Clinical trials: Fascial Closure, open to volunteers
Hernia Incisional, Suture Materials
Fascial Abdominal Closure Evaluation
FACE (Fascial Abdominal Closure Evaluation) Trial is a prospective, single center, open-label, randomized trial of Duramesh versus PDS loop suture for midline incision fascial abdominal closure evaluation in patients with…
- Conditions
- Hernia Incisional, Suture Materials, Duramesh
- Trial name
- FACE (NCT07683546)
- Testing
- DURAMESH, (Ethicon) PDS II 1-0 double loop
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Ventral Hernia
Study of AGN-151607-DP to Assess Adverse Events and Change in Disease Activity in Adult Participants Undergoing Open Abdominal Ventral Hernia Repair
A ventral hernia happens when the muscles in the front of your belly become weak and let organs push through, causing a bulge. If it gets worse, intestines can slip into the bulge, leading to serious pain and health problems.
- Trial name
- NCT07226791
- Testing
- AGN-151607-DP
- Where
- 13 sites in United States
- Volunteers
- 200 people
- Sponsor
- AbbVie
Incisional Hernia Repair, Ventral Incisional Hernia
Standard Closure vs. Integrated Mesh-Fascial Closure (IMFC) for Incisional Hernia Repair
This study compares two surgical techniques for closing the abdominal wall in adult patients who have an incisional hernia (a weakness or opening in a previous surgical incision) or who require prophylactic mesh placement during…
- Trial name
- IMFC (NCT07843225)
- Testing
- Integrated Mesh-Fascial Closure, Standard Fascial Closure with Mesh
- Where
- Argentina
- Volunteers
- 60 people
- Sponsor
- Hospital Zonal General De Agudos Mario V Larrain
Laparotomy, Dehiscence Wound
Barbed Suture vs Non-Barbed Closure for Emergency Exploratory Laparotomy RCT
This randomized control trial aims to compare the efficacy of triclosan-coated barbed suture (TCB) versus conventional non-barbed polydioxanone (PDS) suture in the closure of the abdominal fascia after emergency exploratory…
- Conditions
- Laparotomy, Dehiscence Wound, Surgical Site Infections, Trauma Abdomen
- Trial name
- NCT06043414
- Testing
- triclosan-coated barbed suture, triclosan-coated non-barbed suture, Non-coated non-barbed suture
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Southern California
Ventral Incisional Hernia
Shear-Wave Elastography
Prospective cohort study of patients with midline ventral incisional hernia with a range of hernia morphology who plan to undergo open retromuscular VHR.
- Trial name
- ELASTOGRAPHY (NCT06306976)
- Testing
- Elective Midline Laparotomy, Imaging: Ultrasound, Tensiometry
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Prisma Health-Upstate
Hernia Abdominal Wall, Botox Injection
Preoperative BOTOX® Injection for Large Ventral Hernia Repair
This study is for adults who need open surgery to repair a very large abdominal (ventral) hernia. This study tests whether a one-time, image-guided injection of a medicine commonly known as "BOTOX®" (onabotulinumtoxinA) into the…
- Conditions
- Hernia Abdominal Wall, Botox Injection, Hernia Incisional Ventral, Hernia Repair With Compartment Syndrome
- Trial name
- PRETOX (NCT07220382)
- Testing
- OnabotulinumtoxinA Injection, OnabotulinumtoxinA, 0.9 % Normal Saline
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- The Cleveland Clinic
Open Abdomen, Incisional Hernia
Synthetic Mesh for Prevention of HernIa After opEn Abdomen cLosure stuDy
The aim of this clinical trial is to evaluate whether placement of a synthetic prophylactic onlay mesh during definitive fascial closure can reduce the incidence of incisional hernia in adult patients managed with an open abdomen…
- Conditions
- Open Abdomen, Incisional Hernia, Definitive Fascial Closure, Emergency Abdominal Surgery
- Trial name
- SHIELD (NCT07835334)
- Testing
- Definitive Fascial Closure Without Prophylactic Mesh, Prophylactic Onlay Mesh Placement
- Volunteers
- 30 people
- Sponsor
- Hospital San Juan de Dios Tenerife
Liver and Intrahepatic Bile Duct Neoplasm, Metastatic Malignant Neoplasm in the Liver
Short Stitch Versus Traditional Suture for the Prevention of Incisional Hernia After Open Hepatectomy
This clinical trial compares two different kinds of surgical closing techniques, short stitch suture or traditional suture, in patients who are having liver tumor surgery.
- Conditions
- Liver and Intrahepatic Bile Duct Neoplasm, Metastatic Malignant Neoplasm in the Liver, Primary Malignant Liver Neoplasm
- Trial name
- NCT04982653
- Testing
- Quality-of-Life Assessment, Surgical Procedure
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- M.D. Anderson Cancer Center
Open Abdomen, Temporary Abdominal Closure
Vacuum Assisted Wound Closure and Permanent On-lay Mesh-mediated Fascial Traction in Patients With Open Abdomen
Open abdomen therapy is used in trauma and non-trauma patients where the abdomen is not possible to close, or the intraabdominal conditions is not suitable for closure.
- Conditions
- Open Abdomen, Temporary Abdominal Closure, Incisional Hernia
- Trial name
- VAWCPOM (NCT05568238)
- Testing
- Vacuum Assisted Wound Closure and Permanent On-lay Mesh-mediated fascial traction (VAWCPOM)
- Volunteers
- 100 people
- Sponsor
- Skane University Hospital
Pain Score Reduction, Cesarian Section
Stratafix vs. PDS (Fascial Closure RCT)
This proposed prospective, randomized, single-blinded controlled trial will directly compare Stratafix anti-microbial barbed sutures and standard PDS sutures for fascial closure at the time of Cesarean delivery.
- Trial name
- NCT07574086
- Testing
- Polydioxanone Plus, Polydioxanone (PDS)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Arizona