Clinical trials: Facial Pain
Odontalgia, Toothache
CBD for Dental Pain
The purpose of this study is to evaulate CBD as a therapeutic approach for dental pain. Eligible subjects presented with emergency dental pain will be give a single dose of Epidiolex (FDA-approved CBD) or placebo and will be…
- Trial name
- NCT04642404
- Testing
- Epidiolex 100 mg/mL Oral Solution
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Facial Pain
Treatment of Sinus Headache Using a Novel Device That Combines Acoustic Vibration With Oscillating Expiratory Pressure
The purpose of this study is to investigate if the SinuSonic device decreases facial pain and pressure compared to the placebo device.
- Trial name
- NCT05479604
- Testing
- SinuSonic
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Mayo Clinic
Trigeminal Neuralgia
Efficacy of Guanfacine and Lidocaine Combination in Trigeminal Nerve Block for Pain Management in Trigeminal Neuropathy
A phenome-wide association study (PheWAS) identified an association between a loss of function variant in the human alpha 2B adrenergic receptor gene and trigeminal nerve disorders.
- Trial name
- NCT03865940
- Testing
- Lidocaine, Guanfacine
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Vanderbilt University Medical Center
Pain Disorders
Crossover, Single Dose Randomized, Bioequivalence of Ketoprofen Lysine Salt Immediate Release vs Oral Solution
Objectives: The objective of the study was to investigate the bioequivalence between two formulations containing ketoprofen lysine salt (KLS) when administered as single oral doses in two consecutive study periods to healthy male…
- Trial name
- NCT02350296
- Testing
- KSL 40 mg, OKi® 80 mg
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dompé Farmaceutici S.p.A
Dental Pain
Buffered Local Anesthetic
The purpose of this research study is to compare responses in children during dental injections of local anesthetic (used for numbing), while children are under deep sedation (breathing on their own, often with a loss of…
- Trial name
- NCT05757648
- Testing
- Non-buffered Anesthetic, Buffered Anesthetic, Onset
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Acute Pain
A Study to Assess Efficacy and Tolerability of Ketoprofen 40 mg Granules vs Placebo
Primary objective: To assess the efficacy of OKITASK® 40 mg granules versus Placebo in patients with acute pain syndrome after removal of one molar tooth by comparing AUC0-6h of posttreatment pain profile measured by VAS.
- Trial name
- KSL0117 (NCT03836807)
- Testing
- OKITASK®
- Where
- 3 sites in Russia
- Volunteers
- 70 people
- Sponsor
- Dompé Farmaceutici S.p.A
Pain
Efficacy of Steroid Supplementation After TMJ Rinsing for Pain Management
The hypothesis to be tested is temporomandibular joint (TMJ) rinsing followed by steroid injection is more efficacious than a placebo injection based on standard pain and physical measures that are recorded before and after…
- Trial name
- NCT01770912
- Testing
- Lactated Ringers, Triamcinolone hexacetonide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Florida
Acute Pain
Tramadol/Diclofenac Fixed-dose Combination Phase III Trial in Acute Pain After Third Molar Extraction
This study evaluated a new drug fixed-dose combination tablet (FDC) called tramadol/diclofenac at two different strengths (fixed doses of 25 milligrams [mg] of tramadol and of diclofenac or of 50 mg each).
- Trial name
- NCT03714672
- Testing
- Tramadol/Diclofenac 50/50, Tramadol/Diclofenac 25/25, Tramadol 50
- Where
- 8 sites in Mexico
- Volunteers
- 1,151 people
- Sponsor
- Grünenthal GmbH
Facial Neuropathy
Evaluation of Lamotrigine on Neuropathic Facial Pain Using fMRI
The aim of this project is to evaluate the effects of the anticonvulsant drug lamotrigine (trade name Lamictal) on neuropathic facial pain or neuralgia using functional magnetic resonance imaging (fMRI).
- Trial name
- NCT00243152
- Testing
- Lamotrigine
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Pain and Analgesia Imaging and Neuroscience Group
Chronic Sinusitis, Facial Pain Disorder
Sinusitis and Facial Pain Disorders Anti-Depression Trial
The study hypothesis is that the addition of an antidepressant to the standard treatment regimen in patients with both chronic sinusitis and depression or facial pain disorders and depression will decrease the report of chronic…
- Conditions
- Chronic Sinusitis, Facial Pain Disorder, Depression
- Trial name
- SFPAT (NCT00754793)
- Testing
- escitalopram
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Washington
Plantar Fascitis, Myofacial Pain Syndromes
A Comparative Study of Two Dry Needling Interventions for Plantar Heel Pain
This is a clinical trial that will be done in the state of Kuwait, at the physical rehabilitation medicine hospital. the participants will be recruited from all over Kuwait, there is a clinical registry upon the ethical committee…
- Conditions
- Plantar Fascitis, Myofacial Pain Syndromes, Trigger Point Pain, Myofascial
- Trial name
- NCT03236779
- Testing
- dry needling
- Where
- Kuwait
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
Face Pain
Efficacy of Botulinum Toxin Versus Lidocaine in Treating Masticatory Myofascial Face Pain Using Ultrasound and EMG Guided Techniques
Botulinum toxin-A (BTX-A) prevents the release of acetylcholine in presynaptic terminals of the neuromuscular junction. It has been proposed to be effective in spastic conditions of the head and neck including oromandibular…
- Trial name
- NCT00992108
- Testing
- lidocaine, chemodenervation
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Dental Pain
Study of Naproxen Capsules to Treat Dental Pain
The purpose of the study is to determine whether Naproxen Test Formulation Capsules are safe and effective for the treatment of dental pain.
