Clinical trials: Facial Skin Pigmentation
Melasma
Different Dermatological Approaches the Treatment of Melasma
To compare the efficacy and safety of cryopeeling (using Liquid Nitrogen) and tranexemic acid (cyclokapron) versus chemical peeling (using TCA 20%) in treatment of melasma.
- Trial name
- NCT03923062
- Testing
- chemicalpeeling, cryopeeling, microneedling
- Volunteers
- 40 people
- Sponsor
- Assiut University
Pigmentation Disorder
Fractional Laser as Treatment Option for Various Pigment Disorders (Fractional-3)
The purpose of this study is to determine whether the use of non-ablative fractional laser is safe and effective in the treatment of melasma.
- Trial name
- NCT01085279
- Testing
- Fraxel Restore, Solta Medical Inc. (Non-ablative fractional laser), Modified Kligman's formula (Triple topical therapy)
- Where
- Netherlands
- Volunteers
- 29 people
- Sponsor
- Netherlands Institute for Pigment Disorders
Effect of Drugs, Adverse Effects of Medical Drugs
Comparison of Efficacy of Tranexamic Acid Mesotherapy Versus 0.9% Normal Saline for Melasma
It is a randomized controlled trial in which investigators determine the efficacy of tranexamic acid (TA) by mesotherapy in comparison to normal saline on participants having Melasma.
- Trial name
- NCT04170088
- Testing
- Tranexamic Acid, 0.9% Normal Saline
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Jinnah Postgraduate Medical Centre
Obstructive Sleep Apnea, Vasovagal Syncope
Clinical Association Between Obstructive Sleep Apnea, Facial Pigmentation, and Vasovagal Symptoms.
The goal of this prospective cohort study is to study patients referred for sleep study by in-lab polysomnography in the Jordan University Hospital and the Jordan Hospital or with an at-home sleep study kit.
- Conditions
- Obstructive Sleep Apnea, Vasovagal Syncope, Smoking, Acanthosis Nigricans
- Trial name
- VasOSA (NCT06331819)
- Testing
- In-lab polysomnography, Continuous positive airway pressure, Home sleep study device
- Where
- Jordan
- Volunteers
- 200 people
- Sponsor
- Jordan Collaborating Cardiology Group
Melasma
Efficacy and Safety of Picosecond, Neodymium-doped Yttrium Aluminum Garnet Laser Therapy Using 1,064 nm and 595 nm
This is a prospective, multi-center, split-face, controlled clinical trial that aims to investigate the efficacy and safety of picosecond, neodymium-doped yttrium aluminum garnet laser laser therapy on patients with melasma…
- Trial name
- NCT03040089
- Testing
- PICO+4, Neoquine Cream 2%
- Volunteers
- 40 people
- Sponsor
- CynosureLutronic
Melasma, Melasma (Facial Melasma)
Oral Tranexamic Acid Plus Triple Combination vs Triple Combination Alone in Melasma
The data will be collected after the permission of the ethical committee of hospital. Following the enrollment, patients will be selected by lottery in the two equal groups.
- Trial name
- NCT07732192
- Testing
- Oral tranexamic acid + triple combination cream (fluocinolone acetonide + hydroquinone + tretinoin), Triple combination cream (fluocinolone acetonide + hydroquinone + tretinoin) alone
- Volunteers
- 128 people
- Sponsor
- Combined Military Hospital Abbottabad
Melasma
Fractional co2 Laser Followed by Either Vitamin c or Tranexamic Acid in Treatment of Melasma.
The aim of the study: 1.To compare the efficacy and safety of fractional CO2 laser in combination with vitamin c and tranexamic acid in the treatment of melasma.
- Trial name
- NCT05911698
- Testing
- Fractional co2 laser
- Volunteers
- 25 people
- Sponsor
- Khadija Qenawi
Rosacea, Acne
Clinical Evaluation and Study of the Efficacy of a Centella Asiatica-Infused Facial Mask on Discosmetic Dermatosis
The purpose of this study was to investigate the efficacy and safety of repairing facial mask containing Asiaticum asiatica in treating disjunctive skin diseases.
- Conditions
- Rosacea, Acne, Centella, Melasma
- Trial name
- NCT06763367
- Testing
- Face mask containing Centella sinensis
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Aging Problems, Pigmentation
16-Week Randomized Split-Face Efficacy Study of Cosmetic Formulations in Photoaged Pigmented Skin Subjects
The objective of this study is to determine the efficacy of seven different formulations currently marketed and commercially available cosmetic products on skin tone evenness, post-inflammatory hyperpigmentation, and discrete…
- Trial name
- NCT05160103
- Testing
- Cosmetic Formulations
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Avon Products, Inc.
