impact of perioperative bupivacaine nerve block on PACU recovery metrics.
- Trial name
- LAFF (NCT06429501)
- Testing
- Bupivacaine/Epinephrine, Saline
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Washington University School of Medicine
Ocular Injury, Optic Nerve Diseases
A Phase I Feasibility Study of an Intracortical Visual Prosthesis (ICVP) for People With Blindness
The purpose of this study is to determine the feasibility of producing artificial vision in persons with blindness. Study participants will have wireless electrical stimulators implanted into the cortical vision processing areas…
- Conditions
- Ocular Injury, Optic Nerve Diseases, Photoreceptor Degeneration, Blindness,Acquired
- Trial name
- ICVP (NCT04634383)
- Testing
- WFMA - wireless floating microelectrode array
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Illinois Institute of Technology
Facial Fractures, Maxillofacial Injuries
Epidemiological and Statistical Study of Facial Traumatic Fractures at Assiut University Trauma Hospital
Facial traumatic fractures represent a significant global and regional health burden that can impair essential functions such as breathing, speaking, and chewing, while carrying substantial functional and psychological…
- Conditions
- Facial Fractures, Maxillofacial Injuries, Mandibular Fractures, Maxillary Fractures
- Trial name
- NCT07827209
- Volunteers
- 50 people
- Sponsor
- Assiut University
Epidermolysis Bullosa Dystrophica, Epidermolysis Bullosa Dystrophica, Recessive
A Natural History Study of Corneal Abrasions in Patients With Dystrophic Epidermolysis Bullosa (DEB)
This study is a non-interventional, observational study that will evaluate the natural history of corneal abrasions in patients with Dystrophic Epidermolysis Bullosa (DEB).
- Conditions
- Epidermolysis Bullosa Dystrophica, Epidermolysis Bullosa Dystrophica, Recessive, Epidermolysis Bullosa Dystrophica Dominans
- Trial name
- NCT06563414
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Krystal Biotech, Inc.
Corneal Scarring Fibrosis
Losartan for Corneal Fibrosis
This is a prospective, randomized, double-blinded, controlled clinical trial designed to evaluate the efficacy and safety of topical losartan in improving visual acuity, contrast sensitivity and reducing corneal densitometry…
- Trial name
- NCT07449000
- Testing
- Topical losartan
- Where
- Mexico
- Volunteers
- 46 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Mandibular Fractures, Maxillofacial Injuries
Virtual Surgical Planning and Preoperative Plate Bending for Maxillofacial Fractures
Purpose: Complex mandibular fractures are commonly associated with high-energy maxillofacial trauma and may result in disruption of mandibular continuity, facial deformity, malocclusion, and impaired mastication and speech.
- Conditions
- Mandibular Fractures, Maxillofacial Injuries, Fractures, Comminuted
- Trial name
- NCT07856589
- Testing
- Conventional Open Reduction and Internal Fixation With Intraoperative Plate Bending, Virtual Surgical Planning-Assisted Open Reduction and Internal Fixation With Preoperative Plate Bending
- Where
- Vietnam
- Volunteers
- 30 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Mandible Fracture
Accuracy of Computer Guided Screw Holes Locating Guide and Patient Specific Champy Plate vs Conventional Champy Plate Osteosynthesis in Management of Mandibular Angle Fracture: Randomized Controlled Trial
the aim of our study is to assess computer guided mandibular fracture reduction and to prove its lower rate of complications and higher accuracy of reduction compared to the conventional approach in management of mandibular angle…
- Trial name
- NCT06838377
- Testing
- standard Champy mini plate, computer guided screw holes locating guide and Patient Specific Champy plate
- Where
- 2 sites in Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Endocrine; Deficiency, Hypothalamo-Pituitary Disorder
Brain Irradiation for Childhood Cancer - Endocrine Monitoring During the First Years
BICHE- 1: Brain Irradiation for Childhood cancer - Endocrine monitoring during the first five years is a study of endocrine monitoring after cerebral radiotherapy.
- Conditions
- Endocrine; Deficiency, Hypothalamo-Pituitary Disorder, Radiotherapy Side Effect
- Trial name
- BIChE-1 (NCT06618703)
- Testing
- Blood sample, urine sample, osteodensitometry
- Where
- 3 sites in France
- Volunteers
- 230 people
- Sponsor
- University Hospital, Angers
Corneal Diseases, Corneal Scars and Opacities
Validation of the Use of Terahertz Scanning System on Corneal Scars and Corneal Edema
This observational study aims to validate the use of THz scanning system in corneal edema and corneal scars, and to investigate the accuracy and performance on the use of THz scanning system in the evaluation of the progression…
- Conditions
- Corneal Diseases, Corneal Scars and Opacities, Corneal Edema
- Trial name
- NCT06983652
- Testing
- THz scanning using THz Imaging system.