- Trial name
- NCT01229228
- Testing
- Naproxen Test, Naprosyn
- Where
- United States
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Iroko Pharmaceuticals, LLC
Nasolabial Folds
Evaluate Efficacy, Safety & Subject Satisfaction of Pain Management With Pliaglis® Cream for Dermal Filler Injections
Pliaglis® Cream versus compounded topical anesthetic for pain management during Restylane® injections for the correction of nasolabial folds.
- Trial name
- NCT00716443
- Testing
- tetracaine 7% / lidocaine 7% cream (Pliaglis® Cream), benzocaine 20% / lidocaine 6% / tetracaine 4% ointment
- Where
- 4 sites in United States
- Volunteers
- 51 people
- Sponsor
- Galderma R&D
Irreversible Pulpitis (Toothache)
Effect of Buffered Numbing Solution on Patients With Toothaches
The purpose of this study is to determine the effect of buffered lidocaine (a numbing solution) on the ability to numb patients with toothaches.
- Trial name
- NCT01868776
- Testing
- buffered lidocaine, nonbuffered lidocaine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ohio State University
Trigeminal Neuralgia
Trial for Treatment Refractory Trigeminal Neuralgia
The purpose of this study is to evaluate the efficacy of BHV3000 compared to placebo for subjects with treatment refractory Trigeminal Neuralgia as measured by a 2-point or greater reduction in the average Numeric Pain Rating…
- Trial name
- NCT03941834
- Testing
- Rimegepant
- Where
- 20 sites in United States
- Volunteers
- 65 people
- Sponsor
- Pfizer
Post-operative Pain
Ibuprofen/Acetaminophen Versus Nurofen Plus® and Panadeine® Extra Dental Pain Study
The objective is to assess the efficacy and tolerability of a combination of 400 mg ibuprofen plus 1000 mg acetaminophen, 200 mg ibuprofen plus 500 mg acetaminophen compared with Nurofen Plus® and Panadeine® Extra.
- Trial name
- NCT01229449
- Testing
- Ibuprofen/acetaminophen, Ibuprofen/acetaminophen (higher dose), Nurofen Plus®
- Where
- United States
- Volunteers
- 678 people
- Sponsor
- Reckitt Benckiser LLC
Third Molar Extraction
Analgesic Effect of Peripheral Dexmedetomidine
Dexmedetomidine is an alpha 2-adrenoreceptor agonist, which provides sedation, analgesia and anxiolysis in clinical practice (Cortinez et al., 2004,Hall et al., 2000).
- Trial name
- NCT00971178
- Testing
- local dexmedetomidine, Peripheral normal saline, IV dexmedetomidine
- Volunteers
- 105 people
- Sponsor
- The University of Hong Kong
Dental Anxiety, Dental Pain
Nonpharmacologic Reduction of Periprocedural Distress and Drug Use
Objectives of this Phase I pilot trial are to provide data towards assessing and facilitating feasibility of a larger scale Phase II trial in which the effects of a calmative Comfort Talk® app can be unequivocally evaluated.
- Conditions
- Dental Anxiety, Dental Pain, Drug Use, Opioid Use
- Trial name
- NCT03328208
- Testing
- Comfort Talk® app, White Noise app
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- Hypnalgesics, LLC
Peripheral Nerve Facial Nerve Paralysis, Facial Nerve Diseases
Study of a New Technique to Improve the Symptoms of Orofacial Discomfort in Patients With Peripheral Facial Paralysis
The purpose of this study was to evaluate the effects of Neuro Occlusal Rehabilitation (RNO) in patients with peripheral facial palsy (PFP) disease, noting the decrease in symptoms of masticatory dysfunction.
- Conditions
- Peripheral Nerve Facial Nerve Paralysis, Facial Nerve Diseases, Orofacial Pain
- Trial name
- NCT01327157
- Testing
- occlusal adjustment., Visual analog scale.
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- Federal University of São Paulo