Hyperpigmentation
Efficacy and Tolerability of the Tested Formula After 3 Months in Treatment of Facial Hyperpigmentation of 3 Origins
The objective of this study is to evaluate the efficacy, cosmetic acceptability and improvement of the stigmatization of the tested product (2039125 03) used bis in die (BID) for 3 months in adult patients suffering from mild to…
- Trial name
- NCT06268496
- Testing
- serum formula 2039125 03
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Non Therapeutic Body Modification
Post Market Safety Study and Effectiveness With Evolence in Subjects With Skin Color Types IV-VI
Approximately 165 subjects with Fitzpatrick Skin Color Types IV, V, and VI and a moderate to deep wrinkle between the corner of the nose and the corner of the mouth, will be treated with EVOLENCE® (an approved collagen filler) to…
- Trial name
- NCT00891774
- Testing
- EVOLENCE®
- Where
- 11 sites in United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Skin Roughness, Mottling
Efficacy and Safety Study of Kinerase® for Treatment of Cutaneous Facial Photodamage
The purpose of the K.I.S.S. study is to evaluate the efficacy of Kinerase® Cream (Kinetin 0.1%) in Thai patients, on the basis of the severity and clinical signs of facial photodamage.
- Conditions
- Skin Roughness, Mottling, Blotchiness, Pigmentation
- Trial name
- NCT01885091
- Testing
- Kinerase
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Menarini (Thailand) Limited
Acne, Post-inflammatory Hyperpigmentation
Clinical Efficacy of the Product in the Management of Facial Post Inflammatory Hyperpigmentation (PIHP) Subjects
Double-blind, randomized, clinical study is designed to evaluate the efficacy of Niacinamide A in the management of facial Post Inflammatory Hyper Pigmentation (PIHP) in healthy female and male subjects with moderate to severe…
- Trial name
- NCT06822335
- Where
- Mauritius
- Volunteers
- 65 people
- Sponsor
- Cosmetique Active International
Skin Pigmentation
Prospective Evaluation of Topical Almond Oil vs Hydroquinone
The purpose of this study is to analyze facial pigmentation and skin microbiome changes after topical almond oil application, compared to the use of topical hydroquinone.
- Trial name
- NCT04875715
- Testing
- Almond Oil, Hydroquinone Topical
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, Davis
Melasma
Study of Acid Peel and Laser for the Treatment of Melasma
The objective of this study is to evaluate laser treatment and acid peel for the treatment of melasma.
- Trial name
- NCT00467233
- Testing
- Laser Treatment, Acid Peel
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Northwestern University
Facial Hyperpigmentation
Open-label, Single-arm, Proof of Concept Study in Subjects with Mild-to-moderate Facial Hyperpigmentation
This research study will test how well hyperpigmentation treatment works for subjects with mild-to-moderate facial hyperpigmentation. The study will also test if the hyperpigmentation treatment causes any irritation.
- Trial name
- K-BRIGHT (NCT06473974)
- Testing
- Test cosmetic product
- Where
- 2 sites in United States
- Sponsor
- Kayuraeffect, LLP
Hyperpigmentation
Efficacy and Tolerability of the Tested Formula After 3 Months of Treatment of Facial Hyperpigmentation of 3 Origins
The objective of this study is to evaluate the efficacy, cosmetic acceptability and improvement of the stigmatization of the tested product (2039125 03) used bis in die (BID) for 3 months in adult patients suffering from mild to…
- Trial name
- NCT06234527
- Testing
- tested product
- Where
- Senegal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Hyperpigmentation, Melasma
Combined Q-switched Nd:YAG Laser and Platelet Rich Plasma Versus Q- Switched Nd:YAG Laser Alone in Melasma
Melasma is a common, acquired, esthetically disfiguring hypermelanosis of the face. Melasma is considered a disappointing challenge when treatment options are addressed.
- Conditions
- Hyperpigmentation, Melasma, PRP, Lasers
- Trial name
- NCT04765930
- Testing
- Q-switched nd:YAG laser toning
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Melasma (Facial Melasma), Melasma
Comparative Evaluation of Topical 30% Metformin and Kligman's Regimen in Women With Melasma
It's a prospective, randomised, assessor-blinded clinical study comparing topical 30% metformin with Kligman's regimen for melasma in women aged 35-55 years at Fauji Foundation Hospital, Rawalpindi.
- Trial name
- Melasma (NCT07485777)
- Testing
- Topical 30% metformin cream, Kligman's Regimen
- Where
- Pakistan
- Volunteers
- 82 people
- Sponsor
- Foundation University Islamabad
Melasma
Oral Tranexamic Acid and Laser for Treatment of Melasma
Tranexamic acid and 1927 diode laser non-ablative fractionated laser for the treatment of Melasma.
- Trial name
- NCT03686787
- Testing
- Tranexamic Acid
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Laser and Skin Surgery Center of New York