- Where
- Singapore
- Volunteers
- 150 people
- Sponsor
- Singapore Eye Research Institute
Mandible Fracture
z Mini-plate With Lingual Extension Versus Conventional 2 Mini Plates
The collected patients according to the eligibility criteria will be randomly distributed into one of these groups: Group I : 10 patients suffering class III mandibular fracture will be managed by patient specific Z shape…
- Trial name
- NCT06898710
- Testing
- z mini plate with lingual extension, conventional 2 mini plates
- Volunteers
- 20 people
- Sponsor
- Fayoum University
Orbital Fractures, Unilateral
Comparing Pre-adaptation of In-stock Mesh Over In-house 3D Patient Specific Model to Reconstruct Unilateral Primary Orbital Fracture With and Without Intraoperative Navigation vs Conventional Intraoperative Free-hand Mesh Bending
The investigators study the accuracy of repairing unilateral primary orbital fractures using a new technique, using 3D printed patient specific model to preoperative adapting of the readily available in sock titanium mesh, the…
- Conditions
- Orbital Fractures, Unilateral, Recent
- Trial name
- NCT07882121
- Testing
- 3D printed patient specific model, Conventional, Brainlab navigation system
- Where
- 2 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Face Injuries, Hand Injuries
Craniomaxillofacial and Upper Extremity Allotransplantation
The purpose of this study is to evaluate functional and aesthetic outcomes of combined facial and upper extremity composite tissue allografts on patients who have not achieved functional and aesthetic outcomes with conventional…
- Conditions
- Face Injuries, Hand Injuries, Craniofacial Injuries, Upper Extremity Injuries
- Trial name
- NCT04057638
- Testing
- Combined Craniomaxillofacial and Upper Extremity Allotransplantation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- NYU Langone Health
Mandibular Fractures
Erich Arch Bars, IMF Screws and Hybrid Arch Bars in the Management of Mandibular Fractures
Treatment options of mandibular fractures can be accomplished with either closed treatment or open reduction internal fixation (ORIF).
- Trial name
- Jaw Fractures (NCT07153120)
- Testing
- Erich Arch Bars, Hybrid Arch Bars, IMF Screws
- Where
- 2 sites in Egypt
- Volunteers
- 105 people
- Sponsor
- Mansoura University
Corneal Scar
Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Subjects With Corneal Scars
This study will enroll subjects with recently formed corneal scars that resulted from a corneal insult presenting and diagnosed within the past approximately 30 days and not less than approximately 7 days.
- Trial name
- NCT06257355
- Testing
- CSB-001 Ophthalmic Solution 0.1%
- Where
- 7 sites in United States
- Volunteers
- 20 people
- Sponsor
- Claris Biotherapeutics, Inc.
Orbital Fractures, Orbital Floor Fractures
A Trial to Evaluate Two Ectropion Preventive Measures Using the Subciliary Approach in Orbital Fracture Surgery.
The goal of this clinical trial is to investigate whether preventive surgical techniques can reduce the incidence of lower eyelid ectropion after the subciliary approach in adult patients undergoing surgery for orbital fractures.
- Trial name
- PREVENTECT (NCT07775417)
- Testing
- Subciliary Approach, Lateral Canthopexy, Orbicularis Oculi Suspension
- Volunteers
- 30 people
- Sponsor
- Minia University
Pain, Postoperative, Pain, Chronic
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).
- Conditions
- Pain, Postoperative, Pain, Chronic, Pain, Acute, Surgical Injury
- Trial name
- NCT04439552
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Mandibular Fractures
Optimized Osteosynthesis: Bone Mineral Density Recovery in Mandibular Body Fractures Using Patient-Specific Versus Conventional Plates
The goal of this randomized controlled clinical trial is to evaluate and compare the bone mineral density (BMD) recovery following open reduction and internal fixation (ORIF) of mandibular body fractures using patient-specific…
- Trial name
- NCT07904897
- Testing
- Open reduction and Internal fixation of a mandibular body fracture
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Cairo University
Postoperative Infections, Mandibular Nerve Injuries
Surgeons' Prediction of Dental Surgery Complications and the Influence of Patient Characteristics: Development of an AI Model
The goal of this observational study is to learn how to better predict and prevent intra- and postoperative complications in oral surgery in adult patients referred for oral surgical procedures.
- Conditions
- Postoperative Infections, Mandibular Nerve Injuries, Alveolar Osteitis, Complication
- Trial name
- NCT07461324
- Where
- 2 sites in Denmark
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen